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1 PIMMS43 as a target of malaria transmission blocking.
2 0.82, P < .001) with those measured by HBGA blocking.
3 second-order conditioning without affecting blocking.
4 nucleic acid (siRNA) depletion, and antibody blocking.
5 tate of UBE2S that confers autoinhibition by blocking a catalytically critical ubiquitin binding site
6 nophil activity was adhesion dependent, as a blocking Ab against CD11b significantly reduced adhesion
8 5, was previously demonstrated implicated in blocking Abeta-induced cytotoxicity in neuronal cell cul
9 tance of ~ 80% and a haze of ~ 93%), good UV-blocking ability, and low thermal conductivity (0.24 W m
10 the modulation of autoantibody half-life and blocking access of autoantibodies to fragment cystalliza
11 ng to variations between their efficiency in blocking access to the active layer by water molecules.
20 ous study performed by our group showed that blocking actomyosin interactions within an activated myo
22 causes developmental neurotoxicity partly by blocking adhesion mediated by the L1 neural cell adhesio
23 sorption and bovine serum albumin (BSA) as a blocking agent generated a moderate sensitivity of 0.016
24 Nonradioactive palbociclib was used as a blocking agent to investigate the binding specificity an
27 t not all-trans-RA or previous RA metabolism blocking agents, appears to protect epidermal barrier in
31 ind AhR directly as competitive antagonists, blocking AhR nuclear localization, XRE binding, and targ
32 chanisms of haematin growth inhibition, kink blocking and step pinning(12,13), exhibit both synergist
34 ibodies show more potent S1 binding, S1/ACE2 blocking, and SARS-CoV-2 pseudovirus neutralization than
36 n early after initiation of therapy with PD1-blocking antibodies and predicts a clinical response to
37 and CD11b, and mechanistic experiments using blocking antibodies confirmed a functional role for CD31
41 f-of-concept that combining antiparasite MIF-blocking antibodies with current standard-of-care antibi
42 e results suggest that a combination of Ang2-blocking antibodies with radiation increases tumor growt
44 d functional, primarily Mal d 1-specific IgE-blocking antibodies, whereas rBet v 1 SLIT induced Bet v
47 agents not in widespread clinical use, CD47-blocking antibody (alphaCD47Ab), soluble complement rece
51 up, tumors following BRAFi, aPDL1, and CSF1R-blocking antibody combination therapy did not show great
55 vo tumours with fractionated radiation and a blocking antibody to FGF2 prolongs tumour growth delay,
56 istered with a single dose of IFN-I receptor-blocking antibody to induce a short-term blockade of the
57 MF6 -/- cells, and the addition of the LAG-3-blocking antibody to the adoptive transfer protocol impr
64 This was supported by the observation that blocking bacterial translation with chloramphenicol resu
66 onses against the ABO-blood group Ags, while blocking both BCRs and TLR-MyD88 by using Bruton's tyros
67 n effectively control tumors by sequentially blocking both intrinsic and extrinsic inhibitory signali
68 egions, and bicyclic 14-mer SFTI-1 analogues blocking both, primed and nonprimed binding sites of pla
69 P2 antagonism can be attributed, in part, to blocking brain recruitment of blood-borne monocytes.SIGN
70 avigation guided by boundaries is robust to "blocking" by prior state-reward associations due to lear
75 nt chain CD74, which inhibits viral entry by blocking cathepsin-mediated processing of the Ebola glyc
76 preferentially in HER2-expressing cells, and blocking CD47 or HER2 reduces both receptors with dimini
80 T-lymphocyte antigen 4-Ig), a fusion protein blocking costimulatory signaling between antigen-present
82 umor cell migration to LECs was inhibited by blocking CXCL11 whereas recombinant CXCL11 significantly
96 ormation capture and dCas9 mediated enhancer blocking establish a direct regulatory link between this
98 isinhibiting dormant dopaminergic neurons by blocking excessive astrocytic GABA could be an effective
101 to establish the efficacy of cloth masks at blocking expiratory particles for speech and coughing at
102 PSCs can be stabilized in the naive state by blocking extracellular differentiation stimuli, particul
103 In this study, we have developed an HtrA1-blocking Fab fragment to test the therapeutic hypothesis
106 rupting mitochondrial network homeostasis by blocking fission or fusion synergizes with reduced mitoc
107 ng repressors TLE3, HDAC7, and NFIC, thereby blocking FOXA1-repressive function and activating the in
119 mplicate up-regulated ST6Gal-I expression in blocking homeostatic epithelial cell apoptosis in gastri
121 hosphorylation and depolymerization, thereby blocking HSP27-regulated survival signaling and client-o
122 ng, and a shift in the critical frequency by blocking I (h) Simulating 1000 synchronized layer 5 PCs,
123 role in maintaining HIV latency and whether blocking IC molecules with Abs reverses HIV latency.
