ライフサイエンスコーパス: blood-borne

1 depending on whether an agonist is tissue or blood borne.

2 d by cells that were neither endothelial nor blood borne.

3 To more directly test whether blood-borne Abeta peptides can cross a defective BBB, we

4 (saline-injected controls) blocked entry of blood-borne Abeta peptides into the brain.

5 sions reached a plateau within 20 min as the blood-borne activity was consumed.

6 inal zone B (MZB) cells, which produce Ab to blood-borne Ag.

7 For blood borne Ags, cells localized in situ in the spleen s

8 the ability of the MZM compartment to clear blood-borne Ags and mount proper T-independent immune re

9 for clearance of and rapid response against blood-borne Ags entering the spleen.

10 associated with a smaller ability to capture blood-borne amino acids as protein, the results of a dec

11 e investigated the possibility that soluble, blood-borne amyloid beta (Abeta) peptides can cross a de

12 ly identified from adult male, adult female, blood-borne and uterine microfilariae, and infective L3

13 It has been proposed that blood-borne Ang II can influence the RVLM via a neural c

14 in the MZ and RP facilitates their access to blood-borne antigen and enables the rapid initiation of

15 oss of MZ B cells, deficiencies in capturing blood-borne antigen and suppression of circulating IgM.

16 dies have shown that circulating DCs capture blood-borne antigen and transport it into the extra-vasc

17 bles them to efficiently capture and deliver blood-borne antigens and antigen-containing immune compl

18 st that the BM supports crosspresentation of blood-borne antigens similar to the spleen; uniquely, al

19 Splenic dendritic cells (DCs) present blood-borne antigens to lymphocytes to promote T cell an

20 supports secondary immune responses against blood-borne antigens, but it is unsettled whether primar

21 t has an important role in responses against blood-borne antigens, lymphocyte migration in the margin

22 of MZ B lymphocytes that respond rapidly to blood-borne antigens.

23 ed to the capture and follicular delivery of blood-borne antigens.

24 at produces T-cell-independent antibodies to blood-borne antigens.

25 d and lymphoid tissue, detect and respond to blood-borne antigens.

26 Blood-borne B cells predominately used CCR7 signaling to

27 Life-long latent EBV persistence occurs in blood-borne B lymphocytes, while EBV intermittently prod

28 We found that Kupffer cells directly capture blood-borne bacteria and subsequently nucleate formation

29 rious infection of the CNS that results when blood-borne bacteria are able to cross the blood-brain b

30 In particular, the role played by blood-borne bacteria is controversial.

31 In order to produce meningitis, blood-borne bacteria must interact with and breach the b

32 uring sepsis, one immediate host response to blood-borne bacteria was induction of a refractory perio

33 -/-) animals displayed a 10-fold increase of blood-borne bacteria, C5(-/-) animals exhibited a 400-fo

34 s play an important role in the clearance of blood-borne bacterial infections via rapid T-independent

35 estis and possibly for those caused by other blood-borne bacterial pathogens.

36 er evaluation of PTX3 as a tissue biopsy and blood-borne biomarker to discriminate BPH from prostate

37 r continuous or instantaneous measurement of blood borne biomarkers without compromising sensitivity.

38 and blood-brain barrier markers) as well as blood borne biomarkers.

39 The identification of blood-borne biomarkers correlating with melanoma patient

40 Certain blood-borne biomarkers offer a potent methodology for un

41 We discuss putative mechanisms for blood-borne brain rejuvenation and suggest promising ave

42 regulatory mechanism for polyFn assembly on blood-borne breast cancer cells and depict its effect on

43 Blood-borne Brugia malayi microfilariae survived for sig

44 For a blood-borne cancer therapeutic agent to be effective, it

45 proach has been achieved in the treatment of blood-borne cancers, but the advances with solid tumours

46 uring hematogenously disseminated infection, blood-borne Candida albicans invades the endothelial cel

47 ovel tool that can be utilized for targeting blood borne cells for experimental immunology and drug d

48 e in-depth discussion of human Tfh cells and blood borne cells with similar features and the role of

49 d activation of Fc receptors on infiltrating blood-borne cells and tissue resident cells amplifies an

50 om Tie1-YFP embryos showed that up to 30% of blood-borne cells are Tie1 positive; though cells expres

51 Tissue colonization (homing) by blood-borne cells critically hinges on the ability of th

52 Removing blood-borne cells from analysis by the simple technique

53 logistical limitations on the utilization of blood-borne cells in medical diagnostics and scientific

54 ay discriminate between tissue-localized and blood-borne cells in the mouse lung.

