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1 Ca(2+) transients, and cell contraction were blunted.
2 rees C), a condition in which hypothermia is blunted.
3 oassays, we found that T cell responses were blunted.
4 PreCon upon p38 activation was significantly blunted.
5 h are key antiviral mediators, is reportedly blunted.
6 05), luminal flow-mediated dilation severely blunted (-3.2% of 9.4% [-34%]; P < .001), along with red
7 ered the circulating lactate:pyruvate ratio, blunted a metformin-induced rise in blood lactate:pyruva
8 s, IgE-deficiency in Apoe(-/-) Ige(-/-) mice blunts AAA growth and reduces lesion accumulation of mac
10 sing of reward stimuli, thereby rescuing the blunted activation in the mesolimbic pathway found in pa
11 b) active expiration elicited by hypoxia was blunted after blockade of ionotropic glutamatergic recep
16 e inhibition, tumor growth was significantly blunted and corresponded to a decrease in RTK levels.
17 equently, differentiation of plasma cells is blunted, and Ab responses are transient and devoid of af
20 ynamic features that were enhanced early and blunted at later disease stages, indicating evolving res
23 he unpredictable threat test, animals showed blunted behavioral and cardiovascular responsivity after
25 oxidant effects in WT mice: N-acetylcysteine blunted beta3-AR stimulation-induced browning of white a
27 7b (-/-) mice fed a chow diet presented with blunted body-weight gain over time, had lower fat mass,
28 e dose of ZOL administered at ART initiation blunts bone resorption and BMD loss at key fracture-pron
29 e dose of ZOL administered at ART initiation blunts bone resorption and BMD loss at key fracture-pron
31 ted cell mineralocorticoid receptor ablation blunted, but did not eliminate, aldosterone's effect on
34 of myofilaments to calcium was significantly blunted by human TnI, suggesting that human cTnI phospho
35 and temperature dependence of lung injury is blunted by inhibitors of p38 mitogen-activated protein k
36 ly, TLR8 potentiation by the gapmer ASOs was blunted by locked nucleic acid (LNA) and 2'-methoxyethyl
40 responses elicited by PPTg stimulation were blunted by prior injection of methyl-atropine (5 mm/50-7
43 ed to have negligible effect on APD, whereas blunted Ca(2+) -dependent inactivation of I(Ca,L) by Cav
44 in the exclusion of D(1) R from lipid rafts, blunted cAMP response, impaired sodium transport, and in
45 ar programs induced by cMYC, a response that blunts carcinoma initiation, but does not perturb the no
46 slower rate compared to that of males, with blunted cardiovascular consequences (i.e. inspiratory mu
47 ity to uncertain, low-imminence threat while blunting cardiovascular and behavioral anticipatory arou
48 vaccinated subjects exhibiting significantly blunted CD4 T cell responses and diminished antibody res
49 vaccinated subjects exhibiting significantly blunted CD4 T-cell responses and diminished antibody res
50 ng the IFN-lambda receptor (Ifnlr1(-/-)) had blunted CD8(+) T cell responses relative to wild type an
51 e of GABA release was attenuated, suggesting blunted CeA 5-HT sensitivity, which partially recovered
54 ucleus (RTN) displayed increased apnoeas and blunted CO(2)-stimulated breathing; re-expression of PAC
56 r from insulin-induced hypoglycemia and to a blunted CRR caused by 2-deoxy-d-glucose (2DG) administra
64 udy is comparable to our previous results of blunted dexamphetamine-induced opioid release in gamblin
65 y human studies: increased average levels, a blunted diurnal rhythm, and enhanced response to stresso
67 suggests that repeated exposure to nicotine blunts dopamine release in the NAc core through changes
68 in vivo microdialysis experiments show that blunted dopaminergic signaling is revived after l-DOPA t
70 erestingly, CSR induced by staggered but not blunt, double-stranded DNA breaks was impaired by SAMHD1
71 forced abstinence facilitated extinction and blunted drug-induced reinstatement in female mice, it ha
74 expectedly, the ALVAC-SIV/CD40L vector had a blunting effect on CD4(+) Th1 helper responses and inste
75 f a canonical efferocytosis receptor, MerTK, blunted efferocytic signatures and led to the escalation
77 rrent results provide a model of transiently blunted emotional reactivity in early development, with
78 of empathy and explore the interplay between blunted empathic behavior and neuropsychiatric disorders
79 pen-source bioinformatics pipeline, BLENDER (blunt end finder), then identifies off-target sequences
84 se repairs sticky ends more efficiently than blunt ends and that the ligation efficiency is influence
88 ls results in impaired thymic involution and blunted expansion of natural regulatory T (T(reg)) cells
90 entanyl vaccine administration significantly blunted fentanyl reinforcement and increased food reinfo
92 ain injuries caused by an explosive blast or blunt force is typically presumed to associate with mech
94 diazoxide-mediated calcium influx inhibition blunted glucose up-regulation of miR-199-3p in islets.
