ライフサイエンスコーパス: bone marrow chimera

1 nd this relationship is recapitulated in the bone marrow chimeras.

2 etic or nonhematopoietic cells, we generated bone marrow chimeras.

3 tion of Ag-specific IMP CD8(+) T cells using bone marrow chimeras.

4 egress was demonstrated by generating mixed bone marrow chimeras.

5 an anti-tumor effect induced by RLI in mixed bone marrow chimeras.

6 were competing with wild-type cells in mixed bone marrow chimeras.

7 stitute the Treg population in the thymus of bone marrow chimeras.

8 g excretion compared with infected wild-type bone marrow chimeras.

9 hemokine Grobeta was abrogated in CXCR4(-/-) bone marrow chimeras.

10 rant of MHC class I-deficient cells in mixed bone marrow chimeras.

11 orylation and reduced platelet production in bone marrow chimeras.

12 sponses of flagellin-treated MyD88 radiation bone marrow chimeras.

13 ls and intrinsic renal cells, we constructed bone marrow chimeras.

14 and on circulating CD8 T cells in the mixed bone marrow chimeras.

15 PLZF(-/-) mice and mixed wild-type:PLZF(-/-) bone marrow chimeras.

16 of CD83-cKO B cells in GC responses in mixed bone marrow chimeras.

17 we performed fate-tracing experiments using bone marrow chimeras.

18 ted HO-2(-/-) and wild-type (WT) mice and in bone marrow chimeras.

19 In comparison with BAFF- or APRIL-sufficient bone marrow chimeras, absence of hematopoietic compartme

20 In studies of bone-marrow chimeras, adoptive cell transfer experiments

21 nal hematopoiesis emerged in Casp9-deficient bone marrow chimeras after alkylator exposure.

22 we assessed responses by Zbtb32(-/-) mice or bone marrow chimeras against a panel of chronic and acut

23 same observation in PHD2(+/+) --> PHD2(+/-) bone marrow chimeras also suggests organization of a bet

24 ce showed a reduced CHS response to DNFB, in bone marrow chimera and adoptive transfer experiments, w

25 Bone marrow chimera and adoptive transfer studies indica

26 ion after DSS-induced injury, as revealed by bone marrow chimera and dendritic cell-depletion experim

27 models and monocytopenic mice, together with bone marrow chimera and parabiotic models, we found that

28 mune responses to HSV-1 were dissected using bone marrow chimeras and adoptive cell transfer approach

29 In this study, we used bone marrow chimeras and adoptive transfer analysis to i

30 We used mixed bone marrow chimeras and adoptive transfer of naive CD4(

31 Using mixed bone marrow chimeras and adoptive transfer studies in wh

32 To test this, we created bone marrow chimeras and cell-type-specific knockouts of

33 identify the relevant APC in K14 mice using bone marrow chimeras and found that radioresistant cells

34 Using mixed bone marrow chimeras and Foxo1-deficient mice, we demons

35 Using bone marrow chimeras and immunohistology, we identified

36 Wild-type Treg cells in mixed bone marrow chimeras and in Tet2/3(fl/fl)Foxp3(WT/Cre) h

37 function, and we confirmed that result with bone marrow chimeras and in vitro, where the absence of

38 c role in type 2 responses was explored with bone marrow chimeras and induction of gastrointestinal t

39 Using a combination of bone marrow chimeras and intracellular chemokine stainin

40 We analyzed bone marrow chimeras and mice with a conditional gain-of

41 CD8(+) T-cell response to the VP2 peptide in bone marrow chimeras and mutant mice lacking peripheral

42 rin(+) cells in vivo, together with congenic bone marrow chimeras and parabiotic mice as tools to dif

43 iNKT thymic development in limited-dilution bone marrow chimeras and show that higher TCR avidity co

44 Results from radiation bone marrow chimeras and TCR transgenic mice indicate th

45 nduces a host-versus-graft reaction in mixed bone marrow chimeras and that rejection of donor cells l

46 CNS during EAE development, we created CD24 bone marrow chimeras and transgenic mice in which CD24 e

47 mice was shown to be B cell intrinsic using bone marrow chimeras and was not due to a developmental

48 s, HLA-DR4-transgenic mice, MAIThighHLA-DR4+ bone marrow chimeras, and humanized NOD-scid IL-2Rgamman

49 13 inbred mouse strains, F1 and F2 hybrids, bone marrow chimeras, and neutrophil function assays.

