ライフサイエンスコーパス: birth defect

1 olated clefts (those occurring without other birth defects).

2 art disease (CHD) is the most common type of birth defect.

3 w therapeutic targets to prevent this common birth defect.

4 mation of the head and the third-most common birth defect.

5 action in a multifactorial model of a common birth defect.

6 nital diaphragmatic hernia (CDH) is a severe birth defect.

7 ic hernias (CDHs), a common and often lethal birth defect.

8 te (CP) is the second most common congenital birth defect.

9 information concerning this prevalent human birth defect.

10 NAD synthesis as potential causes of complex birth defects.

11 irus (HCMV) is a leading cause of congenital birth defects.

12 e immunosuppressed and is a leading cause of birth defects.

13 ntly been shown to be associated with severe birth defects.

14 cases in our sample cohort of varied ocular birth defects.

15 foods with folic acid to prevent neural tube birth defects.

16 of pregnant mothers was linked to congenital birth defects.

17 ter chromosome segregation cause significant birth defects.

18 (CHD) is the leading cause of mortality from birth defects.

19 tinues to be the leading infectious cause of birth defects.

20 sis is essential to prevent miscarriages and birth defects.

21 highly associated with an increased risk of birth defects.

22 ng that CL/P is among the most common of all birth defects.

23 derlies human diseases, including cancer and birth defects.

24 s or infants had evidence of Zika-associated birth defects.

25 t exposures and the risk of specific cardiac birth defects.

26 ne flavivirus, causes devastating congenital birth defects.

27 e world's population and is a major cause of birth defects.

28 n and is the most common infectious cause of birth defects.

29 thus implicating new genes in cardiovascular birth defects.

30 n and aneuploidy, contributing to cancer and birth defects.

31 ts (CHDs) are the most common group of major birth defects.

32 after ART had a higher prevalence of certain birth defects.

33 has been associated with increased risks for birth defects.

34 llmark symptoms of deficiency like anemia or birth defects.

35 ch comprise over one-third of all congenital birth defects.

36 ns in which result in highly prevalent human birth defects.

37 679A and R695H) in a novel syndromic form of birth defects.

38 ilure underlies several clinically important birth defects.

39 ower transcription of pathways implicated in birth defects.

40 ), comprise over one-third of all congenital birth defects.

41 aterality is associated with multiple severe birth defects.

42 alies (CPAs) are among the most common human birth defects.

43 ression and is a leading cause of congenital birth defects.

44 to a higher incidence of diabetes-associated birth defects.

45 ategy for intervention in certain classes of birth defects.

46 ncer and prevention of human miscarriage and birth defects.

47 n resolving gene-environment interactions in birth defects.

48 ated with cerebellar abnormalities and other birth defects.

49 sure and thus might underlie some congenital birth defects.

50 ngenital HCMV infection is a major cause for birth defects.

51 n to efforts to prevent isotretinoin-induced birth defects.

52 Cardiac abnormalities are the most common birth defects.

53 es regarding the potential causes of cardiac birth defects.

54 disturbance can produce clinically important birth defects.

55 ns for the biomedicine of sertraline-induced birth defects.

56 egnancy and can cause microcephaly and other birth defects.

57 clefts (OFCs), one of the most common human birth defects.

58 ounts for ~40% of deaths in US children with birth defects.

59 Cleft lip is one of the most common human birth defects.

60 in the child such as microcephaly and other birth defects.

61 such regulations can result in craniofacial birth defects.

62 ity screens to prevent pregnancy failure and birth defects.

63 em for future investigations of HCMV-induced birth defects.

64 microcephaly and less frequently with other birth defects.

65 emic in the Americas that is associated with birth defects.

66 B1 receptor antagonist attenuated CB-induced birth defects.

67 cases associated with microcephaly and other birth defects (2,366 confirmed by 31 December 2016).

