ライフサイエンスコーパス: biotin

1 eacted with MTS-ethyl-ammonium-biotin (MTSEA-biotin).

2 playing desthiobiotin to vesicles displaying biotin.

3 used conjugation pairs, such as streptavidin-biotin.

4 arbitrary locus were covalently labeled with biotin.

5 l particles with either a fluorescent dye or biotin.

6 a mouse infection model with human levels of biotin.

7 terocycles including BODIPY fluorophores and biotin.

8 lumbosacral L6-S1 DRG injected with dextran biotin.

9 and disease history, to receive MD1003 (oral biotin 100 mg three times daily) or placebo.

10 t weaker binding in water as compared to the biotin[6]uril macrocycle.

11 compare the binding properties with that of biotin[6]uril, also studied in acetonitrile and in aqueo

12 ective one-pot synthesis from the macrocycle biotin[6]uril.

13 eline separation is achieved on all covalent biotin additions, for each charge state, for both the ly

14 The affinity of avidin for biotin allows biotinylated liposomes to complex in the p

15 ligase that uses ATP to convert biotin into biotin-AMP, a reactive intermediate that covalently labe

16 ough to survive lysis conditions, enabling a biotin analogue of ipomoeassin F to pull down Sec61alpha

17 evised to dual-labeling of PCR products with biotin and 6-FAM, which are then easily read on a latera

18 ucts (RCPs) pre-labelled simultaneously with biotin and an organic fluorophore.

19 interrogation, i.e., the grafting process of biotin and avidin was directly monitored optically displ

20 cules with low molecular weight that include biotin and many toxins in food.

21 BrdU, IdU as well as EdU alone or coupled to Biotin and other bulky adducts in synthetic DNA template

22 rbon was achieved using direct attachment of biotin and solid phase peptide synthesis (SPPS) of histi

23 By click labeling with biotin and staining with fluorescently labeled streptavi

24 bserved that the effect of fibre, magnesium, biotin and vitamin E on VFM was partially mediated by OT

25 can tolerate the introduction of aryl azide, biotin, and fluorescent rhodamine substituents to obtain

26 Unilateral injections of dextran-biotin (anterograde tracer; 20% in saline, 50-100 nl) we

27 In this competitive immunoassay anti-biotin antibody-modified magnetic beads (Ab-MBs) and bio

28 ld nanorod acting as a plasmonic antenna and biotin as a high-affinity biorecognition element.

29 ept, we demonstrate effective conjugation to biotin as a model for flexible co-targeting, addition of

30 In this study, we used biotin as a model molecule for hapten detection.

31 l-known complex formation between avidin and biotin as a model system.

32 and identified manipulation of the B-vitamin biotin as a potential therapeutic approach in tauopathy.

33 din and target activated affinity-switchable biotin (ASB) probes, for the detection of O(2)(-) and F(

34 erential insertion of a single affinity tag (biotin) at the precise position of target elements and s

35 Here, titrations with the purified ACCase biotin attachment domain-containing (BADC) and biotin ca

36 BIOTIN ATTACHMENT DOMAIN-CONTAINING (BADC) proteins lack

37 ENT DOMAIN-CONTAINING (BADC) proteins lack a biotin-attachment domain and are therefore inactive, but

38 r which encode a BioZ active site mutant are biotin auxotrophs, as are strains defective in CaiB whic

39 The biotin auxotrophy of the pyc::tn strain is due to failur

40 ion of the M. smegmatis tam gene resulted in biotin auxotrophy, and addition of biotin to M. smegmati

41 By pre-dosing with avidin, the biotin-avidin complex can be exploited to promote longer

42 On the example of biotin-avidin detection system it was demonstrated that

43 detection limit of 8.2 x 10(-19) molar for a biotin-avidin model, 10(5) times more sensitive than tha

44 mph nodes was demonstrated with the liposome-biotin-avidin system.

