ライフサイエンスコーパス: blood circulation

1 vasive administration and short half-life in blood circulation.

2 secreted by the tumor and released into the blood circulation.

3 the extracellular tissue milieu back to the blood circulation.

4 of neutrophils from the bone marrow into the blood circulation.

5 and inflow tracts and a complete absence of blood circulation.

6 rdial edema, an elongated heart, and reduced blood circulation.

7 as cleaved by aggrecanases and secreted into blood circulation.

8 eostatic egress from the BM reservoir to the blood circulation.

9 the atrium and inflow tract and compromised blood circulation.

10 esident immune cells are exposed to the open blood circulation.

11 ucture required for efficient clearance from blood circulation.

12 also profoundly affected AAV9 persistence in blood circulation.

13 ma cells to undergo EMT and disseminate into blood circulation.

14 chemotherapy agents while bypassing general blood circulation.

15 antial amounts of glucose into the mammalian blood circulation.

16 e released from healthy and tumor cells into blood circulation.

17 immediate changes in biomarker levels in the blood circulation.

18 ry to prepare for the increase in demand for blood circulation.

19 urther migrate to the lymph nodes and to the blood circulation.

20 lations that include dendritic cells) in the blood circulation.

21 nfolated SCKs, respectively) and a prolonged blood circulation.

22 well examined for the CTCs presence in their blood circulation.

23 endothelial cells, and improved graft tissue blood circulation.

24 of this network of vessels does not require blood circulation.

25 mployed in a rabbit model for extracorporeal blood circulation.

26 ion have dysmorphic hearts and an absence of blood circulation.

27 was lost within 30 min of reestablishing the blood circulation.

28 tinct from its role in establishing coronary blood circulation.

29 ody pigmentation and the inability to affect blood circulation.

30 between EC junctions were able to rejoin the blood circulation.

31 tration efficiency and potential transfer to blood circulation.

32 ived ELA, which reaches the MI heart through blood circulation.

33 rm with active tumor targeting and long-term blood circulation.

34 h tissue barriers that isolate bile from the blood circulation.

35 ows them to flow more efficiently within the blood circulation.

36 esence of bacterial products in the systemic blood circulation.

37 city competing with wildtype counterparts in blood circulation.

38 pathogens from parenchymal tissues into the blood circulation.

39 APN accumulation in spinal cord through the blood circulation.

40 reased endothelial progenitor cell counts in blood circulation.

41 from tumor seemed to be largely impacted by blood circulation.

42 be inactive, was absorbed into the systemic blood circulation.

43 istance of anoikis and increased CTCs in the blood circulation.

44 arterial fluid and tissue metabolites to the blood circulation.

45 oduced locally or reaching the pituitary via blood circulation.

46 ia and lack of enucleated red blood cells in blood circulation.

47 meostasis by returning interstitial fluid to blood circulation.

48 ary or metastatic tumors into the peripheral blood circulation.

49 eliminates about three quarters of LPS from blood circulation.

50 nt is to supply oxygen and nutrients through blood circulation.

51 by malignant prostate cells and released in blood circulation.

52 os prior to the commencement of a functional blood circulation.

53 a(2+)) concentration and finally reached the blood circulation.

54 ells elicited by small-sized tastants in the blood circulation.

55 ity of mutant embryos by E9-10 due to failed blood circulation.

56 livery in a microtissue array with simulated blood circulation.

57 y impairs the development of vasculature and blood circulation.

58 VEGFR2-targeted MBs rapidly cleared from the blood circulation (50% blood clearance after approximate

59 er injection, sufficient time is allowed for blood circulation, accumulation at the tumour site and s

60 EMP seeding the FL upon the establishment of blood circulation acquired c-Myb expression and gave ris

61 Here, we show that MG53 present in blood circulation acts as a myokine to facilitate tissue

62 mpared to the naked enzyme suggesting longer blood circulation after intravenous (iv) administrations

63 d with more visual function loss and retinal blood circulation alterations than those with subfoveal

64 4T1 breast cancer model, owing to prolonged blood circulation and 10-fold higher tumor PTX uptake by

65 t encapsulated drugs from degradation in the blood circulation and allow for slow and prolonged relea

66 AuNR-loaded PLTs (PLT-AuNRs) inherited long blood circulation and cancer targeting characteristics f

67 rate infected erythrocyte sequestration from blood circulation and contribute to adhesion-based compl

68 evealed prolonged Pt persistence in systemic blood circulation and decreased accumulation of Pt in th

69 Radioiodinated BTT-1023 cleared rapidly from blood circulation and distributed to liver and thyroid.

70 Zr-DFO-bexmarilimab cleared rapidly from the blood circulation and distributed to the liver and splee

71 ow physicochemical characteristics influence blood circulation and early distribution.