55 egensis, proliferation occurs only in small, blood-borne cells that express integrin-alpha-6 (IA6), p

56 e capacity to direct migration ('homing') of blood-borne cells to a predetermined anatomic compartmen

57 ted sites, a process initiated by binding of blood-borne cells to E-selectin displayed at target endo

58 aining to discriminate tissue-localized from blood-borne cells, we find substantial accumulation of C

59 ls are mediated by DC-induced recruitment of blood-borne cells.

60 s from multiple tissues as they phagocytosed blood-borne cellular material.

61 tandem with a fibrocyte marker, supports the blood-borne circulating fibrocyte hypothesis of the dise

62 Here we test the hypothesis that thrombin, a blood-borne coagulation factor, contributes to neurovasc

63 re especially selective in determining which blood-borne components gain access to neurons.

64 induces CXCL9 and -10 that support homing of blood-borne CXCR3-expressing NK cells to the liver predo

65 icating that lack of both liver-resident and blood-borne DC ameliorated hepatic warm IR injury.

66 that liver-resident DC and locally recruited blood-borne DC might have distinctive roles in hepatic I

67 differential roles of liver-resident versus blood-borne DC, and points to the importance of the loca

68 By contrast, blood-borne DCs represent a heterogeneous population, th

69 enic cases will be small, the risk of future blood-borne disease transmissions could be entirely elim

70 nuclide for use in targeted alpha therapy of blood-borne diseases and micrometastatic diseases.

71 entify cellular pathways contributing to the blood-borne dissemination of cancer.

72 These data support a role for EMT in the blood-borne dissemination of human breast cancer.

73 l replication in the respiratory system, and blood-borne dissemination to other organ systems.

74 ic regulation of EMT-associated genes during blood-borne dissemination.

75 id analysis reveals lineages not detected in blood-borne DNA, suggesting possible clinical utility.

76 arget specific tissues, we hypothesized that blood-borne drug payloads could be modified to home to a

77 Blood-borne ecdysis-triggering hormone (ETH) activates t

78 IgM and IgG production after infection with blood-borne encapsulated bacteria or immunization with b

79 oduce antibody in response to infection with blood-borne encapsulated pathogens.

80 y are transported to their site of action as blood-borne endocrine hormones but can also be produced

81 This ubiquitously expressed and blood-borne enzyme is the target autoantigen in the K/Bx

82 Transfer of blood-borne EVs from brain-injured animals was also enou

83 However, recent studies performed with blood-borne EVs have been hindered by the lack of effect

84 tudy, we examined the ability of endogenous, blood-borne exosomes to regulate the immune response.

85 inhibitor of metalloproteinases 2 (TIMP2), a blood-borne factor enriched in human cord plasma, young

86 avioral effects of parabiosis, implicating a blood-borne factor.

87 with wild-type mice, suggesting a relay by a blood-borne factor.

88 However, it is unclear how blood-borne factors dynamically access the islets of Lan

89 decline, and highlight a new model in which blood-borne factors in aged animals act through local ni

90 cently published study in Cell proposes that blood-borne factors in the adult systemic environment ar

91 using heterochronic parabiosis we show that blood-borne factors present in the systemic milieu can i

92 eing can be in part attributed to changes in blood-borne factors.

93 genitor cells, and, recently, as a source of blood-borne fibroblasts (CB-BFs).

94 The incorporation of blood-borne forms of tissue factor (TF) into a growing b

95 f the two cDC subsets in the presentation of blood-borne HEL.

96 able from animals to humans and an important blood-borne human parasitic infection.

97 A novel blood-borne human pegivirus (HPgV), HPgV-2, was recently

98 e altered in various diseases, the origin of blood-borne IL-6R is still poorly understood.

