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2 repressive deubiquitinase (PR-DUB) complex, both of which act to remove monoubiquitin from histone H
3 ress or exposed to elevated cortisol stress, both of which activate glucocorticoid receptor signaling
6 ORD6 blindness and recessive LCA1 blindness, both of which affect rods and cones, but they cannot exp
7 of which can be modulated by histidine, but both of which affect sensitivity to important anti-HAT d
8 e Na(+)/K(+) pump, balanced by an h-current, both of which affect the gating of the Na(+) current.
9 nes products, PI3-kinase p110delta and SKAP, both of which appear to play a significant role in the d
11 efects in thermogenesis(2) and lipolysis(3), both of which are adipose tissue functions regulated by
12 rror signals in NAc and OFC during learning, both of which are affected by psychostimulant administra
15 10 mA/cm(2) and a Tafel slope of 39 mV/dec, both of which are among the best values for NiCo(2)O(4)-
16 in either a fragmented or elongated network, both of which are associated with altered metabolic stat
17 ntaining zinc finger genes on chromosome 19, both of which are associated with heterochromatin featur
18 d accumulate in both HIV and CMV infections, both of which are associated with increased risk of card
19 hat correlate with type VI collagen and LOX, both of which are associated with increased type I colla
20 and at the flanking eRNA initiation regions, both of which are associated with mRNA expression QTLs.
21 l aspects of carbon-based quantum particles, both of which are associated with the electronic nature
23 to 4180) and an ICER of $1280 (-58 to 7940), both of which are below the WHO cost-effectiveness thres
24 o orthologs of Eco1, called Esco1 and Esco2, both of which are capable of modifying Smc3, but their r
25 igin of enantio- and diastereoselectivities, both of which are central to the burgeoning domain of st
26 or treatment of obesity and type 2 diabetes, both of which are characterized by high levels of circul
29 degrons and the UBL domain from yeast Rad23, both of which are commonly used in degradation experimen
30 a large anisotropy of the refractive index, both of which are commonly viewed as detrimental in spin
31 t muscle responses (M-waves) and H-reflexes, both of which are comparable to those recorded using con
32 of Lewy bodies and Lewy neurites in the CNS, both of which are composed mainly of aggregated alpha-sy
33 By contrast, corallivores and planktivores, both of which are coral-dependent, experienced the great
34 cells and the intracellular Ca(2+) dynamics, both of which are correlated with the microscope-collect
35 ompartments and promotes B-to-A transitions, both of which are coupled to optimal expression of senes
37 pressure and for nonreplicating persistence, both of which are critically important aspects of M. tub
38 luding some that are missed by radiologists, both of which are critically important elements for this
39 arse-grained secondary structure assignment, both of which are crucial to the speed and accuracy of R
41 ls as well as activation of the GTPase Rac2, both of which are downstream effects of P-Rex1 activity.
42 lly modulated by acetylcholine and dopamine, both of which are essential for basal ganglia function.
43 deficient cochleae expressed FGF8 and FGFR3, both of which are essential for pillar cell specificatio
44 onditional deletion of Wntless or porcupine, both of which are essential for secretion of Wnts, cause
45 chemical diversity of natural channels(1,2), both of which are essential to synthetically achieve pro
46 gages hippocampal Zif268 protein expression, both of which are established mechanisms of memory desta
47 tion of both winter coldness and snow depth, both of which are expected to decline with climate chang
49 loped country, the United States of America, both of which are facing loss and degradation of coastal
50 the only curative option, and chemotherapy, both of which are feasible in only a minority of cases,
51 (UCA) and pyrrolidone carboxylic acid (PCA), both of which are filaggrin breakdown products; and a re
52 hormone (FSH) and luteinizing hormone (LH), both of which are heterodimers specified by unique beta
54 ranscription factor forkhead box A1 (FOXA1), both of which are implicated in shaping the chromatin la
56 ote cellular survival and prevent apoptosis, both of which are important drivers of tumorigenesis.
