ライフサイエンスコーパス: bistable

1 dels, where typically each neuron is at most bistable.

2 which changes the system from monostable to bistable.

3 cells validated that TGF-beta1 activation is bistable.

4 that sigma(d) -dependent gene expression is bistable.

5 itching of two bistable [2]rotaxanes and one bistable [2]catenane composed of CBPQT(4+) rings encircl

6 On average, close to two bistable [2]catenanes can be incorporated per repeating

7 Two redox-active bistable [2]catenanes composed of macrocyclic polyethers

8 These bistable [2]catenanes exemplify a design strategy for ac

9 The reversible redox-switching of the bistable [2]catenanes is retained inside the MOF, as evi

10 (IET) can be subjected to redox control in a bistable [2]rotaxane comprised of a dumbbell component c

11 and digital simulations of the tristable and bistable [2]rotaxanes and [2]catenane reveal a mechanism

12 redox-induced mechanism of switching of two bistable [2]rotaxanes and one bistable [2]catenane compo

13 istinct neural assemblies, each with locally bistable activity, operating far from the collective equ

14 local sensory adaptation and showed the same bistable and mnemonic dynamics as sensory perception.

15 ork of organic reactions with autocatalytic, bistable and oscillatory behaviour, we identify principl

16 pression of the pneumococcal type 1 pilus is bistable and positively regulated by the transcription f

17 zed LimGluR2, on which we focused, was fast, bistable and supported multiple rounds of on/off switchi

18 try, we show that our engineered systems are bistable and that inherent gene expression stochasticity

19 cell of this crease pattern is mechanically bistable, and by switching between states, the compressi

20 y rich phase diagram, which features stable, bistable, and unstable phases depending on the dissipati

21 Here we report a room-temperature bistable antiferromagnetic (AFM) memory that produces ne

22 e investigate photoinitiated snap-through in bistable arches formed from samples composed of azobenze

23 analysis predicted that MAPK activation was bistable as a function of ATRA exposure.

24 First, the CaMKII model system is never bistable at resting calcium concentrations, which sugges

25 rromagnetic and antiferromagnetic phases are bistable at room temperature.

26 hat should be an integrator of inputs into a bistable attractor switching between two highly trusted

27 ree genomically integrated circuits that use bistable autoregulatory transcriptional feedback to reta

28 class of architected materials that contain bistable beam elements and exhibit controlled trapping o

29 hitected soft system composed of elastomeric bistable beam elements connected by elastomeric linear s

30 We reconstitute this bistable behavior and hysteresis using purified componen

31 The development and the ionic nature of bistable behavior in lumbar motoneurons were investigate

32 c fluctuations in transcript numbers, nor of bistable behavior in transcript distributions.

33 and biochemical reconstitution show that the bistable behavior of the Gwl-ENSA pathway emerges from i

34 eC, CckA and its response regulators exhibit bistable behavior, thus providing a scenario for robust

35 oads to the genetic switch can also abrogate bistable behavior.

36 ihood that the resulting system will exhibit bistable behavior.

37 and features a completely new way to create bistable behavior.

38 To conclude, bistable behaviors are, to a large extent, determined by

39 llapse, or one of two qualitatively distinct bistable behaviors where survival is favored in either s

40 gly, we present quantitative analyses of the bistable behaviour, featuring a phase transition from th

41 The potential energy profile of a bistable binary switch is a 'symmetric' double well.

42 Here, we describe optical properties of bistable bubble domain (BD) texture torons in a thin lay

43 On its own, this network can be bistable, but in a larger system, where ERK accelerates

44 the branched polymerization of pH-sensitive bistable [c2] daisy chain rotaxanes by using copper(I)-c

45 In this article we show that bistable [c2]daisy chain rotaxanes (i.e., molecular musc

46 because, in contrast with more conventional bistable catenanes and rotaxanes, the mechanical movemen

47 nature of vernalization is a reflection of a bistable cell autonomous switch in an increasing number

48 that couples adaptive directional sensing to bistable cellular memory.

