ライフサイエンスコーパス: bone

1 ses and the protein-driven mineralization of bone.

2 ine, both being significantly different from bone.

3 disease (GSD) develop ectopic lymphatics in bone.

4 committed BMSC subset in human OA trabecular bone.

5 ion to liver, and at least 4.4 for lesion to bone.

6 2 mineralized tissues, cementum and alveolar bone (AB), both essential for tooth attachment.

7 ces almost completely filled by newly formed bone, against about 75% in C specimens (P = 0.0015).

8 hree decades ago, high-risk NB metastatic to bone and bone marrow in children was not curable.

9 A receptor 1 in FGF23-secreting cells in the bone and bone marrow.

10 Disseminated tumors to the bone and lung are easily detected by microCT, while ultr

11 promising therapeutic agent for early stage bone and lung metastasis from triple-negative breast can

12 ing, and spontaneous age-induced periodontal bone and root loss are observed in this mouse model.

13 olinium (Gd) has been detected in the brain, bone and skin of patients, months and years following GB

14 filled network structure, which pervades our bones and accommodates a cell network of osteocytes.

15 eavily on carbon isotopic analysis of fossil bones and palaeosols.

16 ing breast, lung, ovary, pancreas, melanoma, bone, and brain tumors.

17 4%, and 38% with (68)Ga-PSMA-11 for ganglia, bone, and unspecific lymph nodes, respectively).

18 that would have formed upon friction against bone, antler, ivory or wood.

19 ls with rhBMP-2/ACS exhibited improvement on bone augmentation, mainly BCP (P = 0.033) and beta-TCP (

20 rmine the success rate of (68)Ga-PSMA-guided bone biopsies for molecular diagnostics in mPC patients.

21 on by denosumab (DMAb) and RNA-sequencing of bone biopsies from postmenopausal women to identify oste

22 patients underwent (68)Ga-PSMA PET/CT before bone biopsy.

23 Teeth are attached to alveolar bone by the periodontal ligament (PDL), which contains s

24 nsional MAPK7/MMP9 signalling hub in primary bone cancer metastasis that is clinically actionable.

25 oma, Wilms tumour, soft-tissue sarcomas, and bone cancer) by comparing both groups to siblings of the

26 The latter two components, overlying the bone, constitute the gingival phenotype.

27 Moreover, the newly formed bone contained higher trabecular number, connective dens

28 es were re-entered for study measurements, a bone core sample, and implant placement.

29 Osteomyelitis was confirmed by bone culture or histopathology.

30 freckling, [3] shortened stature, [4] tibial bone curvature, and [5] neurofibroma.

31 tigate the feasibility of regenerating large bone defects in sheep using 3D-printed customized calciu

32 progenitors accelerates healing of cortical bone defects.

33 This study investigated the effects of bone demineralization with citric acid (CA) and tetracyc

34 We conclude by reviewing the loss of bone density in patients with AD, paralleling the increa

35 decreased bone volume fraction and alveolar bone density.

36 forms with FGFR1 a specific receptor for the bone-derived hormone FGF23.

37 ) demonstrated remarkable protection against bone destruction induced by femoral inoculation of Lewis

38 Multiple Myeloma (MM) induces bone destruction, decreases bone formation, and increase

39 understanding and prevention of inflammatory bone destruction.

40 nces our etiologic understanding of diabetic bone deterioration and increased fragility from the aspe

41 teoporotic osteoarthritis (OPOA) is a common bone disease mostly in the elderly, but the relationship

42 ve care to minimize the impact of metastatic bone disease on physical functioning.

43 ring of neurotransmitters, and assessment of bone disease.

44 Extrapulmonary (skin or bone) disease, probably resulting from hematogenous spre

45 malities in common causes of CKD-mineral and bone disorder have been defined, it is unknown if persis

46 m that typically observed in CKD-mineral and bone disorder.

47 Bones do not normally have lymphatics.

48 ivo microCT analysis showed increased radial bone expansion of the midshaft femur in female N-ERalpha

49 Histologically, an enhanced new bone formation and more significant periodontal attachme

50 pid palatal expansion and further facilitate bone formation during retention.

51 teoblastogenesis from MSCs, thus suppressing bone formation in vitro and in vivo.

52 multiple mechanisms mediate the coupling of bone formation to resorption in remodeling.

