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1 R lacking metal, but are buried in the metal-bound form.
2 to the outward-facing state in a KCl- or HCl-bound form.
3 re similar to that of its fully active Na(+)-bound form.
4 s monomeric cytosolic or oligomeric membrane-bound form.
5 ibosylation factor (ARF5) in its active, GTP-bound form.
6 s the reaction product, Chlide, in an enzyme-bound form.
7 of p120RasGAP (RASA1) in its apo and peptide-bound form.
8 s and sometimes sampling the fully open, CD4-bound form.
9 +/- 3 muM and 2.7 +/- 0.1 muM in the calcium-bound form.
10 molecules only upon conversion to its Ca(2+)-bound form.
11 sociation constant of 2-5 muM in the calcium-bound form.
12 ecture of GluN2A LBD compared to the agonist-bound form.
13 rystal structure of human PI4KIIalpha in ADP-bound form.
14 om the inhibitor backbone in the cathepsin-G-bound form.
15 ulate conformations typical of the substrate-bound form.
16 y to exist that, in part, resemble the final bound form.
17 ly clips H3 in its free as well as chromatin-bound form.
18 , 2BC, and 2BC3AB polyproteins in a membrane-bound form.
19 ctivity and remains always in its active GTP-bound form.
20 but was autophagy-independent for a membrane-bound form.
21 zymatic release or restrict it to a membrane-bound form.
22 of cofactor D, specifically when in the GDP-bound form.
23 as accessible when TG2 was in a cell surface-bound form.
24 ate-free form to a pi helix in the substrate-bound form.
25 ormation similar to the gapped DNA-substrate-bound form.
26 cent penicillin, Bocillin-FL, in free or PBP-bound form.
27 t is more similar to the GDP than to the GTP-bound form.
28 rotein moiety, as compared to the nucleotide-bound form.
29 phenolic acids in cereals in either free or bound form.
30 mall molecules that target CDK8 in its MED12-bound form.
31 e inactive GDP-bound state to the active GTP-bound form.
32 endent conformations, alternative to the ATP-bound form.
33 se by converting Hyperkinetic to the NADP(+)-bound form.
34 jority of phenolic acids were present in the bound form.
35 llosteric site that remains in the substrate-bound form.
36 -Ras is not as signaling-competent as its PM-bound form.
37 signaling and helps maintain RAS in the GTP-bound form.
38 o the FANCD2:FANCI heterodimer in only a DNA-bound form.
39 from mouse right atrium was in the prodomain-bound form.
40 -products exist in the soluble and insoluble-bound forms.
41 res and dynamics of their free and inhibitor-bound forms.
42 dynamic than MN4 in the free and both ligand-bound forms.
43 spective (iii) calcium-free and (iv) calcium-bound forms.
44 tes RHEB shuttling between GDP-bound and GTP-bound forms.
45 ermined, both as free proteins and in glycan-bound forms.
46 rom Escherichia coli in apo, GDP-, and ppGpp-bound forms.
47 As, activate PKR in TRAP-free and TRAP/l-Trp-bound forms.
48 cherichia coli RppH (EcRppH) in apo- and RNA-bound forms.
49 ct RIalpha (91-379) in its apo, cAMP2, and C-bound forms.
50 of Roquin paralog RC3H2 in both apo- and RNA-bound forms.
51 splicing factor/splicing factor 2 (ASF/SF2)-bound forms.
52 stinguished by its glass adsorbed versus DNA-bound forms.
53 84 intestinal cells in both the apo and iron-bound forms.
54 in the apo and S-adenosyl-L-methionine (SAM)-bound forms.
55 ocator, in both membrane-associated and PcrH-bound forms.
56 BR2 in the apo, agonist-bound and antagonist-bound forms.
57 ary of ~2,000 binding surface types from the bound forms.
58 ained for the protein in the apo- and Ca(2+)-bound forms.
