ライフサイエンスコーパス: bouton

1 rees Mn bouton and at least one 2 degrees Mn bouton.

2 of total and straight mitochondria per dlPFC bouton.

3 ffect neurotransmitter release from synaptic boutons.

4 larged intraluminal vesicles within synaptic boutons.

5 odia as well as in later-stabilized synaptic boutons.

6 osome markers in soma, neurites and synaptic boutons.

7 olog unc-104 disrupt the formation of mature boutons.

8 c overgrowth and an accumulation of immature boutons.

9 zyme responsible for GABA synthesis in these boutons.

10 es apparent in approximately 20% of observed boutons.

11 VGLUT1 terminal and their coverage of VGLUT1 boutons.

12 active spines contacting pre-existing axonal boutons.

13 d that FLN90 is present surrounding synaptic boutons.

14 dramatically lowers DCV numbers in synaptic boutons.

15 hat initiate contact with presynaptic axonal boutons.

16 ely occurs after the maturation of GABAergic boutons.

17 es and presynaptic met-enkephalin-containing boutons.

18 were 14% lower in the remaining vGAT+/GAD67+ boutons.

19 and across functionally distinct subsets of boutons.

20 somata, proximal extensions and presynaptic boutons.

21 naptic partners in apposition to presynaptic boutons.

22 ins such as dendritic spines and presynaptic boutons.

23 halt at their targets and become presynaptic boutons.

24 to the signalling in the individual synaptic boutons.

25 d dynamics along axon shafts and presynaptic boutons.

26 capture as they circulate through en passant boutons.

27 required for their localization to immature boutons.

28 a dense network of fine fibers bearing small boutons.

29 ither enhanced or suppressed the activity of boutons.

30 erived ATP in individual, living hippocampal boutons.

31 pendent and help enrich actin at presynaptic boutons.

32 ding synaptic size and presence of satellite boutons.

33 ed neurotransmitter release from presynaptic boutons.

34 ew filopodia originating from spine heads or boutons.

35 o better define the specific targets of LJA5 boutons.

36 row and prevent formation of normal synaptic boutons.

37 and functionality of vertebrate presynaptic boutons.

38 alphaTAT results in the formation of ectopic boutons.

39 ng to consolidate small terminals into large boutons.

40 is not attributable to anatomical loss of PV boutons.

41 mpetition over a limited pool of presynaptic boutons.

42 emonstrated that betaARs are expressed in PF boutons.

43 Within this subpopulation of boutons, 35% of observed vesicles exhibited acceleration

44 ifferent locations in MCtx form gradients of boutons across premotor nuclei spinal trigeminal pars or

45 Hence, en passant boutons act as hotspots for activity-dependent de novo M

46 ype human PFN1 increases the number of ghost boutons, active zone density, F-actin content, and the f

47 e optics that allows accurate measurement of bouton activity deep in cortex, we found that around hal

48 ed to construct a statistical model in which bouton addition, elimination, and size changes are descr

49 We recorded from CD and bouton afferents innervating the turtle posterior crista

50 gIA, blocked efferent-mediated inhibition in bouton afferents while leaving efferent-mediated excitat

51 ive efferent-mediated inhibition in adjacent bouton afferents.

52 ut affecting efferent-mediated inhibition in bouton afferents.

53 The varicose geometry of SC boutons alone does not impose differences in spike durat

54 ramidal neurons and form rows of presynaptic boutons along them.

55 nces between MC versus S1 Po synapses in (1) bouton and active zone size, (2) neurotransmitter vesicl

56 ach muscle cell are shared by a 1 degrees Mn bouton and at least one 2 degrees Mn bouton.

57 In particular, en passant bouton and filopodia connections with CA3 interneurons p

58 accumulate between membranes of the terminal bouton and the subsynaptic reticulum.

59 ayers exhibited sharper tuning than thalamic boutons and a greater diversity of preferred orientation

60 properties of approximately 28,000 thalamic boutons and approximately 4,000 cortical neurons in laye

61 motoneuron increased the number of synaptic boutons and AZs it formed.

