ライフサイエンスコーパス: both @3 and

1 ountries for each of the three scenarios for both 4-week and 12-week timeframes, starting from June 2

2 17.7%-20.2%), stable over time (P > .05 for both 2010-2016 and 2003-2009 vs 1996-2002), and higher a

3 .5% at 26 weeks in the CGM group and 8.9% at both baseline and 26 weeks in the BGM group (adjusted be

4 e index (API) were significantly improved in both groups 3 and 6 months after SRP.

5 hic study (12 crystal structures), involving both CA II and a soluble CA IX mimetic (CA IX-mimic), re

6 es modulated by persisting viral Ags exhibit both discrete functional deficits and a notable surplus.

7 and WLN5-6 were detected by NMR spectroscopy both in the presence and absence of Cu at a common inter

8 Despite both control and ACC2 iKO mice exhibiting a similar obes

9 Site-directed mutagenesis of both cofilin and actin revealed residues critical for su

10 Likewise, both obesity and addictive behaviours have similar corre

11 asses of brain endothelial cells (ECs) under both normal conditions and after deletion of Pdcd10 (Ccm

12 4 variants are identified that contribute to both LOAD risk and age at onset of LOAD.

13 A RhoGAP (p190A) is significantly altered by both mutation and allelic deletion in human cancer, but

14 s suggest swine influenza viruses containing both a stabilized HA and alpha-2,6 receptor binding in t

15 g functional-group tolerance with respect to both the alpha-ketoacetal and amine coupling partners, p

16 gely in the phases in crystallography but in both phases and amplitudes in cryo-EM, and that half-map

17 value = 0.0028), which has been reported as both a tumor suppressor and an oncogene.

18 The study evaluates both functional and anatomical outcomes of retinal detac

19 Data from both humans and animal models are consistent in demonstr

20 The duration of VEGF exposure influenced both barrier relaxation and anti-VEGF-mediated closure.

21 Both IgM anti-PC and anti-MDA increased during the first

22 tabaga/+;octbeta1r/+ flies perform poorly in both aversive and appetitive conditioning, while individ

23 rmore, FICZ-induced MMP1 expression required both AHR and ARNT, demonstrating that the AHR-ARNT trans

24 such as The Cancer Genome Atlas (TCGA), with both RNA-Seq and array-based platforms available.

25 ar syphilis increased over the study period, both in absolute numbers and as a proportion of all syph

26 specific metabolomic signature compared with both control subjects and asthmatic patients.

27 lium, using 22,150 urogenital specimens from both symptomatic and asymptomatic men and women collecte

28 which combines the synergistic properties of both CNTs and AuNPs, represents a promising signal ampli

29 iewed as language recognition problems where both languages and automata recognizing them form an inc

30 no significant between-group differences in both worst and average numerical rating scale (NRS) pain

31 s were independently modulated by changes in both foreground and background reward rates.

32 l-life cultural processes, thereby enriching both sociocultural theories and Bayesian accounts of cog

33 Rates of both vascular complications and bleeding events decrease

34 overy of NPQ under equivalent intensities of both red and blue light.

35 inor effect on bound-forms hydrolysis, being both free and bound forms equally affected by temperatur

36 chain populations observed for these sugars both in free solution and bound to nonhydrolytic protein

37 uding those in clusters of polar residues at both the N and C termini, and deletion of up to 11 C-ter

38 ommended as a non-pharmacological therapy in both obese and cancer situations.

39 We have previously demonstrated that both GLP-1 and CCK are produced in the endocrine pancrea

40 Perforin contributed to both CD8+ and CD4+ CAR T cell cytotoxicity but was not r

41 apable of antigen processing and priming for both CD4(+) and CD8(+) T cells and of the direct orchest

42 3 (9.8 +/- 0.7 MPa) and that the dynamics of both canonical and CENP-A nucleosomes are preserved and

43 production of a range of mini-spidroins with both terminal domains, and characterize their response t

44 Both basic and clinical evidence reveal dual roles for G

45 Lack of precision in both neuroanatomical and clinical boundaries have likely

46 (SARs) have been characterized that interact both with the cargo and components of the autophagic mac

47 We demonstrate that this method is suited to both 3D structure determination and correlative light/el

48 aluable for a first response assessment with both PET- and CT-based criteria.