68 jects with CHD and 10 832 with no structural birth defects, 2807 (50%) and 6355 (59%) were linked, re

69 lying causes of child deaths were congenital birth defects (39 [13%] of 304 deaths), lower respirator

70 ter the exclusion of pregnancies affected by birth defects, 409 of 5426 (8%) resulted in preterm birt

71 ntly higher risks than no exposure for major birth defect (65 cases among 1665 exposed pregnancies an

72 tal abnormalities were classified as a major birth defect according to the European Concerted Action

73 Birth defects affect 3% of children in the United States

74 nital heart disease (CHD) is the most common birth defect, affecting about 0.8% of live births.

75 al heart disease (CHD) is the most prevalent birth defect, affecting nearly 1% of live births; the in

76 t patients and is the leading viral cause of birth defects after congenital infection.

77 lant patients and the leading viral cause of birth defects after congenital infection.

78 the utility of AXL inhibitors for preventing birth defects after infection and suggest that further s

79 minary proportion of fetuses or infants with birth defects after maternal Zika virus infection by tri

80 There were 21 infants with birth defects among 395 live births and 5 fetuses with b

81 cts among 395 live births and 5 fetuses with birth defects among 47 pregnancy losses.

82 periconceptional period), with no reports of birth defects among fetuses or infants with prenatal exp

83 A large-scale epidemiologic survey of birth defects among infants born during 2010-2013, was c

84 omegalovirus (CMV) is a significant cause of birth defects among newborns infected in utero and morbi

85 use of assisted hatching was associated with birth defects among singleton births (aRR, 1.55; 95% CI,

86 an ventral wall closure are a major class of birth defect and a significant health burden.

87 nital heart disease (CHD) is the most common birth defect and brings with it significant mortality an

88 Congenital heart defects are the most common birth defect and have a clear genetic component, yet onl

89 sorder (FASD), the most frequent preventable birth defect and neurodevelopmental disability syndrome.

90 It is the most common human birth defect and yet, even with the application of moder

91 galovirus (HCMV) is the major viral cause of birth defects and a serious problem in immunocompromised

92 ernal DNA during meiosis causes infertility, birth defects and abortions.

93 of Zika virus and its unexpected linkage to birth defects and an autoimmune neurological syndrome ha

94 s the most common infectious cause of infant birth defects and an etiology of significant morbidity a

95 s account for approximately one-third of all birth defects and are a significant cause of infant mort

96 (retinol) deficiency poses a risk for ocular birth defects and blindness.

97 ure of neural tube closure results in severe birth defects and can be induced by high glucose levels

98 lizing antibody.Importance Zika virus causes birth defects and can lead to neurological disease in ad

99 in adults; abnormal HH signaling can lead to birth defects and cancer.

100 to control a signaling system that can cause birth defects and cancer?

101 terations in Hedgehog (Hh) signaling lead to birth defects and cancers including medulloblastoma, the

102 r diverse pathologies, including cold sores, birth defects and cancers.

103 its misregulation is implicated in numerous birth defects and cancers.

104 k factors could increase the risk of overall birth defects and cardiovascular system malformation amo

105 ation, given that HCMV is a leading cause of birth defects and causes severe infection in immunocompr

106 netic origins of CIN that lead to congenital birth defects and early pregnancy loss, as well as the m

107 ic variation that is associated with cancer, birth defects and eukaryotic micro-organisms(1-4).

108 ase, but is linked to devastating congenital birth defects and Guillain-Barre syndrome in adults.

109 emic in the Americas is linked to congenital birth defects and Guillain-Barre syndrome.

110 cause aneuploidies responsible for cancers, birth defects and infertility, this new insight into cen

111 uires exceptionally high fidelity to prevent birth defects and infertility.

112 Human cytomegalovirus (HCMV) causes birth defects and it can cause life-threatening diseases

113 understanding of the etiology of associated birth defects and medical conditions among those with tr

114 to many of the structural and developmental birth defects and medical problems seen in individuals w

115 ngs that ZIKV infections are associated with birth defects and neurologic disease, and that the virus

116 in signaling may have implications for renal birth defects and other diseases.