62 metric analysis of presynaptic glutamatergic boutons and dendritic spines was performed on SPNs 1 hou

63 tly increases the parallel fiber presynaptic boutons and functional parallel fiber/Purkinje cell syna

64 ses the number of parallel fiber presynaptic boutons and functional parallel fiber/Purkinje cell syna

65 zed spatial profile of calcium elevations in boutons and helps to expand the dynamic range of mossy f

66 er MT nucleation is regulated at presynaptic boutons and influences overall presynaptic activity rema

67 er of healthy straight mitochondria in dlPFC boutons and inversely correlated with the number of path

68 tassium channels, with clustered hotspots at boutons and restricted expression at adjoining shafts.

69 ally, loss of Cdk8 causes an obvious loss of boutons and synapses at larval neuromuscular junctions (

70 rived miR-274 coordinates growth of synaptic boutons and tracheal branches to modulate larval hypoxia

71 eal cells to modulate the growth of synaptic boutons and tracheal branches, respectively.

72 utonomously modulates the growth of synaptic boutons and tracheal branches.

73 Finally, the spatial organization of boutons and whisker map organization revealed the subdiv

74 l, Schwann cells that ensheathe the terminal bouton, and a highly specialized postsynaptic membrane.

75 al losses of syt2-immunoreactive boutons, PV boutons, and granule cells.

76 dynamic - moving, dividing to generate more boutons, and merging to consolidate small terminals into

77 rafficked to and anchored within presynaptic boutons, and the mechanisms that allow them to function

78 fewer PV interneurons, and fewer PV synaptic boutons, and the ratio of granule cells to PV interneuro

79 r (vGAT+), which is present in all cartridge boutons, and the subset of cartridges that contain calbi

80 ses, and inhibits Ca(2+) entry into synaptic boutons, and we can reverse this by controlled intracell

81 kephalin (mENK) and dynorphin-immunoreactive boutons appeared to contact ARC TH neurons.

82 inals, non-degradative roles of autophagy at boutons are barely described.

83 riable expression density of Kv3 channels at boutons are key determinants underlying compartmentalize

84 However, the source and roles of cranial C boutons are less clear.

85 Inhibitory boutons are only sensitive to Sema4D at a specific stage

86 e genetics, and demonstrate that brainstem C boutons are Pitx2+ derived.

87 nets and perisomatic rings of glutamatergic boutons are present in many subcortical areas and often

88 ey V1 do not differ, the size of presynaptic boutons are significantly larger in monkey V1.

89 parvalbumin-positive presynaptic inhibitory boutons around pyramidal neurons of the hippocampal CA3

90 turnover of dendritic spines and presynaptic boutons as well as the generation of new filopodia origi

91 of O-GlcNAcase affected a number of synaptic boutons at the axon terminals of larval neuromuscular ju

92 F12 is expressed presynaptically in synaptic boutons, axons, and nuclei of motor neurons.

93 anterograde or retrograde DCV transport into boutons, bouton location, and time of arrival in the ter

94 endfeet such as spines, swelling, en passant boutons, boutons, or claws.

95 shaft, MPS is disrupted in most presynaptic boutons but is present in an appreciable fraction of den

96 th CA3 pyramidal cells via large mossy-fibre boutons, but rather to all synapses formed by dentate gr

97 rminal but also its activation in the axonal bouton by PKC-induced calcium-dependent phosphorylation

98 B or photobleaching DCVs entering a synaptic bouton by retrograde transport.

99 haTAT activity limits the growth of synaptic boutons by affecting dynamic, but not stable, microtubul

100 We identified thalamic boutons by their immunoreactivity for the vesicular glut

101 These ectopic boutons can be similarly suppressed by resupplying enzym

102 We reconstructed and quantified the bouton clouds originating from adjacent L5B columns in t

103 Labeled boutons contain dense-core vesicles, and they resemble a

104 less than 50% of hippocampal CA1 presynaptic boutons contain mitochondria, raising the question of wh

105 y found that in schizophrenia, ChC cartridge boutons contain normal levels of the 67 kDa isoform of g

106 and vesicle decrement was greatest in adult boutons containing mitochondria.

107 r that a significant fraction of glycinergic boutons corelease GABA in the ICC.