50 h the use of adoptively transferred T-cells, bone marrow chimeras, and reconstituted severe combined

51 We generated MD-2(-/-) bone marrow chimeras, and showed that MD-2 expression on

52 Using a novel minimal myeloablation-bone marrow chimera approach, we visualized priming of e

53 , we used adoptive transfer, transgenic, and bone marrow chimera approaches to show increased infiltr

54 dependent conditional Blimp-1 knockout mixed bone marrow chimera as well as an adoptive transfer appr

55 ed wild-type (wt)-->MHCI-/- or wt-->MHCII-/- bone marrow chimeras as recipients in GVHD experiments.

56 e Foxp3(-) precursors using studies of mixed bone marrow chimeras as well as TCR-specific generation

57 In mixed-bone marrow chimera assays, we found that CCR4-deficient

58 For dissection between the two, bone marrow chimeras between Cfh-deficient (Cfh(-/-)) an

59 Analysis of bone marrow chimeras between Chop(-/-) and Chop(+/+) mic

60 levant accessory cells in vivo, we generated bone marrow chimeras between either wild-type (WT) and M

61 Radiation bone marrow chimeras between normal and C3(-/-) mice wer

62 In bone marrow chimeras between Slc7a2(-/-) and WT mice, th

63 T regulatory cells (Tregs), we studied mixed bone marrow chimeras between wild-type and IFN-alpha/bet

64 Reciprocal bone marrow chimeras between wild-type and TLR4 mutant m

65 role of TLR4 in lung protection, using used bone marrow chimeras; cell-specific transgenic modeling;

66 Mixed bone marrow chimeras, conditional knockout mice, and ado

67 Bone marrow chimeras confirmed that the myeloproliferati

68 Bone marrow chimeras confirmed that vascular Nck1, but n

69 Irradiated bone marrow chimeras confirmed the protective effects of

70 o failed to inhibit EAE in reciprocal, mixed bone marrow chimeras constructed by transferring IL-10-d

71 beta T cells are poorly established in mixed bone marrow chimeras, contrasting with strong gammadelta

72 In mixed bone marrow chimeras, Crel(-/-)Nfkappab1(-/-)Rela(+/-) n

73 Our studies with bone marrow chimeras demonstrate that PD-L1/PD-L2 expres

74 VitD receptor-deficient (vdr(-/-)) radiation bone marrow chimeras demonstrate that reductions in pulm

75 Bone marrow chimeras demonstrate that this inflammatory

76 Competitive bone marrow chimera demonstrated that intact IRAK4 funct

77 Bone marrow chimera demonstrated that mucosa-derived MMP

78 Mixed bone marrow chimera demonstrated that the increased acti

79 Mixed bone marrow chimeras demonstrated a B cell-intrinsic req

80 Bone marrow chimeras demonstrated retardation of T cell

81 Experiments using bone marrow chimeras demonstrated that AKT3(-/-) mice re

82 Bone marrow chimeras demonstrated that alpha2,6-sialylat

83 Bone marrow chimeras demonstrated that loss of H2-O expr

84 Moreover, bone marrow chimeras demonstrated that LTbR deficiency i

85 Experiments in IL-7Ralpha(-/-) bone marrow chimeras demonstrated that the drainage-enha

86 Finally, mixed bone marrow chimeras demonstrated that the worsening of

87 Mixed bone marrow chimeras demonstrated that these phenotypes

88 Bone marrow chimeras demonstrated that TIMP3 derived fro

89 The use of bone marrow chimeras determined that deletion of caspase

90 S. mansoni-infected Arg I-deficient bone marrow chimeras develop a marked accumulation of wo

91 treatment of DAF(-/-) mice or DAF(-/-) to WT bone marrow chimeras did not.

