ライフサイエンスコーパス: bone matrix

1 h they produce IL-1 through interaction with bone matrix.

2 e of the articular cartilage and subchondral bone matrix.

3 tified in the mineral-associated fraction of bone matrix.

4 e bones caused by a reduction in collagenous bone matrix.

5 graphy (muCT) was used to assess mineralized bone matrix.

6 Type I collagen, the main constituent of the bone matrix.

7 m, and by uptake of calcium and phosphate by bone matrix.

8 n growth plate cartilage and in newly formed bone matrix.

9 o generate osteolytic lesions and invade the bone matrix.

10 ntly metastasizes to the bone marrow and the bone matrix.

11 sue and the vasculature within the calcified bone matrix.

12 owever, the mesenchymal cells do not deposit bone matrix.

13 in the degradation of protein components of bone matrix.

14 oblastic cell interaction with the anorganic bone matrix.

15 e competent osteoblasts capable of producing bone matrix.

16 cytes die and the cartilage is replaced with bone matrix.

17 e cavities that are embedded deep within the bone matrix.

18 final density of osteocytes embedded within bone matrix.

19 ic proteins (BMPs), from demineralized adult bone matrix.

20 ich cartilage matrix to type I collagen-rich bone matrix.

21 acterial collagenase digest of demineralized bone matrix.

22 regulated by TGF-beta, which is abundant in bone matrix.

23 osteocytes, which use glucose to remodel the bone matrix.

24 dental wear, but also a good density of the bone matrix.

25 ction of the proteinaceous components of the bone matrix.

26 tes to 90% of the total organic component of bone matrix.

27 steoblasts is to secrete collagen-containing bone matrix.

28 mechanical degeneration of the rib cortical bone matrix.

29 cification, and osteoblast cells deposit new bone matrix.

30 hape by forming a template for deposition of bone matrix.

31 a(2+) out of osteoblasts into the calcifying bone matrix.

32 alysis confirms their incorporation into the bone matrix.

33 esponsible for the resorption of mineralized bone matrix.

34 orchestrated by osteocytes, cells within the bone matrix.

35 olubilize hydroxyapatite crystals within the bone matrix.

36 asts, they contribute normal collagen to the bone matrix.

37 tiated leukocytes that erode the mineralized bone matrix.

38 ncreased numbers of osteoblasts and expanded bone matrix.

39 ecture, but also influence the nature of the bone matrix.

40 the mineral and non-mineralized moieties of bone matrix.

41 er OCPs secrete IL-1 when they interact with bone matrix.

42 of the mineral and organic components of the bone matrix, a decrease in osteoblast activity and bone

43 ized bone matrix (CMBM) and anorganic bovine bone matrix (ABBM).

44 they do not attach well to anorganic bovine bone matrix (ABM) coated with these same proteins.

45 ptide 15 [P-15] synthetic peptide) anorganic bone matrix (ABM) particulate (PPart) grafts have demons

46 with anorganic bovine-derived hydroxyapatite bone matrix (ABM) was compared to demineralized freeze-d

47 with anorganic bovine-derived hydroxyapatite bone matrix (ABM) was evaluated as a bone replacement gr

48 ic [corrected] bovine-derived hydroxyapatite bone matrix (ABM), was compared to ABM alone in human pe

49 Thus, signals originating from bone matrix activate the NLRP3 inflammasome in the osteo

50 xpressing c-Fos and whether interaction with bone matrix affects OCP cytokine expression.

51 The mechanical properties and composition of bone matrix, along with bone mass and architecture, are

52 The resulting CMF bone matrix also had an abundance of osteoid, and in loc

53 Load-induced microdamage naturally occurs in bone matrix and can be removed by initiating endogenous

54 pecialized mesenchymal cells that synthesize bone matrix and coordinate the mineralization of the ske

55 with a combination of assayed demineralized bone matrix and cortical cancellous chips uniformly disp

56 steocytes, the cells that reside deep in the bone matrix and form dendritic networks.