57 o collagen and to enhance biofilm formation, both of which are important for A. actinomycetemcomitans
58 teria and in defining bacterial cell shapes, both of which are important for existence in the ecologi
59 ircuit (CTCC) and visual association cortex, both of which are important for monitoring and coordinat
61 of DNA to bending and twisting constraints, both of which are important in defining the mechanics of
63 etween IDO1 activity and PI3K/AKT signaling, both of which are important pathways involved in cancer
67 fatty acid hydroperoxides and peroxynitrite, both of which are involved in host-pathogen interactions
68 volved in TGF beta (TGFB) and BMP signaling, both of which are key morphological signaling pathways w
69 per unit time) and the duration of delivery, both of which are key parameters for overcoming tissue h
70 in (DCX) domain and a TPPP/P25-alpha domain, both of which are known modulators of tubulin polymer st
71 nxiety and acutely altered bodily sensations-both of which are known to be associated with insular fu
72 ition of the electron transport chain (ETC), both of which are known to increase aspartate and GOT1 d
73 oral bleaching events and disease outbreaks, both of which are linked to anthropogenic climate change
74 l fusion and a G(1)/S cell cycle transition, both of which are linked to increased cell proliferation
75 lysis, as well as the Abeta42/Abeta40 ratio, both of which are linked to the progression of Alzheimer
76 that produce p.Ile1033Met and p.Ile1040Thr, both of which are located in the S6 transmembrane domain
77 ist, and if these limits vary with latitude, both of which are long-standing and currently debated qu
78 o of FDP-M-net is 1.39%, U-finger is 14.62%, both of which are lower than 39.54%, yielded by our algo
79 tal phase and the second the arterial phase, both of which are mandatory for liver lesion characteriz
81 zation and long spin-lattice relaxation time-both of which are necessary for future clinical investig
83 ovel 10-amino acid aggregation-prone region, both of which are necessary for proper Gle1 oligomerizat
84 omain sizes and to control their morphology, both of which are necessary to fully realize their appli
85 ied previously (rs11265259 and rs181704186), both of which are non-coding and more common in individu
86 ear guest alignment and accessible channels, both of which are observed in CNTs but not in the analog
87 ht < 1750 g and gestational age <= 34 weeks, both of which are observed more frequently in children w
89 te virulence and enhanced biofilm formation, both of which are phenotypic changes associated with a c
92 iological mechanisms underlying trans-eQTLs, both of which are relevant for understanding susceptibil
93 tial frequency (SF) and phase relationships, both of which are represented locally at the earliest st
94 cted from purine and pyrimidine nucleosides, both of which are required for accurate information tran
95 TCF4 comprises two transcriptional isoforms, both of which are required for optimal pDC development i
96 coordinates the attenuation of beta-catenin, both of which are required to execute the osteoclast dev
97 leading to ME1 dimerization and activation, both of which are reversed by NEK1 kinase-mediated S336
98 (PrL), as well as depression-like behaviors, both of which are reversed by selective serotonin reupta
99 Schmallenberg virus (SBV) in Great Britain, both of which are spread by Culicoides biting midges and
102 inosteroid receptors and auxin transporters, both of which are sustained by CLASP, were largely degra
103 e production of HDV mRNA and antigenome RNA, both of which are synthesized from the genome RNA templa
105 repression of both cyclin D1 and cyclin E1, both of which are targets of PRC2-mediated H3K27 methyla
107 swimming and actin-dependent cell migration, both of which are used by animal cells and unicellular e
108 tes decreases expression of COL2A1 and ACAN, both of which are validated as direct targets of miR-308
109 rm distinct components of cognitive ability, both of which are vulnerable to traumatic brain injury.
110 g-range base pairs (500+ nucleotides apart), both of which are well known to be challenging for the c
112 ologic challenges and environmental insults, both of which associate with changes in epigenetic silen
113 constellations with 24- and 48-hour periods, both of which attain nearly continuous global coverage.
116 or the product ion micropacket frequencies, both of which can be converted to product ion m/z throug
117 r viscosity than comparable lysine droplets, both of which can be finer tuned by polymer length.
118 ed AGEs formation and tumour growth in vivo, both of which can be reversed using a MG scavenger.