92 In mixed bone marrow chimeras, Dpy30-deficient HSCs cannot differ

93 TFH cells developed poorly in a competitive bone marrow chimera environment.

94 Bone marrow chimeras established that CD73 expression in

95 In vivo, ARAP3 PH domain point mutant bone marrow chimeras exhibit reduced neutrophil recruitm

96 Lrrc8a(-/-) mice and Lrrc8a(-/-)-->Rag2(-/-) bone marrow chimeras exhibited a severe cell-intrinsic b

97 Bone marrow chimera experiment demonstrated that T cell-

98 Bone marrow chimera experiments confirmed that microglia

99 Mixed bone marrow chimera experiments demonstrate that IL-27 d

100 Bone marrow chimera experiments demonstrated that CXCR3

101 Bone marrow chimera experiments demonstrated that hemato

102 Finally, bone marrow chimera experiments demonstrated that Ifitm3

103 Competitive bone marrow chimera experiments demonstrated that the de

104 Bone marrow chimera experiments demonstrated that TNF ca

105 Bone marrow chimera experiments determined that maximal

106 Bone marrow chimera experiments indicate that TEC expres

107 Bone marrow chimera experiments indicated that CRAMP der

108 Bone marrow chimera experiments indicated that IRAK-M ex

109 Bone marrow chimera experiments indicated that LRIG1 als

110 Bone marrow chimera experiments indicated that PAD4 in h

111 Bone marrow chimera experiments indicated that the obser

112 Mixed bone marrow chimera experiments reveal a markedly reduce

113 In addition, competitive bone marrow chimera experiments reveal that RasGRP1/3 do

114 Mixed bone marrow chimera experiments reveal that, under homeo

115 Bone marrow chimera experiments revealed a cell-intrinsi

116 Bone marrow chimera experiments revealed a T cell-autono

117 Bone marrow chimera experiments revealed that HMGN1 deri

118 Furthermore, bone marrow chimera experiments revealed that MDA5 expre

119 Red blood cell transfer and bone marrow chimera experiments show that the aging phen

120 However, intrathymic injection and bone marrow chimera experiments showed a saturable incre

121 Finally, mixed bone marrow chimera experiments showed that both the pro

122 Bone marrow chimera experiments showed that CD137L-defic

123 Bone marrow chimera experiments showed that hematopoieti

124 Bone marrow chimera experiments showed that resistance i

125 Mixed bone marrow chimera experiments showed this paucity to b

126 prevent autoreactive T cells from deletion; bone marrow chimera experiments suggest that CD24 on rad

127 We show through mixed bone marrow chimera experiments that NKT17 polarization

128 Mixed bone marrow chimera experiments using cells from Flip-de

129 Bone marrow chimera experiments using OVA-treated C57BL/

130 Bone marrow chimera experiments using Rag-1 and beta2-mi

131 Bone marrow chimera experiments verified that bone marro

132 Bone marrow chimera experiments were performed with mice

133 As observed by bone marrow chimera experiments, Mac-1-dependent neutrop

134 In reciprocal bone marrow chimera experiments, the protective phenotyp

135 tion by structural cells was corroborated by bone marrow chimera experiments.

136 -b deficiency in macrophages, as assessed by bone marrow chimera experiments.

137 ressing core protein throughout the body and bone marrow chimeras expressing core protein in either t

138 In experiments with bone marrow chimeras, expression of BCL3 by acinar cells

139 in LPL-deficient hematopoietic cells, using bone marrow chimeras, failed to rescue the phenotype of

140 HNF1A(-/-) bone marrow chimera featured a dramatic defect in B lymp

141 Bone marrow chimeras formed by the transfer of WT bone m

142 Rag2(-/-), but not WT-->IkappaBalpha mutant, bone marrow chimeras formed proper lymphoid organs and d

143 in naive CD8(+) T cells in vivo by creating bone marrow chimera from hematopoietic progenitors trans

144 Analysis of bone marrow chimera generated from a mixture of wild-typ

145 Using a series of bone marrow chimeras generated from 5-lipoxygenase(-/-)

146 The current study used bone marrow chimeras generated from green fluorescent pr

147 mal alpha7nAChRs, as shown by experiments in bone marrow chimeras generated with wild-type and alpha7

148 Using bone marrow chimeras, GILT expression in thymic epitheli

149 In competitive bone marrow chimeras, however, LN3alphabeta thymocytes w

150 Sepsis induction in C5aR(+)/C5aR(-) mixed bone marrow chimeras identified cognate engagement of C5

151 Studies using bone marrow chimeras implicate lung resident hematopoiet

152 Next, we used bone marrow chimeras in an experimental colitis model an

153 cause fibrotic susceptibility, we generated bone marrow chimeras in HPS and wild-type mice.