53 oma (MM) induces bone destruction, decreases bone formation, and increases marrow angiogenesis in pat

54 these cells as a source for loading-induced bone formation.

55 red for loading-induced Sost suppression and bone formation.

56 nce of the vascular pedicle further enhanced bone formation.

57 ated with inflammation, vascularization, and bone formation.

58 rs that promote bone resorption and suppress bone formation.

59 trauma, including nociceptive sensitization, bone fracture, muscle fibrosis and muscle fibre loss.

60 Indeed, several skeletal diseases, such as bone fracture, osteonecrosis, and inflammation are chara

61 ofluidic mixing in the channel with "herring-bone" geometry used with the instrument NanoAssemblr.

62 nd platelet-rich fibrin (L-PRF) + autogenous bone graft (ABG) may be a clinically "non-inferior" trea

63 nd tetracycline (TCN) on the repair of onlay bone grafts.

64 ults show that Hdac3 is required for optimal bone healing and osteoclast fusion, potentially via its

65 that obstruction of vascular invasion during bone healing favours chondrogenic over osteogenic differ

66 y, we demonstrate functional improvements to bone healing following local beta-NGF injections which r

67 The short- (bone healing) and long-term (bone remodeling) effects of

68 US) methods have shown promise in monitoring bone healing, but no quantitative method to assess regen

69 Long-term bone healing/adaptation after a dental implant treatment

70 nly used for its effects on sexual function, bone health and body composition, yet its effects on dis

71 ), CAL, plaque index (PI), and interproximal bone height were evaluated at baseline and 12-months pos

72 that it is associated with thinner cortical bone in adult male mice.

73 rds-including loss of a separate postorbital bone in adults and the emergence of new trade-offs with

74 The absence of bone in modern jawless fishes and the absence of endocho

75 TIMP3 transgenic mice showed compromised bone integrity as opposed to [-1A]TIMP3 mice.

76 the most striking signs of ECD are the long bone involvement (80%-95%), as well as the hairy kidney

77 ing periodontitis, tooth-supporting alveolar bone is resorbed when there is an increased expression o

78 Osteomyelitis, or inflammation of bone, is most commonly caused by invasion of bacterial p

79 The RC was +/-32.5% SUV(max) for bone lesions and +/-37.9% SUV(max) for nodal lesions, me

80 a-PSMA-11 PET/CT imaging revealed additional bone lesions in 6% of patients, but without significantl

81 bition may help to explain the phenomenon of bone loss and increased adipogenesis in some patients du

82 Desipramine administration reduced alveolar bone loss as histologically observed, and modulated key

83 ply that Col6a2 deficiency causes trabecular bone loss by enhancing osteoclast differentiation throug

84 ms fed the low protein diet showed extensive bone loss by the end of lactation, followed by full skel

85 s been reported to protect from pathological bone loss during rheumatoid arthritis and osteoporosis,

86 w that parathyroid hormone (PTH) only caused bone loss in mice whose microbiota was enriched by the T

87 Significant marginal bone loss occurred in the early post-diagnosis period of

88 motherapy, long-term comorbidities including bone loss remain a significant problem.

89 Alveolar bone loss was analyzed by micro-computed tomography and

90 Periodontal bone loss was measured via histological and microcompute

91 Alveolar bone loss was significantly reduced in the ligature + de

92 osis, and rapid joint destruction (including bone loss) may be observed in patients who received IACS

93 h both outcomes (increased probing depth and bone loss).

94 ion, hyperosteoclastogenesis, and trabecular bone loss, uncovering a pathological mechanism underlyin

95 arthritis with joint remodeling and profound bone loss.

96 ch there is a furcal lesion with periodontal bone loss; Group I (intermediate) in which the border of

97 bulin compared with control in patients with bone, lymph node, and chest wall/breast/skin metastases

98 A first MI-induced bone marrow "memory" via a circulating signal, reducing

99 B and CD4 T cell responses are detectable in bone marrow (BM) and blood up to 20 years after vaccinat

100 al residual disease (MRD) status outside the bone marrow (BM) in patients with multiple myeloma (MM).

101 uggested that the hematopoietic niche of the bone marrow (BM) is a major reservoir for parasite repli

102 oietic stem/progenitor cells (HSPC) from the bone marrow (BM) is impaired in diabetes.

103 r cells (HSPC) is tightly regulated by their bone marrow (BM) microenvironment (ME).