124 IT was equally effective as SCIT in terms of blocking IgG induction and suppression of lung inflammat
125 nt of sensitized animals led to induction of blocking IgG, and improvement of lung function, superior
126 es in the skin, and the effects of LamOVA on blocking IgG, IgE, cellular composition of BAL, lung, an
127 a dominant protective role of functional IgE-blocking IgG1 antibodies in the early phase of allergy t
128 ge, leading to therapeutics indiscriminately blocking IL-17A and global inhibition of its target gene
129 Our results indicate that reducing IRI by blocking IL-1Rsignaling pathways with Anakinra or inflam
130 ed multiple means of preventing APOBEC3 from blocking infection, explaining its survival as an infect
132 l to assess therapy response within PDAC and blocking iNOS/NO signaling may improve radiotherapy outc
133 assays to evaluate efficacy of transmission-blocking intervention (TBI) candidates against Plasmodiu
135 torelease by excited state participation and blocking ion pair recombination by internal nucleophilic
136 s, little is known about the consequences of blocking its enzymatic activity during embryonic develop
138 s promote HSC activation by releasing HMGB1; blocking its release with the small molecule inflachrome
139 facitinib, which inhibits IL-15 signaling by blocking Jak3, might decrease CD8-dependent pathology.
140 rted a similar inhibitory effect, completely blocking keratinocyte inflammatory mediator expression i
141 Of note, administration of 5-HD and 8-SPT blocking key protective signaling routes abrogated the s
142 orts to target these enzymes with the aim of blocking leukemia growth and improving disease outcomes.
144 flammasome components and suggest that while blocking LTB(4) actions could be a promising therapeutic
147 NAc neuronal inhibition is required for AMPA-blocking microinjections in medial shell to induce eithe
149 e did a phase 1-2 study of nivolumab, a PD-1 blocking monoclonal antibody, to determine its safety, p
151 e DNA-binding ability of CST is required for blocking MRE11-mediated nascent-strand degradation.
168 bove 565 nm (orange & red) and that targeted blocking of lower wavebands (up to 430 nm) using light r
169 of the related signaling pathways would make blocking of neonatal immune tolerance to retroviruses an
171 otypes (MIC and growth rate with OTC), while blocking of protein synthesis using low concentrations o
172 ion, we employ the assay to measure receptor blocking of sera from SARS-CoV-2-infected patients.
173 depletion of TAMs, reprograming of TAMs, and blocking of the CD47-SIRPalpha pathway, are discussed.
176 mal external region (MPER) results in robust blocking of viral infection by a class of broadly neutra
177 rgen-specific IgE and their interaction with blocking omalizumab-IgE complexes and free omalizumab le
179 n of the TNF family cytokine TL1A through Ab blocking or genetic deletion of its receptor DR3 restric
180 es in vitro; an effect that was inhibited by blocking or mutating the adhesin RadD on Fusobacterium a
181 tributes to osteoblastic lesion formation by blocking osteoclast differentiation, while also contribu
182 adapter, moved slowly and persistently, and blocking p150 led to a 70 nm/s plus-end shift in the ave
185 LA-I APM by RIG-I synergized with antibodies blocking PD-1 and TIGIT inhibitory checkpoints in boosti
187 sts of connexin channels, connexin 43 (Cx43) blocking peptide Gap26, or Cx43 gene knock-down; (2) ant
190 rate that deleting PIR-A in the recipient or blocking PIR-A binding to donor MHC-I molecules blocks m
194 Anopheles mosquitoes facilitates feeding by blocking production of the anaphylatoxins C3a and C5a, w
195 ontrol of these hormonal effects, ultimately blocking proliferative estrogen signaling (i.e., oral co
196 ation requirements function as repressors by blocking promoter access of SHP-bound conformationally a
198 munotoxins causes potent tumor regression by blocking protein synthesis and down-regulating the Wnt s
199 drug thought to kill Plasmodium parasites by blocking protein translation in the essential apicoplast
201 lleles, with defects in a branchpoint enzyme blocking quercetin biosynthesis, formed reduced numbers
203 increases the half-life of activated Ras by blocking recruitment of Ras GTPase-activating protein (R
204 otein function with ApoA-I raising agents or blocking relevant scavenger receptors with neutralizing
206 ingle-cell RNA-sequencing revealed that Ang2 blocking rescued radiation-induced decreases in T cells
208 mitic acid increases Nav1.6 current, whereas blocking S-palmitoylation with 2-bromopalmitate reduces
209 ar V (T) did not change between baseline and blocking scans, indicating that the cerebellum is a suit
213 single-step immunosensing platform, avoiding blocking, separation and washing steps and exploiting a
214 and Western blot analysis, we observed that blocking Ship1/2 abrogated EMC cell survival by exerting
216 metastatic prostate cancer and suggests that blocking SRC-2 to enhance SIRT3 expression may be therap
218 immunity, and cell death are all buffered by blocking stress signaling through a genuine tissue-auton
225 Antibodies generally inhibit proteases by blocking substrate access by binding to active sites or
227 PFC following a reversible neurotransmission blocking technique in D1 or D2 receptor-expressing NAc n
228 ifferentiation and function were enhanced by blocking TGF-beta signalling, promoting bone morphogenic
229 17A1 show some selectivity in differentially blocking the 17alpha-hydroxylation and lyase activities
231 own-regulates type I interferon signaling by blocking the access of Janus-associated kinase 1 (JAK1)
232 tein particles inhibit Lp-PLA(2) possibly by blocking the access of substrates to the active site.
