ライフサイエンスコーパス: bone sialoprotein

1 -regulating endopeptidase homolog), and Bsp (bone sialoprotein).

2 nimal role in mediating the PTH induction of bone sialoprotein.

3 (HA)-binding properties and bone tropism to bone sialoprotein.

4 ontain high levels of sialic acid similar to bone sialoprotein.

5 as Col10, osterix, alkaline phosphatase, and bone sialoprotein.

6 Bone sialoprotein accumulates within bone acidic glycopr

7 veral bone-associated proteins (osteopontin, bone sialoprotein, alkaline phosphatase, type I collagen

8 els prominently accelerated collagen type I, bone sialoprotein and osteocalcin protein expression.

9 rkers of osteoblastic differentiation (i.e., bone sialoprotein and osteocalcin) in the preosteoblasts

10 xpression of osteoblast marker genes such as bone sialoprotein and osteocalcin.

11 ment normalized the altered distributions of bone sialoprotein and osteopontin in Hyp mouse alveolar

12 osteocyte marker), while osteoblast markers, bone sialoprotein and osteopontin, remained unchanged.

13 ndicated that BMP-2 decreased mRNA levels of bone sialoprotein and type I collagen dose-dependently (

14 e increases in the expression of major bone (bone sialoprotein) and cartilage (type II collagen) matr

15 differentiation markers such as osteocalcin, bone sialoprotein, and dentin matrix protein 1 (DMP1) wa

16 bone gamma-carboxyglutamate protein, COL1A1, bone sialoprotein, and dentin matrix protein1.

17 ciated with significant reductions in Runx2, bone sialoprotein, and osteocalcin expression, parallele

18 iation markers Runx-2, alkaline phosphatase, bone sialoprotein, and osteocalcin.

19 N-linked glycoproteins) family of proteins, bone sialoprotein, and osteopontin, bound first to a cel

20 the osteogenic markers alkaline phosphatase, bone sialoprotein, and Runt-related transcription factor

21 total NCPs were separated into osteopontin-, bone sialoprotein-, and dentin matrix protein-1-enriched

22 Surprisingly, osteocalcin and bone sialoprotein are also expressed by malignant but no

23 Osteocalcin and bone sialoprotein are the most abundant noncollagenous b

24 ted transcription factor 2 at 7 days and for bone sialoprotein at days 7 and 10 as well as higher OPN

25 sized that the Staphylococcus aureus MSCRAMM bone sialoprotein-binding protein (Bbp) might recognize

26 gulase, exotoxin, Ser-Asp fibrinogen-binding bone sialoprotein-binding protein, fibrinogen and kerati

27 d osteonectin, whereas alkaline phosphatase, bone sialoprotein, bone Gla protein, and collagen II, al

28 Bone sialoprotein (BSP) and apatite co-localize in the e

29 while BP and IGF promoted gene expression of bone sialoprotein (BSP) and OPN.

30 Bone sialoprotein (BSP) and osteocalcein (OCN) markers w

31 DGF-BB or TGF-beta resulted in a decrease in bone sialoprotein (BSP) and osteocalcin (OCN) mRNAs whil

32 n situ hybridization, for gene expression of bone sialoprotein (BSP) and osteocalcin (OCN), and histo

33 Alendronate suppressed the expression of bone sialoprotein (BSP) and osteonectin in both femurs a

34 lecules associated with mineralized tissues, bone sialoprotein (BSP) and osteopontin (OPN), and a cel

35 Bone sialoprotein (BSP) and osteopontin (OPN, ETA-1) are

36 inical correlation between the expression of bone sialoprotein (BSP) and skeletal metastasis of breas

37 nohistochemistry methods were used to detect bone sialoprotein (BSP) distribution in Hyp and WT mouse

38 study to determine the relationship between bone sialoprotein (BSP) expression and osteocalcin expre

39 ted growth and enhanced osteocalcin (OC) and bone sialoprotein (BSP) gene expression in human prostat

40 The bone sialoprotein (Bsp) gene provides an excellent model

41 Expression of the bone sialoprotein (BSP) gene, a marker of bone formation

42 Bone sialoprotein (BSP) has been shown to induce limited

43 llular phosphoproteins osteopontin (OPN) and bone sialoprotein (BSP) have been implicated in biologic

44 linked glycoproteins), osteopontin (OPN) and bone sialoprotein (BSP) in the Galnt1-null mice relative

45 Bone sialoprotein (BSP) is a member of the SIBLING famil

46 Bone sialoprotein (BSP) is a multifunctional, highly pho

47 Bone sialoprotein (BSP) is a secreted glycophosphoprotei

48 Bone sialoprotein (BSP) is an acidic 301 amino acid prot

49 Bone sialoprotein (BSP) is an acidic phosphoprotein with

50 Bone sialoprotein (BSP) is an extracellular matrix (ECM)

51 Bone sialoprotein (BSP) is an extracellular matrix prote

52 conducted in microdot cultures of UMR-106-01 Bone Sialoprotein (BSP) osteoblast cells.