49 Image analysis of motile cell populations, both primary and cultured, typically reveals an intercel

50 ial memory mediate the aftereffect following both trial-wise and cumulative adaptation, but also show

51 During the subsequent unisensory trial, both trial-wise and cumulative exposure bias the encodin

52 ressing mice and reduced hyperinsulinemia in both S350L and D734A INSR-expressing animals.

53 nown product, confirmed to be the Vi monomer both de-O- and de-N-acetylated by mono- and bidimensiona

54 er burden of premenopausal breast cancer for both new cases and deaths compared with higher income co

55 , and that this impairment may be related to both increased mind wandering and decreased monitoring o

56 C9orf72 and SMCR8 both contain longin and DENN (differentially expressed i

57 ange of flowering land plant families and in both monocots and dicots.

58 Systems biology analyses highlight both similarities and differences between the mood disor

59 Functional connectivity was found both between similar (homotypic) and different (heteroty

60 H3K4me1, H3K27ac, H3K27me3, and H3K36me3) in both hMSCs and differentiated chondrocytes.

61 ights are relevant to CD81's varied roles in both health and disease.

62 vaping of e-cigarettes causes health effects both similar to and disparate from those of cigarette sm

63 ions, and leads to an effective rejection of both virus-injected and distant tumors.

64 te promoter architecture, which can function both coordinately and divergently to diversify RNAs.

65 f the organization of archaeal chromatin, on both the organismal and domain level.

66 en at day 5 postinfection (d p.i.), although both wild-type and DUBmut virus infections resulted in s

67 For nonantioxidants, vitamin B12 use both before and during chemotherapy was significantly as

68 s well as generic defences effective against both Ma549 and E. muscae.

69 d that Zta is subjected to ubiquitination in both EBV-infected and EBV-negative cells.

70 nt protein kinase CPK3 is a key regulator of both pattern-triggered immunity and effector-triggered i

71 omes PD-L1-mediated immunosuppression during both the priming and effector phases, provokes systemic

72 enerate the H(inact) state anaerobically via both chemical and electrochemical oxidation.

73 ltransferases by binding to the same site as both substrates in EmbB and EmbC.

74 With both conceptual and empirical support, we argue that thr

75 apeutics beyond anticoagulants and to target both thrombocytopathy and endotheliopathy.

76 well understood, it is believed to comprise both genetic and environmental factors.

77 nent of human transcription factor TFIIH, in both B lymphocytes and epithelial cells, we hypothesized

78 ed to poly(ADP-ribose) polymerase inhibitors both in vitro and ex vivo These findings might pave a wa

79 the approach using a birth-death model with both synthetic and experimental data, and show that we c

80 Using both synthetic and experimental datasets for comparison,

81 s of white matter and clinical decline using both internal and external datasets.

82 dings that provide a deeper understanding of both parenchymal microglia and extraparenchymal brain ma

83 se mechanism leading to neurodegeneration in both sporadic and familial PD upon parkin loss-of-functi

84 ular endothelial growth factor-A (VEGF-A) in both male and female mice, as well as increased VEGFR1 a

85 rticogenesis during prenatal development, in both males and females.

86 Measurements were collected in both greenhouse and field environments, with plants expo

87 were separated and independently analyzed by both imaging and flow velocity analyses.

88 We identified and profiled both neuronal (glutamatergic and GABAergic) and nonneuro

89 The hysteresis ratio was related to both lung tissue and gas recruitment (R = 0.266, p = 0.0

90 me biology in T. gondii and is important for both mitochondrial and general parasite metabolism.

91 l clones were detected in the circulation by both mRNA-based and genomic DNA-based sequencing.

92 We showed that lncRNAs are distinct from both protein-coding transcripts and genomic background n

93 Using both luciferase and GFP plasmid transfections, we show t

94 Ventralization in Ankmy2 knockout requires both cilia and Gli2 activation.

95 in binding-impaired subunits, as we show for both kainate and GluA2 AMPA receptors.

96 nhibitors of glucose transporters, targeting both GLUT1 and GLUT3.

