ライフサイエンスコーパス: blood coagulation

1 e that plays an important role in initiating blood coagulation.

2 matory effects of thrombin without affecting blood coagulation.

3 othrombinase complex-the molecular engine of blood coagulation.

4 e of complement, inflammatory responses, and blood coagulation.

5 nsmembrane receptor and primary initiator of blood coagulation.

6 processes such as development, immunity, and blood coagulation.

7 tissue factor (TF), the primary initiator of blood coagulation.

8 of membrane lipid asymmetry is a hallmark of blood coagulation.

9 p.prothrombin complexes during initiation of blood coagulation.

10 an important role in regulating TF-initiated blood coagulation.

11 nt serine protease that negatively regulates blood coagulation.

12 flow, activate the endothelium, and increase blood coagulation.

13 emical network of proteolytic enzymes called blood coagulation.

14 gluconeogenesis, amino acid metabolism, and blood coagulation.

15 pts platelet function and platelet-activated blood coagulation.

16 immune response, inflammatory response, and blood coagulation.

17 Ca(2+)-dependent scramblase activity during blood coagulation.

18 ved in kinase activity, immune response, and blood coagulation.

19 process leading to platelet aggregation and blood coagulation.

20 c polyphosphates have been shown to activate blood coagulation.

21 n histone methylation, and genes involved in blood coagulation.

22 cal functions from regulating cell growth to blood coagulation.

23 ost widely used clinical marker of activated blood coagulation.

24 icipates in the contact activation system of blood coagulation.

25 ne (PS)-containing platelet membranes during blood coagulation.

26 r Xa, a Na(+)-activated protease involved in blood coagulation.

27 cal functions from regulating cell growth to blood coagulation.

28 ught to be the key step in the initiation of blood coagulation.

29 cal role of the contact activation system in blood coagulation.

30 er of inhibitors of platelet aggregation and blood coagulation.

31 tissue factor (TF), the primary initiator of blood coagulation.

32 mental processes, complement regulation, and blood coagulation.

33 ctor VIIa (FVIIa) mediates the initiation of blood coagulation.

34 gers the release of F3, the key initiator of blood coagulation.

35 ew blood vessel formation, and modulation of blood coagulation.

36 feeding, to induce vasodilation and inhibit blood coagulation.

37 rm the essential "prothrombinase" complex of blood coagulation.

38 tant for initiating the intrinsic pathway of blood coagulation.

39 The chimera exhibited biphasic effects upon blood coagulation.

40 3-O sulfated HS motif is thought to modulate blood coagulation.

41 n that functions as an essential cofactor in blood coagulation.

42 s a cofactor within the intrinsic pathway of blood coagulation.

43 re of the protein complexes that form during blood coagulation.

44 ithrombin, a protease inhibitor, to regulate blood coagulation.

45 nt noncovalently associated fibrin chains in blood coagulation.

46 both the extrinsic and intrinsic pathways of blood coagulation.

47 rast, Cbs(-/-) mice show no abnormalities in blood coagulation.

48 platelet aggregates and fibrin clots during blood coagulation.

49 contributions to our basic understanding of blood coagulation.

50 nels involved in olfaction, nociception, and blood coagulation.

51 cal for regulating reproductive hormones and blood coagulation.

52 e-dependent enzyme complexes is critical for blood coagulation.

53 platelet surface in the propagation phase of blood coagulation.

54 (ATIII) is a key antiproteinase involved in blood coagulation.

55 h a well defined role in the final stages of blood coagulation.

56 Tissue factor (TF), a primary initiator of blood coagulation, also plays a pivotal role in angiogen

57 surfaces (contact activation), resulting in blood coagulation and activation of the inflammatory kal

58 that phospholipid scrambling is important in blood coagulation and apoptosis, the concomitant activat

59 nd we show that chemerin is activated during blood coagulation and attracts pDC but not mDC in ex viv

60 re shown to degrade host proteins central to blood coagulation and basement membrane integrity, sugge

61 ple important physiological roles, including blood coagulation and beneficial effects on myelin integ

62 Historically known for its role in blood coagulation and bone formation, vitamin K (VK) has

63 itamin K's importance in human health beyond blood coagulation and bone health necessitates its furth

64 Analogous to blood coagulation and complement activation in mammals,

65 ulation, as exemplified by activation of the blood coagulation and complement zymogens.