104 per positioning of B cell progenitors in the bone marrow (BM) microenvironment and their progression

105 (BCG) or beta-glucan reprograms HSCs in the bone marrow (BM) via a type II interferon (IFN-II) or in

106 te, and migratory behavior of eosinophils in bone marrow (BM), blood, lung, and bronchoalveolar lavag

107 Osteoclasts (OC) originate from either bone marrow (BM)-resident or circulating myeloid OC prog

108 Sequestration of HSPCs in bone marrow after SCI is linked to aberrant chemotactic

109 nt was a sustained molecular response in the bone marrow after this treatment.

110 vation of the NF-kappaB signaling pathway in bone marrow and BM-MSC of DeltaNC16A mice.

111 aracterization of the HSC state in the adult bone marrow and embryonic fetal liver, the mechanism of

112 e rise to terminally differentiated cells in bone marrow and intestines.

113 gulators of transcripts downregulated in the bone marrow and involved in lymphoid differentiation and

114 ion of molecular and functional profiling of bone marrow and peritoneal cells provided a detailed roa

115 iption factors, reduces SAMD14 expression in bone marrow and spleen and is lethal in a hemolytic anem

116 for microscopic analysis of blood smears and bone marrow aspirates.

117 led the presence of SSCs not only within the bone marrow but also within the periosteum and growth pl

118 Mechanistically, stimulation of specific bone marrow cell populations in vivo using growth factor

119 Cell Atlas Census of Immune Cells dataset of bone marrow cells and show that it substantially improve

120 Targeting senescence in the BMAd or other bone marrow cells may represent a novel therapeutic appr

121 ated wild-type recipients of PDIA6-deficient bone marrow cells, both in the absence or presence of co

122 Bone marrow chimera and adoptive transfer studies indica

123 The construction of bone marrow chimera mice demonstrated that STAT6 KO in e

124 Using bone marrow chimeras, GILT expression in thymic epitheli

125 ed recovery in peripheral blood cell counts, bone marrow colony forming units, sternal cellularity an

126 entatives from those isolated from blood and bone marrow cultures in southern India, over 26 years (1

127 nes on in vitro osteoclastogenesis in murine bone marrow cultures.

128 Generation of pDCs from bone marrow dendritic cell (DC) progenitors and their ma

129 globulin M declined from 3,520 to 821 mg/dL, bone marrow disease involvement declined from 60% to 20%

130 d a moderate specificity in the detection of bone marrow edema of the wrist.

131 nt readers for tenosynovitis, synovitis, and bone marrow edema.

132 d, we hypothesized that in some patients the bone marrow environment is not permissive to B-cell deve

133 , we showed that sympathetic nerves create a bone marrow environment that supports residence of hyper

134 Bone marrow failure (BMF) in Fanconi anemia (FA) patient

135 using a previously uncharacterized inherited bone marrow failure and pre-leukemic syndrome.

136 iamond Blackfan Anemia (DBA) is a congenital bone marrow failure syndrome associated with ribosomal g

137 described and is a constitutional inherited bone marrow failure syndrome.

138 Dendritic cells (DCs) develop in the bone marrow from haematopoietic progenitors that have nu

139 Glucocorticoids induced rapid bone marrow homing of eosinophils.

140 des ago, high-risk NB metastatic to bone and bone marrow in children was not curable.

141 tions included hepatic, kidney, splenic, and bone marrow involvement, and microvascular injury and th

142 of patients, early B-cell development in the bone marrow is impaired.

143 CI, -11.2 to 52.2]; P = .21), and changes in bone marrow lesion size (-33 mm2 vs -6 mm2; between-grou

144 n mediating RANKL-induced signaling in mouse bone marrow macrophages, known as osteoclast precursors.

145 matopoietic maintenance factor expression in bone marrow macrophages.

146 f our study was to identify and characterize bone marrow MC histopathologic features specific for MCA

147 d strength, partly due to the dysfunction of bone marrow mesenchymal stromal/stem cells (MSCs) during

148 pansion of the engrafted HSPC population and bone marrow microenvironment degradation caused by pre-t

149 It is clear that disruption of the normal bone marrow microenvironment is sufficient to promote le

150 previously unknown heterogeneity within the bone marrow microenvironment, imposed by the stages of b

151 cs of glucocorticoid-induced eosinopenia and bone marrow migration were consistent with those of the

152 y identified neutrophil subsets fit into the bone marrow neutrophil lineage remains unclear.