119 ontribute to distinguishing cancer subtypes, both of which can be simultaneously captured by MutSpace
120 e, and phenolics) and geographical distance, both of which can influence the richness and composition
121 forsythia cells or outer membrane vesicles, both of which carry surface-associated miropin, strongly
125 eptor and Inhibits (HpBARI) and HpBARI_Hom2, both of which consist of complement control protein (CCP
126 including its rostral extension (RVLM(RE) ), both of which contain bulbospinal catecholamine (C1) and
127 s, [Au(8)Pb(33)](6-) and [Au(12)Pb(44)](8-), both of which contain nido [Au@Pb(11)](3-) icosahedra su
129 feed streams are natural river and seawater, both of which contain not only monovalent ions but also
130 MED12 and MED13 as positive gene regulators, both of which contribute broadly to morc1 de-repressed g
131 ers local stability and long-range dynamics, both of which contribute to localized assembly of P gran
132 r time in terms of production and selection, both of which contribute to the actual and available nat
133 HV) has latent and lytic replication phases, both of which contribute to the development of KSHV-indu
134 f nitric oxide (NO) and nitrous oxide (N2O), both of which contribute to the harmful environmental si
135 changes in the host myeloid cell population, both of which contribute to treatment induced toxicity i
136 ls; and cytoplasmic FoxO1 and Phospho-FoxO1, both of which control glycolytic metabolism through upst
139 cell binding and an increase in dissolution, both of which correlated with a small-plaque phenotype.I
141 t IL-7/IL-7R pathway dysfunction in T cells, both of which could be associated with C-IRIS immunopath
142 ent of the cleavage/polyadenylation complex, both of which could cause the observed switch in pA site
143 ctivity levels and increased social support, both of which could improve the outcome after a major ca
144 signaling pathways that are unique to HGSOC, both of which could improve the outcome for women with H
145 inflammatory responses following infection, both of which could trigger GBS-associated pregnancy com
146 h previously discovered mAbs MPE8 and 25P13, both of which cross-react with the respiratory syncytial
148 ment to the swimming stage (small egg size), both of which decrease the amount of time offspring spen
149 l polymeric interactions and local twisting, both of which depart from strict superhelical symmetry.
150 competitive weighting of reward attributes, both of which depend on risk aversion but in opposite di
152 th distinct patterns of responses to decoys, both of which depended on individuals' risk aversion.
153 d $134,573 ($71,782-$239,439), respectively, both of which differed significantly by age group (lengt
154 ty to infection by coccolithoviruses (EhVs), both of which display variation among cells in culture a
155 g promoted the expression of Gdf15 and Bmp4, both of which encode ligands that initiate the expansion
157 the only known Yap8 targets, ARR2 and ARR3, both of which encode proteins that promote arsenic efflu
158 nes in the haltere, Stubble and Notopleural, both of which encode transmembrane proteases that remode
161 to 97%) and 91% (86% to 95%), respectively, both of which exceeded the prespecified performance goal
162 traced back to the Late Jurassic Eocaecilia, both of which exemplify the stepwise acquisition of apom
163 that may have merged ~5.6 million years ago, both of which exhibit strong synteny with other grass sp
164 iformes) and a clade of mammals (Carnivora), both of which exhibit substantial craniofacial diversity
165 lant phenology and environmental conditions, both of which experienced substantial changes in recent
166 Two distinct experiments were performed, both of which exposed subjects to low and high concentra
167 ve and in the YAC128 and BACHD mouse models, both of which express a copy of the human HTT gene.
168 e absence or presence of DOM or glutathione, both of which form strong complexes with Hg via thiol-fu
170 een employed to distinguish these two cases, both of which generally focus on whether the electron (e
171 ays involving the TopBP1 and ETAA1 proteins, both of which harbor ATR-activating domains (AADs).
172 heir biosynthetic precursors the fasamycins, both of which have activity against methicillin-resistan
173 C-C coupling, identifying two active sites, both of which have an under-coordinated surface square s
175 cavities and photonic crystal microcavities, both of which have been developing rapidly over the past
176 and [Cu(II)(carb)3](-) (carb = carbazolide), both of which have been identified under coupling condit
177 tes were higher than those of Ldlr and Lrp1, both of which have been implicated in Abeta uptake.