45 EdU-labeled DNA was conjugated to fluor- or biotin-azide and visualized by confocal, superresolution

46 roved equal or superior to streptavidin (SA)-biotin-based CD38-SA PRIT.

47 of a systematic study applying a variety of biotin-based proximity labeling approaches in several pl

48 approaches based on CRISPR interference and biotin-based proximity labeling, respectively.

49 ity, we implemented a commercially available biotin-benzophenone photo-cross-linking and purification

50 This leaves all four biotin binding sites free for at least bifunctional deli

51 sidual valency can be adjusted to one or two biotin binding sites per immobilized SAv by choosing app

52 posite sides of a flexible loop critical for biotin binding, creating streptavidin muteins (M88 and M

53 lytic performance, depending on the cofactor:biotin-binding site ratio.

54 ated cofactor precisely localized within the biotin-binding vestibule of the monovalent scdSav.

55 on a more precise genetic fine-tuning of the biotin-binding vestibule, unrivaled levels of activity a

56 uring which the ligase transferred activated biotin (BioAmp) to other proteins within the immediate v

57 esized by bacteria, fungi and plants, making biotin biosynthesis a target for antimicrobial developme

58 uted to the lack of attenuation observed for biotin biosynthesis genes during transposon mutagenesis

59 However, biotin biosynthesis has been overlooked for priority pat

60 ur model to uncover in vivo activity for the biotin biosynthesis inhibitor MAC13772.

61 and mice, and explains the failure of potent biotin biosynthesis inhibitors in standard mouse infecti

62 ria tuberculosis and Francisella tularensis, biotin biosynthesis is a key fitness determinant during

63 Our model suggests that biotin biosynthesis is essential during infection with A

64 Genes encoding proteins involved in biotin biosynthesis, protein synthesis and fatty acid bi

65 ilure to transcriptionally induce late stage biotin biosynthetic genes in low biotin conditions.

66 ich enables unrestricted use of streptavidin-biotin biotechnology in cellular uptake.

67 ed to exploit the full power of streptavidin-biotin biotechnology in cellular uptake.

68 g, strategies predicated on streptavidin and biotin, bispecific antibodies, complementary oligonucleo

69 ith tetrazines linked to either a peptide, d-biotin, BODIPY, or N-acetyl-d-galactosamine.

70 and subsequently, connected via streptavidin-biotin bonds to GOx.

71 , increase in the TR-FRET signal between the biotin-bound Eu(III)-labeled streptavidin donor and the

72 Replacement of the single biotin by the biotin-Si-NPs boosted on average a 30 fold

73 We also show that the large adduct Biotin can be distinguished from the smaller analog IdU,

74 ligation, followed by gentle shearing, ChIP, biotin capture and paired-end sequencing.

75 a method that combines RNAPIII mapping with biotin-capture of nascent tRNAs.

76 on the identification of surface labeled and biotin captured peptide fragments by LC/MS/MS.

77 acid), is known to provide seven of the ten biotin carbon atoms including all those of the valeryl s

78 lic acid moiety that contributes most of the biotin carbon atoms is unknown.

79 otin attachment domain-containing (BADC) and biotin carboxyl carrier protein (BCCP) subunits from Ara

80 carboxyltransferase (CT)-alpha, CT-beta, and biotin carboxyl carrier protein (BCCP1 or BCCP2).

81 ylase (LmPC), a biotin-dependent enzyme with biotin carboxylase (BC) and carboxyltransferase (CT) act

82 they can competently and independently bind biotin carboxylase (BC) but differ in responses to pH ch

83 al potency of pyridopyrimidine inhibitors of biotin carboxylase (BC) by up to 64-fold and 16-fold aga

84 enzyme consists of four catalytic subunits: biotin carboxylase (BC), carboxyltransferase (CT)-alpha,

85 The purified CD200-SA protein was bound to biotin-coated fluorescent polystyrene particles of vario

86 experiments included competition with native biotin, comparative tests using PET, histology, and ICPM

87 some formulation was combined with an avidin/biotin complex mechanism.