117 se their fetuses to an infection that causes birth defects and other problems.

118 rus (ZIKV) has recently been associated with birth defects and pregnancy loss after maternal infectio

119 (CAKUT) constitute one of the most frequent birth defects and represent the most common cause of chr

120 opment and its deregulation in humans causes birth defects and several types of cancer.

121 isk in the manifestation of diabetes-related birth defects and shed light on environmental risk facto

122 ging translational evidence of genitourinary birth defects and their impact on male infertility.

123 Congenital heart disease is the most common birth defect, and because of major advances in medical a

124 mia, small for gestational age infant (SGA), birth defect, and perinatal infant death.

125 disorders represent the most common of human birth defects, and anomalies in cardiomyocyte proliferat

126 ases due to folate inadequacy (e.g., anemia, birth defects, and cancer).

127 rbation can lead to developmental disorders, birth defects, and cancers.

128 ) is one of the leading causes of nongenetic birth defects, and development of a prophylactic vaccine

129 ergistic effects of multiple risk factors on birth defects, and examine temporal trend of the synergi

130 ving bariatric surgery was a risk factor for birth defects, and particularly heart and musculoskeleta

131 population, is a leading cause of congenital birth defects, and poses serious risks for immuno-compro

132 onship between bariatric surgery and risk of birth defects are conflicting.

133 he etiology and pathogenesis of craniofacial birth defects are multifactorial and include both geneti

134 ns, and contradicted hypotheses arguing that birth defects are related to a chaotic and random disarr

135 rs had a higher prevalence of nonchromosomal birth defects (aRR, 1.53; 95% CI, 1.13-2.06) than those

136 ses and prevention of a suite of devastating birth defects, as well as basic evolutionary and develop

137 dings have relevance for understanding renal birth defects, as well as efforts to recapitulate nephro

138 Understanding the risk of birth defects associated with Zika virus infection durin

139 ms by which antiepileptic drugs (AEDs) cause birth defects (BDs) are unknown.

140 fection during pregnancy is linked to severe birth defects, but mother-to-fetus transmission routes a

141 Methods for ascertaining birth defect cases varied by state.

142 Cleft palate is a common birth defect caused by disruption of palatogenesis durin

143 ident by severe limb malformations and other birth defects caused by T-box3 mutations in humans.

144 Craniosynostosis is a prevalent human birth defect characterized by premature fusion of calvar

145 livery, maternal adverse effects, congenital birth defects, childhood cancer.

146 Among the birth defects, congenital heart disease and craniofacial

147 ng data from mothers of babies without major birth defects (controls) from the National Birth Defects

148 r eukaryotic parasite that causes congenital birth defects, disease in immunocompromised individuals,

149 f childbearing age and assessing the risk of birth defects during pregnancy.

150 n cause severe disease, including congenital birth defects during pregnancy.

151 ea-esophageal separation leads to the common birth defect esophageal atresia with or without trachea-

152 as associated with a decreased prevalence of birth defects, especially in the cardiovascular system a

153 els promises to advance our understanding of birth defect etiology and improve the identification and

154 Overlooking gene-environment interactions in birth defect etiology limits our ability to identify and

155 g pregnancy is associated with high risks of birth defects/fatality and adverse long-term postnatal h

156 cal abnormalities, cognitive impairment, and birth defects, fetal alcohol spectrum disorder is underd

157 Cleft palate is a common major birth defect for which currently known causes account fo

158 comes, including Guillain-Barre syndrome and birth defects, has brought an urgent need for animal mod

159 KV) epidemic in the Americas and its link to birth defects have attracted a great deal of attention,

160 Recently, birth defects have been observed in patients with varian

161 ponent(s) of cigarette smoke is causative in birth defects, however these data indicate that nicotine