72 the neutral surface charge required for long blood circulation and effectively downregulate MDR gene

73 is also ascribed to significantly prolonged blood circulation and enhanced tumor accumulation of DPP

74 are small ( approximately 50 nm), show long blood circulation and high tumor accumulation, and facil

75 us administration, HUNGER exhibits prolonged blood circulation and hyaluronic acid-CD44 mediated tumo

76 The nanoreactors maintain inactive during blood circulation and in normal tissues.

77 d mosquito, Plasmodium sporozoites enter the blood circulation and infect the liver.

78 The passage of leukocytes out of the blood circulation and into tissues is necessary for the

79 luding primary tumor growth, survival in the blood circulation and metastatic spread) were generated

80 ion studies showed an increased half-life in blood circulation and more effective tumor accuulation f

81 y rapid clearance of mutant virions from the blood circulation and nonspecific sequestration by the s

82 h types of nanotubes inside cells and in the blood circulation and organs of mice without any signifi

83 ), while a minimal amount was present in the blood circulation and quickly eliminated.

84 es within the spleen, an environment of open blood circulation and shear forces unlike other lymphoid

85 Cardiac function is required for blood circulation and systemic oxygen delivery.

86 The interface between the blood circulation and the neural tissue features unique

87 ain vasculature at the interface between the blood circulation and the parenchyma.

88 ) allows them to persist for several days in blood circulation and to ensure transmission to mosquito

89 Functionalization dependent blood circulation and tumor uptake were investigated thr

90 -responsive nanoparticles is inactive during blood circulation and under normal physiological conditi

91 se of its uniform cell properties, exclusive blood circulation, and ability to sustain rattling for p

92 BBB, and decreasing inflammation in the gut, blood circulation, and brain, ultimately mitigating AD p

93 ae destroy the colonic epithelium, enter the blood circulation, and disseminate to other organs such

94 nd neurological systems, sustaining balance, blood circulation, and functional capacity.

95 neurotrophic agents, improved chorioretinal blood circulation, and inhibition of proinflammatory cyt

96 ng in enhanced colloidal stability, extended blood circulation, and reduced toxicity.

97 reduce non-specific cell uptake, enable long blood circulation, and rescue the bioactivity of a conju

98 a-DOTA-Siglec-9 was rapidly cleared from the blood circulation, and several radioactive metabolites w

99 r identities prior to the onset of embryonic blood circulation, and their specification is crucial fo

100 causes global and pericardial edema, loss of blood circulation, and vascular defects characterized by

101 ethylene glycol (PEG) outer shell to prolong blood circulation; and (iii) surface-encoded internalizi

102 polyethylene glycol (PEG) chains to prolong blood circulation; and iii) sharp pH-responsive hydropho

103 chanisms that could be manipulated to ensure blood circulation at low body temperatures in humans, wh

104 ajor challenge of hibernation is maintaining blood circulation at low body temperatures, which strong

105 n in self-assembly systems is limited during blood circulation because of a requisite concentration f

106 Once blood circulation becomes fully functional, the embryoni

107 d extraembryonic vasculatures are fusing and blood circulation begins.

108 A shared blood circulation between 2 mice (aka parabiosis) or rep

109 There was no significant difference in the blood circulation between polymeric carrier and payload;

110 giogenesis-are also thought to mobilize into blood circulation bone marrow-derived cells (BMDCs), whi

111 form possessed an undetectable nature in the blood circulation, but after exposure to the tumor micro

112 ciparum-infected erythrocytes sequester from blood circulation by binding host endothelium.

113 We established a chimeric blood circulation by parabiosis between fetal chicks and

114 ides entails their premature cleavage in the blood circulation by soluble and endothelium-derived NEP

115 d from niches in the bone marrow (BM) to the blood circulation by the cytokine granulocyte colony-sti

116 ts, malaria sporozoites are removed from the blood circulation by the liver within minutes after inje

117 Neutralization of CTCs in blood circulation can potentially attenuate metastases t

118 ministration and membrane destabilization in blood circulation could result in only a very small frac

119 range of physiological activities, including blood circulation, digestion and reproduction.