88 speed force spectroscopy on the streptavidin-biotin complex to determine the binding strength and unb

89 cement, supersandwich assembly, streptavidin/biotin complex, antibody amplification, enzymatic reacti

90 y ligand binding, as shown with streptavidin-biotin complexes.

91 xpressing BirA* fusions were exposed to high biotin concentrations for 24 h during which the ligase t

92 late stage biotin biosynthetic genes in low biotin conditions.

93 ed by binding, aggregation, and clearance of biotin (confirmed by histology).

94 A SAM-TCO biotin conjugate was used to label protein sulfenic acid

95 hich were then visualized with a cocktail of biotin-conjugated CD9, CD63, and CD81 antibodies.

96 The cysteine-biotin conjugates remained fully intact, demonstrating t

97 rge state, for both the lysine- and cysteine-biotin conjugates.

98 roteolytic stability, dephosphorylation, and biotin conjugation of the peptides are indispensable for

99 r activity and safety, based on streptavidin-biotin conjugation.

100 omplexes (PEG-GCSF; an IgG1k; IgG1- and IgG2-biotin covalent conjugates; the membrane protein complex

101 9 ligand-loaded particles using streptavidin-biotin cross-linking.

102 During unbinding, biotin crosses multiple energy barriers and visits vario

103 Chromatin contacts are captured by biotin-dATP incorporation and proximity ligation, follow

104 how that tau transgenic flies have an innate biotin deficiency due to tau-mediated relaxation of chro

105 iptome and metabolome responses to incipient biotin deficiency in seedling leaves.

106 insight into pathogenic mechanisms of human biotin deficiency, the resulting effects on neuronal hea

107 mitochondrial dysfunction as a mechanism in biotin deficiency.

108 In human cells, biotin-dependent carboxylases catalyze key reactions in

109 a cofactor of enzymes collectively known as biotin-dependent carboxylases.

110 assified as a moonlighting protein, with two biotin-dependent cytosolic metabolic roles and a distinc

111 nhibiting its pyruvate carboxylase (LmPC), a biotin-dependent enzyme with biotin carboxylase (BC) and

112 Biotin depletion alone causes mitochondrial pathology an

113 ses an antibody to a target antigen to guide biotin deposition onto adjacent proteins in fixed cells

114 Corticospinal axons traced from biotin-dextran-amine injections in the left motor cortex

115 genin, anti-tacrolimus) and small molecules (biotin, digoxigenin, tacrolimus) using the same platform

116 e-anchored transducer, and membrane-anchored biotin displayed on the surface of a second population o

117 is where fatty acid synthesis plus dedicated biotin enzymes produce the pimelate moiety.

118 pegylated LARLLT peptide and/or a glucose or biotin ethylene diamine group were synthesized, and the

119 Acyl-biotin exchange assay showed that Nav1.6 is modified by

120 m CPS into the cytosol through desthiobiotin-biotin exchange.

121 emonstrate a quantitative site-specific-Acyl-Biotin-Exchange (ssABE) method that allowed the identifi

122 The immunization potential of OVA-biotin-filariae was compared to that of an OVA-bound nan

123 red by 37 immunoassays, ingesting 10 mg/d of biotin for 1 week was associated with potentially clinic

124 rs [range, 31-45 years]) who took 10 mg/d of biotin for 7 days, biotin ingestion-associated interfere

125 ation of 1.7 muM (0.6 mug/mL) against Mtb in biotin-free medium.

126 idin-gold nanoparticles (strep-AuNPs) to the biotin-functionalized nanogap localizes AuNPs, thereby b

127 diated the specific in vitro uptake of 100nm biotin-functionalized nanoparticles by Raji and Jurkat l

128 absent, the solution was transparent because biotin-GNPs bound to Ab-MBs which were caught by an exte

129 ing of the sample and Ab-MBs, the capture of biotin-GNPs by Ab-MBs and the magnetic attraction.