49 mple, analytically solvable, one-dimensional bistable chemical system to demonstrate the validity of

50 orporating functional genelet modules into a bistable circuit, we construct an integrated regulatory

51 system give rise to a positive feedback and bistable collective switching of Rab5.

52 cooperative ion channels can plausibly form bistable conductances.

53 er space for fast excitation, inhibition and bistable control.

54 nductive metal-organic frameworks (MOFs) and bistable coordination polymers (CPs) are carving a niche

55 Our findings provide evidence of bistable cortical networks that exhibit non-rhythmic sta

56 g mechanism of a family of electrochemically bistable 'daisy chain' rotaxane switches based on a deri

57 d their feedbacks are sufficient to create a bistable developmental fate switch in Arabidopsis seeds.

58 A bistable donor-acceptor [2]catenane, which is composed o

59 of the resonant frequency are used to devise bistable dynamic states that can be reversibly switched

60 cise control of the nonlinear and stochastic bistable dynamics of a levitated nanoparticle in high va

61 bset of early genes to mirror the sustained, bistable dynamics of upstream signaling.

62 on PAR-6/PKC-3 endows this core circuit with bistable dynamics, while transport of CHIN-1 clusters by

63 noparticles as a model system for stochastic bistable dynamics, with applications to a wide variety o

64 ct that local neuron assemblies will express bistable dynamics, with spontaneous active-inactive tran

65 ts oscillate (e.g. the cell cycle), some are bistable (e.g. as cells differentiate), some respond sha

66 The bistable electroactive polymer is a new smart material c

67 The combination of the composite and a bistable electroactive polymer produces electrically-ind

68 periments with networks of discrete reactive bistable electrochemical elements organized in regular a

69 ental impacts of a developmental nonvolatile bistable electromechanical CNT switch through its fabric

70 AIA interneurons have bistable electrophysiological properties consistent with

71 Transition waves that sequentially switch bistable elements from one stable configuration to anoth

72 g membrane to investigate the origin of fast bistable engulfment in absence of the cell wall.

73 n of telomeric gene expression is due to the bistable enrichment/depletion of H3K79me and not the flu

74 e impetus for heritable phenotypic change in bistable epigenetic regulatory networks that are suscept

75 We use a bistable epigenetic switch sensitive to transcription er

76 type 1 persistence, and we propose that the bistable expression of both transformability and the gro

77 These cell types arise due to bistable expression of CsgD, the central biofilm regulat

78 A paradigmatic example is the bistable expression of virulence genes in Salmonella typ

79 ically stable enantiotropic SmC* phase and a bistable ferroelectric switching in a surface stabilized

80 VTA DA neurons are bistable, firing in two modes: one characterized by burs

81 Bistable flagellar and virulence gene expression generat

82 he protein and transcriptional levels induce bistable FlhD4C2 levels and heterogeneous numbers of fla

83 We demonstrate sustained bistable fliC expression in virulent Salmonella 14028 an

84 synaptic connections putatively implement a bistable gain control mechanism that either computes odo

85 ing network recapitulates these variable and bistable gastrulation profiles and emphasizes the import

86 elation leads to the experimentally observed bistable gating.

87 onse in single cells has been a paradigm for bistable gene expression.

88 Here, we show decision-making by a bistable gene network in artificial cells with constant

89 use synthetic biology approaches to engineer bistable gene networks to demonstrate that stochastic an

90 e mechanism to stochastic gene expression in bistable gene regulatory circuits.

91 Although a bistable gene regulatory network has been proposed to re

92 e, we investigate the possible structures of bistable genetic networks that can allow two identical c

93 -way junction with an excited state, a 25-nt bistable hairpin, and a 112-nt three-state adenine ribos

94 the structural relationships between the two bistable hairpins, the conformational switch can follow

95 d points at each level of the hierarchy, and bistable Hebbian dynamics enables the learning of such t

96 To this end we recently developed a new bistable hydrazone switch that undergoes efficient photo

97 Here, we demonstrate that bistable hydrazones can drive (chiral) shape transformat

98 ne, they can be coupled to create a strongly bistable, hysteretic switch between normal and toxic sta