66 Proteins involved in blood coagulation and complement/coagulation cascades re

67 of Ebola hemorrhagic fever, neither delayed blood coagulation and disseminated intravascular coagula

68 Activation of blood coagulation and fibrinolysis may be associated wit

69 ndent serine protease with putative roles in blood coagulation and fibrinolysis.

70 binase complex is a pivotal initial event in blood coagulation and has been the subject of investigat

71 enzymatic activation is the central event in blood coagulation and has important biomedical and biote

72 Serine protease cascades are involved in blood coagulation and immunity.

73 Blood coagulation and inflammation are universal respons

74 The protein C pathway plays a key role in blood coagulation and inflammation.

75 For a long time, blood coagulation and innate immunity have been viewed a

76 of proteins, including proteins involved in blood coagulation and its regulation.

77 ausing mutations at the promoters of several blood coagulation and lipid metabolism genes were also i

78 externalizing phosphatidylserine to trigger blood coagulation and mark apoptotic cells.

79 GPI is essential to maintain homeostasis of blood coagulation and neurological function.

80 Excessive activation of blood coagulation and neutrophil accumulation have been

81 cal networks that play a fundamental role in blood coagulation and other patho/physiological processe

82 ion of the immune system strongly influences blood coagulation and pathological thrombus formation.

83 h the growing recognition that components of blood coagulation and platelets have prothrombotic and p

84 nchoring domain found on vitamin K-dependent blood coagulation and regulatory proteins.

85 to all Na(+)-activated proteases involved in blood coagulation and the complement system.

86 er is unique to Na(+)-activated proteases in blood coagulation and the complement system.

87 A unique link between blood coagulation and the ECM is established.

88 the initiation of the consolidation phase of blood coagulation and the generation of thrombin at site

89 nd other Na(+)-activated enzymes involved in blood coagulation and the immune response.

90 display a bleeding diathesis, despite normal blood coagulation and the lack of thrombocytopenia.

91 s glycoproteins and regulatory components in blood coagulation and thrombosis that include von Willeb

92 eletal muscle myosins can directly influence blood coagulation and thrombosis, ex vivo studies of the

93 rane excitability and secretion to mediating blood coagulation and viral infection.

94 ets thrombin and other proteases involved in blood coagulation, and ATIII misfolding can thus lead to

95 ellular activities, including wound healing, blood coagulation, and immune responses.

96 pathways that regulate platelet activation, blood coagulation, and inflammation are emerging as crit

97 proteases that affect cell growth and death, blood coagulation, and inflammation.

98 , glucose metabolism, complement activation, blood coagulation, and inflammation.

99 of proatherogenic lipoproteins, accelerates blood coagulation, and modulates inflammation.

100 ia, regulation of cell migration, effects on blood coagulation, and platelet activation.

101 the ternary TF-VIIa-Xa initiation complex of blood coagulation, and the EPCR-dependent activation of

102 iological functions, including angiogenesis, blood coagulation, apoptosis, extracellular matrix remod

103 of vascular smooth muscle and prevention of blood coagulation are mediated by ligand-induced activat

104 e critical and multiple roles of thrombin in blood coagulation are regulated by ligands and cofactors

105 ctor VIII (FVIII) has a critical function in blood coagulation as the pro-cofactor to the serine-prot

106 usly to cleave human Factor V and deregulate blood coagulation, as the most abundant type II secreted

107 nal thromboelastometry (ROTEM) is a holistic blood coagulation assay.

108 ocking mEPCR and was absent in ex vivo whole blood coagulation assays, implicating a specific mFVIIa-

109 Plasma and whole blood coagulation assays, the latter measured by thrombo

110 es in the pathogenesis of CVD via a platelet/blood coagulation-based mechanism.