97 experimental games confirm the existence of both 'lone wolf' defectors and 'good shepherd' cooperato

98 ile also allowing researchers to account for both individual- and habitat-level covariates.

99 The evolutions for both emission spectra and hardness of molten zone were r

100 In conclusion, both HBsAg production and HDV replication are effectivel

101 ic devices was associated significantly with both myopia and high myopia (OR, 2.43 and 2.31).

102 of yeast cells and reveals ample evidence of both vertical and horizontal pleiotropy.

103 Both BPV-1 and HPV-31 Y102E are similar in that neither

104 In both C. elegans and human cancer cells, ether-lipid synt

105 In both murine and human tumor cells, HOTAIR-sbid impaired

106 ly correlated with fasting plasma glucose in both obese mice and humans.

107 oid precursor protein cleaving enzyme 1, and both total and hyperphosphorylated tau expression, corre

108 and PI therapy, which significantly reduced both class I and II HLA antibodies and increased the lik

109 single-molecule imaging, we demonstrate that both condensin I and II exhibit ATP-dependent motor acti

110 -sensitivity C-reactive protein (hsCRP), and both hsCRP and IL-6 decreased among participants receivi

111 The HLA system plays a pivotal role in both clinical applications and immunology research.

112 First, we demonstrated through both PCR and immunostaining that mouse lymphatic muscle

113 50) in the ER, and measured its fluorescence both in dissociated ommatidia and in vivo from intact fl

114 ciated with increased incidence of diabetes, both in humans and in animal models.

115 , foveal vision is constantly being reshaped both in space and in time with the occurrence of microsa

116 bosomal integrity following oxidative stress both in vitro and in cells to elucidate details of the i

117 s its aggregation, and inhibits its toxicity both in vitro and in vivo In this study, we investigate

118 rus-encoded VP3 antagonizes RNase L activity both in vitro and in vivo These studies highlight an eve

119 dium berghei development inside hepatocytes, both in vitro and in vivo.

120 tuberculosis Tam also replaced E. coli BioC both in vivo and in vitro and complemented biotin-indepe

121 rtation resources to underserved populations both now and in the future.

122 Therefore, both activation and inactivation of PVCV occurred in age

123 echanism conferring tamoxifen resistance via both ERalpha dependent and independent pathways.

124 transformations and have been widely used in both academic and industrial settings.

125 Intriguingly, both optogenetic excitation and inhibition of cerebellar

126 ability of astrocytic ephrin-B1 to influence both excitatory and inhibitory synapses during developme

127 d and selected mutant forms of uPlm that are both catalytically active and insensitive to alpha2-AP i

128 tra are also searchable and interpretable in both commercial and institutional IR databases without m

129 cantly enhances RIG-I mediated production of both proinflammatory cytokines and interferons.

130 tant class of plant signalling molecule with both external rhizospheric and internal hormonal functio

131 travel restrictions or quarantine measures, both locally and internationally, would have reduced the

132 DeltaFIRE/DeltaFIRE) embryos, the arrival of both primitive microglia and intracerebroventricular mac

133 Therefore, we conclude that both atypical 3q26/MECOM and inv(3)/t(3;3) can be classi

134 fractory ITP during pregnancy seems safe for both mother and neonate and is likely to be helpful, esp

135 osophila pioneer-like factor, functions with both SWI/SNF and ISWI family chromatin remodelers to all

136 sk (compared with the general population) of both dementia and its prodrome, mild cognitive impairmen

137 oid arthritis, or sepsis were susceptible to both IgA- and IVIG-mediated death.

138 assess the splicing activity of 34 inteins (both uncharacterized and known) using a rapid split fluo

139 -experienced participants with resistance to both efavirenz and lamivudine, 32 (35.6%) of whom were s

140 Although both early and late viral transcripts contain m(6)A, dep

141 ed in Type 2 Hi asthma, where high levels of both 15LO1-PEBP1 and LC3-II are seen in HAECs, in associ

142 Transcriptional activation in both adipose tissue and liver as well as serum levels we

143 semialdehyde (alpha-AASA) and pipecolic acid both in brain and liver tissues, similar to the biochemi

144 .5) in Delhi, highlighting the importance of both external transport and local emissions to PM(2.5) p

145 isrupts physiological homeostasis and alters both systemic and local microenvironments that impact st

146 opment or treatment regimens that may affect both acute and long-term effects of manipulating the act

147 reased work productivity and activity level, both cross-sectionally (interindividually) and longitudi

148 s of gene products, and the need to consider both gain and loss of function to develop safe and effec

149 -symmetry striped phase that is disrupted at both high and low extremes of chemical potential.