53 ssociated proteins, i.e., osteopontin (OPN), bone sialoprotein (BSP), alkaline phosphatase (ALP), ost

54 aining bone acidic glycoprotein-75 (BAG-75), bone sialoprotein (BSP), and alkaline phosphatase that a

55 runt-related transcription factor 2 (RunX2), bone sialoprotein (BSP), and osteocalcin (OCN) messenger

56 Dentin matrix protein-1 (DMP1), bone sialoprotein (BSP), and osteopontin (OPN) are three

57 The mRNA expressions of bone sialoprotein (BSP), collagen type I (COL-I), osteoc

58 ING proteins: full-length osteopontin (OPN), bone sialoprotein (BSP), dentin matrix protein 1 (DMP1),

59 nsfer and expression of osteocalcin (OC) and bone sialoprotein (BSP), genes pivotal to bone matrix fo

60 ion of a mineralized tissue-specific marker, bone sialoprotein (BSP), indicating that epithelial prod

61 Immunohistochemistry for bone sialoprotein (BSP), integrin beta1 and collagen typ

62 levels of mineral-associated genes including bone sialoprotein (BSP), OC, and osteopontin (OPN) in th

63 Proliferating cell nuclear antigen (PCNA), bone sialoprotein (BSP), osteocalcin (OCN), and tartrate

64 ed cementoblast population (OC/CM) expressed bone sialoprotein (BSP), osteopontin (OPN), and OC, mark

65 of mineralized tissue-associated markers of bone sialoprotein (BSP), Type I collagen (COL I), osteoc

66 truct containing the response element of rat bone sialoprotein (BSP).

67 ted by collagen and potentially nucleated by bone sialoprotein (BSP).

68 ifferentially expressed gene was found to be bone sialoprotein (Bsp).

69 sociated markers, e.g., osteocalcin (OCN) or bone sialoprotein (BSP).

70 prove this hypothesis, we infected 5-day-old bone sialoprotein (BSP)/avian retroviral receptor gene (

71 These blood-based biomarkers were bone sialoprotein (BSP, Discovery false discovery rate [

72 ays for core binding factor alpha-1 [Cbfa1], bone sialoprotein [BSP], osteocalcin [OCN], and osteopon

73 rkers (osteocalcin [OCN], osteopontin [OPN], bone sialoprotein [BSP], osteoprotegerin [OPG] and recep

74 s: bone marrow mesenchymal stem cell, BMMSC; bone sialoprotein, BSP; hydroxyapatite/tricalcium phosph

75 ly of integrin-binding phosphoglycoproteins (bone sialoprotein, BSP; osteopontin, OPN; and dentin mat

76 target genes, osteocalcin, osteopontin, and bone sialoprotein but did not significantly alter Runx2

77 and a significant decrease in expression of bone sialoprotein, characteristics of periodontal ligame

78 moted with AMC spheroids/FDBG treatment, and bone sialoprotein expression and cell proliferation were

79 o OSE2 preceded increases in osteocalcin and bone sialoprotein expression and this increase in Osf2 b

80 , these results suggest that osteocalcin and bone sialoprotein expression is coordinated and regulate

81 study is to investigate how osteocalcin and bone sialoprotein expression is regulated in prostate ca

82 ed osteopontin and osteocalcin and decreased bone sialoprotein expression was detected within 7 days

83 nced by reduced mineralization and decreased bone sialoprotein expression.

84 conditioned medium-mediated osteocalcin and bone sialoprotein gene expression in prostate cancer cel

85 In differentiated MC4 cells, osteocalcin and bone sialoprotein gene expression were both down-regulat

86 evelopment (e.g. Col1a1, Postn/Osf2, and the bone sialoprotein gene or BSP), genes that are expressed

87 Bone sialoprotein (gene: Ibsp; protein: BSP) is a multif

88 transcription factor in the osteocalcin and bone sialoprotein genes that cannot be resolved by tradi

89 ssion of osteoblast-specific osteocalcin and bone sialoprotein genes, alkaline phosphatase activity,

90 g the alkaline phosphatase, osteocalcin, and bone sialoprotein genes, and temporally associates with

91 trix phosphoproteins such as osteopontin and bone sialoprotein have yielded important biological info

92 t differentiation genes osterix (Sp7), Atf4, bone sialoprotein (Ibsp), and osteocalcin (Bglap) withou

93 n 1 (Dmp1/DMP1), osteopontin (Spp1/OPN), and bone sialoprotein (Ibsp/BSP).