162 to teratogenic compounds can lead to various birth defects; however current animal-based testing is l

163 in miscarriages and are the leading cause of birth defects; however, the molecular origins of these d

164 ated with increased risks for nonchromosomal birth defects; however, these associations may be caused

165 be transmitted sexually and cause congenital birth defects, immune control mechanisms in the female r

166 (CP) is one of the most common craniofacial birth defects, impacting about 1 in 800 births in the US

167 ing host-virus interactions and HCMV-induced birth defects.IMPORTANCE Human cytomegalovirus (HCMV) is

168 Cleft palate is a common birth defect in humans.

169 Congenital heart disease is the most common birth defect in newborns and the leading cause of death

170 hsprung disease (HSCR) is a life-threatening birth defect in which the distal colon is devoid of ente

171 ut 1 in 6000 live births and causes multiple birth defects in affected infants.

172 r ZIKV was epidemiologically associated with birth defects in Brazil late in 2015, researchers capita

173 OGT could be a candidate approach to prevent birth defects in diabetic pregnancies.

174 ed the association of bariatric surgery with birth defects in future pregnancies in a large cohort of

175 Orofacial clefts are among the most common birth defects in humans worldwide.

176 eft palate (CL/P), are among the most common birth defects in humans, affecting approximately 1 in 70

177 Congenital heart defects are the most common birth defects in humans, and those that affect the prope

178 lmia (no eye) and microphthalmia (small eye) birth defects in humans-yet its regulation is not well u

179 OFC), which are the most common craniofacial birth defects in humans.

180 of the causes of the frequent lateral facial birth defects in humans.

181 p and/or palate (CL/P) are common structural birth defects in humans.

182 esult in anencephaly, one of the most common birth defects in humans.

183 t palate is among the most common structural birth defects in humans.

184 ng illness in infected adults and congenital birth defects in infants born to mothers infected during

185 l Birth Register data to investigate risk of birth defects in infants born to women who had Roux-en-Y

186 y was associated with 1.20 times the risk of birth defects in later pregnancies (95% CI: 1.01, 1.43),

187 dds ratios (aORs) in a case-control study of birth defects in Massachusetts with complete quarterly 1

188 annabinoids (CBs) potentiate alcohol-induced birth defects in mice and zebrafish, and explored the un

189 ation between folic acid supplementation and birth defects in Northwestern China.

190 utbreaks of Zika virus (ZIKV) and associated birth defects in regions of dengue virus (DENV) endemici

191 mycin and TMP-SMX was associated with select birth defects in some studies.

192 of Biologists Workshop 'Understanding Human Birth Defects in the Genomic Age' held in the UK in Nove

193 Structural birth defects in the kidney and urinary tract are observ

194 cytomegalovirus (HCMV) is a leading cause of birth defects in the United States.

195 us (ZIKV) is a flavivirus linked to multiple birth defects including microcephaly, known as congenita

196 Disruption of Shh signaling is linked to birth defects, including holoprosencephaly (HPE), a malf

197 Zika virus (ZIKV) have been associated with birth defects, including microcephaly and neurologic imp

198 lovirus (HCMV) is the leading viral cause of birth defects, including microcephaly, neurological defi

199 Diabetes mellitus in early pregnancy causes birth defects, including neural tube defects (NTDs).

200 to these cause a significant number of human birth defects, including ocular coloboma.

201 h the subtler manifestations of HCMV-induced birth defects, infection dramatically altered neurologic

202 Our findings have important implications for birth defect intervention with folic acid supplementatio

203 rtance: Giving birth to a child with a major birth defect is a serious life event for a woman, yet li

204 molecular connection between EMC1 and these birth defects is lacking.

205 A leading cause of human birth defects is the incomplete fusion of tissues, often

206 CHDs), which are among the most common human birth defects, is poorly understood because of its compl

207 79A and R695H in a heterozygous state caused birth defects, it would be via haploinsufficiency of MYR

208 lasma gondii is a major health risk owing to birth defects, its chronic nature, ability to reactivate

209 break in Singapore, and the first reports of birth defects linked to ZIKAV in the region.