57 growth factor-beta (TGF-beta) is abundant in bone matrix and has been shown to regulate the activity

58 ls and particle size of ground demineralized bone matrix and its osteoinductive potential were invest

59 ound that the concentrations of IGF-1 in the bone matrix and marrow of aged rats were lower than in t

60 activities lead to enhanced turnover of the bone matrix and may explain the propensity of prostate c

61 Sockets were grafted with demineralized bone matrix and mineralized particulate allograft then c

62 Slightly demineralized bone matrix and overly demineralized bone matrix possess

63 phosphonates (BP), ensuring adherence to the bone matrix and reducing impact on noncalcified tissues.

64 wth factor-beta (TGFbeta) is enriched in the bone matrix and serves as a key factor in promoting bone

65 increased the concentration of IGF-1 in the bone matrix and stimulated new bone formation in aged ra

66 xcl9l recruits mpeg1-positive macrophages to bone matrix and triggers their differentiation into oste

67 are consistent with preservation of multiple bone matrix and vessel proteins, and phylogenetic analys

68 sitive macrophages get activated, migrate to bone matrix, and differentiate into osteoclasts.

69 val of colorectal cancer cells to and in the bone matrix, and inhibited osteoblast differentiation.

70 GF-I was incubated with the anorganic bovine bone matrix, and the amount of adsorbed growth factor wa

71 the bone mineral density, the quality of the bone matrix, and the evolution of microcracks.

72 wth factor beta (TGF-beta) potently enhances bone matrix apposition.

73 In rheumatoid arthritis (RA), cartilage and bone matrix are degraded, and extracellular matrix (ECM)

74 Some regions of the demineralized bone matrix are highly fibrous, and the matrix possesses

75 NK, since reduced levels of pyrophosphate in bone matrix are known to increase mineralization.

76 the mechanical properties and composition of bone matrix are largely unknown.

77 n, abundant factors previously buried in the bone matrix are released into the bone marrow microenvir

78 ch inhibit osteoclast-mediated resorption of bone matrix, are especially important because they decre

79 teocytes, cells ensconced within mineralized bone matrix, are the primary skeletal mechanosensors.

80 tion on the structural reorganization of the bone matrix as a function of temperature, from room temp

81 Osteoblasts build bone, becoming embedded in bone matrix as mature osteocytes.

82 properties and mineral concentration of the bone matrix, as well as the bone mass, enabling the bone

83 Above 700 degrees C, the inorganic bone matrix became highly symmetric, devoid of carbonate

84 ne (BG), or OFD with BG and anorganic bovine bone matrix (BO/BG).

85 bit bone marrow-derived osteoclasts released bone matrix-bound TGF-beta via LTBP1 cleavage.

86 entiated osteoblasts embedded in mineralized bone matrix but are connected with the BM.

87 (caBMPR-IB) induced formation of mineralized bone matrix by 2T3 cells without addition of BMP-2.

88 Resorption of type I collagen-rich bone matrix by activated osteoclasts results in the rele

89 h in turn stimulated the deposition of a new bone matrix by osteoblasts.

90 Osteoblasts mineralize bone matrix by promoting hydroxyapatite crystal formatio

91 growth factor-beta (TGF-beta), released from bone matrix by the action of osteoclasts, may foster met

92 oclasts, immune cells, and extracellular and bone matrixes caused when metastatic tumor cells coloniz

93 Some osteoblasts embed within bone matrix, change shape, and become dendrite-bearing o

94 Our findings suggest that bone-matrix changes in osteogenic niches regulate metast

95 Previously published haversian cavity and bone matrix chord length distributions for cortical bone

96 BM) by comparing with cancellous mineralized bone matrix (CMBM) and anorganic bovine bone matrix (ABB

97 , which occurs both by direct degradation of bone matrix collagen I and by cleavage of other factors

98 In addition, two protein components of bone matrix, collagen and osteonectin, have been shown t

99 secreting type I collagen, the most abundant bone matrix component.

100 inflammasomes, we tested the hypothesis that bone matrix components function as DAMPs for the NLRP3 i

101 applied to discern how the interaction among bone matrix constituents (collagen and mineral), microcr

102 ation procedures using an allograft cellular bone matrix containing native mesenchymal stem cells.

