ライフサイエンスコーパス: bottleneck

1 me, it must be compressed through a "genomic bottleneck".

2 chip for large numbers of embryos remains a bottleneck.

3 dversely affect inferences of the population bottleneck.

4 pes and invasion constitutes an evolutionary bottleneck.

5 ic data for large numbers of plants remain a bottleneck.

6 nd metagenomics have alleviated some of this bottleneck.

7 ty in bulk and nanoscale materials remains a bottleneck.

8 rovide a route to overcome this experimental bottleneck.

9 nalysis of these images constitutes a severe bottleneck.

10 ed to map genomic locations) remains a major bottleneck.

11 a result of diversification after a genetic bottleneck.

12 ed parallel processing, rather than a serial bottleneck.

13 er of genomic variability after a population bottleneck.

14 pansion of infected cells or a viral genetic bottleneck.

15 orting hLMSC remains a serious translational bottleneck.

16 s repeatedly or involves a wide transmission bottleneck.

17 enerally associated with a stringent genetic bottleneck.

18 ssing overhead quickly becomes a prohibitive bottleneck.

19 n have been recognized as a key experimental bottleneck.

20 patible with a very early HIV-1 transmission bottleneck.

21 ll-clusters, is a potential solution to this bottleneck.

22 , the time required to generate them poses a bottleneck.

23 y of free drugs still constitutes a critical bottleneck.

24 RNAs) to make aminoacyl-tRNA substrates is a bottleneck.

25 importance of the source partner during this bottleneck.

26 stfledging ones, resulting in a postfledging bottleneck.

27 , particularly those with extreme and recent bottlenecks.

28 cated in terminal modules lacking downstream bottlenecks.

29 each one having its very own challenges and bottlenecks.

30 table habitat area and promotes evolutionary bottlenecks.

31 eir content, leading to significant analysis bottlenecks.

32 t internal fracture geometry, flow paths and bottlenecks.

33 to develop strategies to overcome catalytic bottlenecks.

34 is likely to indicate a previous population bottleneck; (4) Allelic richness was lower among culture

35 We find evidence for a severe germline bottleneck (7-10 mtDNA segregating units) that occurs in

36 Bottleneck analyses revealed that the L. trifolii popula

37 oing so, it can decrease the severity of the bottleneck and increase mean population fitness whenever

38 introduced population going through a severe bottleneck and serving as the source for the next introd

39 llowed trees to overcome an early population bottleneck and successfully establish in areas without t

40 ovide us potential solutions to relieve this bottleneck and to explore advanced methods for large-sca

41 l Faroese populations showed signs of strong bottlenecks and declining effective population size.

42 LH) compensates for fitness losses caused by bottlenecks and discuss whether bottlenecks have driven

43 Further research is needed to identify bottlenecks and evaluate interventions to ensure all chi

44 graphic history, characterized by population bottlenecks and expansions, population structure, migrat

45 relieve pressures on conventional diagnostic bottlenecks and expediate work at lower containment.

46 We applied CRISPRi-seq to assess bottlenecks and identify pneumococcal genes important in

47 terogeneous RNA folding, preventing assembly bottlenecks and initiating assembly within the transcrip

48 hat antibiotics can induce severe population bottlenecks and likely play a role in shaping the popula

49 erein presented toward the identification of bottlenecks and potential strategies to alleviate them.

50 However, the genomic aspects of population bottlenecks and selection pressure from geographical iso

51 milar malignant potential in absence of late bottlenecks and suggests that barriers to invasion are m

52 of generation times around the Out-of-Africa bottleneck, and that current diversity levels were affec

53 s 1,000 yr ago and were subject to a genetic bottleneck, and that genomic regions containing 87 putat

54 ate energetic pathways, metabolite sinks and bottlenecks, and dysregulated glucose storage in patient

55 Because such bottlenecks are frequent in fluctuating environments, an

56 lineages from the same mother, while somatic bottlenecks are less severe.