111 During the process of blood coagulation, BDNF is released from platelets, whic

112 s down their chemical gradients and mediates blood coagulation, bone development and viral infection.

113 ates include vertebrate proteins involved in blood coagulation, bone mineralization, and signal trans

114 Tissue factor (TF) initiates blood coagulation, but its expression in the vascular sp

115 The lipid scramblase TMEM16F initiates blood coagulation by catalyzing the exposure of phosphat

116 The metalloprotease ADAMTS13 regulates blood coagulation by cleaving von Willebrand factor (VWF

117 he bloodstream during infection, in inducing blood coagulation by direct proteolytic ProT activation.

118 Vitamin K epoxide reductase (VKOR) sustains blood coagulation by reducing vitamin K epoxide to the h

119 of the most important natural inhibitors of blood coagulation, carries a higher risk.

120 Thrombin, a key protease of the blood coagulation cascade and a potent inducer of angiog

121 ice partially restored the activation of the blood coagulation cascade and accumulation of platelets.

122 ein S, which is both an anticoagulant in the blood coagulation cascade and an activating ligand for t

123 as a key enzyme for the intervention of the blood coagulation cascade and for the development of new

124 he initiator of the extrinsic pathway of the blood coagulation cascade and normally released from dam

125 ntly showed that polyphosphate modulates the blood coagulation cascade at 3 steps: it triggers the co

126 r for factor VIIa (fVIIa) that initiates the blood coagulation cascade during vascular injury.

127 It utilizes components of the blood coagulation cascade in the presence of polystyrene

128 The blood coagulation cascade includes a step in which the s

129 elet-CTC interactions inherently rely on the blood coagulation cascade including platelet activation.

130 rombin, and its activation at the end of the blood coagulation cascade results in the formation of th

131 cular understanding of a key reaction of the blood coagulation cascade where cofactor Va enhances act

132 flammatory protease that is regulated by the blood coagulation cascade, exerts similar effects depend

133 , without inhibiting serine proteases in the blood coagulation cascade.

134 R, maintain vitamin K levels and sustain the blood coagulation cascade.

135 re primarily restricted to components of the blood coagulation cascade.

136 tein complexes formed, and regulation of the blood coagulation cascade.

137 Va is central for amplified flux through the blood coagulation cascade.

138 th the cell membrane are critical within the blood coagulation cascade.

139 Blood coagulation caused, in a thrombin-dependent manner

140 e range of biological activities, regulating blood coagulation, cell differentiation, and inflammator

141 ry event for many cellular processes such as blood coagulation, cell proliferation, and migration.

142 ncluding measurements of enzyme kinetics and blood coagulation, cell-based assays, and chemical react

143 Although blood coagulation changes such as disseminated intravasc

144 During porcine whole blood coagulation, changes in the elastic property of th

145 tion of nonlinear reaction networks, such as blood coagulation (clotting), by small quantities of act

146 lished that, apart from its distinct role in blood coagulation, coagulation factor FVIIa enhances agg

147 ce the pigs' immunological compatibility and blood-coagulation compatibility with humans.

148 ulate proteases of plasma, mostly enzymes of blood coagulation, complement, and inflammatory systems.

149 also emerged: genes related to inflammation, blood coagulation, detoxification, serum proteins, amino

150 al. recently identified a class of diseases--blood coagulation disorders--that were associated with a

151 omarker in characterization and treatment of blood coagulation disorders.

152 ease were observed including petechial rash, blood coagulation dysfunction, and various biochemistry

153 cell life, such as cholesterol homeostasis, blood coagulation, EGFR binding, p53 binding, Notch sign

154 Factor XIa (FXIa) is a blood coagulation enzyme that is involved in the amplifi

155 ants capable of functionally expressing this blood-coagulation enzyme.

156 bited excellent selectivity against relevant blood coagulation enzymes and displayed antithrombotic e

157 d excellent selectivity against the relevant blood coagulation enzymes.