154 the development of PGIA, we generated mixed bone marrow chimeras in which CD80/CD86 is specifically

155 addressed through analyses of NOD background bone marrow chimeras in which H2(nb1) molecules were sel

156 ing wild-type and DNMAML T cells together in bone marrow chimeras increased accumulation of Notch-dep

157 EAE adoptive transfer experiments and bone marrow chimeras indicated that expression of LIGHT

158 ransgenic CD4 T cells and studies with mixed bone marrow chimeras indicated that indirect effects and

159 Reciprocal bone marrow chimeras indicated that IRF-3 or IRF-7 expre

160 Experiments with bone marrow chimeras indicated that RSV-induced lung pat

161 Studies with mixed bone marrow chimeras indicated that the defect is intrin

162 ellular MZ microenvironment, and analysis of bone marrow chimeras indicated that the MZ B cell develo

163 LTbeta(-/-), LTalpha(+/-)beta(+/-) mice and bone marrow chimeras, indicated that rapid protective Th

164 Mouse bone marrow chimeras lacking Casp9 or its cofactor Apaf1

165 Using bone marrow chimeras, lineage labeling, and proliferatio

166 Bone marrow chimeras, luminex, and quantitative reverse

167 In parallel, Mertk(-/-)/Mfge8(-/-) bone marrow chimeras manifested increased accumulation o

168 Experiments with bone marrow chimera, mast cell-deficient animals, platel

169 The construction of bone marrow chimera mice demonstrated that STAT6 KO in e

170 tion of CD4(+) T cell adoptive transfers and bone marrow chimera mice in which the presence or absenc

171 autoimmune encephalomyelitis (EAE), we used bone marrow chimera mice that allowed us to distinguish

172 e macrophage inflammatory phenotype by using bone marrow chimera mice with conditional PU.1 knockout.

173 g the use of p47(phox-/-) mice, p47(phox-/-) bone marrow chimera mice, adoptive transfer of macrophag

174 Using bone marrow chimera mice, we demonstrated that CD73 expr

175 nflamed cremaster muscle microcirculation in bone marrow chimera mice.

176 In addition, IL-1R1(KO) bone marrow-chimera mice showed that IL-1R1 expression w

177 We have used a mixed bone marrow chimera model to generate mice in which the

178 Using a bone marrow chimera model, we determined that IRAK-M's e

179 ze of a differentiating Treg population in a bone marrow chimera model, which correlated with reduced

180 Bone marrow chimera models were used to localize the sit

181 ngs using age- and sex-matched wild-type and bone marrow chimera mouse models.

182 In radiation bone marrow chimeras, NK resistance was significantly di

183 In this study, we used bone marrow chimeras of IFN-alphabetagammaR(-/-) (AG129)

184 Bone marrow chimeras of MyD88 deficient/wild type and TR

185 Restoring CCR4 on myeloid cells in bone marrow chimeras or intracerebral microinjection of

186 Once niche effects are neutralized in mixed bone marrow chimeras, positive and negative selection ar

187 Bone marrow chimeras produced using Cxcl5(-/-) donors an

188 CD28 wild-type/CD28-deficient mixed bone marrow chimeras provided evidence of both cell-auto

189 In bone marrow chimeras, radioresistant and, likely, nonhem

190 s transferred into wild-type mice, but mixed bone marrow chimeras receiving wild-type and Crel(-/-)Nf

191 examined this possibility using XX versus XY bone marrow chimeras reconstituted with a common immune

192 Moreover, using mixed bone marrow chimeras reconstituted with Bim(+/+) and Bim

193 in neutrophil trafficking using mouse mixed bone marrow chimeras reconstituted with Cxcr2(-/-) and W

194 was abrogated in IL-4R-deficient mice and in bone marrow chimeras reconstituted with myeloid cells th

195 l populations, and DT injection into zDC-DTR bone marrow chimeras results in cDC depletion.