178 enerate linear Ub chains), HHARI and TRIAD1, both of which have been recently demonstrated to work to
179 er acid (HFPO-DA, referred to here as GenX), both of which have been reported as contaminants in drin
180 erization and CRY2-CIB1 hetero-dimerization, both of which have been widely used to optically control
181 blood eosinophil count and serum periostin, both of which have demonstrated utility in identifying p
182 ce between the cortical and cancellous bone, both of which have different material properties and com
183 reme than those in Ashkenazi Jews and Finns, both of which have high rates of recessive disease due t
184 el equivalent) during the last deglaciation, both of which have implications for interpreting geodeti
186 l pathways, including BMP and Wnt signaling, both of which have repeatedly been implicated in the mor
188 ly and disrupts mTORC2-robosome association, both of which inactivate mTORC2 leading to inhibition of
189 OH affords two isomeric dimers, MD1 and MD2, both of which incorporate a methoxy moiety and exist in
190 ead compounds are discovered, YLL3 and YLL8, both of which increase osteoprogenitor osteogenic differ
191 d an aversion to viewing oneself as a thief, both of which increase with the material benefits of dis
193 1A (TNFSF15) and its cognate DR3 (TNFSRF25), both of which increased in the relative virus control ph
194 ression to changes in macrophage metabolism, both of which influence subsequent inflammatory activiti
195 be categorised by population and indication, both of which influence the balance between benefits and
196 as protein aggregation and oxidative stress, both of which involve metal ions like copper, manganese
198 ine ferric complex [PyPzFe(III) (OH)L(ax) ], both of which involve positively charged substituents on
199 giography or ventilation-perfusion scanning, both of which involve radiation exposure to the mother a
201 ients as well as an animal model (nob mice), both of which lacked functional nyctalopin protein (NYX,
202 causes abnormal placental vessel remodeling, both of which lead to the development of preeclampsia-li
203 down-regulation of host antiviral proteins, both of which likely require virion incorporation of the
205 n be suppressed by IRP2 and FDXR deficiency, both of which may be explored to target tumors carrying
206 id (ARA) and dihomo-y-linolenic acid (DGLA), both of which may be synthesized from GLA and result in
207 ations required for single molecule imaging, both of which may bias native subunit interactions.
208 tumors with MIR17HG gains or amplifications, both of which may contribute to dysregulation of MYC and
209 verse driver-derived neoepitope:HLA binding, both of which may contribute to PDGFRA-mutant GIST immun
210 emperature responses are likely constrained, both of which may have implications for climate change r
211 variation and selection on polygenic traits, both of which may leave faint genomic signals indistingu
212 t two distinct temporal phases of dispersal, both of which most likely emanated from the Near East.
213 e neither limb nor brain patterning defects (both of which occur in mice completely lacking LRP6), we
214 d V(3+) and V(4+) substituted into titanite, both of which occur in the spilled Mount Polley tailings
215 ssue and expansion of activated macrophages, both of which occurred prior to changes in body weight,
216 ET/CT images with 6R-(18)F-1 and 6S-(18)F-1, both of which outperformed the corresponding oxidized (1
217 ant and generating H(2) O(2) as a byproduct, both of which oxidatively degrade thiourea under the rea
218 y-associated variants decreased contraction, both of which paralleled changes in myofilament calcium
219 modulates neuronal and immune cell function, both of which play key roles in pain, therapeutics targe
220 ovial sarcoma and malignant rhabdoid tumors, both of which possess aberrations in canonical BAF (cBAF
221 actone mACP constructs, mH0ACPa and mH0ACPb, both of which possess an additional alpha-helix that beh
222 ynthesis of two new spin labels, EC and ECm, both of which possess the rigidity and the reduction res
223 as well as modification of vegetation type, both of which potentially influence CH(4) emissions.
224 unication and features like cryptic pockets; both of which present new therapeutic opportunities.
225 ) is an even rarer autoimmune disease (AID), both of which present with inflammatory vasculitis of la
227 by reacting 2-MP with 4-OPA or limonene SOA, both of which produced BrC with absorption bands at 475
228 her cell walls within a mucilaginous matrix, both of which progressively dry before sporophyte dehisc
229 tic constriction, or to free-wheel exercise, both of which promote adaptive cardiac myocyte hypertrop
230 clines and varied flow disturbance regimes, both of which promote habitat heterogeneity, high biolog
231 ation and endoplasmic reticulum (ER) stress, both of which promote metabolic disease progression.
232 tification and immunohistochemical analyses, both of which provide limited information on immune cell
233 ce between hypothetical screening scenarios, both of which reduce the benefits as well as the harms o
234 acid and 2-hydroxy-imino phenylpyruvic acid, both of which reduced polyposis by more than half compar
236 uctase inhibitors reduce K-RAS farnesylation both of which remove K-RAS from the plasma membrane, abo
237 es and affinity reagents (i.e., antibodies), both of which require a priori knowledge of the sample.
238 cytosis and targeting by autophagy proteins, both of which require many of the same proteins that med
239 ently evolved NLRs, MR5 from apple and RPS2, both of which require proteolytically processed RIN4 for
240 thy or clinically significant macular edema, both of which require timely intervention to preserve vi
241 YNTAX and Fourth Universal Definition of MI, both of which required CK-MB elevation and electrocardio
245 generate osmotic pressure or volume changes, both of which result in increased cellular tension.
246 observed, and in the motor rotational bias, both of which scale with the osmotic shock magnitude.