153 trophil subsets arise from distinct maturing bone marrow neutrophil subsets.

154 Progenitor cells are mobilized from bone marrow niches in response to remote ischemic injury

155 LT-HSCs are not found in bone marrow niches with the deepest hypoxia and instead

156 iated phenotypic alterations (MDS-PA) in the bone marrow of 285 patients with MM enrolled in the PETH

157 cture), adoptive transfer of Pink1-deficient bone marrow or pharmacological inhibition of mitophagy p

158 Masked central review of bone marrow pathology was done if available to confirm l

159 tment of bone marrow-derived macrophages and bone marrow progenitors promoted M2-like macrophage pola

160 tro osteoclastogenesis from Fndc5-transgenic bone marrow progenitors.

161 sponse, with single-cell analysis of primary bone marrow revealing perturbed UPR in myeloid precursor

162 The bone marrow senses distant tissue transformation at prem

163 Bone marrow stem cell transplantation had not been acces

164 revealed that the transmembrane glycoprotein Bone marrow stromal antigen 2 (Bst2) expression was redu

165 s in Functional Assessment of Cancer Therapy-Bone Marrow Transplant (FACT-BMT) score relative to base

166 kinase (SR-uPA(+/0) mice) and of SR-uPA(+/0) bone marrow transplant recipients, and we used bioinform

167 CMV viremia in a Cynomolgus macaque model of bone marrow transplantation (BMT) for tolerance inductio

168 e utilized in modulation of HSC activity and bone marrow transplantation studies.

169 lication after peripheral blood stem cell or bone marrow transplantation, rarely occurs in kidney and

170 sed quiescence and increased HSC activity in bone marrow transplantation.

171 Bone marrow was microscopically free of disease, but mol

172 Heparinized venous blood and bone marrow were collected from the patient after obtain

173 DNA in the genome of hMSCs derived from the bone marrow, adipose tissue, and umbilical cord blood wi

174 ntrols the formation of blood vessels in the bone marrow, and also regulates the differentiation of r

175 poietic precursors were quantified in blood, bone marrow, and organs.

176 In bone marrow, CSF1R-FRed was absent in lineage-negative h

177 During granulopoiesis in the bone marrow, distinct neutrophil granules are successive

178 ope, to mitigate HIV-induced pathogenesis in bone marrow, liver, thymus (BLT) humanized mice.

179 nd early depletion of Vi-specific B cells in bone marrow, resulting in hyporesponsiveness and lack of

180 several organs in HIS mice including blood, bone marrow, spleen, and draining lymph nodes.

181 ial potential during their maturation in the bone marrow, where they differentiate from hematopoietic

182 Adoptive transfer of labeled bone marrow-derived cells validated the results in a mur

183 Historically, SSCs have been defined as bone marrow-derived cells with inconsistent characterist

184 regulated CCR7 on Y. enterocolitica-infected bone marrow-derived DCs and purified MLN DCs, which may

185 was also a poor stimulator of maturation of bone marrow-derived dendritic cells compared to E. coli

186 roblasts and prevented activation of primary bone marrow-derived dendritic cells ex vivo.

187 primary human foreskin fibroblasts or mouse bone marrow-derived dendritic cells infected with the pr

188 ent livers enhanced macrophage activation in bone marrow-derived macrophage cultures.

189 Bone marrow-derived macrophages (BMDMs) are recruited to

190 ome and Ingenuity Pathway Analysis of murine bone marrow-derived macrophages after exposure to this v

191 MV treatment of bone marrow-derived macrophages and bone marrow progenit

192 t cytokine that prompts the proliferation of bone marrow-derived macrophages and granulocytes.

193 id compartments, causes long-term changes in bone marrow-derived macrophages by suppressing interleuk

194 This response was lost in bone marrow-derived macrophages from mice deficient in A

195 uce mTOR signalling in the microglia but not bone marrow-derived macrophages in both in vitro and in

196 h MEK1/2 inhibitor U0126 or genetically with bone marrow-derived macrophages or DCs from Tpl2(-/-) mi

197 In mouse bone marrow-derived macrophages, heme induced HO-1, lipi

198 g pathways are delayed in P2-deficient mouse bone marrow-derived macrophages, mouse embryonic fibrobl

199 Patient bone marrow-derived neutrophils and white blood cells sh

200 sistant multiple myeloma cells as well as on bone marrow-derived primary multiple myeloma cells from

201 B cells was dispensable for stability of the bone marrow-resident, long-lived plasma cell population,

202 serum and IgG(+) antibody-secreting cells in bone marrow.

