ライフサイエンスコーパス: blockage

1 administered mice and was reduced upon PAR-2 blockage.

2 d hyperexcitable following chronic M-channel blockage.

3 x pump inhibitors (EPIs) to control catheter blockage.

4 d forecasts a danger over one month ahead of blockage.

5 in mouse lungs, which was reduced upon PAR-2 blockage.

6 nocytosine (epsilonC) causes transcriptional blockage.

7 s well as apoptotic cells in the lungs after blockage.

8 escued PDXK disruption induced proliferation blockage.

9 esence of species that do not cause catheter blockage.

10 f Proteus mirabilis infection and subsequent blockage.

11 ertaken to confirm the role of interleukin-1 blockage.

12 provide a clear visual warning of impending blockage.

13 ons or provide warning of impending catheter blockage.

14 proliferation and erythroid differentiation blockage.

15 y 1-10 MPa) that likely stemmed from conduit blockage.

16 ha (GPIbalpha) receptor, thereby causing its blockage.

17 cumulation but may cause irreversible vessel blockage.

18 hindering effect on Hg(0) uptake due to pore blockage.

19 more resilient cake layer and membrane pore blockage.

20 nts (12.7%) had perifimbrial adhesion and/or blockage.

21 d in LUTO etiology as a result of anatomical blockage.

22 ome species have the ability to remove these blockages.

23 s those oriented head-on were severe, stable blockages.

24 ence VAS -10 mm (95% CI -18 to -2) P = 0.02, blockage -0.7 (95% CI -1.3 to -0.1) P = 0.02, with recov

25 st doses: VAS 15 mm (95% CI 4-25) P = 0.009, blockage 1.1 (95% CI 0.5-1.6) P = 0.001.

26 The blockage also becomes less pronounced upon reduced RNA p

27 tm1a/tm1a) mice revealed severe nasal airway blockage and abnormal ciliary morphologies in nasal MCCs

28 xazole compound with potent AM2-S31N channel blockage and antiviral activity, in this study we report

29 Pharmacological blockage and genetic deletion of D2R in DA neurons preve

30 case Rep, resulting in increased replication blockage and thus increased reinitiation away from oriC,

31 miniature coils could be effective in axonal blockage and, if so, what the underlying mechanisms are.

32 II)-catalyzed transformation by surface-site blockage and/or organic Fe(II) complexation.

33 s like a brush layer to prevent SERS-hotspot blockages and fouling by blood-serum proteins.

34 e of alphaHL, resulting in decreased current blockages and slower unzipping.

35 atings provide up to 12h advanced warning of blockage, and are stable both in the absence of infectio

36 influenced by cannabinoid or opioid receptor blockage, and euphoria cannot be studied in mouse models

37 of struvite crystals, catheter encrustation, blockage, and formation of urinary stones.

38 sociated with proliferation, differentiation blockage, and leukemia initiation were differentially ex

39 symptoms (rhinorrhea, mucus in throat, nasal blockage, and sense of smell), patient-reported outcomes

40 ligonucleotide effective charges and current blockages, and between their diffusion constants and DNA

41 omplete evacuation, and a sense of anorectal blockage are just as important as decreased stool freque

42 determined not to cause cardiac ion channel blockage are more likely to pass successfully through cl

43 dicating selective and prolonged replication blockage at 6-4PPs.

44 Bypassing requires translational blockage at a "takeoff codon" immediately upstream of a

45 hin approximately 10 min of replication fork blockage at a site-specific barrier in fission yeast, le

46 nd they suggest that the Gac system senses a blockage at the aconitase step of the tricarboxylic acid

47 queduct are critical for preventing physical blockage between the third and fourth ventricles and the

48 n factor IIS, which is in contrast to pol II blockage by a nucleosome barrier.

49 , the CPP modified drug is released from the blockage by a second triggering agent, while remaining i

50 sign, the electrode surface is less prone to blockage by any formed gas bubbles.

51 asymmetrical extrusion until unidirectional blockage by CTCF that is presumed to occur in mammals.