103 Moreover, the density and architecture of bone matrix correlated with the intensity and pattern of

104 Demineralized bone matrix (DBM) and guided tissue regeneration (GTR) s

105 Demineralized bone matrix (DBM) is used for the treatment of osseous d

106 Demineralized bone matrix (DBM) is widely used in the repair of pathol

107 hether alendronate remained in demineralized bone matrix (DBM) procured from donors with a documented

108 y and clinically compare human demineralized bone matrix (DBM) putty with one size of bone particles

109 ct of allogenic, freeze-dried, demineralized bone matrix (DBM) to guided tissue regeneration (GTR).

110 allograft (DFDBA), also called demineralized bone matrix (DBM), is osteoinductive but requires a carr

111 larized adult tissues, such as demineralized bone matrix (DBM).

112 Demineralized bone matrix (DBX) paste and putty are particulate demine

113 fect may contribute to the action of IL-6 on bone matrix degradation and bone resorption.

114 1-MMP plays a direct and/or indirect role in bone matrix degradation, thus favoring intraosseous tumo

115 erentiation, enhanced osteoclast number, and bone matrix degradation.

116 ase in the induction of cathepsin K, a major bone matrix degrading protease.

117 Col12a(-/-) osteoblasts have decreased bone matrix deposition with delayed maturation indicated

118 hat serves as the scaffolding for subsequent bone matrix deposition.

119 sphatase as well as through the detection of bone matrix deposition.

120 interconnected osteocyte network within the bone matrix differentiates from bone-forming osteoblasts

121 We now report that IGF-1 released from the bone matrix during bone remodeling stimulates osteoblast

122 t is stimulated by factors released from the bone matrix during osteoclastic resorption, estrogen def

123 mly sampled to create alternating regions of bone matrix, endosteum and haversian canal tissues durin

124 lesional bone in fibrous dysplasia produce a bone matrix enriched in certain anti-adhesion molecules

125 hypothesized that atherosclerosis and early bone matrix expression in the aortic valve occurs second

126 Osteonectin (SPARC, BM-40) is a bone matrix factor that is an in vitro chemoattractant f

127 s, including the release of factors from the bone matrix following bone resorption and direct cell-ce

128 nd bone sialoprotein (BSP), genes pivotal to bone matrix formation and calcification.

129 enes crucial for osteogenic differentiation, bone matrix formation and mineralisation were expressed

130 components may be particularly important for bone matrix formation and mineralization.

131 esults in a significant increase in lamellar bone matrix formation at the endosteum; but this increas

132 he expression of TRPS1 modulates mineralized bone matrix formation in differentiating osteoblast cell

133 n essential transcription factor involved in bone matrix formation in vitro and in vivo.

134 ling is blocked and BMP2-induced mineralized bone matrix formation was inhibited.

135 s elevate Col1a2 expression, contributing to bone matrix formation, and drive cell differentiation to

136 lated gene expression and led to mineralized bone matrix formation.

137 d osteoblast differentiation and mineralized bone matrix formation.

138 I collagen in osteoblast differentiation and bone matrix formation.

139 ssing TGF-beta2 also have increased rates of bone matrix formation; however, this activity does not r

140 ction between S. aureus and osteoblasts, the bone matrix-forming cells, while interactions between S.

141 tebral bodies (centra) arise by secretion of bone matrix from the notochord rather than somites; cent

142 entiated osteoblasts and entombed within the bone matrix, from established bone metastatic breast can

143 control their own adherence and migration to bone matrix, functions that facilitate tumor growth and

144 tibility of growth factor-rich demineralized bone matrix (GDBM) by comparing with cancellous minerali

145 some 5q21 in close proximity to other dentin/bone matrix genes.

146 produced an abnormal resorption-stimulating bone matrix high in BSP content.

147 e a hybrid cellular automata model of normal bone matrix homeostasis and the prostate cancer-bone mic

148 ities in sulfate transport and regulation of bone matrix homeostasis.

149 ixture of human allograft with demineralized bone matrix human allograft putty, and then covered with

150 at may be implicated in calcification of the bone matrix, illustrates the analytical power of this ap

151 ssed only in cells that were embedded within bone matrix in contrast to the earlier expression of kno

152 Why is there increased turnover of the bone matrix in the presence of prostate cancer?

153 eover, isolated, cultured notochords secrete bone matrix in vitro, and ablation of notochord cells at

154 tudy of their central role in remodeling the bone-matrix in healthy and disease states.