59 re known to occur in free and glycosidically bound forms.
60 pha-Syn exists in both solution and membrane-bound forms.
61 ated the total phenol pools in both free and bound forms.
62 d N-Ras, and can identify GEFs by use of GDP-bound forms.
63 es as well as between cytosolic and membrane bound forms.
64 ellular sensor domain in both apo and ligand-bound forms.
65 rved yeast protein Rtt107 in free and ligand-bound forms.
66 n NEK1 in its apo- and ATP-mimetic inhibitor bound forms.
67 rhodopsin, accelerating the decay of ligand-bound forms.
68 ng between inactive GDP-bound and active GTP-bound forms.
69 mations in succinyl-CoA-bound and acetyl-CoA-bound forms.
70 nt crystal structures of AgeI in apo and DNA-bound forms.
71 full-length hexameric Mtb Mpa in apo and ADP-bound forms.
72 argely as a result of dissolution of surface-bound forms.
73 ions of the tandem domains in different cAMP-bound forms.
74 herapeutics present in free-(49.3-75.4%) and bound-forms (24.6-50.7%) in tissues, even without a targ
76 wer levels, we expressed CD40L in a membrane-bound form, along with SIV antigens, in a nucleic acid (
78 s, (i) as a Ca(2+)-binding protein in Zn(2+)-bound form and (ii) as a protease in Zn(2+)-free form, c
80 urface molecule that is found in both a cell-bound form and cell-free form in the host during an infe
81 coupled in the unliganded and single agonist-bound form and only upon binding both agonists the trans
83 inactive apo state, two intermediate agonist-bound forms and an active form in which the heterodimer
84 tein alpha subunit in its apo and nucleotide-bound forms and characterized their dynamical features a
85 nd VanXYG in apo and transition state analog-bound forms and of VanXYC in complex with the D-Ala-D-Al
86 rystal structure of RovA in the free and DNA-bound forms and provide evidence that thermo-induced los
87 HAR) in the native, ascorbate-bound, and GSH-bound forms and refined their resolutions to 1.9, 1.7, a
88 occur in the free, esterified and insoluble-bound forms and serve as natural antioxidants by prevent
90 levels of terpenes (indicating hydrolysis of bound forms) and fermentation-derived volatiles, compare
91 petitive antagonist-bound states, an agonist-bound form, and a state bound with agonists and the allo
92 that Rabs are soluble in their inactive GDP-bound form, and only upon activation and conversion to t
93 G11.2) that recognizes, in both free and HDL-bound forms, apoA-I harboring a 3-nitrotyrosine at posit
96 rganic and iron-bound P species into calcium-bound forms, as a possible consequence of the partial mi
97 domain of CD23 in its Ca(2+)-free and Ca(2+)-bound forms, as well as the crystal structure of the Ca(
98 FAAH) from Arabidopsis in its apo and ligand-bound forms at 2.1- and 3.2- angstrom resolutions, respe
101 delta2 interacts with omega2 and, in the ATP-bound form, binds to nonspecific DNA (nsDNA), forming sm
102 in plants and plant foods not only in their bound form but also as free acids that can be extracted
103 sults not from faster association of the ATP-bound form but faster dissociation leading to less stabl
105 Heme-free mPGES2 was converted to the heme-bound form by mixing it with pig liver extract, indicati
106 o it is possible to gain insight into ligand-bound forms by considering conformational variation in a
107 glycosylated HIV gp120 in unliganded and CD4-bound forms by using small-angle X-ray scattering to vis
109 can be toxic when it occurs in a non-protein-bound form; cells maintain a fine balance between heme s
110 structures of TgAMA4 in the apo and TgRON2L1-bound forms complemented with alanine scanning mutagenes
111 phenolic acids increased (30%) and insoluble-bound forms decreased (17%), suggesting partial conversi
112 es of LarE in ligand-free and several ligand-bound forms, demonstrating that LarE is a member of the
113 was observed for hydroxytyrosol and tyrosol bound forms, determinant for the health claim, which wer
114 rmations for E108 residue in the ATP and ADP bound forms, E108Q adapts the same conformation irrespec
116 xo-1(2H)-pyri midinepropanoic acid (UBP-282)-bound form exhibiting the widest range of cleft closure
119 x properties of both the Fe(III)- and Fe(II)-bound forms have been characterized using the UV-visible
120 mperature range tested had a minor effect on bound-forms hydrolysis, being both free and bound forms
121 ved for an activated transition-state analog-bound form II ribulose-1,5-bisphosphate carboxylase/oxyg
125 ween an inactive soluble and active membrane-bound form in response to changes in membrane lipid comp
126 propose that conversion of ARF6 into the GDP-bound form in the apical domain of hair cells is essenti