57 have not been subject to intense population bottlenecks as experienced by populations of European an

58 Plasmodium parasites experience significant bottlenecks as they transit through the mosquito and are

59 ravity in a quiescent fluid can overcome the bottleneck associated with aggregation of equal-size sph

60 seven organ recipients to assess the genetic bottleneck associated with HCV transmission following re

61 We found no significant genetic bottleneck associated with the introduction of mango int

62 Despite bottlenecks associated with domestication and improvemen

63 lytical toolkit that eliminates barriers and bottlenecks associated with this specialized data type b

64 Nunavik Inuit went through a bottleneck at approximately the same time and might have

65 s sites, but there was evidence of a genetic bottleneck at one site in Florida where past mass mortal

66 Despite these new bottlenecks, AT engineering provided the first full-leng

67 mber of viruses, albeit with slightly looser bottlenecks being inferred, with between 1 and 13 partic

68 sed to evaluate the size of the transmission bottleneck between humans infected with the influenza vi

69 crop and model plants identified a metabolic bottleneck between phosphatidylcholine (PC), the site of

70 on of optimal specimens, creating a critical bottleneck blocking clinical laboratories' ability to pe

71 sibility specifically in pre-HE cells at the bottleneck, but loses accessibility thereafter.

72 We overcome this thermal-transport bottleneck by crosslinking the ligands to exchange a wea

73 Here, we overcome this bottleneck by devising a novel method based on labelling

74 elected folding routes avoid the topological bottleneck by locking the cysteine bridge after the topo

75 d, the clade passes through an evolutionary "bottleneck" by substantially reducing its species richne

76 abitat fragmentation and repeated population bottlenecks, by increasing the genome-wide mutation load

77 lineages emerged from sequential population bottlenecks, carrying mutations potentially involved in

78 aline ecosystems can experience evolutionary bottlenecks caused by habitat reduction during transgres

79 expansions across the islands and subsequent bottlenecks consistent with European colonization.

80 ir exclusive reagent supplies quickly become bottlenecks, creating an urgent need for approaches to b

81 analysis of topological characteristic like bottleneck, degree, GO term/pathways analysis, bio-kinet

82 all of these populations experienced severe bottlenecks down to effective population sizes of around

83 single haplotype J1-H1 indicating a genetic bottleneck during domestication.

84 gesting that endosome-to-ER trafficking is a bottleneck during infectious entry.IMPORTANCE MCPyV is t

85 uenza A virus and experience a tight genetic bottleneck during transmission.

86 communities bypass member-specific metabolic bottlenecks (e.g. histidine- and transport-related react

87 for its ability to circumvent the synthetic bottlenecks encountered in the preparation of 12 chemica

88 r study, our results indicate that drift and bottleneck events can explain the minimal diversity foun

89 an is contemporary with the first population bottleneck experienced by bison at the end of the Pleist

90 We examined the between-subject bottleneck, finding considerable variation in the amount

91 of the viral population, indicating a recent bottleneck followed by limited viral replication.

92 us mutations, consistent with severe genetic bottlenecks followed by rapid population expansion.

93 Data processing is a key bottleneck for 1H NMR-based metabolic profiling of compl

94 ever, the resonance assignment constitutes a bottleneck for broader applicability of methyl-based NMR

95 ive sampler campaigns and removes a critical bottleneck for citizen-derived data to be used for compl

96 imal-based testing regimes, creating a major bottleneck for clinical translation.

97 line silicon ones, their stability remains a bottleneck for commercialization partly due to the use o

98 SIMMS(2) thus overcomes the bottleneck for decoding the informational content of fun

99 ucts from single microbial cells remains the bottleneck for determining the specific turnover numbers

100 ast cellular signaling, and presents a major bottleneck for high-throughput structural imaging.

101 ults show that the stomach can act as a size-bottleneck for ingested MPs, enhancing the retention of

102 Identification of unknowns is a bottleneck for large-scale untargeted analyses like meta

103 However, one major bottleneck for routine implementation and accessibility

104 ids for large numbers of experiments poses a bottleneck for screening enzyme immobilization condition

105 roscience, the rarity of brain tissue is the bottleneck for such study.