130 d biotinylated thiol-DNA gold nanoparticles (biotin-GNPs) were used.

131 est upon irradiation with UV light, and 3) a biotin group which allowed affinity purification of the

132 was then immobilized via coordination of the biotin groups with the NTA-Cu(II) complex.

133 be completely removed by 3min injections of biotin, guanidinium thiocyanate, pepsin, and SDS, which

134 and new C-C bond formation in the absence of biotin has remained a mystery since these enzymes were d

135 buffer compositions, type of detection tag (biotin, His- or cMyc-tag), and spacer length.

136 erase, binding of a ternary complex of T(30)-biotin/horseradish peroxidase (HRP)-biotin/streptavidin

137 dues with 2,2'-dithiodipyridine prior to the biotin-HPDP reaction.

138 Through proximity-dependent biotin identification (BioID) and co-immunoprecipitation

139 e performed the unbiased proximity-dependent biotin identification (BioID) approach to define TRIM9 a

140 ractome of NP1 using the proximity-dependent biotin identification (BioID) assay combined with mass s

141 we apply a chemicogenetic approach, in vivo biotin identification (iBioID), to discover aspects of t

142 nderstand this functional interplay, we used Biotin Identification in human embryonic kidney cells to

143 J recombination, we used proximity-dependent biotin identification to analyze the interactomes of ful

144 o-proteome profiling and proximity-dependent biotin identification to identify hCDC14A substrates.

145 e protein-ligand binding pairs (streptavidin/biotin; IgG/anti-IgG) were quantified.

146 ynthesis pathway is a bona fide precursor of biotin in B. subtilis.

147 Excess biotin in blood due to supplemental biotin ingestion may

148 s review, we discuss the function of HCS and biotin in metabolism and human disease, a putative role

149 consider the 40-fold higher concentration of biotin in mouse plasma compared to human plasma.

150 lyzes the second step in the biosynthesis of biotin in Mycobacterium tuberculosis (Mtb) and is an ess

151 system, which labels proximal proteins with biotin in vivo, to study the protein-protein interaction

152 C both in vivo and in vitro and complemented biotin-independent growth of the M. smegmatis tam deleti

153 arbon source.Some aerobic bacteria contain a biotin-independent malonate decarboxylase (MDC), which a

154 as species and other aerobic bacteria have a biotin-independent malonate decarboxylase that is crucia

155 ent cytosolic metabolic roles and a distinct biotin-independent nuclear coregulatory function.

156 Excess biotin in blood due to supplemental biotin ingestion may affect biotin-streptavidin binding,

157 ars]) who took 10 mg/d of biotin for 7 days, biotin ingestion-associated interference was found in 9

158 In contrast, although MTSEA-biotin inhibited 9 of 10 TM10 cysteine-substituted mutan

159 Preadministration of nonradioactive biotin inhibited organ uptake and increased excretion.

160 At eight positions, MTSEA-biotin inhibited transport, and at four positions substr

161 Avidin-biotin interaction is one of the strongest non-covalent

162 eered biotin ligase that uses ATP to convert biotin into biotin-AMP, a reactive intermediate that cov

163 Biotin is an essential cofactor utilized by all domains

164 The vitamin biotin is an essential nutrient for the metabolism and s

165 Biotin is attached to apocarboxylases by a biotin ligase

166 The water-soluble vitamin biotin is essential for cellular growth, development, an

167 show that intravenously administered [(11)C]biotin is quickly distributed to the liver, kidneys, ret

168 gh affinity binding between streptavidin and biotin is widely exploited, the accompanying low rate of

169 antigen-antibody, DNA-DNA, and streptavidin-biotin) is a generic, yet highly versatile and powerful

170 Vitamin H (biotin) is delivered to the fetus transplacentally by an

171 we present the chiral macrocyclic structure biotin-l-sulfoxide[6]uril as a host molecule that binds