210 Case-control studies of birth defects might be subject to selection bias when th

211 ort study using data from the North Carolina Birth Defects Monitoring Program, North Carolina Departm

212 ight, small for gestational age, stillbirth, birth defects, neonatal death), results were mixed and d

213 us associated pathologies, including cancer, birth defects, neuropathy, cardiovascular disease, chron

214 he risk of folic acid-responsive neural tube birth defects (NTDs).

215 Birth defects occur in up to 3% of all live births and a

216 Cleft palate (CP) is a common birth defect occurring in 1 in 2,500 live births.

217 Congenital heart disease (CHD), a prevalent birth defect occurring in 1% of newborns, likely results

218 ft lip and/or palate (NSCL/P) is a prevalent birth defect of complex etiology.

219 However, nonsyndromic birth defects often exhibit non-Mendelian inheritance, i

220 ) signaling and aberrant HH signaling causes birth defects or cancers.

221 ysregulation of the cytoskeleton can lead to birth defects or enable cancer progression.

222 They often have specific birth defects or other physical abnormalities that sugge

223 ations in regulatory sequences can result in birth defects or predisposition to disease.

224 Both scenarios can result in severe birth defects or pregnancy loss.

225 There was no significant increase in birth defects or pup deaths resulting from prenatal apig

226 Women with DM also had a higher risk of birth defect (OR 1.42; 95% CI 1.15-1.91; P = 0.002).

227 noptimal folic acid supplementation (overall birth defects: OR = 0.71, 95% CI = 0.57-0.89, P = 0.003;

228 pation, could not be reached by mail, or had birth defects other than clefts.

229 ation between folic acid supplementation and birth defects other than neural tube defects remains unc

230 Some relate to birth defects other than neural tube defects, neurologic

231 infection has been linked to severe clinical birth defects, particularly microcephaly, warranting urg

232 , or CP 55,940 caused a greater incidence of birth defects, particularly of the eyes, than did either

233 which 12 (4%; 2-6) were adjudicated as major birth defects potentially related to DOAC exposure.

234 nce of possible recent Zika virus infection, birth defects potentially related to Zika virus were ide

235 Birth defects potentially Zika associated: brain abnorma

236 eroids of any potency with mode of delivery, birth defects, preterm delivery, fetal death, and low Ap

237 llustrative example using data from National Birth Defects Prevention Study (1997-2009) to examine th

238 ld Cohort Study, 1999-2009; and the National Birth Defects Prevention Study (United States), 1999-200

239 Data from the National Birth Defects Prevention Study (United States, 1997-2006

240 ng data directly available from the National Birth Defects Prevention Study and other published infor

241 nd hypospadias, using data from the National Birth Defects Prevention Study, a population-based case-

242 r birth defects (controls) from the National Birth Defects Prevention Study, we examined the relation

243 s or infants had evidence of Zika-associated birth defects, primarily brain abnormalities and microce

244 virus (HCMV) infection is a leading cause of birth defects, primarily manifesting as neurological dis

245 for symptomatic Zika virus disease (ZVD) and birth defects provided complementary information on the

246 is a leading cause of central nervous system birth defects, ranging from microcephaly to hearing impa

247 After propensity score matching, the overall birth defect rate, cardiovascular system defect rate and

248 , we linked state educational records with a birth defects registry and birth certificates.

249 hese relationships using data from the Texas Birth Defects Registry and statewide vital records for d

250 ed ART surveillance, birth certificates, and birth defects registry data for 3 states (Florida, Massa

251 essed conditions and is the leading cause of birth defects related to infectious disease.

252 ch maternal TH insufficiency results in this birth defect remains unknown.

253 the Brazilian ZIKV (ZIKV(BR)) strain causes birth defects remains absent.