99 They are bistable in function, and are, in a sense, the electrofl

100 T3SS expression is bistable in the homogeneous environment of nutrient-limi

101 ment front, in which vegetation dynamics are bistable: in this zone, vegetation can be stable both as

102 The advantages include near-bistable isomers and an increased separation of the n ->

103 xperiments and analyses to show that, if the bistable joints are properly designed, transition waves

104 geometrical and mechanical properties of the bistable Kresling pattern with a magnetically responsive

105 However, so far bistable lac induction has only been observed using grat

106 e question about the biological relevance of bistable lac induction in the natural setting with lacto

107 ingle-cell analysis confirmed monostable and bistable-like behavior.

108 We then demonstrate that such bistable linkages can be used as building blocks to real

109 o far, the smallest individually addressable bistable magnetic bits have consisted of 3-12 atoms.

110 for manipulating information encoded in the bistable magnetization state of the ferromagnet.

111 d between the streamed and fused states in a bistable manner.

112 We describe the incorporation of a bistable mechanically interlocked molecule (MIM) into a

113 show that decisions of orientation rely on a bistable mechanism between LFA-1-mediated upstream and V

114 opsin and may function through a reversible, bistable mechanism.

115 Our results demonstrate that two interlinked bistable mechanisms provide a robust solution for irreve

116 Recently, experimental bistable memories have been realized using fully compens

117 e for applications in spintronics as well as bistable memory devices and sensing materials.

118 This research demonstrates that bistable MIMs are capable of exhibiting robust dynamics

119 information through switching collections of bistable MIMs contained in arrays of MSTJs.

120 is a direct consequence of the switching in bistable MIMs that leads to a relatively small remnant m

121 ion of MEDs, it is likely that monolayers of bistable MIMs will be replaced by robust crystalline ext

122 rein the switchable components, derived from bistable MIMs, are organised precisely in a periodic man

123 and remnant molecular signatures produced by bistable MIMs.

124 None of these fit our data, but a simple bistable model extended to have three states reproduced

125 of the regulatory core and two subordinated bistable modules responsible for cell cycle arrest and a

126 The cell cycle is composed of bistable molecular switches that govern the transitions

127 Epigenetic switches are bistable, molecular systems built from self-reinforcing

128 e molecules, and also how to integrate these bistable molecules into organized, hierarchical assembli

129 redict that a new phase of matter occurs for bistable molecules on the kagome lattice, which is intri

130 On the other hand, when the bistable molecules switch "out of phase," the assemblies

131 In this regard, situations where all the bistable molecules switch synchronously appear desirable

132 by analogy with single-molecule magnets, as bistable molecules with a toroidal magnetic state, and s

133 We used a novel bistable motion illusion that induced alternating and mu

134 When hyperpolarized, bistable motoneurons displayed a characteristic slow aft

135 the knot on the landscape, the origin of the bistable nature of the knotted protein, and broaden the

136 Some bistable networks are entirely based on posttranscriptio

137 Cell-autonomous bistable networks have been previously sampled using an

138 We obtain a variety of simple bistable networks that we classify into major subtypes.

139 Furthermore, we demonstrate the bistable nonvolatile memory states that can be switched

140 switch stochastically between epigenetically bistable ON and OFF expression states.

141 transition between these 2 states, forming a bistable on-off switch of EADs.

142 tate to storage charges and cause reversible bistable (ON and OFF states) switching upon application

143 oit the propagation of transition waves in a bistable one-dimensional (1D) linkage as a robust mechan

144 We have prepared a bistable, optically triggered, metal-organic framework (

145 Moreover, bistable optokinetic responses cannot be entirely attrib

146 progenitor cells leads to the appearance of bistable or bi-modal growth behaviors, ultrasensitivity

147 to activate these molecular switches between bistable or even multiple states by manipulating molecul

148 e feedback loop architecture, which exhibits bistable or oscillatory network dynamics depending on ir

149 icroscopic ratchets can explain the observed bistable orientation of the actin-propelled ellipsoidal

150 the signaling pathway is linear, rather than bistable, over a broad range of extracellular pheromone

151 lished and generalized across several visual bistable paradigms.