120 ect may lead to severe disruptions of normal blood circulation due to capillary occlusions.

121 sue with ischemia-reperfusion injury and the blood circulation during polymicrobial sepsis in mice.

122 heart (sih) embryos, lacking a heartbeat and blood circulation, exhibited severely reduced HSCs.

123 Cells and biomolecules exposed to blood circulation experience hydrodynamic forces that af

124 effector B cells that transiently appear in blood circulation following infection or vaccination.

125 und receptor, tissue factor (TF), exposed to blood circulation following tissue injury and/or vascula

126 produced by the AAV vector were detected in blood circulation for >250 days after the one-time vecto

127 utants unable to bind to CAR remained in the blood circulation for a prolonged period.

128 y mobilized from the bone marrow (BM) to the blood circulation for clinical transplantation.

129 these nanoplatforms are not activated during blood circulation for efficient tumor tissue accumulatio

130 the lacteal, sending fats into the systemic blood circulation for energy production.

131 nimizing nonspecific binding while improving blood circulation for therapeutic/imaging agents.

132 nt breast cancer cells that have entered the blood circulation from primary mammary fat pad tumors or

133 r lectin of hepatocytes, rapidly clears from blood circulation glycoproteins bearing glycan ligands t

134 size (~36 nm, determined by TEM), increased blood circulation half-life (median reported half-life i

135 vo, T-gly-HP9 exhibited significantly longer blood circulation half-life and superior tumor uptake co

136 the hybrid formulations drastically improve blood circulation half-life from <1 h (PC7A) to 18 h (Hy

137 r phagocyte system (MPS) in vivo with a long blood circulation half-life of 10.1 +/- 3.3h, and potent

138 spherical nanoparticles have shown prolonged blood circulation half-lives and higher cellular interna

139 e mononuclear phagocyte system and excellent blood circulation half-lives of 16.4 +/- 2.9 and 12.0 +/

140 ll-functionalized SWNT formulation with long blood circulation (half-life of approximately 30 h) in v

141 bute to subintestinal vasculature even after blood circulation has been initiated.

142 These endothelial cells, without exposure to blood circulation, have an abnormal distribution within

143 ecise information on localized variations in blood circulation holds the key for noninvasive diagnost

144 ity in pneumococcal sepsis to eliminate from blood circulation host factors that contribute to coagul

145 s, which regulate the return of lymph to the blood circulation; however, these valves lacked the fibr

146 was arrested from E7.5, the time of onset of blood circulation; (ii) heterozygous G6PD(+/-) females s

147 EV) particles can be removed from the murine blood circulation in a phagocyte-dependent manner which

148 ed GAG-binding WT SINV-EEEV virions from the blood circulation in a reductionist, experimental viremi

149 fection by accelerating viral clearance from blood circulation in addition to neutralization.

150 acity to perform overdrive pacing to augment blood circulation in an anesthetized pig model.

151 tention of SINV-EEEV particles in the murine blood circulation in an experimental viremia model.

152 gh felodipine dosage (780 nmol/eye) improved blood circulation in endothelin-1-induced ischemic eyes.

153 eristics, because it is actively shed in the blood circulation in humans via specific cleavage of the

154 putational models can help us understand the blood circulation in patients with AF, no current models

155 udy, we demonstrate a new method to evaluate blood circulation in the eye by combining in vivo PAM im

156 aser Doppler perfusion imaging revealed that blood circulation in the ischemic limb was significantly

157 reticuloendothelial system, causing a short blood circulation in vivo.

158 and monocyte-derived macrophages (MDMs) from blood circulation infiltrate glioblastoma (GBM) and prom

159 ietic cells, megakaryocytes do not enter the blood circulation intact.

160 ain tissue fluid homeostasis by returning to blood circulation interstitial fluid that has extravasat

161 cretion of small molecules from the systemic blood circulation into urine is one of the physiological

162 onor-derived cell-free DNA (dd-cfDNA) in the blood circulation is an early marker of injury in solid

163 nd root, left ventricular outflow tract, and blood circulation is crucial for AVA's functions: unidir

164 Blood circulation is dependent on heart valves to direct

165 e respiratory pump, pulmonary parenchyma and blood circulation is essential for a normal lung functio

166 +) events, while neither neural activity nor blood circulation is necessary or sufficient.