155 Proton solid-state MRI shows the density of bone matrix including its organic constituents, which co

156 crospectroscopy, to assess the properties of bone matrix independently of bone mass and architecture.

157 Implantation of demineralized bone matrix into subcutaneous sites results in local bon

158 cesses that are engaged within the malignant bone matrix involve the production of cytokines, which r

159 Bone matrix is degraded by osteoclasts, which differenti

160 osteoclast enzyme required for resorption of bone matrix, is underway.

161 ry as pluripotent cytokines extractable from bone matrix, it has been speculated how bone morphogenet

162 s) as pluripotent cytokines extractable from bone matrix, it has been speculated how targeting of BMP

163 teocyte and osteocyte lacuna counts, percent bone matrix loss, and fungal spheroid element counts cou

164 F-1), the most abundant growth factor in the bone matrix, maintains bone mass in adulthood.

165 Bone matrix markers (biglycan, COL1A1, tenascin C, and f

166 llular proliferation, Lrp5/beta-catenin, and bone matrix markers.

167 o examine the ability of an anorganic bovine bone matrix material as an alternative to autogenous bon

168 t tumor-associated proteolytic remodeling of bone matrix may underlie the capacity of tumor cells to

169 d alkaline phosphatase activity and improved bone matrix mineralization capacity.

170 , leading to osteopenia, but also suppressed bone matrix mineralization.

171 tive Hey1 expression augmented BMP9-mediated bone matrix mineralization.

172 Although the relationship between bone-matrix mineralization and tumour-cell phenotype in

173 astic differentiation in vitro and inhibited bone-matrix mineralization.

174 , cellularity (osteoblasts and osteoclasts), bone matrix (mRNA expression and IHC), and mineralizatio

175 transplanted progenitors embedded within the bone matrix near active bone-forming surfaces in respons

176 ease of mineral density in the cartilage and bone matrix of TNAP-deficient mice.

177 fore, only sinus lifts with inorganic bovine bone matrix or demineralized bone matrix were included,

178 cancellous bone allograft, anorganic bovine bone matrix, or biphasic calcium phospate.

179 lular protein involved in bone formation and bone matrix organization, as the potential candidate gen

180 In summary, demineralized bone matrix paste, demineralized bone matrix putty, and

181 e notion that osteolysis releases DAMPs from bone matrix, pharmacologic inhibition of bone resorption

182 , the most abundant cells in the mineralized bone matrix, play a key role in sensing mechanical force

183 Osteoclasts from these mice resorb bone matrix poorly, and the structure, stability, and ce

184 ralized bone matrix and overly demineralized bone matrix possessed a degree of osteoinductive potenti

185 is of type I collagen, the main component of bone matrix, precedes the expression of Runx2, the earli

186 Our results provide evidence that bone matrix properties are controlled by growth factor s

187 Bone matrix properties correlated with the level of TGF-

188 ion of the ruffled border in osteoclasts and bone matrix protein deposition in osteoblasts, without a

189 ERK and p38 inhibitors on the regulation of bone matrix protein expression and JunB and JunD levels

190 th delayed maturation indicated by decreased bone matrix protein expression.

191 C-E1a was constructed using a noncollagenous bone matrix protein osteocalcin (OC) promoter to drive t

192 d the fact that plasmin specifically cleaves bone matrix protein osteocalcin (OC).

193 nifested by under-gamma-carboxylation of the bone matrix protein osteocalcin, may be common.

194 ity of Lrp5-/- osteoblasts to synthesize the bone matrix protein osteopontin after a mechanical stimu

195 ppresses bone formation in vivo and disrupts bone matrix protein synthesis by osteoblasts in vitro.

196 DMP1, a key regulatory bone matrix protein, can be endocytosed by preosteoblast

197 Osteocalcin (OC), a noncollagenous bone matrix protein, is expressed in high levels by oste

198 associated with lysosomes in osteoclasts and bone matrix protein-containing vesicles in osteoblasts.

199 ynthesis of type I collagen, the predominant bone matrix protein.