152 MP-receptor interactions reveals a spatially bistable pattern of BMP signaling centered on the dorsal

153 er-increasing asymmetry between blastomeres (bistable pattern), supposedly controlled by negative or

154 whether higher-order visual stimuli such as bistable perception and attention tasks involving visual

155 an brain to decode perceptual content during bistable perception and simple unambiguous perception.

156 e compared with previous studies of auditory bistable perception and suggested that perceptual transi

157 s, we find that the activity dynamics during bistable perception are well described as fluctuating be

158 ividuals to form aberrant beliefs from their bistable perception behavior.

159 onger durations of perceptual transitions in bistable perception compared with replay conditions.

160 d predominantly to posterior visual regions, bistable perception involved additionally many higher-or

161 Here, we propose that bistable perception is due to our prior beliefs being re

162 We model bistable perception within this system by applying adapt

163 plaid stimuli revealed that mice demonstrate bistable perception, sometimes tracking individual stimu

164 ons every few seconds, a phenomenon known as bistable perception.

165 ortical structure and behaviour underpinning bistable perception.

166 ain activity link focal brain structure with bistable perception.

167 influences were dramatically enhanced during bistable perception.

168 etal cortex in perceptual transitions during bistable perception.

169 frontoparietal areas for transitions during bistable perception.

170 of the alternating representations of their bistable perception.

171 Bistable perceptual phenomena and attention tasks asymme

172 Models of such bistable perceptual phenomena posit spontaneous fluctuat

173 novel paradigm in which human subjects view bistable perceptual stimuli or perform complex attention

174 The present transducer records bistable pH modulation from an "enzymatic flip-flop" cir

175 hought not to exist since the rhodopsins are bistable photopigments, which consist of a chromophore t

176 These defects resulted in bistable populations of cells occupying alternate "on" a

177 istical models with fusion as a higher-level bistable process alternating with rivalry against our fi

178 on periods during tristability matched other bistable processes.

179 of direct competition, rather than separate bistable processes.SIGNIFICANCE STATEMENT When inputs to

180 al ranges of cell density when compared with bistable quorum-sensing systems.

181 cell fates were also observed outside of the bistable range, evidenced by bimodality and hysteresis.

182 terminant of the transition rates inside the bistable range.

183 al-radical recognition motif is harnessed in bistable redox-active MIMs in order to achieve close to

184 nhibitory (I) populations exhibiting a novel bistable regime between a quiescent and an inhibition-st

185 , milling and polarized states co-exist in a bistable regime with transitions largely driven by pertu

186 netochore, the force-velocity relation has a bistable regime with two possible steady-state velocitie

187 cI repressor would drive the system into the bistable regime.

188 As substrate increases, the bistable region acquires 8-dimensional volume which incr

189 t the transition is discontinuous and that a bistable region appears where healthy and endemic states

190 Surprisingly, the saturating bistable region occupies a much smaller proportion of th

191 apparent monotonic increase in volume of the bistable region remains perplexing because the region it

192 Kinetochore phosphorylation shifts the bistable region to higher tensions, so that only the rap

193 n DAG and PKC regulates the span of anabolic bistable region with respect to plasma glucose levels.

194 eta frequencies; (2) the network can reach a bistable region, between the low firing frequency networ

195 ace in reversible dynamic chemistry into the bistable region.

196 s than 6 kV/cm induce large, reversible, and bistable remanent strains.

197 aker attractor basins that promote abnormal, bistable representations under certain conditions.SIGNIF

198 results in the observation of an all-or-none bistable response over a much wider range of external si

199 zation, structurally modulated layers, and a bistable response to applied electric field which origin

200 normal to high levels gradually shifted the bistable response towards higher glucose range, eventual

201 on of the sampled parameter space produced a bistable response.

202 iferation and death in T cells establishes a bistable response: the population is driven to either ex

203 n concert with a reaction-transport model of bistable reversible charge and fluorescence photoswitchi

204 nism for the conformational switches between bistable RNA hairpins.