52 Replication blockage by DPC did not produce damaged forks or detecta

53 The channel activity is susceptible to blockage by known drugs and structurally diverse compoun

54 bited new protein synthesis, indicating that blockage by NPPB enhances the degradation of ABCB transp

55 o found using PAGE mass assay that metabolic blockage by phosphate starvation surprisingly increased

56 r tetramethylrhodamine (TMR)-dextran and its blockage by the Na(+)/H(+) exchanger ethylisopropyl amil

57 he results provide information regarding how blockage caused by 1-MCP may be circumvented at the meta

58 nsing mechanism was based on the nanochannel blockage caused by MS2 binding to immobilized capture an

59 Capillary blockages colocalised strongly with pericytes, where cap

60 Pharmacological xCT blockage counteracts NAC prophylactic effects.

61 il identified significant differences in the blockage current and the unzipping duration between the

62 urrent fluctuations that reflects a discrete blockage current level structure.

63 translocation times, ion-current noise, and blockage currents.

64 The phenotypic results of this blockage define patterns of communication among distant

65 stis biofilm formation that is important for blockage-dependent plague transmission from fleas to mam

66 Surprisingly, the effect of ACAT1 blockage does not alter mTOR signaling or endoplasmic re

67 ation of the nanochannels (20 nm pore sized) blockage due to the immunocomplex formation.

68 rent methods to detect drought-induced xylem blockages (e.g., embolisms) and quantify corresponding d

69 ctrical approaches, the underlying geometric blockage effect provides a robust and sensitive signal,

70 rases (Pols) in ameliorating the replication blockage effects elicited by the straight- and branched-

71 ation, and other nBu-PTEs displayed moderate blockage effects, with none of them being mutagenic.

72 By providing reversible nerve blockage, electric stimulation with an implanted electro

73 GCGR antibody blockage expanded alpha-cell mass 5.7-fold, and S961 had

74 tion with optogenetics, reveal that pericyte blockage facilitates axonal regeneration and neuronal in

75 diffusion constants and DNA-induced current blockage fluctuations.

76 s agencies, leakage for indigenous lands but blockage for federal PAs, suggesting a stronger external

77 m(-1) to 15.1+/-2.6 bar m(-1) due to spacer blockage from the developing biofilm.

78 Amount of UV-A blockage from windshields and side windows.

79 We confirmed the blockage function of Tbf1 using synthetic promoters.

80 y tuft input and (simulated) calcium-channel blockage functionally acts as a composite sigmoidal func

81 A high level of side-window UV-A blockage (>90%) was found in 4 of 29 automobiles (13.8%)

82 whether congenital LUTO caused by anatomical blockage has a monogenic cause.

83 ased pumping energy requirements from spacer blockage highlight the serious challenges of using high

84 active cancer vaccination, immune checkpoint blockage (ICB) and chimeric antigen receptor (CAR) for T

85 some to overcome the translation termination blockage imposed by an arrest peptide.

86 iated by tumor associated macrophages, whose blockage improves the effect of CI ablation.

87 Further analysis indicates a blockage in autophagic flux associated with lysosomal dy

88 Furthermore, this blockage in cell surface expression was correlated with

89 onstruct markedly reduced APP-induced axonal blockage in Drosophila.

90 antiviral activity based on percent channel blockage in electrophysiological assays.

91 leading edge, the latter is consistent with blockage in membrane trafficking.

92 y and ELISA experiments revealed that GM-CSF blockage in monocytes stimulated production of the chemo

93 ed conditional reduced growth, near complete blockage in PSII supercomplex formation, and concomitant

94 high temperatures is not able to reverse the blockage in ripening.

95 Chronic autophagy blockage in several conditions, including DRPLA and Vici

96 ilm formation in vitro and biofilm-dependent blockage in the oriental rat flea Xenopsylla cheopis res

97 betaIII-Tubulin blockage in vivo reduced tumor incidence and growth.

98 h Chlamydia trachomatis may lead to fibrotic blockage in women's upper genital tracts, resulting in t

99 bidopsis (Arabidopsis thaliana) mutants with blockages in the pathway simply redirect carbon flux to

100 Blockages in this network stabilize ligand-activated EGF

101 at losses in pedicel kh were associated with blockages in vessel elements, whereas air embolisms were

102 correlated with direct competition and pore blockage indicators.