158 ct of antibodies and mitigate the binding of blood coagulation factor (Factor X) in vitro.

159 or of blood coagulation in vivo and the only blood coagulation factor for which a human genetic defec

160 leeding disorder hemophilia B [deficiency in blood coagulation factor IX (F.IX)] by gene replacement

161 F9, a gene on the X chromosome that encodes blood coagulation factor IX, and is predicted to alter R

162 Blood coagulation factor IXa (fIXa) is a trypsin-like se

163 Blood coagulation factor IXa has been presumed to be reg

164 Activation of blood coagulation factor V (FV) is a key reaction of hem

165 Blood coagulation factor V circulates as a procofactor w

166 The uptake and processing of blood coagulation factor VIII (FVIII) by antigen-present

167 tor (LDLR) was shown to mediate clearance of blood coagulation factor VIII (FVIII) from the circulati

168 Blood coagulation factor VIII (fVIII) is activated by th

169 Development of neutralizing Abs to blood coagulation factor VIII (FVIII) provides a major c

170 which shares homology with the C2 domains of blood coagulation factor VIII and factor V.

171 Blood coagulation factor VIII has a domain structure des

172 a genetic disease caused by a deficiency of blood coagulation factor VIII or IX.

173 , and 23/26del) which cannot bind platelets, blood coagulation factor VIII, or collagen, causing VWD

174 raction between the capsid hexon protein and blood coagulation factor X (FX), whilst penton-alpha(v)i

175 Ad5 transduction requires blood coagulation factor X (FX); FX binds to the Ad5 cap

176 sAd24 virions formed unstable complexes with blood coagulation factor X and, because of that, transdu

177 protein Z (PZ), to regulate the function of blood coagulation factor Xa on membrane surfaces.

178 In the intrinsic pathway of blood coagulation factor XIa (FXIa) activates factor IX

179 l synthesis of selective inhibitors of human blood coagulation factor XIIa and thrombin exhibiting a

180 to transamidation by both TG2 and activated blood coagulation factor XIII (FXIIIa).

181 During blood coagulation, factor IXa (FIXa) activates factor X

182 Some recombinant vitamin K-dependent blood coagulation factors (factors VII, IX, and protein

183 prothrombin activator, trypsin-like enzymes, blood coagulation factors and prophenoloxidase cascade a

184 Spatial distribution of blood coagulation factors on the surface of procoagulant

185 r which tracks with reduced plasma levels of blood coagulation factors V, VII, VIII, IX, X, and XII.

186 Deficiency of blood coagulation Factors VIII, IX, or XI is associated

187 nctions as a cofactor-dependent regulator of blood coagulation factors Xa (FXa) and XIa.

188 nctions as a cofactor-dependent regulator of blood coagulation factors Xa and XIa.

189 vectors can bind several vitamin K-dependent blood coagulation factors, which contributes to virus se

190 inone to sustain gamma-carboxylation of many blood coagulation factors.

191 nvolves virus binding to vitamin K-dependent blood coagulation factors.

192 gulate complex proteolytic pathways, such as blood coagulation, fibrinolysis, and inflammation.

193 as well as proteolytic cascades that affect blood coagulation, fibrinolysis, and pericellular proteo

194 family of enzymes responsible for digestion, blood coagulation, fibrinolysis, development, fertilizat

195 nd further extend the molecular link between blood coagulation/fibrinolysis and CMKLR1-mediated immun

196 ssed by eosinophils can induce activation of blood coagulation generating thrombin which in turn can

197 The biochemistry of blood coagulation has been well defined over the past 50

198 egulator of endothelial barrier function and blood coagulation, has been proposed to be involved in t

199 enriched in biological pathways involved in blood coagulation, hemostasis and tissue repair.

200 ly in the process of tissue factor-initiated blood coagulation; however, the catalytic sequence leadi

201 We propose that PSGL-1 plays a role in blood coagulation in addition to its known role in leuko

202 perimental thrombosis in mice and suppresses blood coagulation in an extracorporeal membrane oxygenat

203 vated form) crosslinking leads to defects in blood coagulation in FXIII deficiency; loss of TG1 and T

204 vitamin K epoxide reductase (VKOR) supports blood coagulation in humans and is the target of the ant

205 Blood coagulation in humans requires the activity of vit

206 onary artery endothelial cells and activated blood coagulation in mice.