94 tein (DSPP), dentin matrix protein 1 (DMP1), bone sialoprotein II (IBSP), and bone morphogenetic prot

95 line phosphatase/ALPL, osteopontin/SPP1, and bone sialoprotein II/IBSP) in a subset of the hMSC popul

96 ne phosphatase), Ocn (osteocalcin), and Bsp (bone sialoprotein) in response to recombinant PP and sta

97 of osteoblastic marker genes, namely Ocn and bone sialoprotein, in Atf4(-/-) developing bones.

98 Bone sialoprotein is a 70-kDa extracellular matrix compo

99 Bone sialoprotein is a major noncollagenous protein of b

100 AP could promote periodontal regeneration in bone sialoprotein knockout mice (Ibsp(-/-) mice), which

101 Similar fragments of bone sialoprotein, like the intact protein, did not func

102 at calcium deposition and gene expression of bone sialoprotein, lipoprotein lipase, and fatty acid bi

103 A1 and osteocalcin mRNA levels and increased bone sialoprotein mRNA, consistent with an inhibition of

104 -fold increase in the steady-state levels of bone sialoprotein mRNAs within primary cultures of embry

105 ophages in response to added native purified bone sialoprotein (nBSP) and its dephosphorylated form (

106 versus normal human valves for osteopontin, bone sialoprotein, osteocalcin, alkaline phosphatase, an

107 educed osterix-producing cells and increased bone sialoprotein, osteocalcin, and BMP-7 expression.

108 vealed increased mRNA levels of osteopontin, bone sialoprotein, osteocalcin, and Cbfa1 in the calcifi

109 parallel, a decreased expression of Runx-2, bone sialoprotein, osteocalcin, and RANK-L.

110 ogenic markers such as Runx2, Osterix, DMP1, Bone sialoprotein, Osteocalcin, NFATc1, and Schnurri-2,

111 ranscription factor 2, Type I collagen, ALP, bone sialoprotein, osteopontin), osteocalcin, CEMP1, and

112 ng ligand N-linked glycoproteins (SIBLINGs): bone sialoprotein, osteopontin, and dentin matrix protei

113 ulation of interleukin-6, interleukin-1beta, bone sialoprotein, osteoprotegerin, receptor activator o

114 g demonstrated that a sizeable proportion of bone sialoprotein particles were located within a 50-nm

115 tion revealed that (a) human osteocalcin and bone sialoprotein promoter activities in an androgen-ind

116 ediated stimulation of human osteocalcin and bone sialoprotein promoter activities occurs through inc

117 um was found to induce human osteocalcin and bone sialoprotein promoter activities via increased CRE/

118 increased or repressed human osteocalcin and bone sialoprotein promoter activities.

119 of an osteoblast-specific element within the bone sialoprotein promoter and demonstrate its regulatio

120 ) Deletion analysis of human osteocalcin and bone sialoprotein promoter regions identified cyclic AMP

121 tronectin, type I collagen, osteopontin, and bone sialoprotein) showed any detectable effect on PG me

122 Bone sialoprotein specifically binds proMMP-2 and active

123 alkaline phosphatase, bone Gla protein, and bone sialoprotein, suggesting an osteogenic phenotype.

124 tein 1, and higher levels of osteopontin and bone sialoprotein than the normal.

125 nding of the Col11a1 "6b" exonal sequence to bone sialoprotein was demonstrated with overlapping pept

126 ble in both genotypes, and the expression of bone sialoprotein was similar in tumor-bearing bones of

127 Bone sialoprotein was the only osteoblast marker strongl

128 tic protein (BMP)-2, BMP-7, osteopontin, and bone sialoprotein were evaluated in alveolar sockets.

129 bone proteins, osteopontin, osteonectin, and bone sialoprotein, were identified in the protein extrac

130 ion factor 2), osteocalcin, osteopontin, and bone sialoprotein, were reduced proportionate to the red

131 n the pro-adhesive molecules osteopontin and bone sialoprotein, which is in contrast to the high leve