106 The key bottleneck for the continued success of precision medici

107 A bottleneck for the large-scale application of today's ba

108 eralization over varied test cases remains a bottleneck for these methods.

109 of visual processing converge into a serial bottleneck for word recognition.

110 This study thus shows that the ultimate bottlenecks for bimolecular photoredox processes involvi

111 Thus, precapillary sphincters are bottlenecks for brain capillary blood flow.

112 s in sporogonic development and transmission bottlenecks for Plasmodium.

113 onduction, but they also represent potential bottlenecks for the axonal transport of neurofilaments,

114 onduction, but they also represent potential bottlenecks for the movement of axonally transported car

115 tation and database representation are often bottlenecks for utilization of machine learning algorith

116 For this we use the Predictive Information Bottleneck framework used for the first two problems, an

117 nt system consisting of the Lucilia sericata bottleneck gene promoter driving expression of the tTA g

118 rivation, (b) thermal stress and (c) genetic bottlenecking had similar impacts on fitness declines an

119 upled to inbreeding following the population bottleneck has largely purged the ancient polymorphisms

120 hlorophyll degradation and a unique pathway "bottleneck," has been recruited as a signaling molecule

121 es caused by bottlenecks and discuss whether bottlenecks have driven the evolution of hypermutable lo

122 To address this bottleneck, here we compared eight reporters from three

123 phenotypic data has become one of the major bottlenecks hindering crop breeding and functional genom

124 bilization. Our results support a population bottleneck hypothesis during the Last Glacial-Interglaci

125 to limit the phage produced from infection, bottlenecking ICP1.

126 ties that can contribute to the transmission bottleneck.IMPORTANCE Mother-to-child-transmission of HI

127 However, the bottleneck imposed by the requirement for isolates precl

128 A bottleneck in a gate-model quantum computer is the requi

129 characteristics of PHT have been a critical bottleneck in attaining this goal.

130 aying for enzymatic activity is a persistent bottleneck in biocatalyst and drug development.

131 Proteomic analysis can be a critical bottleneck in cellular characterization.

132 scopy (cryo-EM) represents a major practical bottleneck in cryo-EM data analysis.

133 One bottleneck in developing this technology is the time, ex

134 te-based screening assays represents a major bottleneck in directed evolution and limits the improvem

135 oligosaccharides and glycoconjugates pose a bottleneck in enabling the remarkable promise of advance

136 nty in flood losses has been called the main bottleneck in flood risk studies, an obstacle that may b

137 A bottleneck in fragment-based lead development is the lac

138 A major bottleneck in identifying therapies to control citrus gr

139 Crystallization is the bottleneck in macromolecular crystallography; even when

140 Protein production remains a major bottleneck in membrane protein structural biology.

141 Phenotyping is the current bottleneck in plant breeding, especially because next-ge

142 or tissue culture and promises to overcome a bottleneck in plant gene editing.

143 crucial quality control step that creates a bottleneck in plasmid fabrication workflows.

144 Microscopy image analysis is a major bottleneck in quantification of single-cell microscopy d

145 A longstanding bottleneck in realizing this, is various non-idealities

146 ility of suitable instrumentation is often a bottleneck in reliable mycotoxin detection.

147 bjects that may be tightly packed is a major bottleneck in standard deep learning-based models.

148 nd drug sensitivity profiles present a major bottleneck in targeting kinases for personalized medicin

149 ex and cumbersome library preparation to the bottleneck in terms of reproducibility and costs in the

150 ple consuming and represents the fundamental bottleneck in the application of nanodiscs for NMR studi

151 of highly similar sequences remains a major bottleneck in the evaluation of high-throughput sequenci

152 et with the same enthusiasm and remained the bottleneck in the field for some time.