196 Adoptive transfer experiments and radiation bone marrow chimera reveal that a Txb21(+/+) environment

197 .L2 WT and n3.L2 PKCtheta(-/-) thymocytes in bone marrow chimeras revealed a more dramatic defect, wi

198 Moreover, bone marrow chimeras revealed a role for type I IFN sign

199 Bone marrow chimeras revealed a specific reduction in AT

200 Mixed bone marrow chimeras revealed an alteration of immune re

201 Bone marrow chimeras revealed STING-mediated MCMV contro

202 The analysis of mixed bone marrow chimeras revealed that cGVHD resistance was

203 Other experiments with bone marrow chimeras revealed that inflammation was not

204 Analyzing mixed bone marrow chimeras revealed that intact Zap70-dependen

205 Mixed bone marrow chimeras revealed that Itch acts within B ce

206 However, analysis of mixed bone marrow chimeras revealed that Nfkb1(SSAA/SSAA) FM B

207 Mixed bone marrow chimeras revealed that the aforementioned gp

208 Additional studies using bone marrow chimeras revealed that this hyperinflammator

209 Bone marrow chimeras revealed that TLR4 expression on he

210 Experiments using bone-marrow chimeras revealed that it is the lack of A(2

211 Experiments with bone marrow chimeras (S1pr2(+/+) --> S1pr2(+/+), S1pr2(+

212 Bone marrow chimeras showed that bone marrow-derived cel

213 Experiments using bone marrow chimeras showed that FcRn expression in thes

214 Bone marrow chimeras showed that Mif expression in bone

215 Neutrophil transmigration studies and bone marrow chimeras showed that neutrophil MMP-9 is nei

216 Bone marrow chimeras showed that platelet, not endotheli

217 Flow cytometry and GFP bone marrow chimeras showed that spinal cord microglia w

218 Bone marrow chimeras showed that the anti-inflammatory r

219 Rather, mixed bone marrow chimeras showed that the factor(s) responsib

220 Evidence from mixed bone marrow chimeras shows that the ability of Egr1 to c

221 Bone marrow chimera studies demonstrate that mTORC1 cont

222 Bone marrow chimera studies revealed that STAT6 expresse

223 Consistent with this, bone marrow chimera studies show that aberrant Pkhd1 mus

224 Bone marrow chimera studies showed reduced lesions in ap

225 Bone marrow chimera studies suggest that pulmonary paren

226 one marrow transplantation studies and mixed bone marrow chimera studies suggested an involvement of

227 In bone marrow chimera studies, recipient irradiated Ifnar(

228 From adoptive reconstitution and mixed bone-marrow chimera studies in B cell-deficient (microMT

229 nflammatory responses, and lipid uptake, and bone marrow chimeras suggest that hematopoietic EphA2 de

230 tion of Ly6-G(+) cells and use of C5aR1(-/-) bone marrow chimeras suggested an essential role of C5aR

231 sing from bone marrow precursors in neonatal bone marrow chimeras suggested that Foxp3(+) DP cells ar

232 e with wild-type T cell progenitors in mixed bone marrow chimeras, suggesting that in normal mice, th

233 ed iNKT cell frequencies in Myb heterozygous bone marrow chimeras suggests that miR-150 differentiall

234 In bone marrow chimeras, synthesis of C3 by radioresistant

235 rim24 deficiency to T cells by using a mixed bone marrow chimera system and found that T-cell-intrins

236 kely to contribute to disease, we utilized a bone marrow chimera system to distinguish between these

237 using IFN-gamma receptor knockout mice in a bone marrow chimera system, we show that the IFN-gamma p

238 ow-density lipoprotein-deficient (Ldlr(-/-)) bone marrow chimeras that express a transgene containing

239 iNKT cells in bone marrow chimeras that reconstituted thymic cellulari

240 Intriguingly, in mixed bone marrow chimeras the phenotype conferred by DTR-expr

241 In bone marrow chimeras, the development of DC cancer could

242 Using TLR4-deficient bone marrow chimeras, the priming phenotype was restrict

243 In these studies, we first used bone marrow chimeras to demonstrate a requirement for My

244 viduals and, more importantly, use radiation bone marrow chimeras to demonstrate that restriction of

245 ing sepsis, we used CXCL1-deficient mice and bone marrow chimeras to demonstrate the importance of th

246 We used bone marrow chimeras to determine if SAMP ileitis result

247 In this study, we use bone marrow chimeras to show that clinical and histologi

248 use mixed G-CSF receptor (G-CSFR)-deficient bone marrow chimeras to show that G-CSF-induced mobiliza

249 We created bone marrow chimeras to test the role of IRF3 within leu

250 In mixed bone marrow chimeras, Tpl2 was shown to play a T cell-in

251 ly inhibited in Selplg(-/-) mice or Syk(-/-) bone-marrow chimeras treated with pertussis toxin.