205 crown-ether based wheel along the axis of a bistable rotaxane are triggered by the decarboxylation o

206 A halogen-bonding and hydrogen-bonding bistable rotaxane is prepared and demonstrated to underg

207 interlocked molecules (MIMs)--specifically, bistable rotaxanes and catenanes--which exhibit reset li

208 movements backward in a homologous series of bistable rotaxanes.

209 anometer scale translational movement in two bistable rotaxanes.

210 the first structurally defined magnetically bistable semiconductors assembled with the TCNQ(.delta-)

211 We sought to design bistable sequences for which both states are accessible,

212 This suggests that melanopsin employs a bistable sequential photon absorption mechanism typical

213 relies on the balance between a propagating bistable signal that is opposed by an advective flow gen

214 ted Ubiquitin- Cyclin E- Retinoblastoma- E2F bistable-signalling pathway controlling restriction poin

215 We show that bistable skyrmionic textures undergo hysteretic behaviou

216 from interphase to mitosis and suggest that bistable spatiotemporal switches may be widespread in bi

217 Molecules with bistable spin states are widely studied because of their

218 We further find a novel bistable state of a hexagonal structure and concentrical

219 otoreceptor and bipolar genes, existing in a bistable state.

220 rough positive feedback mechanisms, generate bistable states.

221 field and current, proving the existence of bistable states: droplet and non-droplet states.

222 hallenge the assumed privileged link between bistable stimuli and visual awareness.

223 the interstimulus interval (ISI), we created bistable stimuli that caused subjects to perceive either

224 asy-axis melts long-range order, revealing a bistable, strongly correlated spin state.

225 order in gamma-lithium iridate and reveal a bistable, strongly correlated spin state.

226 modal (population-wide or 'analog') input to bistable (subpopulation-specific or 'digital') output.

227 trial-and-error oscillation and a stochastic bistable switch as two elegant mechanisms with the poten

228 ministic model, we show that an irreversible bistable switch between a transformed and a non-transfor

229 Thus, MAD2L2 helps to ensure a robustly bistable switch between APC/C(CDC20) and APC/C(CDH1) dur

230 There is a bistable switch between lysogenic and lytic growth that

231 The mechanisms controlling this bistable switch between non-active and transfer competen

232 endocytosis and adhesion are components of a bistable switch controlling neurite initiation in a subs

233 diagram indicates that the pathway acts as a bistable switch for the given optimization parameters.

234 Thus, DCP1A flips a bistable switch for the mutually exclusive determination

235 system heterogeneity, without the need for a bistable switch in the underlying regulatory network.

236 hows that APC(Cdh1) inactivation is a rapid, bistable switch initiated shortly before the start of DN

237 te the utility of the approach by creating a bistable switch library that programmatically samples th

238 A bistable switch model has been invoked to explain how pa

239 Tissue simulations showed that this bistable switch of cellular EADs provided both a trigger

240 ssembly, despite both parameters producing a bistable switch possessing a hysteresis.

241 sm involving a Nucleolin-dependent Nanog-p53 bistable switch regulating the homeostatic balance betwe

242 ls have suggested that CaMKII functions as a bistable switch that could be the molecular correlate of

243 controlled by a low-barrier, noise-sensitive bistable switch that involves random transitions in the

244 sitive feedback in Cdk1 activation creates a bistable switch that makes mitotic commitment irreversib

245 tch1a-mediated lateral inhibition produces a bistable switch that reliably gives rise to cell pairs o

246 s study emphasizes the function of Tbx6 as a bistable switch that turns mesoderm fate 'on' and progen

247 matin-modifying activities that can act as a bistable switch to drive cells into either the CSC or th

248 or activation by creating an ultrasensitive, bistable switch to selectively enhance responses to fore

249 ting partial Rb phosphorylation to trigger a bistable switch whereby cyclin E-CDK2 and Rb mutually re

250 definitive hematopoiesis, is an irreversible bistable switch whose dynamical properties are modulated