99 ury, resident immune cells are activated and blood-borne immune cells are recruited to the site of in

100 Hepatitis C virus is a blood-borne infection and the leading cause of chronic l

101 s (HCV) infection is the most common chronic blood-borne infection in the United States and a leading

102 tis C virus (HCV) is the most common chronic blood-borne infection in the United States and will beco

103 s C virus (HCV) infection is the most common blood-borne infection in the United States, with estimat

104 Although efforts to reduce blood-borne infection incidence have had impact, this wo

105 Hepatitis C virus (HCV) is a blood-borne infection readily transmitted by transfusion

106 Hepatitis C virus (HCV) is a blood-borne infection that can lead to progressive liver

107 rus infection is well-recognized as a common blood-borne infection with global public health impact a

108 Occupational acquisition of blood-borne infections has been reported following expos

109 utrophils from blood to tissues in models of blood-borne infections versus bacterial invasion through

110 s (eg, methadone and buprenorphine) prevents blood-borne infections via reductions in injection in pr

111 Ninety-eight individuals at risk of blood-borne infections were tested for PARV4 IgG.

112 Beyond acute injuries and blood-borne infections, back and neck pain is a poorly r

113 nfection is common in individuals exposed to blood-borne infections, independent of their HCV or HIV

114 ant role in mounting protective responses to blood-borne infections.

115 Because HIV is a blood-borne infectious disease, from the early days of t

116 ss to OTC syringes would potentially prevent blood-borne infectious diseases among IDUs.

117 In animal studies, central and blood borne inflammatory cytokines that can be elevated

118 es engage the complement cascade, recruiting blood-borne inflammatory cells and initiating tissue inf

119 n carotid body-mediated sensing of asthmatic blood-borne inflammatory mediators.

120 that is independent of either leukocytes or blood-borne inflammatory molecules.

121 we observed no increase in the oxidation of blood-borne lactate in the T1D subjects, as reflected by

122 usively from migratory LCs, but also include blood-borne langerin(+) DCs that transit through the der

123 a collagen matrix in vitro, suggesting that blood-borne leukocyte penetration through the arterial b

124 degrading elastin and collagen and regulates blood-borne leukocyte transmigration and lesion progress

125 Tat protein released from HIV-infected blood-borne leukocytes can contribute to the breakdown o

126 +/- 3 mm(3); n = 10; p < 0.01), implicating blood-borne leukocytes in the damage.

127 In many of these responses, infiltration of blood-borne leukocytes into the kidney is central to the

128 ident cells (e.g., mast cells), migration of blood-borne leukocytes, mirrored by blood neutrophilia.

129 Sphingosine 1-phosphate (S1P) is a blood-borne lipid mediator implicated in the regulation

130 Recently, adipose-derived blood-borne lipids ("lipokines") have emerged as a disti

131 on of lipid species, a process that requires blood-borne lipids to initially traverse the blood vesse

132 Blood borne Listeria monocytogenes enter the CNS via mig

133 Despite the importance of oxidation of blood-borne long-chain fatty acids (Fa) in the cardiomyo

134 Blood-borne lymphocytes home to lymph nodes by interacti

135 EVs) that are chief portals for the entry of blood-borne lymphocytes into lymphoid organs.

136 Sphingosine 1-phosphate (S1P) is a blood-borne lysosphingolipid that acts to promote endoth

137 helial junctions in steady-state and capture blood-borne macromolecules.

138 Phagocytosis activity of blood-borne macrophages decreased with age at 18 months

139 Human blood-borne macrophages repopulated the meninges and per

140 hat ART carriage could be facilitated within blood-borne macrophages traveling across the blood-brain

141 Thymic lymphopoiesis depends on blood-borne, marrow-derived progenitors, but characteriz

142 Here we show that splenic or, unexpectedly, blood-borne MDSC execute far-reaching immune suppression

143 obilised from the bone marrow in response to blood-borne mediators and subsequently recruited to the

144 synchronously throughout the lung, caused by blood-borne mediators of inflammation, voluminous aspira

145 Blood-borne metastasis accounts for the vast majority of

146 ferentially promote single cell motility and blood-borne metastasis and therefore activation of this

147 d up to 30-fold in cancer patients, promotes blood-borne metastasis in an animal cancer model.

148 Blood-borne metastasis to the brain is a major complicat

149 act mechanisms as to how platelets influence blood-borne metastasis, however, remain poorly understoo

150 ls, mediating a cytoprotective effect during blood-borne metastasis.