150 In both high- and low-income countries, HIV-negative childr

151 of these strains, finding that strains with both higher and lower basal levels tend to enrich their

152 On the neural level, both OXT and LZP inhibited responses to fearful faces vs

153 Structural changes in both the peripapillary and macular retina and changes in

154 ntly localized in a punctate distribution in both N. benthamiana and maize (Zea mays) protoplasts.

155 10 healthy participants (each group included both females and males).

156 nce homology but high structural homology to both yeast Get2 and mammalian CAML.

157 Both SARS-CoV and MERS-CoV have caused serious outbreaks

158 roach it is necessary to better characterize both the primary metabolism and metabolic regulation of

159 ection of over 10,000 bacterial genomes from both cultured isolates and metagenomic datasets, reveali

160 associated with pathogenic PBX1 variants in both humans and mice.

161 Both epiboly and microtubule defects were partially rest

162 s observational multiplatform data capturing both desktop and mobile use to demonstrate that coexposu

163 tem should be regarded as a new standard for both small-bowel diagnosis and monitoring in inflammator

164 lved in the production of specific sfRNAs in both mammalian and mosquito cells.

165 tributions, we show that the H2A.B status of both the father and mother, but not of the zygote, affec

166 of several essential neural nodes engaged in both cognitive and motor processing.

167 otoxicity of melatonin was carried out using both live/dead and MTT assays.

168 Here, we show that both IFN-gamma stimulation and murine norovirus (MNV) in

169 Both AECs and NECs might provide better diagnostic accur

170 aks are observed for CA and its fragments in both the positive and negative modes.

171 in why the 20rDNA line is hyper-resistant to both bacterial and nematode infections.

172 ffects the maternal intestinal microbiota of both mother and newborn.

173 Both LF and NF groups had similar demographics, valve ar

174 IG provides consensus recommendations to aid both expert and non-expert clinicians in the diagnostic

175 of tens of nanoamperes, which flowed through both homogeneous and non-homogeneous base-pair sequences

176 strains can cause death in individuals from both risk and non-risk groups, including young adults.

177 as associated with lower mortality risk from both cardiovascular and noncardiovascular causes in low-

178 In both mice and nonhuman primates, cocktails of three de n

179 9 (At1g05940) was consistently envisaged for both NUE and NUPEFF.

180 e a distinct representational signature from both scene and object views in visual cortex.

181 d particularly the NAWH requires considering both atmospheric and oceanic mechanisms.

182 PFHxS lowered thyroid hormone levels in both dams and offspring in a dose-dependent manner, but

183 verlapping ecology, they deviate strongly in both visual and olfactory investment.

184 more, phosphorylation of AGO2(Y393) disrupts both the wild-type and oncogenic KRAS-AGO2 interaction,

185 For the diagnosis of early glaucoma, both macular and optic disc scans should be used.

186 d scaling relations in the delay suffered by both event participants and other citizens doing their u

187 ynamics simulation approaches, we found that both OTUB1 and OTUB2 display a catalytic triad character

188 tive double-duty intervention that addresses both stunting and overweight in children aged 4 years an

189 As the expressions of both HO-1 and P450s are affected by xenobiotic exposure,

190 Both CFS and PAC networks coupled theta and alpha oscill

191 mony and Transcript Distribution) which uses both transcriptomic abundances and parsimony of overall

192 in the L-type calcium influx is observed in both glutamatergic neurons and parvalbumin (PV) GABAergi

193 diversity of HIV-1 is a major challenge for both active and passive immunization.

194 te additional immune functions that may have both protective and pathological consequences.

195 rt good therapeutic relationships that serve both staff and patients.