153 ther pathogens, also regarded as the biggest bottleneck in the fight against the spread of antimicrob

154 wth and survival at the sapling stage, a key bottleneck in the life cycle of tropical trees.

155 to uncover a previously unappreciated clonal bottleneck in the response of HSCs to injury.

156 ng of genetic variation has become the major bottleneck in the search for new drug targets for AD.

157 Protein crystal production is a major bottleneck in the structural characterization of protein

158 e 1 (HIV-1) is associated with a significant bottleneck in the viral quasispecies population, yet the

159 in tertiary referral centers, represents the bottleneck in the work-up of PA.

160 Data analysis remains a bottleneck in the workflow.

161 poor mechanistic understanding has caused a bottleneck in therapeutic development.

162 w-frequency off-target editing, presenting a bottleneck in therapeutic genome editing, because even a

163 in the mouse orofacial area remains a major bottleneck in uncovering molecular mechanisms that gover

164 One key bottleneck in understanding the human genome is the rela

165 However, there is a critical bottleneck in using these citizen-derived data sets for

166 ameters in time-consuming experiments causes bottlenecks in a broad range of scientific and engineeri

167 used in the clinic to monitor disease due to bottlenecks in biomarker identification.

168 One of the major bottlenecks in building systems biology models is identi

169 canSAR informs researchers to help solve key bottlenecks in cancer translation and drug discovery.

170 Grazing on zoospores may circumvent bottlenecks in carbon transfer imposed by the dominance

171 Potential bottlenecks in central carbon metabolism are highlighted

172 sequencing applications is one of the major bottlenecks in clinical genetics, with the inference of

173 tter and Vernier acuity may be due to common bottlenecks in early visual cortex but not because the t

174 etabolites still represents one of the major bottlenecks in metabolomics data processing.

175 In this review, we describe the progress and bottlenecks in research on NTM epidemiology, immunology

176 f aspects of EFM computation that elucidates bottlenecks in scaling EFM computation.

177 ricarboxylic acid cycle metabolites revealed bottlenecks in substrate flow, with build-up of intermed

178 The presence of kinetic bottlenecks in such surfaces often renders a direct appr

179 eloping solutions should take to address the bottlenecks in the acoustofluidic applications in bioana

180 variability after two parallel species-wide bottlenecks in the genus Capsella.

181 We trace this effect to repeated population bottlenecks in the harsh environments, which result in s

182 ropsychiatric diseases and overcome existing bottlenecks in their diagnosis and treatment.

183 However, there are two bottlenecks in their widespread application, low power o

184 One of the critical bottlenecks in this endeavor is the computational recons

185 rub interactions for ameliorating population bottlenecks in tree establishment.

186 ocesses remains, however, fragmentary due to bottlenecks in understanding redox-driven conformational

187 cines and antivirals, and the elimination of bottlenecks in vaccine development, will be essential to

188 C. albicans faces both low and high zinc bottlenecks in vivo as Zrt2 and Zrc1 are required for ki

189 rably and in isolation following a series of bottlenecks, individuals of these populations have numer

190 truction with maximum likelihood methods for bottleneck inference.

191 omorphic computers could overcome efficiency bottlenecks inherent to conventional computing through p

192 Understanding the drivers of this bottleneck is crucial to developing effective infection

193 The transmission bottleneck is defined as the number of viral particles t

194 This bottleneck is not present during IAV superinfection, fac

195 involves a tight population bottleneck, the bottleneck is not so tight as to universally prevent the

196 sispecies population, yet the timing of that bottleneck is poorly understood.

197 The main bottleneck is that functional annotations of isoforms ar

198 s applied to these species; however, a major bottleneck is the identification and prioritization of c

199 The main bottleneck is the lack of dimer structures, hindering th

200 This bottleneck is thought to be lifted once the boundary lay

201 e host to another, known as the transmission bottleneck, is an important factor in determining how th

202 riorly incorporated functions, resolve three bottleneck issues in the CTL epitope presentation pathwa

203 AEMS has the potential to eliminate bottlenecks known from classical MS approaches, such as

204 Nevertheless, some bottlenecks limit their further development, including l

205 mates despite the recent introductions and a bottleneck limiting genetic variation in Australia.