127 LC-DAD was the most abundant compound in its bound form in the OHF, but decreased by 57% in TNF.
128 s been investigated to assess the role of Fe-bound forms in NIF-specific Fe-S cluster biogenesis.
130 with the circulating form of BMP9 (prodomain-bound form) in solution leads to the release of the prod
131 fluorescence was also observed in its actin-bound form, indicating that the dystrophin N-ABD binds t
132 7 in the apo structure but not in the ligand-bound form, indicating that this region likely confers p
133 not PsV expressing a cytoplasmic or membrane-bound form, induced circulating and intravaginal-tissue-
134 within the ER both in secretory and membrane-bound forms, inducing their degradation following retrot
136 s suggest that conversion of ARF6 to its GDP-bound form is necessary for final stabilization of the h
137 ugh the function of its predominant membrane-bound form is well established, the source and biologica
138 mponent in both membrane-bound and chaperone-bound forms is a key step for the eventual development o
140 gh it is known that the carboxyl-terminus of bound-form Lpp is located in the periplasm, the precise
142 d conformation, in contrast to the inositide-bound form obtained previously in a closed conformation.
143 of the protein from the unbound form to the bound form occurs before or after encountering the ligan
144 for an allosterically inhibited and agonist-bound form of a functional NMDA receptor; however, other
146 o70, and Sec5 bind preferentially to the GTP-bound form of Arl13b, consistent with the exocyst being
147 nd of ppGpp to BipA, indicate that the ppGpp-bound form of BipA adopts the structure of the GDP form.
150 quired the specific interaction of the Cu(+)-bound form of CopA with apo-CusF for subsequent metal tr
152 n agreement with previous work, the membrane bound form of Cripto-1 potentiated signaling, revealing
153 gene regulatory region occupancy by the DNA-bound form of cyclin D1 and induction of CIN gene expres
154 -wide ChIP sequencing and found that the DNA-bound form of cyclin D1 occupied the regulatory region o
155 ridging sulfides in the [4Fe-4S](2+) cluster-bound form of FNR facilitated identification of resonant
157 that VVC-resistant viruses use the inhibitor-bound form of Galphai-coupled CCR5 more efficiently than
162 sticity of the dimeric state of the [2Fe-2S] bound form of human GRX5 (holo hGRX5) is the crucial fac
164 in the inactive guanosine diphosphate (GDP)-bound form of KRAS(G12C), sparing the wild-type protein.
165 tein-Barr virus (EBV) increases the membrane-bound form of LC3 (LC3-II) and LC3-containing punctate s
166 )C}(7)Li dipolar recoupling experiments, the bound form of lithium in the active site of wild-type E.