196 male brain, we map all inputs and outputs to both pC1d and pC1e.

197 ic proline-rich domain to be dispensable for both HSP90 interaction and PDE6 activity.

198 oninvasively assess acidosis associated with both central and peripheral innate immune activation.

199 ngle residue, aspartate 348, that determines both cation selectivity and pH gating.

200 of experiment for studies of IDRs or IDPs in both dilute and phase-separated environments, in particu

201 ned this question by separately manipulating both the value-driven and physical salience of targets i

202 and AR-V7 transcription activation required both PRMT5 and pICln but not MEP50.

203 te collagen destruction and Hyp release into both saliva and plasma.

204 G central conserved domain are protective in both prophylactic and postinfection animal models.

205 Using murine models of both perinatal and postnatal GBS acquisition, we assesse

206 nd their potential evolutionary implications-both their opportunities for and potential consequence t

207 Both complications and preoperative patient risk have be

208 ully map the site-binding energetics of Syt1 both in the absence and presence of Ca(2+).

209 he promoter activation rate is influenced by both enhancer and promoter sequences, whereas Pol II loa

210 Vaccination with both vaccines prevented fever and protected against abor

211 s implemented in Rosetta and is suitable for both structure prediction and protein design.

212 dent, supporting alignment of sequences from both genomes and proteins.

213 Venous thromboembolism (VTE), which includes both deep venous thrombosis and pulmonary embolism, is a

214 cancer cells, proved to be able to stabilize both G-quadruplexes and R loops and showed a potent cell

215 Notably, mice in which both Nf1 and Rac1 loci were disrupted (Nf1(flox/flox)Rac

216 Both amoeboid and ramified cells from mesial temporal lo

217 We further show that loss of both Trp53 and Rb1 disables transcription of genes in th

218 s-reactive warhead-were designed to leverage both affinity and reactivity.

219 to the working memory subnetwork relates to both working memory and reasoning performance whereas di

220 l comparisons identify essential elements of both the allosteric ligands and receptor binding sites i

221 of ex vivo normothermic perfusion (EVNP) in both organ viability assessment and reconditioning is in

222 ep heights are displayed and shown to define both deformed and recovered structures.

223 phot2 or chup1 and analyzed the kinetics of both the onset and recovery of NPQ under equivalent inte

224 The structures show that both substrate translocation and release involve movemen

225 During both NREM and REM sleep, mice showed large increases in

226 of CO(2) to chemical feedstocks, which uses both CO(2) and renewable energy(3-8).

227 replenishment are identified and resolved in both the filament core and reservoir regions.

228 iratory distress syndrome is associated with both systemic and respiratory severity of illness and is

229 EKEF improved dewatering of both foodstuffs and resulted in net dewatering efficienc

230 Chronic stress in both humans and rodents induces a robust downregulation

231 These cells, which express both RB and S18-2 at high levels, exhibited the potentia

232 em cell-derived cardiomyocytes (PSC-CMs) for both patient health and scientific investigation is the

233 ancer metastasis poses a challenging problem both clinically and scientifically, as the stochastic na

234 Both CP-101,606 and scopolamine induced similar positive

235 Both spikes and seizures were associated with intense sy

236 Higher-order many-body errors are small in both SCAN and self-interaction-corrected SCAN.

237 Thus, TH signaling coordinately regulates both spectral sensitivity and sensory plasticity.

238 esults should be carefully interpreted using both molecular and serological findings.

239 ucity of translational investigations taking both development and sex into account.

240 Both hydrolytic and signaling functions require precise

241 Here, we report both experiments and simulations on the dynamic network

242 al regions, from 20 degrees to 40 degrees of both northern and southern latitudes, mostly in areas wi

243 ification and to assess genetic diversity of both Chilean and Spanish germplasm collections.

244 Coupling specificity extends to both size and spatial topologies, thereby rivaling the s

245 ons at 12 months and completely abolished in both TH+ and SST+ neurons by 18 months.

246 Both the electronic and steric nature of the sulfonyl mo

247 ated in coastal lowlands that are exposed to both wind and storm surge hazards.

248 n the regulation of root morphogenesis under both normal and stress conditions.