167 One of the most important functions of the blood circulation is O2 delivery to the tissue.

168 lls and increased tumor cell survival in the blood circulation, it was insufficient to affect the abi

169 drug leakage during preparation, storage, or blood circulation, lack of active targeting to tumor tis

170 e endothelial wall, but this also slows down blood circulation, leading in some cases to severe cereb

171 ubility, reduce off-target toxicity, enhance blood circulation lifetime, and increase the amount of d

172 f VSV improved the persistence of VSV in the blood circulation, maintaining a more than 1-log-unit in

173 aller circulatory mucins protruding into the blood circulation may be one source of O-glycans that we

174 T cells obtained from the peripheral blood circulation may not reflect the biologically relev

175 fore organ retrieval and before cessation of blood circulation, metabolic pathways related to hypoxia

176 ne marrow-derived progenitors that enter the blood circulation, migrate through the pulmonary endothe

177 l show muscle degeneration, strongly reduced blood circulation, mispatterning of vessels, impaired sp

178 surgical procedures to be done, a patient's blood circulation needs to be stopped.

179 ained at least partly by the presence in the blood circulation of CGAs and their metabolites.

180 of these four muscle-specific miRNAs in the blood circulation of DM1 patients.

181 ce of miRNAs encapsulated within exosomes in blood circulation of DM1 patients.

182 ion) has become a standard method to prolong blood circulation of imaging probes and other proteins,

183 y GSH depletion, which in turn prolonged the blood circulation of intact ICG-Au(25) SG(18) and enhanc

184 evere combined immunodeficiency mice extends blood circulation of intravenous Ad5 but decreases its e

185 ed carbon nanotubes (SWNTs), we measured the blood circulation of intravenously injected SWNTs and de

186 g dams, are efficiently transferred into the blood circulation of lactationally-exposed neonatal pups

187 nding activity also cleared rapidly from the blood circulation of mice, with radioactivity accumulati

188 following the recovery of liposomes from the blood circulation of ovarian carcinoma patients.

189 PG-PEG block polymer) significantly enhanced blood circulation of the drug and accumulation in tumor

190 The half-lives in blood circulation of two phosphorylated GALNS enzymes we

191 soluble endoglin (sEng), is elevated in the blood circulation of women with preeclampsia and contrib

192 opportunity to study the effects of lack of blood circulation on the morphogenesis of endothelial ce

193 In vivo studies of blood circulation pathologies have great medical relevan

194 into the accumulated membrane damage during blood circulation, paving the way for further investigat

195 species and neurofilament light chain to the blood circulation, potentially facilitating diagnosis of

196 Temporary occlusion of liver blood circulation prevented CBLB502 from protecting hema

197 of platelet production and removal from the blood circulation prevents anomalies in both processes f

198 Venous valves play a crucial role in blood circulation, promoting the one-way movement of blo

199 ially be used as a novel tool to analyze the blood circulation proteome.

200 cell obstruction and interference with local blood circulation, rather than direct tissue penetration

201 Sporozoites enter the blood circulation, reach the liver, and infect hepatocyt

202 protein outflux from these populations into blood circulation remains poorly understood.

203 toxicity via diminishing Pb in the brain and blood circulation, resulting in the prevention of the ox

204 -8.5, prior to cardiac function and systemic blood circulation, revealed that capillary plexi formed

205 that eliminating plasma fibronectin from the blood circulation reverses the prometastatic effects of

206 es reliable vascular access to the patient's blood circulation, such as an arteriovenous access in th

207 ne content and presence of heme in LDL after blood circulation suggest that LDL is modified, in part,

208 Bioluminescence was dependent on intact blood circulation, suggesting that the colonic environme

209 polymer-coated SWNTs exhibit remarkably long blood circulation (t(1/2) = 22.1 h) upon intravenous inj

210 bcutaneous A549 lung tumors showed prolonged blood circulation (t(1/2), approximately 28 h) and incre

211 ead to distant non-malignant tissues via the blood circulation, termed circulating tumour cells (CTCs

212 ate, using Ncx1(-/-) mice that lack systemic blood circulation, that the E9 yolk sac (YS) and the int

213 ncluding severe destabilizing effects in the blood circulation, the blood-brain barrier/blood-brain t

214 that at the interface between the brain and blood circulation, the epithelial layers of the choroid

215 abiotic mice with separate organs but shared blood circulation, the majority of dermal DCs failed to

216 nd monocytes that infiltrate tumors from the blood circulation, their heterogeneity, and their intera

217 f protochordate colonial tunicates sharing a blood circulation, there exists an exchange of somatic s

218 otic mice with separate organs, but a shared blood circulation, there was no mixing of LCs.