151 ls are capable of being activated in situ by blood-borne microbes in a T-independent manner to genera

152 Production of blood-borne microparticles (MPs), 0.1-1 um diameter vesi

153 mph node (MLN) and continuing recruitment of blood-borne migrants into the lung airways during antige

154 ild-type [WT]) and knockout mice, we tracked blood-borne miR-210 using bone marrow transplantation an

155 is: raw data of 1539 microarrays and 705 NGS blood-borne miRNomes were statistically evaluated, sugge

156 Delivery of blood-borne molecules and nanoparticles from the vascula

157 tricting entry of circulating leukocytes and blood-borne molecules into the CNS.

158 the ventricular side allows the diffusion of blood-borne molecules into the parenchyma of the ME whil

159 Blood-borne molecules must therefore be able to circumve

160 d cells such as brain-resident microglia and blood-borne monocytes are thought to be critically invol

161 assumed that they have a high turnover from blood-borne monocytes.

162 mmatory cytokines, and brain infiltration of blood-borne monocytes.

163 d, in part, to blocking brain recruitment of blood-borne monocytes.SIGNIFICANCE STATEMENT Unabated se

164 that EBV latently infects a unique subset of blood-borne mononuclear cells that are direct precursors

165 laque macrophages are thought to derive from blood-borne myeloid cells.

166 e that SAP inhibits the differentiation of a blood-borne, myeloid cell population into fibroblasts by

167 hesion molecule that supports recruitment of blood-borne naive and central memory cells into lymph no

168 To reach sites of inflammation, a blood-borne neutrophil first rolls over the vessel wall,

169 Blood-borne neutrophils are excluded from entering lymph

170 ow that HEVs are the major route of entry of blood-borne neutrophils into TDLNs through interactions

171 f hIL-37tg mice, along with lower numbers of blood-borne neutrophils, macrophages, and activated micr

172 throughout the lung, mediated by inhaled or blood-borne noxious agents.

173 ffinity, interpreted as the likelihood for a blood-borne NP to firmly adhere to the vessel walls, is

174 e and the specific, vascular accumulation of blood-borne NPs.

175 mains unclear, they are likely released from blood borne or distant cells.

176 ood but also as the major lymphoid organ for blood-borne or systemic infections.

177 The blood-borne origin of these cells was confirmed in exper

178 gen atmosphere, raising the possibility that blood-borne oxygen itself might induce astrocyte differe

179 The disease is caused by blood-borne parasites, Plasmodium species, and is transm

180 rne and other pathogenic bacteria, and other blood-borne parasites.

181 bridging channels promotes DC encounter with blood-borne particulate antigen.

182 in facilitating capture and presentation of blood-borne particulate antigens.

183 Hepatitis C virus (HCV) is a blood borne pathogen mostly transmitted via percutaneous

184 tutes an interesting approach to investigate blood-borne pathogen diversity in wild vertebrates and c

185 tis C virus (HCV) is the most common chronic blood-borne pathogen in the US and a leading cause of co

186 nfected fibrin clot-and show that the common blood-borne pathogen Staphylococcus epidermidis influenc

187 Hepatitis B virus (HBV) is an important blood-borne pathogen that causes hepatic inflammation an

188 Hepatitis C virus (HCV) is a common blood-borne pathogen that relies heavily on nucleic acid

189 operations (142/373) were found to involve a blood-borne pathogen when tested: HIV (26%), hepatitis B

190 rne Zika virus (ZIKV) is now recognized as a blood-borne pathogen, raising an important question abou

191 the priming of splenic T-cell responses to a blood-borne pathogen.

192 timal timing of live donor testing for these blood borne pathogens has not been determined.

193 say for the multiplexed identification of 20 blood-borne pathogens (Staphylococcus epidermidis, Staph

194 een play an important role in the capture of blood-borne pathogens and are viewed as an essential com

195 using severe malaria syndromes as well other blood-borne pathogens and blood-related diseases.

196 an aberrant MZ that may affect responses to blood-borne pathogens and peripheral B-cell tolerance.