207 ut drug leakage and can sustainably regulate blood coagulation in response to thrombin.

208 During surface-initiated blood coagulation in vitro, activated factor XII (fXIIa)

209 ssue factor (TF) is the primary initiator of blood coagulation in vivo and the only blood coagulation

210 ating that one pathway for the initiation of blood coagulation in vivo involves the accumulation of t

211 an essential cofactor for the activation of blood coagulation in vivo.

212 and differentiation, lipoprotein metabolism, blood coagulation, inflammation, tissue regeneration, tu

213 elium maintains blood fluidity by inhibiting blood coagulation, inhibiting platelet aggregation, and

214 sms include acetylation of other proteins in blood coagulation, inhibition of COX-2 activity, and oth

215 Absence of the blood coagulation inhibitor thrombomodulin (Thbd) from t

216 ogate to evaluate the vascular modulation of blood coagulation initiated by relipidated recombinant t

217 digm of how MCs hinder fibrin deposition and blood coagulation internally.

218 Blood coagulation involves activation of platelets and c

219 Blood coagulation is a finely regulated physiological pr

220 The interplay between inflammation and blood coagulation is an essential part of host defense d

221 Regulation of blood coagulation is critical for maintaining blood flow

222 Blood coagulation is essential for physiological hemosta

223 led submodel of the tissue factor pathway of blood coagulation is introduced within the framework of

224 The binding of Factor IX to membranes during blood coagulation is mediated by the N-terminal gamma-ca

225 A computational model of blood coagulation is presented with particular emphasis

226 Blood coagulation is regulated through protein-protein a

227 Blood coagulation is sensitive to the local concentratio

228 Blood coagulation is strongly dependent on the binding o

229 ritical step in injury-induced initiation of blood coagulation is the formation of the complex betwee

230 for factor VIIa (FVIIa), besides initiating blood coagulation, is believed to play an important role

231 g tissue factor and PAI-1, diminished global blood coagulation markers (fibrinogen, fibrin-degradatio

232 t for this class of molecules, inhibition of blood coagulation may be occurring through a mechanism i

233 invariably associated with activation of the blood coagulation mechanism, secondary to the inflammati

234 r brush coatings are effective in preventing blood coagulation or bacterial attachment, but their cha

235 thways related to cell adhesion, chemotaxis, blood coagulation, oxidoreductases, matrix metalloprotei

236 Enzymes of the blood coagulation pathway enhance the inflammatory respo

237 mophilia occurs from deficiency of intrinsic blood coagulation pathway factor VIII or IX, pharmacolog

238 ne system activation and prolongation of the blood coagulation pathway.

239 blocks thrombin generation via the extrinsic blood coagulation pathway.

240 domains is one of the essential steps in the blood coagulation pathway.

241 re the ultimate proteolytic reactions in the blood coagulation pathway.

242 one enriched for platelet degranulation and blood coagulation pathways and the other for complement

243 An upregulation of genes involved in blood coagulation, platelet activation was characteristi

244 propose that RAGE is involved in modulating blood coagulation presumably in conditions of lung injur

245 n our understanding of the physiology of the blood coagulation process and the translation of this un

246 ced our understanding of the dynamics of the blood coagulation process beyond end point assays and ar

247 th and inflammatory responses as well as the blood coagulation process.

248 Pro-inflammatory signaling by the blood coagulation protease thrombin through protease act

249 we have directly investigated a role for the blood-coagulation protease thrombin in regulating the ad

250 Mutants of blood coagulation proteases have been reported with Glu,

251 tithrombin, a key serpin family regulator of blood coagulation proteases, is transformed into a poten

252 Here we show that fibrinogen, a central blood coagulation protein deposited in the CNS after blo

253 s that bind human neutrophil elastase or the blood coagulation protein factor IXa.

