ライフサイエンスコーパス: brachyury

1 ops (nodal) and schmalspur, but not no tail (brachyury).

2 expression of mesoderm markers, including T (Brachyury).

3 idates for direct transcriptional targets of Brachyury.

4 overlap with those of several Wnt genes and brachyury.

5 have screened for downstream target genes of Brachyury.

6 sis of tumor cells expressing high levels of brachyury.

7 s mediated by a key developmental regulator--Brachyury.

8 types produced by loss of the conserved gene brachyury.

9 d the pan-mesodermal expression territory of Brachyury.

10 e that hypoxia accelerates the expression of Brachyury (a mesoderm-specific transcription factor), BM

11 entified as cells that co-express Sox2 and T/brachyury, a criterion used to derive NMP-like cells fro

12 Gli2 directly induces brachyury, a gene required and sufficient for mesodermal

13 Brachyury, a member of the T-box gene family, is require

14 to measure previously undetectable levels of Brachyury, a tissue biomarker for chordoma, in plasma sa

15 in mesoderm differentiation and induction of Brachyury, a transcription factor essential for mesoderm

16 a13b and hoxd13a in combination with reduced Brachyury activity have synergistic posterior body defec

17 pression, we demonstrate that high levels of brachyury also significantly reduce the susceptibility o

18 subpopulation of mesoderm that co-expresses brachyury (also known as T) and Flk-1 (also known as Kdr

19 positive feedback loops, GATA factors, SoxB, Brachyury and a previously underemphasised role for beta

20 t signalling, while high-level FGF maintains Brachyury and can induce ectopic CNH-like cell foci.

21 ts, Notch, and transcription factors such as brachyury and caudal.

22 downregulation of the FGF target genes tbxt/brachyury and cdx4, which mediate anterioposterior axis

23 rved DNA-binding motif originally defined in Brachyury and characteristic of the Tbx family of transc

24 neural factor Sox2 and the mesodermal factor Brachyury and differentiate into neural and paraxial mes

25 reconstitution with WT Shp-2, expression of brachyury and flk-1 and differentiation to hemangioblast

26 pression of the primitive streak (PS) marker brachyury and Flk-1.

27 use embryos have shown that co-expression of Brachyury and FoxA class transcription factors is requir

28 vidence of a synergistic interaction between Brachyury and FoxA in the activation of an individual no

29 expressed by the endoderm downstream of the Brachyury and FoxA transcription factors in the endomeso

30 Here we show that the genes brachyury and goosecoid are expressed in association wit

31 in the second wave of expression, including Brachyury and Mixer, contribute to the regulation of gen

32 sults in a similar motif to that of metazoan Brachyury and other T-box classes.

33 s an amino acid motif similar to a region in Brachyury and Pax9 transcription factors.

34 mong a subfamily of T-box proteins including Brachyury and Tbx10, and among additional nuclear protei

35 wo T-box transcription factors-No tail (Ntl)/Brachyury and Tbx16/Spadetail-cooperatively regulate an

36 Loss-of-function studies of mouse Brachyury and the zebrafish Brachyury ortholog Ntl indic

37 , indicating a potential association between Brachyury and tumor progression.

38 pilin-1 (NRP-1) coincides with expression of Brachyury and VEGFR-2 and identifies endothelial precurs

39 oposed correlation between the expression of Brachyury and Wnt3, two genes reported as expressed radi

40 lated in mouse ES cells by the binding of T (Brachyury) and STAT3 to an enhancer element in the mouse

41 lysis and the examination of sonic hedgehog, Brachyury, and HNF-3 beta gene expression.

42 so known as Kdr), c-Kit, and Nkx2-5, but not Brachyury--and subsequently expressed Isl1.

43 Finally, Brachyury appears to be an excellent marker for the prog

44 Some of the endodermal genes that respond to Brachyury are cytoskeletal modulators that may play a ro

45 itional colonies indicated that they express Brachyury as well as flk-1, SCL/tal-1, GATA-1, (beta)H1

46 nic analysis of the T promoter identifies T (Brachyury) as a direct transcriptional target of the Wnt

47 RNA population from embryos that mis-express brachyury at a stage just prior to the normal onset of e

48 sequence population from embryos expressing brachyury at its peak stage of expression was subtracted

49 ors uniquely establish their own niche--with Brachyury being essential for creating a domain of high

50 show that TBX5 binds to the full palindromic Brachyury binding site and to the half-palindrome, where

51 We find that Tbx3 binds the canonical Brachyury binding site as a monomer and represses transc

52 Mga binds the preferred Brachyury-binding sequence and represses transcription o

53 ts that if the target gene contains multiple Brachyury-binding sites it will be activated early in de

54 to the E2F-binding site but also to Myc- and Brachyury-binding sites.