103 as risking injuries due to gastro-intestinal blockage, ingestion of foamed PS exposes animals to harm

104 nfocal microscopy to show that the secretion blockage is due to the stabilization of open fusion pore

105 during recovery from arterial restriction or blockage is essential for health, but mechanisms are poo

106 Notably, this blockage is exacerbated in Cockayne Syndrome and xeroder

107 This transcription blockage is much less pronounced for a C-rich sequence,

108 Remarkably, the blockage is not pronounced if transcription is performed

109 om control experiments, we conclude that the blockage is primarily due to the formation of stable RNA

110 ts prevent ion currents indicating that pore blockage is primarily responsible.

111 Detailed analysis of the blockage kinetics of VDAC reconstituted into planar lipi

112 "leakage," more deforestation elsewhere, to "blockage," less deforestation elsewhere.

113 Comparison of current-blockage levels of each protein yields volumetric inform

114 We further presented evidence that the blockage mechanism is widely used among genome-wide DGPs

115 biosynthesis pathway by chemical and genetic blockage mimicked these transcriptional responses, indic

116 nfer identical defects, including late onset blockage near the terminal cell-stalk cell junction and

117 human cancer cells that evade the cell cycle blockage normally imposed by DNA damage experience susta

118 In vitro assays indicated blockage of (11)C-sarcosine uptake into PC-3 and LNCaP t

119 The blockage of androgen receptor significantly increased ra

120 s in attenuation of caspase 3 activation and blockage of apoptosis.

121 features were phenocopied by pharmacological blockage of Arf6 activation.

122 opQ targets host-cell V-ATPase, resulting in blockage of autophagic flux and neutralization of acidic

123 duced alterations in autophagy result from a blockage of autophagosome degradation rather than an inc

124 Blockage of autophagy upregulated radiation-induced cyto

125 Blockage of Axl gene expression by small interfering RNA

126 vide an interesting alternative for electric blockage of axonal conductance in clinical settings.

127 f thymus and bone marrow, and stage-specific blockage of B cell development.

128 Blockage of B cell-specific PD-L1 restored Th1 responses

129 h p62-dependent inclusion body formation and blockage of Bardet-Biedl syndrome 4 (BBS4) entrance into

130 and the potential benefits arising from the blockage of both inflammation-related enzymes were thoro

131 -6 trans-signaling pathway, but not combined blockage of both, the classical and trans-signaling path

132 Blockage of canonical signaling using Sfrp1, Dkk1, or fi

133 ity for its own better survival; conversely, blockage of caspases strongly reduces the severity of th

134 estigate whether the enhancement of ADCML by blockage of CD59 function is mediated by nAbs, non-nAbs,

135 After blockage of CD59 function, the reactive Abs, regardless

136 have led to different models, including (i) blockage of cell wall synthesis, (ii) membrane pore form

137 erve in real-time formation of the thrombus, blockage of cerebral perfusion and eventually stroke les

138 We found that blockage of Ces3 by WWL229 or siRNA dramatically attenua

139 Furthermore, blockage of CMA leads to hyperphosphorylation and destab

140 Specific blockage of Cx43 HC function by TAT-Gap19, a Cx43 mimeti

141 Induction or blockage of CYP3A1 by a miR-23b inhibitor or mimic could

142 m the ER, a process that correlates with LFG blockage of cytochrome c release to the cytosol and casp

143 Moreover, blockage of D1R or D2R signaling could alleviate normal

144 Blockage of Delta-like 4 (DLL4)-directed Notch signaling

145 ive strain that fails to remove Pxr-mediated blockage of development and reintroduced variably trunca

146 ting in uncontrolled cell proliferation, and blockage of differentiation and chondrodysplasia in mice

147 tional twin-boundary (TB) strengthening from blockage of dislocations impinging on TBs, coupled with

148 this inhibition is primarily mediated by the blockage of DL-glyceraldehyde binding to ALR2.

149 Blockage of DNA recognition by the innate immune system

150 yl-DL-tyrosine methyl ester hydrochloride or blockage of DOP1 receptor with antagonist SCH23390 impai

151 lerotic action in vivo via the AMPK-mediated blockage of Drp1-mediated mitochondrial fission.

152 tical for PTHrP action in chondrogenesis, as blockage of ECM1 nearly abolishes PTHrP regulation of ch

153 of both enzymes appears more promising than blockage of either protein alone.