197 idly generate Ag-specific IgM in response to blood-borne pathogens and play an important role in the

198 ism and the phagocytosis of erythrocytes and blood-borne pathogens are significantly reduced prior to

199 ining the risk of iatrogenic transmission of blood-borne pathogens by less invasive routes, such as s

200 The spread of blood-borne pathogens by mosquitoes relies on their taki

201 3 to 4 days, and are critical for preventing blood-borne pathogens from evolving into life-threatenin

202 es have hampered the identification of novel blood-borne pathogens in these animals.

203 While the incidence of these blood-borne pathogens is increasing in the general popul

204 y, 380 000-400 000 occupational exposures to blood-borne pathogens occur annually in the United State

205 ings, risks of occupational infection with 3 blood-borne pathogens remain in the health care workplac

206 number of recipients becoming infected with blood-borne pathogens such as HIV and hepatitis C.

207 th fenestrations that can potentially permit blood-borne pathogens to access the brain(2).

208 Testing for blood-borne pathogens was performed in 53% (N = 373) of

209 ify, in a multiplexed fashion, a panel of 20 blood-borne pathogens with high sensitivity and specific

210 d in mounting rapid immune responses against blood-borne pathogens, including conventional dendritic

211 require the rapid and accurate detection of blood-borne pathogens, including human immunodeficiency

212 nsidered to be important for TI responses to blood-borne pathogens, MZ B cells were not responsible f

213 erences in transmission of the 3 most common blood-borne pathogens, the natural history of early HCV

214 re part of the first line of defense against blood-borne pathogens, their increase following a breach

215 B cells, providing early immune responses to blood-borne pathogens.

216 ons requiring rapid and reliable testing for blood-borne pathogens.

217 sk for allergic reactions and infection with blood-borne pathogens.

218 ific procedure days were offered testing for blood-borne pathogens.

219 hus restricting their capacity to respond to blood-borne pathogens.

220 role of the complement system in response to blood-borne pathogens.

221 ) (P < 0.01) were most often associated with blood-borne pathogens.

222 mature B cell subset that rapidly respond to blood-borne pathogens.

223 independent humoral immune responses against blood-borne pathogens.

224 It functions as a chemosensor for blood-borne peptides and solutes, and converts this info

225 endocrine systems must detect and integrate blood-borne peripheral signals.

226 the basal lamina, which are then engulfed by blood-borne phagocytes.

227 caused by Borrelia spirochetes with distinct blood-borne phases of infection.

228 nts, including hemoglobin and bilirubin, are blood-borne photoreceptors, regulating gasotransmitters

229 ic technique for assessing relative rates of blood-borne precursor recruitment, we examined Mphi and

230 ietic stem cells (HSCs), nor which potential blood borne precursors lead to the formation of histiocy

231 - to 14-day period and were replenished from blood-borne precursors at a rate of nearly 4,300 cells p

232 n important input for the risk assessment of blood-borne prion disease transmission and for refining

233 n important input for the risk assessment of blood-borne prion disease transmission and for refining

234 Observations that show the efficacy of blood-borne prion transmission is more dependent on the

235 ur data suggest that the initial delivery of blood-borne prions to FDC in the spleen occurs independe

236 ure did not affect the early accumulation of blood-borne prions upon splenic FDC or reduce susceptibi

237 gulatory role of Plvap in the development of blood-borne protein detection machinery at a neuroendocr

238 d direct proof that Plvap limits the rate of blood-borne protein passage through fenestrated endothel

239 in the blood and that tissue damage exposes blood-borne Pvf1 to Pvr receptors on wound-edge epiderma

240 169-expressing macrophages captured incoming blood-borne retroviruses and limited their spread to the

241 Lymph- and blood-borne retroviruses exploit CD169/Siglec-1-mediated

242 In addition, the blood-borne RNA molecules were correlated with SLE disea

243 NA inputs, we are able to detect three major blood-borne RNA viruses - HIV, HCV and HEV.

244 nation with previous efforts to characterize blood-borne RNA viruses in wild primates across sub-Saha

245 e central nervous system (CNS) by a strictly blood-borne route.

246 The spleen and C3 provide resistance against blood-borne S. pneumoniae infection.

247 a genome-based investigation of a recurrent blood-borne Salmonella enterica serotype Enteritidis (S.