254 of the most important recent discoveries in birth defect research, the mechanism by which folic acid

255 Cleft palate is a common major birth defect resulting from disruption of palatal shelf

256 al to understanding the neuropathogenesis of birth defects resulting from congenital infection.

257 omic clefts of the lip and palate are common birth defects resulting from gene-gene and gene-environm

258 s the most common infectious cause of infant birth defects, resulting in permanent neurological disab

259 Variations in birth defect risks according to type of ART procedure ha

260 as, in contrast, more weakly associated with birth defects (RR: 1.09; 95% CI: 1.07, 1.12).

261 ential contribution to etiologically complex birth defects should be rigorously examined.

262 uded spontaneous abortion, stillbirth, major birth defect, small size for gestational age, low birth

263 To our knowledge, this is the first birth defect study to develop multi-DBP adjusted regress

264 controls from the Slone Epidemiology Center Birth Defects Study (1993-2012) who were interviewed wit

265 In the Slone Birth Defects Study (case-control design; North America,

266 sing data from the Slone Epidemiology Center Birth Defects Study collected from 1998 to 2012, we comp

267 virus that causes several diseases including birth defects such as microcephaly.

268 tion for countries with a high prevalence of birth defects, such as China.

269 y pregnancy increases the risk in infants of birth defects, such as neural tube defects (NTDs), known

270 TE) morphogenesis and cause life-threatening birth defects (TEDs); however, the underlying cellular m

271 ital diaphragmatic hernia (CDH) is a serious birth defect that accounts for 8% of all major birth ano

272 syndrome), an X-linked dominant multisystem birth defect that is frequently accompanied by ocular ab

273 processes could cause cleft palate, a common birth defect that significantly affects patients' qualit

274 and timing to target segmentation disorders, birth defects that affect the spinal column.

275 e of selected chromosomal and nonchromosomal birth defects that are usually diagnosed at or immediate

276 Yet many pregnancy complications and birth defects that become more frequent in older mothers

277 n cytomegalovirus (HCMV) is a major cause of birth defects that include severe neurological deficits,

278 rus (HCMV) infection is the leading cause of birth defects that primarily manifest as neurological di

279 Congenital hydrocephalus is an important birth defect, the genetics of which remains incompletely

280 palate-one of the most common of congenital birth defects-treatment following surgery is prolonged o

281 Hug mutants exhibit multiple birth defects typical of ciliopathies, including skeleta

282 ns between bariatric surgery and the risk of birth defects, using log-binomial regression models adju

283 sease, including Guillain-Barre syndrome and birth defects, was not recognized until recent outbreaks

284 us (ZIKV) could cause microcephaly and other birth defects, we have scrambled to understand how.

285 significant associations of ZIKV with other birth defects were also detected, but at lower relative

286 cts of optimal folic acid supplementation on birth defects were assessed by a conditional logistic re

287 Most frequently reported birth defects were congenital heart disease and cataract

288 Birth defects were reported for 16 of 271 (6%; 95% CI, 4

289 Birth defects were reported in 9 of 85 (11%; 95% CI, 6%-

290 No birth defects were reported.

291 Hypospadias is a common birth defect where the urethral opening forms on the ven

292 ting the underlying etiology of human caudal birth defects, which affect 1 in 10 000 live births.

293 cell-type-specific gene networks results in birth defects, which affect 5% of live births.

294 or without cleft palate (NSCL/P) is a common birth defect with a complex genetic architecture.

295 art disease (CHD) is the most common type of birth defect with family- and population-based studies s

296 late (nsCL/P) is among the most common human birth defects with multifactorial etiology.

297 t-sided lesions (LSLs) are relatively common birth defects with substantial morbidity and mortality.

298 Failure to close the neural tube results in birth defects, with severity ranging from spina bifida t

299 orofacial clefts are one of the most common birth defects worldwide.

300 Cleft lip is one of the most common human birth defects, yet our understanding of the mechanisms t