154 Conversely, blockage of endogenous GM-CSF with antibody treatment no

155 DAMB-231 and MDAMB-468 cells and resulted in blockage of ER stress-mediated GRP78 up-regulation.

156 Blockage of ETAE distinguishes Fe(III) reduction of laye

157 Hydrosalpinx, the blockage of fallopian tubes, can result from pelvic infl

158 ose tissues (KLB AdipoKO) or pharmacological blockage of FGF21 signaling.

159 led glucose or glutamine revealed a dramatic blockage of flux of these two metabolites into nucleotid

160 Pharmacological blockage of fructose uptake ameliorates leukemic phenoty

161 are relevant to RTT because pharmacological blockage of GAT3 can normalize tonic inhibition and intr

162 Blockage of glutaminolysis had the same inhibitory effec

163 The blockage of H4R could be a new therapeutic modality for

164 fore, S. flexneri infection induces a global blockage of host cell intracellular transport, affecting

165 of influenza NS1 protein that causes potent blockage of host gene expression and contributes to inhi

166 duction of reconstitution potential due to a blockage of HSC differentiation.

167 naptic connectivity; chronic pharmacological blockage of Ih channels reproduced these phenotypes, sug

168 The results of this small study suggest that blockage of IL-1beta using gevokizumab may be beneficial

169 However, blockage of IL-1R signaling did not abolish the deleteri

170 ioprotective effects against DCM through the blockage of inflammation, oxidative stress, and apoptosi

171 se results provide a basis for a therapeutic blockage of inhibitory guidance molecules to improve vas

172 Blockage of integrin alpha5beta1 with ATN161 abolished t

173 in, suggesting inhibition occurs by physical blockage of its allosteric activation, preventing the al

174 p53 expression, which in turn, leads to the blockage of key apoptotic molecules.

175 erol accumulation, we propose that AnxA6 and blockage of LE cholesterol transport are critical for en

176 Based on these analyses, blockage of lignin monomer methylation by down-regulatio

177 The blockage of m(6)A inhibited splicing of the pre-mRNA enc

178 aging, while systemic or V2a neuron-specific blockage of Mc4r promotes locomotion.

179 Coprecipitation led to a complete blockage of mineral surface sites and pores with >/=177

180 Moreover, blockage of miR-30b or 378 by locked nucleic acid inhibi

181 ntribution to peroxide metabolism during the blockage of mitochondrial electron transport.

182 Blockage of more than one oncoprotein or pathway is now

183 Improving potencies through concomitant blockage of multiple epitopes and avid binding by fusing

184 ed secretory response to HTS treatment after blockage of neuronal activity.

185 Blockage of NOS activity with the inhibitor L-NG-nitroar

186 ling that was more potent than pharmacologic blockage of Notch activation via gamma-secretase inhibit

187 Furthermore, blockage of nSMase in monocytes/macrophages inhibited th

188 Further, blockage of nuclear export of p27 by inhibition of Expor

189 Therefore, blockage of one of these molecules might represent a nov

190 eighbor directly overhead, possibly to avoid blockage of overhead light needed for orientation.

191 Blockage of P-selectin by administration of anti-P-selec

192 technologies, including genetic tracking and blockage of pericytes in combination with optogenetics,

193 enhanced in Itk(-/-)Btk(-/-) mast cells, and blockage of phosphatidylinositol-4,5-bisphosphate 3-kina

194 static synaptic plasticity elicited by acute blockage of postsynaptic receptors.

195 meliorated the inflammatory response through blockage of proliferation of activated B cells, inhibiti

196 Conversely, blockage of proteolipid protein production exacerbated m

197 Thus, blockage of RCA function represents a novel approach to

198 olution resulting in complete and incomplete blockage of reproductive tract in infertile and fertile

199 an be substantially reduced by an additional blockage of residual free cysteine residues with 2,2'-di

200 Blockage of sclerostin accelerates the PDLSCs lineage co

201 moval of mature microRNAs or pharmacological blockage of signalling pathways drives PSCs into a low-n

202 Blockage of some ion channels and in particular, the hER

203 l to vitamin A-deficient (VAD) mice; (2) the blockage of spermatogonial differentiation by impaired r

204 -pool is gradually silenced, leading to full blockage of synaptic transmission.