247 How symbionts and phenotypic plasticity, both of which shape aphids' stress response, influence o
248 g and drying, especially during late season, both of which should further expand the water-limited re
249 cluding the iodide transporters Nis and Pds, both of which showed enhanced GLIS3 binding at their pro
250 mic ELMO1, or functional disruption of RAC1 (both of which signal downstream of BAI1/BAI3), also affe
251 ries that it has not physically experienced, both of which significantly contribute to the TSP behavi
252 tional variants p.Thr391Ile and p.Thr391Pro, both of which, similarly to p.Arg373Gln and p.Cys390Arg,
253 hypoxic signals can stimulate angiogenesis, both of which stimulated SRC-2 expression in vitro Furth
254 condition with reduced cardiac muscle cBIN1, both of which support cBIN1 release in MPs from human he
255 ifedipine, 200 mg oral labetalol (hourly, in both of which the dose could be escalated if hypertensio
256 ing of the treatments and monitoring visits, both of which took place before the peak malaria season,
258 ffusion-based methods, BirgRank and AptRank, both of which use PageRank to diffuse information on thi
259 decreases with solution crowding by solutes, both of which we confirm with molecular dynamics simulat
260 hology and improved cognition in 5xFAD mice, both of which were abrogated by additional TREM2 knockou
262 mikacin (Amikacin Inhale) or saline placebo, both of which were aerosolised, administered every 12 h
263 (other than pain) identified by the patient, both of which were assessed 2 hours after the dose of ri
265 ools (upper boundary of the 98.75% CI, 0.8), both of which were below the noninferiority margin (2 st
266 ints (upper boundary of the 98.75% CI, 2.8), both of which were below the noninferiority margin of 4
267 ) complex, Fe(III)(OH)(BNPA(Ph2)O)(OTf) (2), both of which were characterized by X-ray diffraction, e
268 whole-genome sequences revealed two groups, both of which were closely related to but distinct from
269 r (AR) but suppression by estrogen receptor, both of which were dependent on hepatocyte nuclear facto
270 80 mg every 4 weeks at the approved dosing), both of which were given intravenously at the study site
271 HDL-P size was greater in HFrEF than HFpEF, both of which were greater than in no HF (all 2-way p <
272 ular bodies docked on the inclusion surface, both of which were immunogold-labeled by a GFP-tagged 2x
273 +SM and 8.5% (five of 59 cancers) with FFDM, both of which were lower than the proportion in the cont
274 tive oxygen species and necrotic cell death, both of which were mitigated by ATF6 overexpression.
275 igher mitochondrial reactive oxygen species, both of which were normalized when MAT1A was overexpress
276 parasitaemia and 10% P. falciparum, by qPCR, both of which were predominantly sub-microscopic and asy
277 0.45 and r = 0.33, respectively; P < .001), both of which were present in ex-smokers without COPD.
278 d with a 50% decrease in SR calcium content, both of which were prevented by the ryanodine receptor i
279 ) caused cytochrome c release and apoptosis, both of which were prevented in C674S-expressing cells.
280 Confederate race and socioeconomic status, both of which were randomized, are shown to interact suc
282 ium influx and release from internal stores, both of which were required for activation of a MAPK cas
283 : NF-kappaB recruitment and further H3K27ac, both of which were required for enhancer RNA (eRNA) tran
284 epeat sequence within this targeting region, both of which were required for the scaffold to target a
285 d perturbed ribosomal subunit stoichiometry, both of which were rescued by a single K214R substitutio
286 administration of reconsolidation blockers, both of which were restored by concomitant theta burst s
287 e and positively associated with wind speed, both of which were retained in models as a significant p
288 mia and impaired the recovery of blood flow, both of which were reversed by ANG-(1-7) in both models
289 P9 mRNA and protein significantly increased, both of which were reversed by reintroducing NAT1 into t
290 cell growth and defects in cell morphology, both of which were suppressed by overexpressing the LPS
291 d the validation of classification criteria, both of which were the products of international, multi-
293 ated to emphysema and small airways disease, both of which were unexpectedly present in ex-smokers wi
294 1 and a regulator of tumor microenvironment, both of which were unrecognized components of its tumor
295 spiratory failure in the closed-loop group), both of which were unrelated to study interventions.
297 tinct from its role in phosphorylating MLC2, both of which will contribute to the enhancement of card
298 aids in interpretation of existing datasets, both of which will facilitate application of molecular m
299 transmission) were central to our analyses, both of which will inform the future translation of E. f
300 the AHA2 proton pump and the FRO2 reductase, both of which work in concert with IRT1 in the acidifica