252 n murine T cell function, we generated mixed bone marrow chimeras using bone marrow from NIK knockout

253 ulation in the intestines of Arg I-deficient bone marrow chimeras was associated with intestinal hemo

254 Furthermore, using bone marrow chimeras we show that deletion of AhR in the

255 Using mixed bone marrow chimeras we then determined that MyD88 expre

256 phosphate (NADPH) oxidase 2 (NOX2) and their bone marrow chimera, we demonstrated that NOX2 from both

257 Using MHC class II (MHC II) mixed bone marrow chimeras, we compared the bacterial burdens

258 Using mixed bone marrow chimeras, we compared wild-type and cytokine

259 Using reaggregated thymic organ culture and bone marrow chimeras, we demonstrate that positive selec

260 In addition, using bone marrow chimeras, we demonstrate that PVM are the ce

261 al microscopy with DREAM-null mice and their bone marrow chimeras, we demonstrated that both hematopo

262 First, using mixed bone marrow chimeras, we established that Ag-targeted, b

263 Using mixed bone marrow chimeras, we evaluated the effect of TSSP de

264 Using mixed bone marrow chimeras, we found that activating Fc recept

265 horiomeningitis virus-mediated hepatitis and bone marrow chimeras, we found that Bim has a dual role

266 forms of the serine/threonine kinase AKT and bone marrow chimeras, we found that hematopoietic cell-a

267 , PLZF reporter/fate mapping mice, and mixed bone marrow chimeras, we identified two distinct populat

268 Using retroviral vectors and bone marrow chimeras, we observed similar activity with

269 Using mixed bone marrow chimeras, we observed that IL-6 enhances ASC

270 Importantly, using mixed bone marrow chimeras, we revealed that the proinflammato

271 udy, using adoptive transfer experiments and bone marrow chimeras, we show that at least some of thes

272 By analyzing CD160(-/-) mice and mixed bone marrow chimeras, we show that CD160 is not essentia

273 Using conditional mutants and bone marrow chimeras, we show that intravascular activat

274 sing reciprocal adoptive transfer models and bone marrow chimeras, we show that Myd88(-/-) CD8 T cell

275 Finally, by generating mixed bone marrow chimeras, we showed that the effect of Sle1b

276 Using bone-marrow chimeras, we found that the signaling molecu

277 Bone marrow chimeras were constructed to test the effect

278 Bone marrow chimeras were constructed with TLR4 only on

279 Mixed bone marrow chimeras were established in which all B cel

280 Bone marrow chimeras were generated and similarly treate

281 esident cells contribute to ischemic injury, bone marrow chimeras were generated by transplanting bon

282 Bone marrow chimeras were generated by transplanting ICO

283 Mixed bone marrow chimeras were generated to assess the effect

284 Bone marrow chimeras were generated using MKK-3(-/-) and

285 in T cells under noncompetitive conditions, bone marrow chimeras were generated, in which the T cell

286 endothelium or other nonhematopoietic cells, bone marrow chimeras were generated.

287 protein receptor-deficient, S100A9-deficient bone marrow chimeras were generated.

288 sangial cells in pathogenesis, (NZB x NZW)F1 bone marrow chimeras were generated.

289 Bone marrow chimeras were performed between young and ag

290 Bone marrow chimeras were performed using bone marrow ce

291 F(-/-) mice, wild-type littermates, or mixed bone marrow chimeras were treated with the protease alle

292 These models, together with bone marrow chimeras, were used to explore the role of a

293 ss accumulation in the inflamed CNS in mixed bone marrow chimeras, when compared with CCR2(+/+) DCs;

294 ock-in mice as well as Sap(R78A) competitive bone marrow chimeras, which retained NKT cells but at si

295 lls (TECs) in Treg selection, we constructed bone marrow chimeras with disrupted CD28/B7 signaling in

296 To clarify the latter, we generated murine bone marrow chimeras with enforced Erg expression in eng

297 a by differential CD45 staining and by using bone marrow chimeras with fluorescent leukocytes.

298 endothelium-specific deficiency in JAM-A and bone marrow chimeras with JAM-A-deficient leukocytes.

299 Using IL-15(WT/WT) and IL-15(-/-) mice, bone marrow chimeras with normal cellularity, and a sele

300 lation on wild-type bystander cells in mixed bone-marrow chimeras with KLF2-deficient cells.