205 high levels of Dio3 provides double-pronged blockage of T3 action during glial lineage commitment.

206 Blockage of TEAD activity by TEADi in human keratinocyte

207 Blockage of tetrapyrrole biosynthesis in the AtHEMN1 mut

208 To permit selective blockage of the accessory site, alpha4 threonine 126 loc

209 ly used in the clinics, and most of them use blockage of the active site for their mode of inhibition

210 hibition that until now has mainly relied on blockage of the active site or occupation of a regulator

211 iers inactivating the proviral promoter, and blockage of the assembly of the host elongation factor P

212 iting phosphoinositide production leads to a blockage of the autophagy flux in LSD chondrocytes.

213 sidue 132 with phenylalanine caused a steric blockage of the B-type channel and no other material str

214 data, for the first time, demonstrated that blockage of the biological function of RCA members rende

215 Blockage of the biological function of RCA members, part

216 t obstruction (LUTO) is caused by anatomical blockage of the bladder outflow tract or by functional i

217 f circumventing the physical and biochemical blockage of the blood-brain barrier, could be a precious

218 Blockage of the c-met/hepatocyte growth factor axis atte

219 evated oxidative stress, cellular death, and blockage of the cell cycle.

220 occlusion (RVO) can cause vision loss due to blockage of the central retinal vein (CRVO) or a branch

221 Transient, ~95% blockage of the channel current by alpha-syn was observe

222 could be retarded due to competition and/or blockage of the CYP2D6 enzyme by Amphetamine; We also fo

223 s a pivotal role in cell cycle regulation by blockage of the G1-to-S-phase transition.

224 iated interruption of the GABA signaling and blockage of the GABAA receptor by the specific inhibitor

225 In 2 mouse models of AAA, selective blockage of the IL-6 trans-signaling pathway, but not co

226 accumulation of autophagosomes occurs due to blockage of the lysosomal degradation process.

227 lication of reverse voltages or irreversible blockage of the macroscopic conductance of lysenin chann

228 lated to external mechanisms due to complete blockage of the membrane surface followed by cake format

229 Nonetheless, the consequences of sustained blockage of the mesoaccumbal circuit for motivation and

230 Remarkably a single-time blockage of the mGluR5 resulted in chronic neuropathic p

231 Blockage of the mGluRs alone only modestly reduced the m

232 ation in mitochondria, which is prevented by blockage of the mitochondrial calcium uniporter.

233 Blockage of the mTORC2 signal pathway prevented cytokine

234 Complete blockage of the nanopore with Pt metal forms a closed bi

235 our previous studies showing that concurrent blockage of the NF-kappaB and Akt signaling pathways sen

236 unveils that PL enhancement arises from the blockage of the optically excited electron transfer from

237 ses chemoresistance, which is accompanied by blockage of the PD-L1 immune checkpoint.

238 tion for a substrate analogous inhibitor and blockage of the predicted ubiquinone binding site provid

239 at selective, unidirectional, and reversible blockage of the primarily dopaminergic mesoaccumbal circ

240 the hematopoietic compartment resulted in a blockage of the progenitor B-cell-to-precursor B-cell de

241 In addition, blockage of the STIM1-Orai pathway effectively abolishes

242 Inhibition of TLR4 resulted in differential blockage of the targets.

243 The blockage of the translation in CD14(+) monocytes protect

244 th four affected individuals with anatomical blockage of the urethra identified a rare nonsense varia

245 of dendritic beading during pharmacological blockage of these cotransporters.

246 Blockage of these pathways may improve muscle quality an

247 Pharmacologic blockage of these target pathways reduced CSLCs, and thi

248 transmission of TCR signals, a developmental blockage of thymocytes at the transition from double-neg

249 Blockage of TREM-1 signaling caused a more severe proinf

250 s as a dual-targeting agent that invokes the blockage of two signal transduction pathways that are ce

251 Blockage of ubiquitination at Lys124 was proposed to abr

252 activate the NRF2 signaling pathway through blockage of ubiquitylation and degradation of NRF2 in a

253 he Ba(2+) and hydroxide ions, as well as the blockage of unwanted pathways by adding methanol.

254 ihydroorotate dehydrogenase (DHODH), and the blockage of uridine transport into cells.