200 blasts, osteoclasts and osteocytes, and that bone matrix proteins are present in vessel-associated ca

201 Unlike ALP, expression of the major bone matrix proteins by the osteoblasts was only minimal

202 The bone matrix proteins dentin sialoprotein and osteopontin

203 protein are the most abundant noncollagenous bone matrix proteins expressed by osteoblasts.

204 p junctional communication and production of bone matrix proteins in osteoblastic cells.

205 s of increased macrophages, PCNA levels, and bone matrix proteins in the aortic valve during experime

206 to expose osteoinductive or osteoconductive bone matrix proteins that should facilitate osteogenesis

207 in and osteocalcin (osteoblast endochrondral bone matrix proteins), and proliferating cell nuclear an

208 hyrin-I decreased mineralization, aggregated bone matrix proteins, activated endoplasmic reticulum st

209 d by vascularization and the presence of the bone matrix proteins, BSP and BAG-75.

210 ssential cofactor for gamma-carboxylation of bone matrix proteins.

211 e phosphatase activity and the deposition of bone matrix proteins.

212 ding type I collagen, osteopontin, and other bone matrix proteins.

213 mineralized bone matrix paste, demineralized bone matrix putty, and demineralized freeze-dried bone a

214 Developing clinical tools that assess bone matrix quality could improve the assessment of a pe

215 ould help enhance efficient osteogenesis and bone matrix regeneration.

216 increased adhesion to basement membrane- and bone matrix-related filaments and enhanced soft agar gro

217 ent evidence that maspin inhibits PC-induced bone matrix remodeling and induces PC glandular rediffer

218 ect of tumor-associated maspin on PC-induced bone matrix remodeling and tumor growth, we injected the

219 g required for transcriptional activation of bone matrix remodeling enzymes during osteoclast differe

220 Osteoclast-mediated bone matrix resorption has been attributed to cathepsin

221 adult skeleton by a critical contribution to bone matrix resorption.

222 ormation of multinucleated OCs and decreases bone matrix resorption.

223 lone or in combination with anorganic bovine bone matrix resulted in increased amounts of bone, perio

224 rs leads to the premature differentiation of bone matrix secreting osteoblasts.

225 icated in development of the osteoblast, the bone matrix-secreting cell of the vertebrate skeleton.

226 Osteocytes reside in bone matrix, sense changes in mechanical load, and produ

227 Patients treated with inorganic bovine bone matrix showed a better implant success rate (P = 0.

228 the apatite crystal structure, increased the bone matrix stiffness, and reduced bone brittleness.

229 inantly an intramembraneous path, with woven bone matrix subsequently maturing into fully mineralized

230 d in the secretome of these cells and in the bone matrix, suggesting an extracellular function during

231 , gelatin, and hydroxyapatite, mimicking the bone matrix, supported robust attachment, proliferation,

232 later role in mature osteoblasts to promote bone matrix synthesis.

233 ltered levels of mineral and collagen in the bone matrix that is also distinct from the type I collag

234 d strength of bone result from the nature of bone matrix, the mineralized extracellular matrix produc

235 topoietic lineage that develop and adhere to bone matrix, then secrete acid and lytic enzymes that de

236 ajority of them induce excessive mineralized bone matrix, through undefined mechanisms, as opposed to

237 sorb and replace the surrounding perilacunar bone matrix to maintain mineral homeostasis.

238 omeostasis requires continuous remodeling of bone matrix to maintain structural integrity.

239 ins regulate dilatational band formation and bone matrix toughness.

240 itu osteocytes embedded within a mineralized bone matrix under dynamic loading remains unknown.

241 sis requires remodeling of the collagen-rich bone matrix, we investigated the role of cancer cell-der

242 norganic bovine bone matrix or demineralized bone matrix were included, and 1,536 periapical radiogra

243 collagen I cause defects in the structure of bone matrix while mutations in genes encoding cartilage-

244 vated and lead to destruction or loss of the bone matrix will be described.

245 Porous bone matrix with known amounts of adsorbed PDGF-BB or IG

246 , active and inactive marrow, endosteum, and bone matrix within 22 skeletal sites in the adult.

247 referentially incorporates into newly formed bone matrix within osteoblastic metastatic lesions.

248 esulted in the maintenance and maturation of bone matrix, without the formation of teratomas that is