219 d space and, ultimately, resorption into the blood circulation through arachnoid granulations.

220 young healthy mouse, thus providing a shared blood circulation through parabiosis, or through repeate

221 pleen) and are rapidly cleared from systemic blood circulation through the renal excretion route.

222 The tracer remained stable in blood circulation throughout the study and accumulated t

223 In vivo, these nanoparticles showed a longer blood circulation time (t(1/2) approximately 24.2 min) t

224 DLTPT displayed prolonged blood circulation time and efficiently accumulated at th

225 The copper nanodrugs had prolonged blood circulation time and enhanced accumulation at tumo

226 radable nanoparticles (NPs) to sustain their blood circulation time and made them small enough to ext

227 lding the Ad surface, accomplishing extended blood circulation time and reduced immunogenicity as wel

228 onjugation of PEG on proteins prolongs their blood circulation time and reduces immunogenicity by inc

229 It exhibited longer blood circulation time compared with free Dox, and there

230 n excels against other NPs in prolonging the blood circulation time of Ppa (up to 13-fold), penetrati

231 The ultralong blood circulation time suggests greatly delayed clearanc

232 he design of the dendrimer carrier optimized blood circulation time through size and molecular archit

233 er accumulation at tumor sites and prolonged blood circulation time versus an uncoated control in mic

234 BCMs possessed a longer in vivo blood circulation time when compared to NCM.

235 ake, and oral bioavailability, with extended blood circulation time, increased tumor accumulation, en

236 nducted to characterize the biodistribution, blood circulation time, neutralizing antibody formation,

237 lexes exhibited greater stability, increased blood circulation time, reduced renal clearance, increas

238 ctions; second, the nanoemulsions had a long blood circulation time; finally, the concentrated glutat

239 oaded with an anticancer drug displayed long blood-circulation time and high specificity in inducing

240 ~10-200 nm), such as those required for long blood circulation times and appreciable tumor localizati

241 ion 6 (G6, 6.7nm) dendrimers showed extended blood circulation times and increased accumulation in th

242 to form the envelopes and obtained extended blood circulation times following i.v. administration an

243 greater than the renal threshold have longer blood circulation times in mice than do linear polymers

244 ze of the overall assembly promotes extended blood circulation times in vivo.

245 -weight platinum anticancer drugs have short blood circulation times that are reflected in their redu

246 noprobes can be engineered to achieve longer blood circulation times, specific clearance pathways, an

247 hat AuNP that are 15 nm or smaller have long blood circulation times, while larger AuNP accumulated i

248 s with high haemocompatibility and increased blood circulation times.

249 ofunctionalization efficiencies, and enhance blood circulation times.

250 By contrast, in the absence of blood circulation, tissue P(O2)in vitro decreases more m

251 is thought to require transport through the blood circulation to reach distal sites.

252 The migration of neutrophils from the blood circulation to sites of infection or injury is a k

253 rst objective in treating CLI is to increase blood circulation to the affected limb.

254 ge and homing of newborn Treg cells from the blood circulation to the gut.

255 ty to deliver antigens rapidly from the open blood circulation to the secluded follicles.

256 iciently permeates through the skin into the blood circulation; transdermal administration of OP-conj

257 ation is limited due to rapid clearance from blood circulation, transfection of nontarget tissues, to

258 ity of the cardiovascular system to maintain blood circulation under a broad range of haemodynamic wo

259 eveloped, enabling thus far the longest SWNT blood circulation up to 1 day, relatively low uptake in

260 of LDL- formation was studied during ex vivo blood circulation using a model system resembling clinic

261 nsplanted cells, are linked to the patient's blood circulation via an anastomosis graft.

262 cent nanoparticles can be delivered into the blood circulation via i.v. injection, recharged by 400-n

263 across the epithelial monolayer to enter the blood circulation via the mesenteric lymphatic system.

264 ecific binding, undesired toxicity, and poor blood circulation which contribute to poor therapeutic e

265 This necessitates the establishment of blood circulation, which is initiated during the early s

266 ich maintain the vascular barrier and enable blood circulation while dampening leukocyte extravasatio

267 le to minimize the premature drug release in blood circulation while releasing drug on-demand at tumo

268 ly in combination with a simplified model of blood circulation with three ammonia-detoxifying compart