255 Results demonstrated a significant blockage of VEGF-VEGFR binding by bevacizumab.

256 everse transcription stalls, consistent with blockage of viral reverse transcriptase at gRNA branch p

257 ns must occur without fault to prevent fatal blockages of the airway.

258 NA-PKcs is necessary to relieve the physical blockage on end-ligation imposed by the DNA-PKcs protein

259 pped on the paper leads to the ion diffusion blockage on microelectrodes, therefore cell concentratio

260 Blockage or activation of TREM-1 signaling lowered or ra

261 n with C. muridarum readily induces fibrotic blockage or hydrosalpinx in mice and is used for investi

262 stinal tract while inducing oviduct fibrotic blockage or hydrosalpinx.

263 Pharmacological blockage or knockdown of STIM1 or ORAI1 reduced ENO-1-de

264 be a promising approach to control catheter blockage, or biofilm formation on other medical devices.

265 dinated apical constriction nor its complete blockage prevent internalization and tube formation, alt

266 mbination of antiretroviral therapy with RCA blockage, provirus activators, and therapeutic vaccines

267 of accessible focusing parameters, including blockage ratio, volumetric flow rate, cell concentration

268 P-selectin blockage resulted in a marked reduction of PASMC prolife

269 ase in internal resistance and physical pore blockage resulting from extensive cycling may be importa

270 activation pharmacological protein synthesis blockage results in mnemonic failure in hippocampus-depe

271 tion (D1(-/-) , D2(-/-) ) or pharmacological blockage (SCH23390: 0.1 mg/kg/day/5 days; Raclopride: 0.

272 ence between doxazosin and placebo for nasal blockage score and heart rate after single but not chron

273 Nasal visual analogue scale (VAS) and blockage scores were worse between baseline vs. first do

274 The joining of a durable PD-1 blockage significantly boosted the efficacy of PTX@HSST

275 ion of several inflammatory markers, and its blockage significantly increases bone loss.

276 citive device is able to detect and forecast blockages, similar to early detection procedures in canc

277 established based on the results of antibody blockage, siRNA depletion of Mincle and its adaptor sple

278 ardly removable old hemorrhagic clot as self-blockage site of posterior scleral penetrating trauma, a

279 We found multiple transcription blockage sites adjacent to and within sequences engaged

280 (starvation or mammalian target of rapamycin blockage) stimulated RACK1-ATG5 interaction.

281 Analysis of the detailed pattern of the blockage suggests that RNA polymerase is sterically hind

282 low inhibitory activity in hERG K(+) channel blockage testing, negativity in the Ames test, and 5/5 c

283 port into alpha-cells link glucagon receptor blockage to alpha-cell hyperplasia.

284 However, the beneficial actions of ACAT1 blockage to treat Alzheimer's disease remained not well

285 inhibition of JNK was, similar to NF-kappaB blockage, toxic to autonomously proliferating CARD11(L22

286 Triplex-mediated transcription blockage varied significantly with changes in ambient co

287 itochondrial outer membrane permeabilization blockage via BCL2 overexpression or BAX deletion.

288 average percentage of front-windshield UV-A blockage was 96% (range, 95%-98% [95% CI, 95.7%-96.3%])

289 y of the networks was not achieved if IL-17A blockage was delayed two or more hours postreperfusion.

290 This blockage was not observed in DM1 fibroblasts, demonstrat

291 This blockage was quantified by measuring the oxidation curre

292 by FFSS was blocked by PGE2 and CM and this blockage was reversed by U0126 and the CM depleted of PG

293 ogressive increase in sIgG(4) levels and FAB blockage were also found.

294 ted with the replication fork were transient blockages, whereas those oriented head-on were severe, s

295 r than the average percentage of side-window blockage, which was 71% (range, 44%-96% [95% CI, 66.4%-7

296 perturbed axonal transport by causing axonal blockages, which were enhanced by reduction of kinesin-1

297 were 49 patients (10.9%) with cornual tubal blockage, while 57 patients (12.7%) had perifimbrial adh

298 low emissive CDs was quenched due to analyte blockage, while that of the blue emissive CDs stayed alm

299 Furthermore, PAPPA blockage with antibody inhibited embryo implantation in

300 ring ischemia of various severity or channel blockage with realistic timescales.