206 This work breaks the long-standing bottlenecks limiting materials innovation of n-type poly

207 enotypes (WhoGEM) that overcomes some of the bottlenecks limiting the current methods.

208 We find that a tight transmission bottleneck limits the onward transmission of these early

209 highly polymorphic diploids and single-cell bottleneck lineages revealed a diverse spectrum of loss-

210 er, analysis of huge data sets can present a bottleneck linking phenotypes to their molecular basis,

211 of the stringency of the underlying genetic bottleneck, making it possible to predict the ability of

212 Understanding how to counter this bottleneck may improve our ability to elicit antibodies

213 Understanding the timing and nature of this bottleneck may provide insight into HIV-1 vaccine design

214 By reducing genetic diversity, bottlenecks may alter individual or population-wide adap

215 ess, involving successive founder events and bottlenecks, may either promote random evolution or faci

216 f Taijma's D, suggesting a recent and severe bottleneck, most likely resulting from a single event of

217 iversity was limited likely due to long-term bottlenecks observed in all eight populations.

218 among songbird species and why postfledging bottlenecks occur.

219 om both cellular expansion and viral genetic bottlenecks occurring prior to ART initiation and follow

220 A critical bottleneck occurs at 48 h with few bacteria causing syst

221 incorporation of the first C9 is the kinetic bottleneck of MAC formation, after which rapid C9 oligom

222 A major bottleneck of mass spectrometric metabolomic analysis is

223 tary oxygen is beneficial and eliminates the bottleneck of oxygen allowing a potentially more efficie

224 Water oxidation is the key kinetic bottleneck of photoelectrochemical devices for fuel synt

225 he hourglass waist represent the information bottleneck of the system, balancing the representation a

226 Bottlenecks of information processing within this modula

227 AVA-Seq) and utilizes NGS to remove multiple bottlenecks of the two-hybrid system.

228 nts and modeling to obtain evidence that the bottlenecks of yeast glycolysis depend on intracellular

229 Here, we examine the effects of bottlenecks on bacterial commensal-pathogens during tran

230 While a tight bottleneck operates in human influenza transmission, it

231 nterfaces of cellular aggregates by means of bottleneck or Wasserstein distances of persistent homolo

232 cleic acid sensors, face an analogous design bottleneck; our limited understanding of how sequence im

233 el approach for inferring viral transmission bottlenecks; our method combines an algorithm for haplot

234 the ability of noise to mitigate population bottlenecks, particularly in environments that fluctuate

235 ntification of local adaptations in strongly bottlenecked populations, as well as the importance of c

236 tatic lesions and identify a tight selective bottleneck preceding distant metastasis.

237 ty and sample preparation before MS remain a bottleneck preventing high-throughput proteomics.

238 r, behavioral data demonstrate that a serial bottleneck prevents recognition of more than one word at

239 promotes awareness of and addresses this key bottleneck problem by investigating methods that can acc

240 ed that these proteins have distinct hub and bottleneck properties in the brain protein interaction n

241 ification of previously poorly characterized bottlenecks provides a platform for future advancements

242 The key idea for breaking this bottleneck pursued in this work is to move beyond the lo

243 Bottlenecks reduce the size of the gene pool within popu

244 s tools; however, interfacing and throughput bottlenecks remain.

245 and experienced founder effects and genetic bottlenecks resulting in decreased genetic diversity.

246 A developmental bottleneck separates pre-HE from HE, with RUNX1 dosage r

247 In pre-steady-state glycolysis, pathway bottlenecks shift from downstream to upstream reactions

248 ts that IBV experiences a tight transmission bottleneck similar to that of influenza A virus.

249 nce data has suggested that the transmission bottleneck size for influenza A transmission between hum

250 sult, albeit that we infer a slightly higher bottleneck size in some cases, of between 1 and 13 virio

251 e on planning behavior, such as detection of bottleneck states and transitions.