167 The Clp protease system destabilizes a zinc-bound form of Mpy recruitment factor (Mrf), which is sta
168 ollectively, these results show that the ATP-bound form of MRN is the critical conformation for ATM a
173 ions to refine the structure of the membrane-bound form of Pf1 coat protein in explicit lipid bilayer
177 -bound RAB7, but not a dominant-negative GDP-bound form of RAB7, promoting rapid transfer and lysosom
181 ognate eukaryotic effectors, as only the GTP-bound form of RhoA family members stimulates enzymatic a
182 y of Ssq1 and is most pronounced for the ADP-bound form of Ssq1, which interacts with Isu1 most tight
185 ciated with characterization of the membrane-bound form of talin have prevented us from understanding
186 The chlorowillardiine- and nitrowillardiine-bound form of the agonist-binding domain probes a narrow
187 sociated with the expression of the membrane-bound form of the CD40L by CD4(+) T cells in lymph nodes
188 as 1B6 that recognize the more abundant GAG-bound form of the chemokine may not be the optimal strat
190 ntify an unforeseen principle by which a GDP-bound form of the conserved small G protein Rho GTPase d
191 d conformation and propose that the membrane-bound form of the cytodomain represents its native confo
193 ction occurs whereby mutations shift the ADP-bound form of the enzyme towards an ATP-like state in a
194 otably, the methyl-thiazole prefers the NADH-bound form of the enzyme with a Kd of ~13.7 nM, as again
199 fection of human tumor cells with a membrane-bound form of the human costimulatory molecule CD80 prev
200 iptional expression switch from the membrane-bound form of the immunoglobulin heavy chain to its secr
203 osure states relative to the iodowillardiine bound form of the protein, with the antagonist (alphaS)-
205 resistance describe an ability to use a drug-bound form of the receptor, leading to reduction in maxi
206 r modeling docking studies using the agonist-bound form of the X-ray crystal structure of the acetylc
207 nism involves signaling between the membrane-bound form of TNF-alpha on activated CD8(+) T cells and
208 he cleaved form of alphaKlotho, the membrane-bound form of which is an FGF23 coreceptor, serves as a
209 a are consistent with a model in which a DNA-bound form of Yap8 acts directly as an As(III) sensor.
212 rved under acidic conditions, whereas sulfur-bound forms of Ag dominated in neutral to alkaline soils
214 he crystal structures of apo- and ADP/Mg(2+)-bound forms of Aquifex aeolicus LpxK to a resolution of
215 free, esterified, glycosylated and insoluble-bound forms of araticum pulp, peel and seed were for the
216 ent in the free, soluble ester and insoluble-bound forms of blackberry, black raspberry and blueberry
218 nalysis demonstrates that the apo and Mg(2+)-bound forms of CBD12 are highly flexible, whereas Ca(2+)
221 contrast to the prevailing view that the GDP-bound forms of G proteins are inactive, our study reveal
223 We determined structures of ATP-free and -bound forms of human TRPV4-ARD and compared them with av
224 o detect conformational dynamics in free and bound forms of IDPs under conditions approaching physiol
225 h to spatially map NADH in both the free and bound forms of live undifferentiated and differentiated
227 lyzing purified preparations of apo- and ion-bound forms of NCX_Mj-WT and its mutant, NCX_Mj-5L6-8.
228 le, atomistic simulations of the unbound and bound forms of NorM in a phospholipid lipid bilayer allo
230 striking exception to the rule that only GTP-bound forms of Ras-superfamily GTPases have active confo
234 00-ns trajectories of the free and substrate-bound forms of TEM-1 (with benzylpenicillin) and PSE-4 (
236 n microscopy reconstructions of free and DNA-bound forms of the Cascade/I-C surveillance complex reve
238 e report here structures of the free and DNA-bound forms of the DBD of NtrC4 (4DBD) from Aquifex aeol
239 the nucleotide binds to the free and singly bound forms of the enzyme with nearly equal affinity ove
241 arrangement in the apo form and GDP- and GTP-bound forms of the factor, raising the question of how S
242 and remarkably different for GDP- and GppNHp-bound forms of the G domain, indicating that the GTP-bin
243 uce mRNAs encoding the secreted and membrane-bound forms of the immunoglobulin (Ig) heavy chain.