108 inje cells with functional adherent synaptic boutons, demonstrating the presynaptic locus of modulati

109 ecific increases in the formation of LA axon boutons, dendritic spines of ACx layer 5 pyramidal cells

110 ynapse formation is restricted to biological bouton densities and numbers of synapses per connection,

111 Baseline bouton density and gains during training correlate with

112 vGAT+ bouton density did not differ between subject groups, co

113 cluding those on cholinergic interneurons; C bouton density increased correspondingly.

114 ouse cortical cultures, knowing if GABAergic bouton density is altered in schizophrenia would provide

115 Although presynaptic bouton density or size was not significantly different a

116 erized by extensive ramifications and a high bouton density, characteristics thought to preserve the

117 n brain slices showed that, despite high GoC bouton density, fast phasic inhibition was very sparse r

118 has low fractions of false positive/negative bouton detections (2/0 out of 18), and that 2PLSM-based

119 to probe the effects of Wnd and Ttk69 on R7 bouton development and conclude that Ttk69 coordinates m

120 Synaptic bouton development relies on an underlying network of bo

121 ling of microtubule networks during synaptic bouton development.

122 ce or absence of mitochondria at presynaptic boutons dictates neurotransmitter release properties thr

123 served in the remaining approximately 80% of boutons did not exhibit apparent dynamical changes in re

124 GSI treatment did neither affect spines and boutons distant from plaques in amyloid precursor protei

125 mphisomes that signal locally at presynaptic boutons during retrograde transport to the soma.

126 rons, exhibited a gradual increase in axonal boutons during training.

127 In contrast, axon "en passant" boutons dynamics were impervious to this novel sensory e

128 ticity, amphisomes dissociate from dynein at boutons enabling local signaling and promoting transmitt

129 aneous branches before developing unramified bouton endings that contact the hair cells.

130 activate integrin signaling, induce synaptic bouton enlargement, and increase postsynaptic glutamate

131 Optical stimulation of Type II boutons evokes exocytosis of octopamine, which is detect

132 Occupancy in boutons exceeds that at nearby extrasynaptic axonal site

133 Inhibitory boutons exhibit robust orientation-tuned responses with

134 % of CG neurons was associated with terminal boutons expressing GAD-immunoreactivity in addition.

135 ecture and robustly decreases the density of bouton filopodia that provide feedforward inhibition.

136 to the transient enlargement of the synaptic boutons, followed by a sustained increase in conduction

137 that the types of synaptic connections these boutons form are altered with aging and menopause in rhe

138 We found that the Ipc terminal boutons form glomerulus-like structures in the superfici

139 4 inhibits Hts to regulate the initiation of bouton formation from presynaptic terminals.

140 MD affected bouton formation, but with a delay, blocking it after 3

141 oad tracks specifically wrap around immature boutons formed during development and in response to ele

142 ron microscopic observations revealed septal boutons forming axosomatic or axodendritic type II synap

143 thalamic axons are myelinated and make large boutons, forming multiple asymmetric, adherent, and perf

144 nificant loss of contralateral corticospinal boutons from M2 compared with controls.

145 with anterogradely labeled Ipc axon-terminal boutons, further supporting a glutamatergic function for

146 The small size of synaptic boutons has hampered efforts to define the dynamical sta

147 se data support the concept that presynaptic boutons have a robust highly regulated clearance system

148 C boutons have also been identified on the motor neurons o

149 measurement of structural changes in axonal boutons imaged with time-lapse two-photon laser scanning

150 itatory neurons, showed a decrease in axonal boutons immediately after the training began, whereas pa

151 Vs) relative to vGlut1(+) stable presynaptic boutons in a time window during which MT nucleation at b

152 dynamics at individual excitatory en passant boutons in axons of cultured hippocampal neurons and in

153 The cross-sectional area of vGluT1-positive boutons in both VApc and CM of parkinsonian monkeys was

154 yzed 147 neuroanatomical regions for labeled boutons in every brain (n = 11).

155 o quantify significant structural changes in boutons in long-term imaging experiments.

156 Axonal boutons in LPFC were also larger in volume and contained

157 Furthermore, thalamic boutons in M1 targeted spiny dendrites exclusively, wher

158 VGluT2(+) boutons in M1 were smaller and formed fewer synapses per

159 tons results in a lower density of GABAergic boutons in mouse cortical cultures, knowing if GABAergic

160 to be collected from populations of synaptic boutons in mouse primary visual cortex during locomotion

161 djacent to fluorescently labeled presynaptic boutons in physiological levels of extracellular Mg(2+).