55 reporter genes containing promoter-proximal Brachyury-binding sites.

56 ne invertebrate, an essential protein called Brachyury binds to specific sites in its target genes.

57 led distinct sequence signatures enriched in Brachyury-bound enhancers.

58 Markers of the early body axis, Brachyury (BRA) and FOXA2, usually showed a concentratio

59 date embryos, the T-box transcription factor Brachyury (Bra) is required for specification and differ

60 of the embryo and consequently tail length: Brachyury, Brachyury the second, and the t-complex tail

61 ic background, such as that of Black and Tan Brachyury (BTBR) mice (a previously reported autism mode

62 The black and tan, brachyury (BTBR) mouse strain with leptin deficiency (Le

63 as identified some direct genomic targets of Brachyury, but little is known about Brachyury targets i

64 in no binding site can still be activated by Brachyury, but only indirectly by an earlier Brachyury-d

65 solution chromosomal localization mapping of Brachyury by ChIP sequencing and ChIP-exonuclease reveal

66 While the T-box transcription factor Brachyury (called No Tail in zebrafish) is a key mediato

67 developmental expression patterns of Notch, brachyury, caudal, and eight Wnt genes have now been det

68 e development, and mis-expression of Xenopus Brachyury causes ectopic mesoderm formation.

69 tion of cells generated from activin-induced brachyury(+) cells to the kidney capsule of recipient mi

70 ains functional binding sites for both Ciona Brachyury (Ci-Bra) and FoxA (Ci-FoxA-a).

71 We found that Ciona Brachyury (Ci-Bra) controls most of its targets directly

72 re recently used to identify potential Ciona Brachyury (Ci-Bra) target genes.

73 pstream of the known enhancer that regulates Brachyury (Ci-Bra), a key determinant of notochord speci

74 otochord-specific transcription factor Ciona Brachyury (Ci-Bra).

75 ed an 8 bp core sequence that is part of the Brachyury consensus-binding site.

76 Here we employ a hormone-inducible Brachyury construct and subtractive hybridization to sea

77 Use of the T (brachyury)-cre line led to Fgfr1 inactivation in all lim

78 pment including somite formation, we used T (Brachyury)-Cre mouse line to inactivate Dicer in most ce

79 hat the stromal cells express proteins (Scl, brachyury, Csf-1R, Gata-1, Flk-1, and Tie-2) that charac

80 Brachyury, but only indirectly by an earlier Brachyury-dependent gene product, so later than the dire

81 evolutionary comparison unveiled a detailed Brachyury-dependent gene-regulatory network that directl

82 Here we demonstrate that Xenopus Brachyury directly regulates expression of eFGF by bindi

83 ing site and to the half-palindrome, whereas Brachyury does not bind to the TBX5 site.

84 o carry out a systematic characterization of Brachyury-downstream notochord CRMs.

85 embryo, thereby providing insights into the Brachyury-driven genetic regulatory network and allowing

86 ntify genes that are expressed downstream of brachyury during gastrulation of the sea urchin embryo.

87 on, we show that the only essential role for Brachyury during somite formation is non-cell autonomous

88 homologs, suggesting that the specificity of Brachyury emerged at the origin of Metazoa.

89 is of en route cell populations by utilizing Brachyury, Etv2, or Scl reporter embryonic stem cell lin

90 At no time is Brachyury expressed in the stomochord, the putative homo

91 the animal, separated from the anterior oral brachyury-expressing region by a dorsal domain of ectode

92 e UTX KO embryos show severe defects in both Brachyury expression and embryonic development of mesode

93 Brachyury expression cannot be detected again until meta

94 uired for Wnt/beta-catenin signaling-induced Brachyury expression in ES cells.

95 ychodera and, by comparison with patterns of Brachyury expression in the indirect development of echi

96 Brachyury expression in the vegetal plate is confined to

97 age of human lung tumor tissues positive for Brachyury expression increased with the stage of the tum

98 at UTX controls mesoderm differentiation and Brachyury expression independent of H3K27 demethylase ac

99 , UTX regulates mesoderm differentiation and Brachyury expression independent of its enzymatic activi

100 Brachyury expression is not detected during the 5 months

101 Brachyury expression occurs in two distinct phases.

102 Brachyury expression patterns for Strongylocentrotus pur

103 nts of the proximal epiblast do not restrict Brachyury expression to the posterior epiblast.

104 cell colonies in that they typically lacked Brachyury expression, consistent with their post-mesoder

105 vel genetic interaction in which Mix induces Brachyury expression, standing in contrast to the relati

106 nstituted ES cells to mesoderm, by measuring brachyury expression, to hemangioblasts, by measuring bl

107 nic cancer cell lines with various levels of brachyury expression, we demonstrate that high levels of

108 in portions of the endoderm coincident with brachyury expression.