244 vey common foods for free and glycosidically bound forms of the nonhuman sialic acid N-glycolylneuram
245 ive NMR analysis of the apo, cGMP-, and cAMP-bound forms of the PKG cyclic nucleotide-binding domain
246 the labeled sites between the apo and ligand-bound forms of the proteins, which are easily distinguis
249 ch FKBP51 binds to both the apo- and hormone-bound forms of the steroid receptor to modulate its affi
251 esent crystal structures of the free and CMP-bound forms of WaaA from Aquifex aeolicus, an ancient Gr
252 r previously reported data for the glutamate-bound forms of wild type and T686S mutant proteins, show
253 Omicron-(gamma-thio)triphosphate (GTPgammaS)-bound) form of Tr*, we found that Tr* activated PDE at a
255 ions of active (GTP-bound) and inactive (GDP-bound) forms of wild-type and mutant K-Ras, with an inte
256 by the interconversion between GTP- and GDP-bound forms partly regulated by the binding of the guani
257 ermination of protein-free and total (free + bound forms) positron emission tomography (PET) radiolig
260 lexibility, when three Ca2+ or two Mg2+ were bound forming probably the structural basis for the modi
261 d form promoted by GEFs and its inactive GDP-bound form promoted by GAPs to affect the control of var
262 Ras GTPase cycles between its active GTP-bound form promoted by GEFs and its inactive GDP-bound f
264 excited kynurenines in both free and protein-bound forms rapidly oxidized ASC, and such oxidation occ
265 e ligand "slips" between bidentate and arene-bound forms: rather than dissociation, the cobalt slides
268 as switchable landmarks with the active GTP-bound form recruiting to the membrane a specific set of
269 free or weakly bound molecule and a tightly bound form released by acid hydrolysis, at concentration
271 in ligand-free, antagonist-bound, or calcium-bound forms, revealing how robust conformational changes
274 of ligand-free CouR and its p-coumaroyl-CoA-bound form showed no significant conformational differen
275 s of the IL-2 superkine in free and receptor-bound forms showed that the evolved mutations are princi
276 an open conformation, whereas the nucleotide-bound form shows a half-closed conformation, in contrast
277 of E. coli ACPS in unliganded and holo-ACPP-bound forms solved by X-ray crystallography to 2.05and 4
278 nsition of Cas9 from its apo form to the RNA-bound form, suggesting a mechanism for RNA recruitment i
281 ecular switch in a constitutively active GTP-bound form that drives, unchecked, oncogenic downstream
282 tively unfolded and monomeric and a membrane-bound form that is composed of an alpha-helical multimer
284 of transcription factor signaling via a DNA-bound form, the induction of chromosomal instability, en
285 nly binds MreB in the guanosine triphosphate-bound form, the motility complexes are assembled at the
286 lanine is not specially favored in the lipid-bound form; the chimeric construct with polyalanine prod
287 of this dual domain in both apo- and ligand-bound form: thermodynamic analysis of the ligand associa
289 droxymethyl of Thr(772) rotates to stabilize bound Form(+) through water molecules, and 3) the rotame
291 o the [4Fe-4S] cluster, and exposure of this bound form to O2 results in cluster conversion to the [2
292 mploys quantification of PSA in its free and bound forms to enumerate the risk of prostate cancer and
293 We find that cryoreduction at 77 K of the O2-bound form, trapped in the conformation of the parent ox
294 creased fluctuations are seen in the camphor-bound form using all three techniques, dominated by chan
295 undetectable in its parent form, whereas the bound form was readily quantified, employing the modifie
296 atural peptides in their free and HLA-B*0801-bound forms, we characterized the mode of action of ERAP
297 t DDXs promote phase separation in their ATP-bound form, whereas ATP hydrolysis induces compartment t
299 s of HiNmlR in both the DNA-free and two DNA-bound forms, which suggest that HiNmlR enhances target g