203 r 1 in FGF23-secreting cells in the bone and bone marrow.

204 ow that TBI places significant stress on the bone marrow.

205 tations in telomere biology genes leading to bone-marrow failure, these data provide evidence that ge

206 and restrains the osteoclastogenesis of rat bone-marrow macrophages (BMMs).

207 tumors, soft-tissue metastases, and bone or bone-marrow metastases was 72%, 33%, and 38%, respective

208 PET/CT in detecting soft-tissue and bone or bone-marrow metastases was 77% and 86%, respectively-sig

209 n in the blood and tissues of ART-suppressed bone-marrow-liver-thymus (BLT) humanized mice and rhesus

210 n transgenic C57BL/6J mice resulted in lower bone mass at three ages and greater in vitro osteoclasto

211 Affected patients have a high bone mass coupled with a distinctive appearance where th

212 t of PolgA(mut/mut) mice showed no effect on bone mass or mineralised matrix formation in vitro.

213 xcl9l recruits mpeg1-positive macrophages to bone matrix and triggers their differentiation into oste

214 cluding section thickness, may affect linear bone measurements of periodontal intrabony defects.

215 Bone mesenchymal stem cells (BMSCs) on the 3D nanofiber

216 f2 activation by disruption of Keap1 impacts bone metabolism.

217 The described improvements in the imaging of bone metastases and their response to therapy have led t

218 Bone metastases are common, especially in more prevalent

219 proportion of breast cancer patients develop bone metastases, but the mechanisms regulating tumor cel

220 n manipulating the tumor microenvironment in bone metastases.

221 alysis of matched primary breast tumours and bone metastasis-derived patient-derived xenografts (PDX)

222 ced an objective response with regression of bone metastatic lesions.

223 s effective at preventing most decrements in bone micro-architectural and mechanical properties due t

224 tosis/necroptosis gene RIPK3, show disturbed bone micro-architecture and increased osteoclast number,

225 o quantify biologic processes related to the bone microenvironment as well as tumor cells.

226 l and volumetric bone mineral density (BMD), bone microstructure and strength, fracture risk, and DAL

227 n about the effects of eradication of HCV on bone mineral density (BMD) and biomarkers of bone remode

228 Bone mineral density (BMD) was measured using DXA.

229 Plasma bone turnover markers and bone mineral density (BMD) were quantified at weeks 0, 1

230 ions between changes in areal and volumetric bone mineral density (BMD), bone microstructure and stre

231 r trabecular number, connective density, and bone mineral density.

232 ine-1-phosphate acts in paracrine to promote bone mineralization.

233 rly-stage disease should not be treated with bone-modifying agents to prevent recurrence, but could s

234 ransforming growth factor beta (TGFbeta) and bone morphogenetic protein (BMP) signal transduction in

235 Recombinant human bone morphogenetic protein 2 (rhBMP-2) is an osteoinduct

236 les, histochemical, and immunohistochemical (bone morphogenetic protein 2/4 [BMP2/4], osteocalcin [OC

237 BMP9 and BMP10 (bone morphogenetic protein) are known to regulate endoth

238 Bone morphogenetic protein-9 (BMP-9) is a circulating cy

239 Bone morphogenetic proteins (BMPs) are members of the TG

240 d by blocking TGF-beta signalling, promoting bone morphogenic protein (BMP) signalling.

241 no quantitative method to assess regenerated bone morphology in US images has been presented yet.

242 The periodontal phenotype consists of the bone morphotype, the keratinized tissue (KT), and gingiv

243 nt placement in grafted (GG) and non-grafted bone (NGG).

244 uals with MAS; no uptake was observed in the bones of healthy controls.

245 1 site of distant metastasis, and 42.9% had bone-only metastases.

246 atus, cT stage, tumor grade, and presence of bone-only metastases.

247 primary tumors, soft-tissue metastases, and bone or bone-marrow metastases was 72%, 33%, and 38%, re

248 8)F-DOPA PET/CT in detecting soft-tissue and bone or bone-marrow metastases was 77% and 86%, respecti

249 mRNA expression were identified in alveolar bone osteocytes with aging.