172 The biotin-l-sulfoxide[6]uril generally exhibits stronger re

173 Biotin-l-sulfoxide[6]uril is prepared in a highly diaste

174 Using a biotin-labeled artemisinin, we identified the intermedia

175 We also used biotin-labeled ghrelin to visualize ghrelin binding site

176 This approach utilizes a novel biotin-labeled polymer-mediated signal amplification pro

177 The sensor incorporates two identical biotin-labeled truncated aptamers, one of which is immob

178 restingly, immunoprecipitation studies using biotin-labeled viral dsRNA or poly(I.C) and cell lysate-

179 Proximity-dependent biotin labeling (BioID) may identify new targets for can

180 a protein of interest, enabling the covalent biotin labeling of proteins and subsequent capture and i

181 elements by combining the simplicity of RNA biotin labeling with the specificity of the CRISPR/Cas9

182 examination of double-stranded breaks using biotin-labeling DNA break assay, and End-seq analysis in

183 Third, biotin labels are detected by scanning the microarray su

184 Finally, carboxylase biotin levels are reduced in mammalian tauopathies, incl

185 Our model addresses the disconnect in biotin levels between humans and mice, and explains the

186 ch these products are immobilized by a fixed biotin-ligand and visualized with anti-FAM antibody-coat

187 inylation (RNA-BioID) technique by tethering biotin ligase (BirA*) via MS2 coat protein at the 3' UTR

188 ID is a method that exploits a "promiscuous" biotin ligase (BirA118R or BirA*) to identify proteins w

189 asmic regions of a "bait" protein with BioID biotin ligase and identify proximal proteins that are bi

190 By fusing eCRs to the biotin ligase BASU, we established ChromID, a method for

191 Here, we show that fusion of the promiscuous biotin ligase BirA(R118G) with RAD18 leads to localized

192 We engineered a biotin ligase into a coronaviral replication/transcripti

193 ximity labeling techniques use a promiscuous biotin ligase or a peroxidase fused to a protein of inte

194 TurboID is an engineered biotin ligase that uses ATP to convert biotin into bioti

195 gical improvements, namely two highly active biotin ligase variants (TurboID and miniTurbo), allowed

196 ly higher activity than previously described biotin ligase-related proximity labeling methods, such a

197 Biotin is attached to apocarboxylases by a biotin ligase: holocarboxylase synthetase (HCS) in mamma

198 We target the biotin-ligase BirA* to the AIS by generating fusion prot

199 chmark the efficiency of various promiscuous biotin ligases in comparison with one-step affinity puri

200 C-terminally biotinylated dCas9, endogenous biotin ligases, and pooled sgRNAs, we describe the dCas9

201 signed a ZEA mimicking peptide extended by a biotin-linker and confirmed its excellent suitability to

202 anscripts, with 4SU residues being tagged by biotin linkers and captured using streptavidin beads bef

203 alue accuracy can be obtained for the higher biotin-load when using standard ESI conditions as oppose

204 ighlighting an intriguing connection between biotin, lysine metabolism and systemic disease resistanc

205 in transducing surface and the dual-function biotin-MB-AuNPs bio-label, provides a simple and robust

206 eate an integrated, dual function bio-label (biotin-MB-AuNPs) for both biorecognition and signal gene

207 High-dose, pharmaceutical-grade biotin (MD1003) might enhance neuronal and oligodendrocy

208 Capture of the miR-96 targetome by biotin-miR-96 identified that RARgamma and a number of R

209 After labeling the hybridized biotin-miRNA with streptavidin-HRP conjugates, amperomet

210 A biotinylated miRNA (biotin-miRNA) of identical sequence to that of the targe

211 in insect cells and efficiently displayed on biotin-modified mouse islet surface without a negative i

212 Immunohistochemistry using a biotin-modified peptide (RK-10-Biotin) was tested agains

213 oxygen-cleavable aminoacrylate linker, and a biotin moiety as a tumor-targeting ligand.