162 cally form a single synapse, thalamocortical boutons in S1 usually formed multiple synapses, which me

163 3) there is a loss of larger S1 CST terminal boutons in the affected dorsal horn, but no change in th

164 new study reveals that excitatory en passant boutons in the axon are hotspots for activity-induced mi

165 lted in enhanced numbers of terminal labeled boutons in the iCSP from cM1 compared with controls.

166 in cortex, we found that around half of the boutons in the main thalamorecipient L4 carried orientat

167 mical imaging of dendritic spines and axonal boutons in the mouse hippocampus, and functional imaging

168 roduction is markedly reduced in a subset of boutons in the PFC of schizophrenia subjects and that th

169 wever, the spatial organization of L5B giant boutons in the POm and other subcortical targets is not

170 re, the balance of inhibitory and excitatory boutons in the spinal cord and the level of an ion co-tr

171 labeled somata in the cerebellar nuclei and boutons in the ventrolateral thalamus.

172 ual experience, the formation of presynaptic boutons increased during the critical period and then de

173 Blockade of Kv channels at individual boutons indicates that currents immediately local to a r

174 percentage of retrograde comets initiated at boutons, indicating that gamma-tubulin and augmin are re

175 ng anterograde transport vesicles entering a bouton inhibits neuropeptide replenishment after activit

176 es the intensity of muscle activation via 'C-bouton' inputs to motoneurons.

177 translates to GAD67 protein levels in axonal boutons is important for understanding the impact it mig

178 irming that the number of cortical GABAergic boutons is not lower in schizophrenia.

179 a time window during which MT nucleation at boutons is promoted upon induction of neuronal activity,

180 in lamina VIII, at the expense of lamina VII bouton labeling.

181 aintaining near normal levels of ATP even in boutons lacking mitochondria.

182 ere we report that the destruction of SVs in boutons lacking Piccolo and Bassoon was associated with

183 m Bassoon inhibited presynaptic autophagy in boutons lacking Piccolo and Bassoon, providing insights

184 We find that boutons lacking Piccolo have deficits in the Rab5/EEA1 d

185 s mice showed deficiency of GABA perisomatic bouton-like puncta and processes in the KF nucleus; (ii)

186 inct morphological features such as terminal bouton-like structures that contact mitotic NPCs in the

187 ture calyx of Held synapses whose numbers of bouton-like swellings on stalks of the nerve terminals i

188 de or retrograde DCV transport into boutons, bouton location, and time of arrival in the terminal.

189 ning correlate with rule exploitation, while bouton loss correlates with exploration and scales with

190 e significant differences in the size of the boutons made in each area by individual Po axons, as wel

191 tion produced also a higher loss of synaptic boutons, mainly at the dendritic level.

192 Boutons making axosomatic symmetric synapses in the gran

193 allows presynaptic AMPARs to depolarize the bouton membrane sufficiently to modulate both phasic and

194 synaptic, single-synaptic, and multisynaptic boutons (MSBs) in the dlPFC.

195 Multisynaptic boutons (MSBs) were of particular interest, because they

196 4 distributes broadly, including in synaptic boutons, muscle cells, and tracheal cells.

197 Whether the same boutons, neurons or sources provide these kinetically di

198 er vGAT, CB, or GAD67 protein levels per ChC bouton nor the number of boutons per cartridge differed

199 ssion of Shank result in defects in synaptic bouton number and maturation.

200 development, including controlling synaptic bouton number and the ability to bud new varicosities in

201 parietal injury blocked this response; total bouton number was similar to controls, demonstrating tha

202 ddress this, we evaluated PV interneuron and bouton numbers in California sea lions (Zalophus califor

203 However, compared with controls, elevated bouton numbers occurred in lamina VIII, at the expense o

204 l innervation is target specific in terms of bouton numbers, density, and projection volume.