252 ion of Bik1 (polyketide synthase) as a major bottleneck step in the pathway, and a promoter exchange

253 y in dendritic cells (DCs) that has multiple bottleneck steps and hence is inefficient.

254 frameworks (COFs) with atomic precision is a bottleneck that hinders the development of COF chemistry

255 However, off-target effects remain a major bottleneck that precludes safe and reliable applications

256 y responses are characterized by a clonality bottleneck that restricts the engagement of the large di

257 rate of private-metabolizers and population bottlenecks that are frequently associated with microbia

258 However, there are experimental bottlenecks that may limit the image reconstruction qual

259 The main bottlenecks that prevent efficient transformation in a g

260 yo-EM and identify persisting challenges and bottlenecks that will require further methodological and

261 a A transmission involves a tight population bottleneck, the bottleneck is not so tight as to univers

262 rest (e.g. the strength of the domestication bottleneck, the timing of domestication, the targets of

263 To better understand this gap and identify bottlenecks, the Burkina Faso Ministry of Health, along

264 The effective bottleneck time (the ratio of the linkage disequilibrium

265 eased purifying selection reducing effective bottleneck times compared to gene-poor autosomes.

266 e reduction in chromosome-specific effective bottleneck times from the least to the most gene-dense a

267 Reduced effective bottleneck times indicate stronger residual linkage dise

268 (RBPs) remain unclear, highlighting a major bottleneck to a full understanding of gene expression re

269 e of RNA extraction kits has caused a severe bottleneck to COVID-19 testing.

270 A major bottleneck to device performance is the high charge inje

271 Filamin acts synergistically with Bottleneck to facilitate hexagonal patterning, while Fim

272 photosynthetic capacity remains a recognized bottleneck to improving plant productivity.

273 One recognized bottleneck to progress has been the paucity of reliable

274 This poses a bottleneck to the deployment of NFRHT concepts in practi

275 provides an opportunity to overcome a common bottleneck to yield improvement across many crops.

276 l depictions likely reflect new and emerging bottlenecks to continental migration.

277 Bottlenecks to informing models with observations have r

278 This work addresses these bottlenecks to the automation of hepatocyte spheroid cul

279 pear to alleviate energetic and biosynthetic bottlenecks to viral production.

280 ty of MHP LEDs currently remains the biggest bottleneck toward their practical usage.

281 Three key bottlenecks toward increasing the pace of diffusion and

282 ositive organs was unlike the narrow genetic bottleneck typically observed with acute HCV acquisition

283 We also find an extreme bottleneck until about 1,000 y ago, which is followed by

284 Evidence for genetic bottlenecks was detected in the South China and Jiangnan

285 was fast, and no significant evidence of any bottlenecks was found.

286 Also, with the help of bottlenecks we have found, developers can improve the cu

287 To address this bottleneck, we combine automated sample preparation, an

288 To overcome this discovery bottleneck, we developed a high-throughput functional se

289 To overcome this bottleneck, we have developed high-efficiency delivery o

290 To overcome this bottleneck, we here present a method in which tip-enhanc

291 To solve this bottleneck, we introduce a methodology for the generatio

292 To address this bottleneck, we investigated the response of the maximum

293 does not seem to create a clear evolutionary bottleneck, we observe a more complex clonal architectur

294 Toward addressing this critical bottleneck, we report herein a high-throughput analysis

295 Consequently, populations experience a bottleneck when the environment changes from the superio

296 tured, likely reflecting a recent population bottleneck, whereas BeHV envelope gene sequences showed

297 d of the Pleistocene and includes the second bottleneck which occurred in the late 19(th) century.

298 ent computers are limited by the von Neumann bottleneck, which constrains the throughput between the

299 lation types-has contributed to a complexity bottleneck, with quantitative fits to experimental data

300 he thioesterase (TE) domain as a significant bottleneck within engineered PKS systems.