214 The single biotin moiety at the C-terminus and the small size of th

215 When biotin molecules were absent, the solution was transpare

216 ent residues reacted with MTS-ethyl-ammonium-biotin (MTSEA-biotin).

217 ovirus uptake exceed the binding strength of biotin-neutravidin anchoring viruses to a biofunctionali

218 ynucleotidyl transferase (TdT)-mediated dUTP-biotin nick end labeling (TUNEL) assays revealed that S.

219 l deoxynucleotidyl transferase-mediated dUTP-biotin nick end labeling assay and Hoechst staining.

220 transcription is coregulated with the other biotin operon genes.

221 eous UCNPs covered with carboxylated silica, biotin, or streptavidin with recovery rates of 30 to 50%

222 This was demonstrated using avidin-biotin particles as a simple bead-based bioassay model.

223 The biotin pathway genes responsible for pimelate moiety syn

224 We detected GFP with pre-embedding avidin-biotin-peroxidase and GABA with post-embedding immunogol

225 [(11)C]Biotin PET imaging therefore provides a dynamic in vivo

226 Biotin plays an essential role in growth of mycobacteria

227 lementation with pimelic acid fully restored biotin production in cerulenin-treated cells.

228 SVG or a RUSH GPI-anchored construct using a biotin pulse to release the marker proteins from the ER.

229 A biotin pulse-chase/subcellular fractionation approach to

230 seedling phenotypes identified mutations in biotin, pyridoxine and niacin biosynthetic pathways.

231 r-positive HepG2 cells compared with the low biotin-receptor-expressed HCT-116 cells used as the nega

232 jugate showed preferential uptake toward the biotin-receptor-positive HepG2 cells compared with the l

233 d consequent aberrant expression of multiple biotin-related genes, disrupting both carboxylase and mi

234 e this architecture to create ultrasensitive biotin-responsive imaging agents, which we apply for wid

235 Replacement of the single biotin by the biotin-Si-NPs boosted on average a 30 fold chemiluminesc

236 Characterization of biotin-Si-NPs onto a paper with immobilized DNA was done

237 emonstrated that the new dot blot coupled to biotin-Si-NPs successfully detected Campylobacter from n

238 he use of biotinylated silica-nanoparticles (biotin-Si-NPs).

239 CRISPR-dCas9 system to guide synthetic tags (biotin) site-specifically on chromatin employing copper-

240 s an early metabolic response to sub-optimal biotin status highlighting an intriguing connection betw

241 APE-Seq by developing a sequence-independent biotin-streptavidin (SAv) roadblocking strategy that sim

242 Using biotin-streptavidin (Sav) technology, artificial copper

243 to supplemental biotin ingestion may affect biotin-streptavidin binding, leading to potential clinic

244 ated to horseradish peroxidase (HRP) through biotin-streptavidin binding.

245 The biotin-streptavidin bond is the strongest noncovalent bo

246 Probing the force-dependent lifetime of biotin-streptavidin bonds, we find that monovalent strep

247 steps, thus avoiding the general paradigm of biotin-streptavidin chemistry and iii) a microfluidic pl

248 unctionalization strategy was connected with biotin-streptavidin interactions to demonstrate the capa

249 The biotin-streptavidin technology has been extensively expl

250 of T(30)-biotin/horseradish peroxidase (HRP)-biotin/streptavidin to the poly(A) tails, and the oxidat

251 ta indicate that mycobacterial cells monitor biotin sufficiency through a metabolic signal generated

252 prevalence and trends in use of high-dosage biotin supplementation among US adults between 1999 and

253 ngs should be considered for patients taking biotin supplements before ordering blood tests or when i

254 Pre-saturation of the transporters with free biotin suppressed b-BSA-Gd-DTPA uptake.

255 e form of pimelic acid is an intermediate in biotin synthesis although this is not the case in E. col

256 nscription is not coregulated with the other biotin synthesis genes.