254 The blood coagulation protein factor XI (FXI) consists of a

255 hence the regulation of vitamin K-dependent blood coagulation protein synthesis.

256 Proteolysis of the multimeric blood coagulation protein von Willebrand Factor (VWF) by

257 A structure-function analysis of a blood coagulation protein, antithrombin III and a protea

258 Factor XI (FXI) is a homodimeric blood coagulation protein.

259 s with sequence homology to the C domains of blood coagulation proteins factor V and factor VIII.

260 been used to explore the role of platelets, blood coagulation proteins, endothelium, and the vessel

261 f proteases, growth factors, chemokines, and blood coagulation proteins.

262 equirement for TF during the progress of the blood coagulation reaction and have extended these analy

263 ar cofactor tissue factor (TF) initiates the blood coagulation reactions.

264 nts of substrate affinity and specificity in blood coagulation reactions.

265 In mice lacking the blood coagulation regulator thrombomodulin, fibrinolytic

266 on membranes, is essential for the amplified blood coagulation response.

267 The blood coagulation scheme for the puffer fish, Fugu rubri

268 From our data, we propose a revised blood coagulation scheme in which direct FXa-mediated FV

269 iological and pathological processes such as blood coagulation, skeletal development, viral infection

270 Consequently, dynamic blood coagulation status can be measured quantitatively

271 Exploiting the blood coagulation system as an exquisite biological sens

272 lammatory processes and abnormalities of the blood coagulation system.

273 t can potentiate several interactions in the blood coagulation system.

274 thological states caused by a malfunctioning blood coagulation system.

275 include abnormal ocular blood flow, abnormal blood coagulation, systemic hypotension, ischemic vascul

276 Platelets are important mediators of blood coagulation that lack nuclei, but contain mitochon

277 The inhibition of the final step in blood coagulation, the factor XIIIa (FXIIIa) catalyzed c

278 During blood coagulation, the protease factor XIa (fXIa) activa

279 of tissue factor action in the initiation of blood coagulation, the structure and membrane-binding pr

280 on mechanism requisite for the complexity of blood coagulation, they are stepping-stones towards furt

281 In blood coagulation, thrombin helps to activate factor XII

282 he physiological regulation of intravascular blood coagulation (thrombosis) by the endogenous protein

283 I) contributes substantially to pathological blood coagulation (thrombosis), whereas it contributes o

284 rocesses, ranging from nutrient digestion to blood coagulation, thrombosis, and beyond.

285 eed for rapid, low-cost, portable testing of blood coagulation time or prothrombin time (PT).

286 alsalva, applied research on circulation and blood coagulation to devise whole-body fasting and bleed

287 iety of physiological processes ranging from blood coagulation to embryo- and oncogenesis, tissue reg

288 tures seem endowed with multiple roles, from blood coagulation to inter-cellular communication in pat

289 potent inhibitor of tissue factor-initiated blood coagulation, to the macaques either 10 min (n=6) o

290 t that proteases of the extrinsic pathway of blood coagulation transactivate the MASP matriptase, thu

291 membrane-bound tissue factor (TF) initiates blood coagulation upon vascular injury.

292 dynamic and quantitative assessment of whole blood coagulation using acoustic radiation force orthogo

293 the proteolytic enzyme thrombin, involved in blood coagulation, utilizing a library of beta-sheet epi

294 In order of increasing fluence we observed: blood coagulation, vasoconstriction, thread-like appeara

295 tor IX, respectively, resulting in deficient blood coagulation via the intrinsic pathway.

296 as shown that platelet contribution to whole blood coagulation was unrelated to the generation of act

297 rameters of tissue injury, regeneration, and blood coagulation were assessed in tissue/blood samples.

298 At low concentrations it accelerated blood coagulation, while at higher concentrations it act

299 Studies of the mechanisms of blood coagulation zymogen activation demonstrate that ex

300 C), a potent conformational activator of the blood coagulation zymogen, prothrombin (ProT).