249 g cardiac pressure overload, contributing to both electrical and structural remodeling.

250 the presence of saturating concentrations of both Na(+) and succinate.

251 e relationship between handgun ownership and both all-cause mortality and suicide (by firearm and by

252 e survival across treatments, expecting that both carbon stability and survival probability would inc

253 nanohaloarchaeon-haloarchaeon association is both mutualistic and symbiotic; in this case, each micro

254 s accounted for a disproportionate number of both oral concurrent sessions and symposium speakers.

255 jmj14 mutants were compromised in both local and systemic defences.

256 s a pathogenic role for PAD enzymes in RA as both promoters and targets of the autoimmune response, a

257 ecies that are key invertebrate predators in both aquatic (as larvae) and terrestrial ecosystems (as

258 xperimentally elucidate the underpinnings of both actomyosin activity and the dynamics of microtubule

259 ends and spatial structures in SOC and TN in both croplands, and the fertilization effect appeared mo

260 c lesion formation introduces complexity for both early detection and the study of metastasis in prec

261 Our observations have implications for both fork restart and the division of labor during leadi

262 b3 nanobody represents a potent inhibitor of both the alternative pathway and the terminal pathway, w

263 It was determined that both the bromine atom and the phosphate group were succe

264 th the chemical composition and structure of both the cell walls and the phytolith structures.

265 indicated that PLA2 required calcium ion for both the hydrolyzing activity and the antioxidant effect

266 ade ago, providing an important resource for both the research and the clinical communities.

267 r the maximum of the likelihood surface, for both the selection coefficient and the allele age, to a

268 hitecture of these diseases could illuminate both their pathophysiology and the computational archite

269 tion that allowed for granular assessment of both tumor cells and the tumor microenvironment.

270 In both the affected individuals and their asymptomatic car

271 Both experimental and theoretical studies have attempted

272 mediated murine model of cardiac fibrosis in both preventive and therapeutic settings, as well as in

273 In mice, both prophylactic and therapeutic RDV improve pulmonary

274 t that (1) S-nitrosothiols covalently modify both NBT and TNBT, but only change the reduction potenti

275 otein substrates via simultaneous sensing of both chemo- and stereoselectivity; and to create general

276 ffected by species richness and lake size in both ecoregions and alkalinity and total phosphorus in n

277 Both raw CPS and TPS were reported, as well as positivit

278 type of ASD with shared dysregulation across both the epigenome and transcriptome.

279 hat some types of linear features, including both roads and transmission lines, are substantial sourc

280 Both depletion of Pyk2 and treatment with a Pyk2 kinase

281 es, we studied the formation and exchange of both dialdehydes and triamines of two different [2 + 3]

282 eneration of "renovascular units" comprising both vessels and tubules with potential interaction.

283 clonal origin, as well as instances in which both NAT tissue and tumor tissue harbor a gain of the sa

284 However, isolated ciliated cells from both polyps and turbinates maintained basolateral PAR-2

285 Our results, both for all CIDP and typical CIDP presentations, suppor

286 uids suggests a long reaction path involving both mafic and ultramafic lithologies.

287 As both a flagship and umbrella species, the giant panda (A

288 e digestion affects the compounds content in both encapsulated and unencapsulated extracts.

289 Ccl17(E/+) reporter mice; it also exploited both CCL17-dependent and unique CCL17-driven inflammator

290 duction velocity (CV) across a wide range of both stable and unstable VTs delineated by high-resoluti

291 tended to be involved in co-infection among both unvaccinated and vaccinated girls.

292 Both macrophage number and Vegf-A expression increased i

293 ism for phenomena observed in experiments on both atrial and ventricular cardiac cells.

294 ues, are now recognized as key regulators of both cellular and viral mRNA function.

295 hange and provide a framework for predicting both when and where these events may occur.

296 We observed variability both between and within examiners in the diagnosis of pl

297 nalyses of cortical thickness were conducted both with and without normalization by ICV.

298 ew prospective hallmarks that might apply to both cancer and wound healing and discuss how wounding,

299 t attack and was observed after injection of both syngeneic and xenogeneic cells.

300 duced a similar early metabolic response for both WT-ER and Y537S-ER tumors.