248 us, we proposed that RIIb of LSEC eliminates blood-borne SIC, thereby controlling immune complex-medi

249 Testing the capacity of liver RIIb to clear blood-borne SIC, we infused mice intravenously with radi

250 cells lining cerebral microvessels, but how blood-borne signaling molecules influence permeability i

251 ses and is anatomically privileged to detect blood-borne signals.

252 mosensory information with oropharyngeal and blood-borne signals.

253 source of relevant accessible biomarkers are blood-borne small extracellular vesicles (sEVs).

254 racellular and transcellular barrier to many blood-borne solutes via tight junctions (TJs) and scarce

255 were found among week-to-week assessments of blood-borne SPC HIF factors.

256 c regression demonstrated that the number of blood-borne SPCs and the cellular content of HIFs at stu

257 The blood-borne ST6Gal-1 produced and secreted by the liver

258 ng-disk intravital microscopy to monitor the blood-borne stage in a murine bacteremic model of P. aer

259 pose future threats, particularly those with blood-borne stages that are resistant to viral-inactivat

260 on route allowing exclusive direct access of blood-borne substances to hippocampal NSCs.

261 es, such as the brain that is impermeable to blood-borne substances.

262 othesized that a poxvirus, which evolved for blood-borne systemic spread in mammals, could be enginee

263 y be the optimal location for it to abrogate blood-borne TF activity that incorporates within the blo

264 The low penetration of blood-borne therapeutics into the brain can oftentimes b

265 subset that represented approximately 15% of blood-borne Tmem cells.

266 the brain while also blocking the passage of blood-borne toxins and pathogens to brain and central ne

267 at the blood-brain barrier prevents unwanted blood-borne toxins and signalling molecules from enterin

268 AIV H5N1 infection may increase the risk of blood-borne transmission between humans.

269 e of early events of HTLV-1 spread following blood-borne transmission of the virus in vivo hinders a

270 on pathway, but not in Bartonella, which use blood-borne transmission pathways.

271 Endogenous blood-borne transport of miR-210 into pulmonary vascular

272 merged as a relevant model for assessing the blood-borne vCJD transmission risk.

273 iors that increase the risk of transmissible blood-borne viral (BBV) infection, but the impact of thi

274 om seronegative donors at increased risk for blood-borne viral infection (DIRVI).

275 tis C virus (HCV) is the world's most common blood-borne viral infection for which there is no vaccin

276 meta-analysis to estimate the prevalence of blood-borne viral infection in people with serious menta

277 nlikely to be a sole risk factor and risk of blood-borne viral infection is probably multifactorial a

278 The prevalences of blood-borne viral infections in people with serious ment

279 al illnesses have a high risk of contracting blood-borne viral infections, sexual health has largely

280 e with serious mental illness are at risk of blood-borne viral infections.

281 phetamine use on mortality, suicidality, and blood borne virus incidence.

282 ric approaches can address mental health and blood borne virus infection risk if better tailored to m

283 lobal health concern, and the most prevalent blood-borne virus in Australia.

284 cause of disease burden and a contributor to blood-borne virus transmission.

285 opulation in regions with high prevalence of blood-borne viruses (Africa for HIV and southeast Asia f

286 The elevated risk of blood-borne viruses (BBVs) in people with severe mental

287 ted harms from injection drug use, including blood-borne viruses (BBVs), but gender-based differences

288 outinely discuss sexual health and risks for blood-borne viruses (including risks related to drug mis

289 c or molecular markers for various unrelated blood-borne viruses (n = 6) and sera obtained from healt

290 Blood-borne viruses detected through large-scale routine

291 iency virus (SIV) (family Retroviridae), the blood-borne viruses harbored by these animals in the wil

292 for detection and identification of multiple blood-borne viruses that infect millions of people world

293 population in places with low prevalence of blood-borne viruses, such as the USA and Europe, and on

294 ut nucleic acid amplification test (NAT) for blood-borne viruses, suitable for use in the screening o

295 ial interest for assessment of the impact of blood-borne viruses.

296 t was tested anonymously for the presence of blood-borne viruses.

297 ge of interventions to prevent the spread of blood-borne viruses.

298 role in the surveillance and diagnostics of blood-borne viruses.

299 rategy could help reduce the transmission of blood-borne viruses.

300 latory factor (IRF) as a model, we show that blood-borne ZIKV administration can lead to pronounced e