257 The essentiality of BioW for biotin synthesis indicates that the free form of pimelic

258 domonas aeruginosa the bioH gene is within a biotin synthesis operon and its transcription is coregul

259 Although the late steps of mycobacterial biotin synthesis, assembly of the heterocyclic rings, ar

260 ichia coli) the gene is not located within a biotin synthetic operon and its transcription is not cor

261 Biotin synthetic pathways are readily separated into two

262 ies of the coupled moieties makes the avidin-biotin system a versatile platform for nanotechnology.

263 h as little as 12% (v/v) phenol, leaving the biotin tag active and reusable after extraction.

264 UV exposure at different time points, and a biotin tag for subsequent enrichment and mass spectromet

265 gase and identify proximal proteins that are biotin tagged on both their extracellular and intracellu

266 om-temperature phenol is employed to release biotin-tagged DNA constructs from streptavidin rapidly a

267 real-time PCR, immunoblots, reporter assays, biotin-tagged promoter pulldown with proteomics, and los

268 ed regions, an RNA fragmentation step before biotin tagging was introduced, in an approach known as t

269 pid II by photo-cross-linking and subsequent biotin-tagging.

270 ide tools to insert 3xHA, His(6)FLAG, His(6)-Biotin-TEV-RGSHis(6), mCherry, GFP, and the auxin-induci

271 on with amine groups and covalently attached biotin, the device has been applied for label-free biose

272 ecies modulated the availability of iron and biotin to bacterial species, which suggests that these m

273 sulted in biotin auxotrophy, and addition of biotin to M. smegmatis cultures repressed tam gene trans

274 The SP was labelled with biotin to measure current signal by means of a final inc

275 angle resulting from successful binding of d-biotin to streptavidin immobilized on functionalized acr

276 ovel peptides that mimic key interactions of biotin to streptavidin.

277 de molecule tagged with a fluorescent dye or biotin to the alkyne of the analog, which can then be us

278 eptavidin-SBP interaction by the addition of biotin to the culture medium rapidly dissociates the mot

279 ography (PET) radionuclide carbon-11 ([(11)C]biotin) to enable the quantitative study of biotin traff

280 dynamic in vivo map of transporter-mediated biotin trafficking in healthy rodents.

281 his technique will enable the exploration of biotin trafficking in humans and its use as a research t

282 ]biotin) to enable the quantitative study of biotin trafficking in vivo.

283 d to the fetus transplacentally by an active biotin-transport mechanism and is critical for fetal dev

284 he placenta's perfusion pattern modulated by biotin transporter activity and trophoblast mediated ret

285 op a comprehensive MRI technique for mapping biotin transporter activity in the murine placenta.

286 -consistent with the known expression of the biotin transporter-and there is a surprising accumulatio

287 mab conjugated to emtansine via streptavidin-biotin (Trastuzumab-SB-DM1) to the clinically approved t

288 eline (day 0) measures on the seventh day of biotin treatment and 7 days after treatment had stopped

289 Additional genes for reactions involved in biotin, ubiquinone, and pyridoxine biosynthesis in Z. mo

290 olism, HCS participates in the regulation of biotin utilization and acts as a nuclear transcriptional

291 Streptavidin-biotin was chosen as a model system for evaluating the s

292 filarial proteins with fluorescent probes or biotin was not immediately detrimental to larval movemen

293 When biotin was present, the supernatant was red because the

294 Orally administered [(11)C]biotin was rapidly absorbed in the small intestine and s

295 istry using a biotin-modified peptide (RK-10-Biotin) was tested against the FDA-approved SP263 clone

296 unit, cholera toxin B Subunit, modified with biotin, was then immobilized via coordination of the bio

297 mmobilized surface will be activated to form biotin, which can then bind with the enzyme-tagged strep

298 Thus, biotin, which has a dissociation constant 3 orders of ma

299 -RA16 in the extents of RNA modifications by biotin, which may affect RA16's anti-tumor effects.

300 This paper describes the radiolabeling of biotin with the positron emission tomography (PET) radio