250 hickness and volume reduction at thin buccal bone plates.

251 rein, we describe a novel, biomimetic, human bone platform for advanced testing of implants in vitro,

252 cal, histometric (percentage of newly formed bone [PNFB], percentage of remaining graft particles, hi

253 h one of the most iconic artefacts being the bone point.

254 Furthermore, the marked change in bone points coincides with a change in lithic technology

255 MOC2 dynamically marks a range of dental and bone progenitors.

256 In terms of bone resorption and bone quality parameters, no implant material was superio

257 mesh pore size specifications may influence bone quality.

258 in NN dams, partial recovery in LN and poor bone recovery in LL dams.

259 P-2) is an osteoinductor frequently used for bone regeneration in oral and maxillofacial surgery.

260 s histologically observed, and modulated key bone remodeling and inflammatory mediators in rats with

261 bone mineral density (BMD) and biomarkers of bone remodeling in HIV/HCV coinfected patients.

262 oclasts were regulated by T cells during the bone remodeling process.

263 The short- (bone healing) and long-term (bone remodeling) effects of initial implant micromotion

264 m the aspect of microdamage accumulation and bone remodeling.

265 In terms of bone resorption and bone quality parameters, no implant

266 pression of Ocy-derived factors that promote bone resorption and suppress bone formation.

267 ge activity of DOCK5, which is essential for bone resorption by osteoclasts.

268 utants had increased osteoclast activity and bone resorption surrounding the extracted molar.

269 f giant hypernucleated osteoclasts, enhanced bone resorption when cultured on bone slices, and altere

270 topic formation of osteoclasts and excessive bone resorption, which can be assessed by live imaging.

271 functions of Vn, especially those related to bone resorption.

272 CT and bone scanning yielded comparable diagnostic performance

273 ct metastases for CNN- and gaussian-filtered bone scans with half the number of counts was compared w

274 number of counts was compared with standard bone scans.

275 ve imaging methods such as echocardiography, bone scintigraphy and cardiovascular MRI.

276 ltaneous (9 total) BM components in 152 full-bone sections from different bone types and 3 HSC report

277 dema, necrotizing encephalitis and decreased bone size (Alizarin red staining) were noticed.

278 s, enhanced bone resorption when cultured on bone slices, and altered mRNA expression of related chem

279 At 60 days, CA15, CA60, and TCN60 presented bone surfaces almost completely filled by newly formed b

280 This care should include bone-targeted agents to inhibit tumour-associated osteol

281 hysical location between skeletal muscle and bone, tendon is a surprisingly genetically heterogeneous

282 he capability of developed microcarriers for bone tissue formation was examined in vivo.

283 ), gadolinium was detected in human cortical bone tissue.

284 There have been no reports of cartilage to bone transdifferentiation or vasculature in human-releva

285 Osteosarcoma is the most frequent primary bone tumor with poor prognosis.

286 CNS tumors (9.5%; 95% CI, 5.2% to 13.8%) and bone tumors (8.1%; 95% CI, 5.1% to 11.1%) had the highes

287 ght into the biological behaviour of various bone tumours is highlighted.

288 ral to the detection and characterisation of bone tumours; however, magnetic resonance imaging (MRI)

289 Plasma bone turnover markers and bone mineral density (BMD) wer

290 w microenvironment, imposed by the stages of bone turnover.

291 nts in 152 full-bone sections from different bone types and 3 HSC reporter lines.

292 h facial and palatal laminae, and that these bones underwent divergent evolutionary trajectories in p

293 Bone volume (BV/TV%) and iliac crest were similar at bas

294 sis is characterized by the deterioration in bone volume and strength, partly due to the dysfunction

295 of osteoid, and micro-CT confirmed decreased bone volume fraction and alveolar bone density.

296 d in a decrease in cartilage and increase of bone volume.

297 ically significant in the density of grafted bone was found with the addition of steroids (P-value >

298 not simply the consequence of producing more bone, we use transgenic zebrafish in which Hh levels cou

299 Hyp mandibles demonstrated expanded alveolar bone with accumulation of osteoid, and micro-CT confirme

300 In this study, cleaned, dried, and powdered bones yielded 31.4 +/- 0.6% calcium content.