233 ssess dual activity against these enzymes by blocking the ACE-dependent conversion of angiotensin I t
234 GIX helps to establish pESBL in new hosts by blocking the action of restriction enzymes, in an orient
235 with activating mutations and a caged lysine blocking the active site, we can rapidly switch on catal
237 that is required to sustain NGF signaling by blocking the activity of its phosphatase that shuts off
243 stimulated neutrophils to delay NETosis; and blocking the beta integrin receptor, alpha(M)beta(2,) ab
244 ls with naturally acquired antibodies highly blocking the binding of PvDBP to the Duffy receptor.
245 and modulate pre-mRNA splicing by sterically blocking the binding of splicing factors to the pre-mRNA
246 echanisms employed by pairs of inhibitors in blocking the crystallization of haematin, which is a mod
247 Collectively, our findings suggest that blocking the cytokine-mediated inflammatory cell death s
248 er promote cancer metabolic reprogramming by blocking the expression of the AKT inhibitor PHLDA3.
249 s the intrinsic pathway is mainly induced by blocking the expression or activity of intracellular ant
251 method that boosting BDNF expression through blocking the function of Pdcd4 in depression, indicating
253 previously shown to inhibit HIV-1 egress by blocking the interaction between Tsg101, a member of the
255 or erythroid 2-related factor 2) arises from blocking the interaction of NRF2 with its negative regul
256 Taken together, our results suggest that blocking the interplay between GSCs and TAMs by targetin
258 essment tool explains under which conditions blocking the L-type calcium current can delay or even en
261 neutralizing anti-gB MAbs and suggests that blocking the membrane fusion function of gB could be one
262 emained unclear how this would contribute to blocking the metastasis promoting function of CAV1.
264 transcription factors (in this case NF-KB), blocking the normal signaling processes that tell the nu
265 Lm-induced intestinal barrier dysfunction by blocking the nuclear factor-kappaB and myosin light chai
267 s Al(3+) was attributed to the strategies of blocking the photo-induced electron transfer (PET) and C
268 ng, and protects from DNA damage, ultimately blocking the proneoplastic effects of Nkx3.1 allelic los
269 ancing its G protein-dependent signaling and blocking the recruitment and signaling of beta-arrestin
270 gineering or forced to fuse spontaneously by blocking the replication of Chr2, the secondary chromoso
272 utralizing antibodies that act by sterically blocking the site on the virus used to bind human cells
274 d cut off the secretion of exosomal PD-L1 by blocking the transcription of CD274, which combined with
277 n alpha(IIb)beta(3) receptor and sulfatides, blocking their association to fibrinogen and P-selectin,
278 al benefit of targeted and immune checkpoint blocking therapeutics, current strategies have limited s
281 to both GPVI and integrin alpha(IIb)beta(3) Blocking these pathways may therapeutically reduce amylo
282 driving leukemogenesis, and demonstrate that blocking this interaction in NUP98-PHF23 expressing AML
283 ation of T cells, but some studies show that blocking this pathway exacerbates certain autoimmune dis
284 a 30-fold (geometric mean titer) increase in blocking titers (BT50) and a 161-fold increase in GI.1-s
285 tes and by the clinical success of therapies blocking TNF and IL-23 in IBD and in some forms of SpA.
286 binding to the SARS-CoV-2 spike protein and blocking to the Angiotensin-converting enzyme 2 (ACE2) r
287 n or knock-down of VCAM-1, as well as VCAM-1-blocking treatment in the spontaneous mouse model of pan
288 naling effectors may be a useful therapy for blocking tumor progression in patients with primary or r
289 r MavC modulates the host immune response by blocking Ube2N activity employing an E1-independent ubiq
294 d immune cells infiltration, indicating that blocking VEGF-C signaling can reduce local chronic infla