205 amate with low probability, whereas the next bouton of the same axon has high release probability whe

206 o the mitochondrial matrix or to presynaptic boutons of cortical pyramidal neurons, we demonstrate th

207 image dendritic spines and axon "en passant" boutons of layer 2/3 pyramidal neurons in S1 of male and

208 Syt2 is also expressed in boutons of PV interneurons.

209 awake, intact brain, we imaged the synaptic boutons of retinal axons in the superior colliculus.

210 onotopic arrangement was observed across the boutons of the corticocollicular axons, which form a den

211 of filopodial-like protrusions from synaptic boutons of the Ib input.

212 1 were smaller and formed fewer synapses per bouton on average (1.3 vs 2.1) than those in S1, but VGl

213 eurons in the medial intermediate zone and C boutons on motoneurons.

214 es and numbers of OC inhibitory dopaminergic boutons on neonatal SGN fibers.

215 s the high-density accumulation of GABAergic boutons on sensory terminals.

216 C boutons on spinal motor neurons stem from spinal interne

217 The efferent boutons on vestibular cells in alpha9, alpha10, and alph

218 erent synapses and presynaptic inhibition (P-boutons) on retrogradely labeled motoneurons.

219 treated rats are not attributable to smaller boutons or fewer docked vesicles.

220 uch as spines, swelling, en passant boutons, boutons, or claws.

221 tein levels per ChC bouton nor the number of boutons per cartridge differed between subject groups.

222 the average numbers of PV- or syt2-positive boutons per granule cell between control and sclerotic h

223 ignificant decrease in the number of GAD65 P-boutons per VGLUT1 terminal and their coverage of VGLUT1

224 not experience of reward alone, enhances OFC bouton plasticity.

225 c points along the axon, such as presynaptic boutons, play critical roles in axon morphogenesis [4, 5

226 ant activity-evoked change across the entire bouton population.

227 he spared/sprouted primary afferent terminal boutons post-lesion.

228 minance decrements versus increments, and in boutons preferring motion along directions or axes of op

229 ished in the dissociated Purkinje cell-nerve bouton preparation.

230 d proportional losses of syt2-immunoreactive boutons, PV boutons, and granule cells.

231 Stabilized boutons rapidly recruited synaptic vesicles, followed by

232 However, any given bouton responded with stereotypic polarity across multip

233 , but not after, the maturation of GABAergic boutons results in a lower density of GABAergic boutons

234 onstruction and quantification of GoC axonal boutons revealed tightly clustered boutons that focus fe

235 rousal-related modulation also varied with a bouton's preference for luminance changes and direction

236 Here, excitatory synaptic boutons (SBs) in layer 4 (L4) of the temporal lobe neoco

237 Recordings from mouse cerebellar mossy fiber boutons show that HCN channels ensure reliable high-freq

238 mic MTs preferentially grow from presynaptic boutons, show biased directionality in that they are alm

239 , tracking of individual DCVs moving through boutons shows that activity selectively increases captur

240 how that AP width varies between presynaptic bouton sites, even within the same axon branch.

241 ing, optogenetics in slice preparations, and bouton size analysis in the mouse (both sexes) to docume

242 1) Bouton size increases with proportionally rising number

243 tochondrial volume was a strong predictor of bouton size independent of pathology.

244 pses, probability of release correlates with bouton size, active zone area, and number of docked vesi

245 ptic transmission is attributable to smaller boutons, smaller synapses, and abnormally low numbers of

246 rol neurotransmitter release properties in a bouton-specific way through presynaptic Ca2+ clearance.

247 g cascade triggered by Sema4D and found that bouton stabilization occurs through rapid remodeling of

248 contractions, loss of neuromuscular junction bouton structures, impaired olfactory perception, and se

249 We recorded instead from small boutons supplied by intact axons identified with scannin

250 Presynaptic boutons support neurotransmitter release with nanoscale

251 n-positive interneurons (INs) than in low Pr boutons synapsing onto mGluR1alpha-positive INs.

252 higher Ca(2+) inflow per AZ area in high Pr boutons synapsing onto parvalbumin-positive interneurons

253 nt of pyramidal neurons, forming an array of boutons termed a cartridge.

254 associated with greater numbers of terminal boutons than smaller frontal lobe lesions.