95 findings suggest that although lack of GLUT1 blunted glycolysis and the pentose phosphate pathway, MP
96 acing analyses revealed that HDAC inhibitors blunted glycolysis in a c-Myc-dependent manner and lower
97 r, it remains unknown whether Notch blockade blunts GVHD through its effects on Tconv, Tregs, or both
99 e H(dAc) vaccine granted greater efficacy in blunting heroin analgesia in murine behavioral models co
101 transient hepato-centric insulin action and blunts hypoglycaemia in dogs in response to overdosing.
102 lescents, with depressed individuals showing blunted (hyporeactive) striatal response to monetary rew
103 alance.CONCLUSIONThese results indicate that blunted hypothalamic glucose reactivity might be related
106 -specific CD8 T cell responses, but severely blunted IAV-specific CD4 T cell responses compared to wi
107 vaccination with the same strains tended to blunt IIV neutralization responses to all strains in you
110 monstrated on over-activation induced reward blunting, illustrating the symptom-specificity of its ac
112 stresses, such as high salinity and drought, blunted immune responses in older rosette leaves through
113 gnized as an appealing therapeutic target to blunt immunosuppression in GBM with the hope of maximizi
114 to CH for 1 week, ventilation in hypoxia was blunted in CNS-HIF-1alpha(-/-) and significantly decreas
119 le of MNRR1 in stimulating UPR(mt), which is blunted in MELAS cells, was surprising and further inves
122 tamine, yet maximal respiratory capacity was blunted in MPhi lacking GLUT1, demonstrating an incomple
123 ic markers such as VEGFA and CDH5 which were blunted in skeletal muscles of 28 week old mice were fou
124 and anaphylaxis responses were significantly blunted in Tfr cell-deficient Foxp3-Cre Bcl6fl/fl mice.
129 Previously we reported that resident AMs can blunt inflammatory signaling in alveolar epithelial cell
130 ruited AM implicated increased apoptosis and blunted inflammatory responses in the R213G strain exhib
133 elevant for accurate assessment of potential blunt injuries and elucidating underlying injury mechani
135 ards understanding potential mechanism(s) of blunt injury and implementing novel therapeutic strategi
139 nterferon stimulated genes (ISGs) and causes blunted interferon responses to mycobacterial pathogens
143 its RbBP5 and disruption of this interaction blunts its methyltransferase activity in cells and in vi
144 Hence, delta-secretase cleaves TrkB and blunts its phosphorylation of APP, facilitating AD patho
145 Deleting Notch3 receptors on resident cells blunts kidney fibrosis, ablates NF-kappaB signaling, and
146 xhibited improved left ventricular function, blunted left ventricular hypertrophy, greater preservati
147 targeted Igf1r mRNA, and iii) p53 knock-down blunted let-7b expression, restored Igf1r expression, an
148 ior, normalized stereotypies and anxiety and blunted locomotor sensitization in morphine abstinent mi
149 odel to screen for pharmacological agents to blunt LV dysfunction and associated pathophysiologic cau
151 15), injury severity score = 17 (10-25), 75% blunt mechanism, 32% severe TBI, 11% mortality, 28% func
156 of sorting nexin 1 (SNX1) in mice results in blunted natriuretic response and hypertension due to imp
157 xerts its antidepressant efficacy, via rapid blunting of aberrant sgACC hyper-reactivity to positive
158 SNX1 in RPT cells from NT subjects led to a blunting of D(5) R agonist-induced increase in cAMP prod
160 lymorphonuclear leukocyte efferocytosis, (2) blunting of NF-kappaB activation, and (3) a reduction in
163 s, we found that aging was associated with a blunting of the diurnal rhythm and a significant linear
164 find that acute stress leads to circuit-wide blunting of the DRN output, while the SSRI fluoxetine no
165 jection fraction (HFrEF) is characterized by blunting of the positive relationship between heart rate
167 ilized OPTN, and consequently, loss of MaIL1 blunted OPTN aggregation, TBK1-dependent IRF3 phosphoryl
168 back loop between NMDARs and SK channels was blunted or absent in MNNs of heart failure (HF) rats.