251 sequestering by stathmin, this establishes a bistable switch with two stable states: one stable state

252 rial-and-error oscillation; and a stochastic bistable switch), and assess their impact on the bi-orie

253 show that this transition is an irreversible bistable switch, and we map the point of commitment to d

254 Mathematical modelling reveals that a bistable switch, created by CRL4(Cdt2), promotes irrever

255 eracting phosphatase PP2A-B55 functions as a bistable switch, even when the bistability of Cdk1 activ

256 ed with the stochastic dynamics of an Rb-E2F bistable switch, jointly and quantitatively explain quie

257 6, which in turn acts to irreversibly flip a bistable switch, leading to maintenance of the mesoderma

258 n the sister kinetochores can give rise to a bistable switch, which allows robust distinction between

259 that allows Warts-Yki-Melted to operate as a bistable switch.

260 hereby ensuring that mitotic commitment is a bistable switch.

261 as an ionic diode with electrolyte-dependent bistable switchable states.

262 Such coupled bistable switches are robust to parameter variation and

263 e report the construction of robust, tunable bistable switches in Escherichia coli using three hetero

264 Building simple bistable switches, synthetic biologists have learned the

265 k with slower downstream transcription-based bistable switches, we can construct synthetic dual-times

266 erned by coupled reversible and irreversible bistable switches.

267 by a phosphatase that also participates in a bistable switching mechanism.

268 iscovered to conduct electricity and display bistable switching.

269 d quantitatively characterized an inducible, bistable synthetic gene circuit controlling the expressi

270 to reproduce experimental data obtained on a bistable system and to interpret discrepancies between m

271 lication of a high-amplitude stimulus to the bistable system can temporarily render it quiescent befo

272 Mitosis is initiated by a bistable system of regulatory proteins centred on Cdk1,

273 of tension sensitive SAC and Cdk1 creates a bistable system that ensures complete activation of sepa

274 Our EMT wave is a generic property of a bistable system with diffusion and we present a single q

275 oblem is the interpretation of the flow as a bistable system with nonlinear propagation (advection) o

276 n essential feature with the transition in a bistable system.

277 Bistable systems are one of the main building blocks of

278 e also find for a closely related model that bistable systems tend to have a specific kinetic conform

279 e propose that the development of biomimetic bistable systems will pave the way towards the study of

280 r, pose a challenge for designing reasonably bistable systems.

281 The refolding kinetics of a bistable terminator antiterminator segment involved in t

282 A bistable toggle switch is a paradigmatic model in the fi

283 motif responds to signals in the manner of a bistable toggle switch, and then we discuss how this tog

284 biquitous gene regulatory network motif, the bistable toggle switch, in which two mutually repressive

285 nstruction and testing to build single-copy, bistable toggle switches with improved performance and r

286 teady-state analysis predicted a switch-like bistable transition between two levels of active TGF-bet

287 red in fMRI, are reshaped from predominantly bistable transitions between two relatively indistinct s

288 BACH1 and RKIP involving both monostable and bistable transitions that can potentially give rise to n

289 ow transport with a single velocity; and 3), bistable transport, where the filament velocity stochast

290 motors is associated with the occurrence of bistable transport.

291 results hold promise for a new generation of bistable, ultrahigh-resolution, and flexible display tec

292 ollective activity of a finite population of bistable units (i.e., a generalized Ehrenfest process) q

293 Each digital logic gate utilizes a single bistable valve-the pneumatic equivalent of a Schmitt tri

294 ght-activated chloride channels (iC++) and a bistable variant (SwiChR++) with net photocurrents incre

295 he visual perception of the flies, we used a bistable variant called ChR2-C128S.

296 During bistable vision, perception oscillates between two mutua

297 nstrate for the first time that mice exhibit bistable visual perception of plaid stimuli, and that th

298 d prefrontal cortex predict the stability of bistable visual perception.

299 The phosphorylation of mitotic proteins is bistable, which contributes to the decisiveness of the t

300 ich spontaneous hair bundle oscillations are bistable, with sporadic transitions between the oscillat