255 vesicles were decreased only in presynaptic boutons that contained mitochondria at P15, and vesicle

256 found that only a small fraction of dopamine boutons that exhibited Ca(2+) influx engaged in exocytos

257 oC axonal boutons revealed tightly clustered boutons that focus feedforward inhibition in the neighbo

258 Neuronal axons terminate as synaptic boutons that form stable yet plastic connections with th

259 Pitx2- neurons, in contrast to spinal cord C boutons that originate solely from Pitx2 neurons.

260 s, where MSBs comprised approximately 40% of boutons, the vast majority of dlPFC boutons were single-

261 the perisomatic chemical GABAergic synaptic boutons to the distal AIS, lacks both sodium channels an

262 s physiological interactants at the synaptic bouton toward trafficking vesicles and organelles, as ob

263 motion, with greater response suppression in boutons tuned to luminance decrements versus increments,

264 In contrast, at high spatial frequencies, boutons tuned to regions of visual space ahead of the mo

265 Unlike M1, where thalamocortical boutons typically form a single synapse, thalamocortical

266 der after high-frequency AP firing: synaptic boutons undergo a rapid enlargement, which is mostly tra

267 in adults, while presynaptic DG mossy fiber boutons undergo significant structural rearrangements wi

268 To test whether fewer boutons was attributable to loss versus reduced immunore

269 The percent coverage of motor neurons by boutons was reduced by 20%; more specifically, flattened

270 s with detectable GAD67 levels (vGAT+/GAD67+ boutons) was 16% lower and mean GAD67 levels were 14% lo

271 ics and heterogeneity of individual dopamine boutons, we developed fluorescent false neurotransmitter

272 Within individual presynaptic boutons, we find no nanoscopic co-localisation of evoked

273 hanges in individual GFP-labeled presynaptic boutons, we found that the primary action of Sema4D is t

274 ctions (2/0 out of 18), and that 2PLSM-based bouton weights are correlated with their volumes measure

275 Lamina IX boutons were also elevated in two frontoparietal lesion

276 o restore normal pH and PCO2Tac1-Pet1 axonal boutons were found localized to brainstem areas implicat

277 ined cortical regions, many septal GABAergic boutons were in close apposition to somata or dendrites

278 inous synapses, as well as multiple synaptic boutons were increased in the perilesion cortex by NPT.

279 At the synaptic level, axonal boutons were larger, and dendritic spines were predomina

280 >GC boutons were predicted to be smaller in volume, have few

281 CGRP(+) SP(-) boutons were prevalent in lateral lamina I and in lamina

282 by 20%; more specifically, flattened-vesicle boutons were reduced by 46%, and were normalized in reco

283 onses to drifting gratings in retinal axonal boutons were robustly modulated by arousal level in a ma

284 y 40% of boutons, the vast majority of dlPFC boutons were single-synaptic, whereas MSBs constituted a

285 Responses of feedback boutons were sparse, odor specific, and often outlasted

286 s, acoustically responsive corticocollicular boutons were sparse, produced unreliable responses, and

287 mediate spatial frequencies, the majority of boutons were suppressed by arousal.

288 channel density in high release probability boutons, whereas freeze-fracture immunolocalization demo

289 ton Ca(2+) imaging in cerebellar mossy fiber boutons, which fire at exceptionally high rates.

290 mber of gamma-aminobutyric acid (GABA)-ergic boutons, which may result from impaired localization and

291 c synapses on spinal motor neurons, called C boutons, which seem to control motor neuron excitability

292 es that provide structural stability for the boutons while also allowing for their growth and remodel

293 izophrenia subjects, the proportion of vGAT+ boutons with detectable GAD67 levels (vGAT+/GAD67+ bouto

294 aberrant wiring of glutamatergic presynaptic boutons with GABAergic postsynaptic positions.

295 epileptic pilocarpine-treated rats displayed boutons with over twice the average volume, active zone

296 udies revealed a reduced size of mossy fiber boutons, with fewer synaptic vesicles and altered synapt

297 ll PNs reduce synaptic branching and enlarge boutons, with ultrastructural and synaptic reconstitutio

298 4D is to induce stabilization of presynaptic boutons within tens of minutes.

299 y for synaptic vesicle cycling is similar in boutons without mitochondria as in those with mitochondr

300 However, as R7 growth cones become boutons, Wnd levels are further repressed by a temporall