170 ment with the BCL-2 family inhibitor ABT-737 blunts p21 expression, enhancing liver regeneration.
172 uggest that low dose ketamine administration blunts pain perception and reduces blood pressure, but n
173 and female) primary somatosensory cortex yet blunts pain reactivity in higher-order valuation and dec
174 st1 in Kras(G12D) ;Tgif1(KO) mice completely blunted PDAC formation, providing the proof-of-principle
176 tested the hypothesis that low dose ketamine blunts perceived pain, and blunts subsequent sympathetic
177 In summary, although reslizumab was able to blunt peripheral eosinophilia post-DEC treatment in subj
179 e other hand, Gfat1 inhibition significantly blunts phenylephrine-induced hypertrophic growth in cult
181 responses to bronchoconstrictor agonist via blunted plasma membrane Ca(2+) influx: effects blocked b
182 lammation accelerates clearance of bacteria, blunts PMN accumulation, and promotes PMN apoptosis and
183 y be important in the excessive negative and blunted positive internal states that can stimulate suic
186 may be useful dietary supplements capable of blunting postprandial glycaemia in humans, including tho
190 ses on tumor cell-intrinsic alterations that blunt productive anti-tumor immune responses by directly
192 ss dopamine D(2/3) receptor availability and blunted psychostimulant-induced dopamine release in coca
195 Furthermore, patients with AN displayed blunted reactivity in the nucleus accumbens and amygdala
196 ironmental enteropathy (EE) refers to villus blunting, reduced absorption, and microbial translocatio
197 r co-ordination in ssTnT-knockout mice and a blunted response to a spindle sensitizer, succinylcholin
198 tive depression severity was associated with blunted response to anticipation across a cortico-striat
199 ction neurons in the octbeta1r brain exhibit blunted responses to octopamine when cAMP levels are mon
200 g adrenergic stimulation (ISO), while having blunted responses to SNS, providing important insight in
202 antly reduced the numbers of sensory fibers, blunted revascularization, and delayed ossification of t
203 s that depressive illness is associated with blunted reward activation in the basal ganglia and other
204 reward learning (P = 0.02), a trend towards blunted reward-related prediction error signals (P = 0.0
206 l-molecule inhibitor AS1842856 significantly blunts sGC alpha and beta mRNA expression by more than 9
208 esults showed that aortas have significantly blunted sodium nitroprusside-induced (NO-dependent) vaso
209 er interferon production and responsiveness, blunted STAT1 phosphorylation and reduced MHCII expressi
210 anolone, was involved in presentation of the blunted stress response phenotype by its interaction wit
212 First, mood symptoms are associated with blunted striatal reward prediction error signals in a la
213 low dose ketamine blunts perceived pain, and blunts subsequent sympathetic and cardiovascular respons
214 ic differences can impart either enhanced or blunted susceptibility to the effects of such pathogenic
215 ypothalamic-pituitary-adrenal axis feedback, blunted sympathetic responsiveness, and chronically elev
216 g in plasmacytoid dendritic cells (pDCs) and blunts systemic production of type I interferon (IFN).
218 diomyocytes decreased Yap protein levels and blunted target gene transcription without affecting Yap
219 dysfunctional reward-system may exist, with blunted temporal difference reward-related learning sign
221 Thus, we propose a model in which B12 and FA blunt the effect of natural AhR agonists at baseline to
223 nociception models, our lead mAb (6A4) could blunt the effects of both fentanyl and carfentanil in a
224 in the intermediate postoperative period and blunt the hypertensive phase compared with AGV implantat
225 e lead to stabilizing feedbacks that tend to blunt the impact of N cycle perturbations at larger spat
226 in CNS neurons in transgenic mice tended to blunt the increase in HVR that occurs in wild-type mice
228 on that similar approaches could be taken to blunt the signaling of non-Galpha(q/11) G proteins.
230 n normoxia, whereas loss of Wnt7a/b function blunted the angiogenic response to hypoxia, resulting in
233 tion following eosinophil lineage commitment blunted the decrease in EoPs without increasing neutroph
235 PH in dogs, and the PDE5A:E90K polymorphism blunted the efficacy of sildenafil in terms of QOL impro
236 t (bzip60-2) knocking down bZIP60 expression blunted the HSR at elevated temperatures and prevented t
238 tivation or prostaglandin E2 supplementation blunted the induction of the innate immune response in m
239 on of co-expressed NEDD4-2 and significantly blunted the negative effect of NEDD4-2 on I (Na) We conc
241 ated that PS-mediated increase in TAC uptake blunted the pro-injurious effects of LPS, suggesting a s
242 ng inhibitory G(i/o) signaling in DA neurons blunted the reinforcing and priming effects of cocaine,
244 deletion of P2Y(2) from smooth muscle cells blunted the ventilatory response to CO(2), and re-expres
245 creasing p65 nuclear translocation, although blunting the degradation of IkappaBalpha was due, at lea
246 ved ASLN in mice through immunoregulation by blunting the MAPK (ERK, JNK)-mediated priming signal of
247 ed and modulated the hydrologic inputs of N, blunting the rise in coastal N sources during the early
248 e expression and activity of NOS1 via SGLT1, blunting the TGF response and promoting glomerular hyper
249 nt nitric oxide (NO) in the macula densa and blunting the tubuloglomerular feedback (TGF) response, t
250 Lastly, we demonstrated that p38 inhibition blunts the aberrant temperature-dependent increase in re
251 s cellular levels of GLUT4 and concomitantly blunts the ability of insulin to stimulate glucose trans
252 indicate that Sirt1 knockdown or inhibition blunts the anti-inflammatory properties of LDN in vitro
253 Mechanistic studies have shown that morphine blunts the antiplatelet effects of oral adenosine diphos
254 n, skeletal muscle-specific deletion of ATG7 blunts the beneficial effects of beta(2) -adrenoceptor o
255 revailing carbon dioxide tension (Pa(CO(2))) blunts the brain's response to hypoxia, effects of disea
256 l systems, which occur when one perturbation blunts the effect of another, are typically interpreted
258 peroxisomal beta-oxidation in the intestine blunts the effects of neural serotonin signaling on feed
259 eptor (beta1AR) blocker atenolol during CSDS blunts the elevation of plasma acyl-ghrelin and exaggera
260 Pharmacological inhibition of PI3K in cells blunts the ER stress-dependent phosphorylation of IRE1al
261 deficiency reduces monocyte infiltration and blunts the expression of pattern recognition and defense
262 olecular activation of small intestinal mTOR blunts the glucose-lowering effect of the oral anti-diab
263 a model wherein hyperglycemia-induced REDD1 blunts the Nrf2 antioxidant response to diabetes by acti
264 Anxa6 in cancer cells or Ccr2 in host cells blunts the pro-metastatic effects of chemotherapy-elicit
266 n the PFC, we also find that WIN preexposure blunts the typical mRNA response to cocaine and instead
267 dent of VSG, while removal of CD36 signaling blunts the VSG-induced shift toward carbohydrate prefere
268 esis and mitochondrial function in BAT and a blunted thermogenic (rectal temperature, BAT temperature
271 ated NCC and total NCC and had significantly blunted thiazide-induced natriuresis as well as renal po
274 type 1 diabetes, the finding that abatacept blunts this relationship renders the biomarkers nonpredi
275 nt and in-hospital mortality associated with blunt thoracic aortic intimal tears (IT) within the Amer
277 ts to an evolutionarily conserved profile of blunted threat extinction learning during adolescence, u
278 targeting agents as mechanism-driven ways to blunt tissue injury, morbidity, and mortality of COVID-1
279 tion and areas in which our current range of blunt tools need to be refined to bring about long-term
280 on of Atf6 (ATF6 cKO [conditional knockout]) blunted transverse aortic constriction and exercise-indu
281 4 eyes); sequelae of macular edema (3 eyes); blunt trauma (2 eyes); retinal phototoxicity resulting f
284 ood leukocyte gene expression can be used in blunt trauma cohorts at 24 hours to distinguish patients
288 CI], 0.22-0.91), whereas RRD associated with blunt trauma was more likely to occur in the oldest coho
289 patients with a thoracic aortic IT following blunt trauma were captured from Level I and II North Ame
290 ded by traumatic brain injury resulting from blunt trauma, blast exposure, and highly physically dema
293 of CD40L did increase humoral responses, it blunted type 1 CD4(+) T cell responses against the SIV e
295 vant yet ubiquitously expressed antigens can blunt various liver autoimmune disorders in a non-diseas
296 facilitated graft immune cell infiltration, blunted vascular repair, and worsened occlusive vasculop
297 ced blooms of E. coli LF82 are significantly blunted when amino acids-particularly L-serine-are remov
298 lateral medulla (RVLM)] cytokine surges were blunted, whereas oxidative stress was higher in SHR.
299 nfected cells to human recombinant HMGB1 was blunted with decreased MX1 expression and JAK activation