109 n of the 11-bp NREs in the promoter elevated Brachyury expression.

110 ompensates for the loss of UTX in regulating Brachyury expression.

111 the role of Brachyury is supportive of a Wnt-Brachyury feedback loop during PAE in S. kowalevskii, es

112 We propose that caudal/Cdx, brachyenteron/Brachyury, fork head/HNF-3, and wingless/Wnt constitute

113 lation defined by the coexpression of either Brachyury, Foxa2 and c-Kit, or c-Kit and Cxcr4.

114 gene-regulatory feedback loop consisting of Brachyury, Foxa2, and Sox17 directs proper stem-cell lin

115 how that sudden loss of the mesodermal gene (Brachyury) from CNH and the mesoderm progenitor domain c

116 with message sequence from embryos in which Brachyury function had been "knocked-out" by injection o

117 in sea urchins, and with known or suggested Brachyury function in other species.

118 in gastrulation induced by interfering with Brachyury function in sea urchins, and with known or sug

119 We also show that Brachyury functions primarily as a transcriptional activ

120 -8/18, carbonic anhydrase-12, and NC markers brachyury, galectin-3 and CD24 in cells of the NP irresp

121 rs of the mesendodermal regulators Gata4, T (Brachyury), Gata6 and Foxa2, together with Brd4, and act

122 iptomic data, immunolocalization of EOMES, T brachyury, GDF15 and active beta-catenin revealed differ

123 The Ciona Brachyury gene (Ci-Bra) is regulated, in part, by a 434-

124 hancer from the promoter region of the Ciona Brachyury gene (Ci-Bra), which is sufficient to direct a

125 the regulation of a notochord-specific Ciona Brachyury gene (Ci-Bra).

126 Ptychodera flava, and the expression of the Brachyury gene during this process.

127 d in this study with that of the orthologous Brachyury gene in an indirectly developing enteropneust

128 loss of Fgf8b disrupts the induction of the brachyury gene in the pregastrular embryo and, in additi

129 hese results and other data suggest that the brachyury gene transduces information about the state of

130 lopment, inducing the mesodermally expressed brachyury gene up to 10 cell diameters from a localised

131 However, the brachyury gene was present in the common ancestor of fun

132 at is the product of a premature stop in the brachyury gene.

133 and SpBra, the orthologue of the vertebrate Brachyury gene.

134 xpressing P19 cells resulted in decreased T (Brachyury) gene expression, a DNA-binding transcription

135 The duplicated region contains only the T (brachyury) gene, which is important in notochord develop

136 ilencing of the one-eyed-pinhead and no-tail/brachyury genes.

137 re defined a 'developmental clock' using the Brachyury-GFP signal onset timing.

138 Onset timing of Brachyury-GFP was highly variable across EBs, while the

139 strated that FGF-2 induced the expression of brachyury, goosecoid, and myo-D in regions of treated ex

140 s enhancer contains two sets of low-affinity Brachyury half-sites, which are bound in vitro by a GST/

141 A homologue of the T-box gene, Brachyury, has been isolated from hydra.

142 T-box genes related to brachyury have also been implicated in hindgut patternin

143 Our results indicated that resistance of brachyury-high tumor cells to immune-mediated attack was

144 ce between unicellular holozoan and metazoan Brachyury homologs, suggesting that the specificity of B

145 escued by coinjection of the T-box gene ntl (Brachyury homologue), which is typically required for th

146 A comparison of the function of the Brachyury homologues suggests an evolutionary conservati

147 Lysine 149 of Xbra is conserved in all Brachyury homologues, while the corresponding amino acid

148 ays 7.5 and 8.5 expressed both HNF-3beta and Brachyury in a pattern similar to those of pre- and earl

149 represses Brachyury in Xenopus, it activates Brachyury in axolotl.

150 Here, recent advances targeting Brachyury in chordoma are discussed and how these might

151 k and allowing us to compare the function of Brachyury in different species.

152 promoter microarrays to identify targets of Brachyury in embryoid bodies formed from differentiating

153 Overexpression of Brachyury in human carcinoma cells induced changes chara

154 expression of the T-box transcription factor brachyury in human carcinomas drives the phenomenon of e

155 Our results point to an ancient role for brachyury in morphogenesis, cell polarity and the patter

156 phenotype, demonstrating an ancient role for Brachyury in patterning all but the most anterior somite

157 The selective expression of Brachyury in tumor cells and its role in EMT and cancer

158 T(c) mouse model supports a crucial role of Brachyury in up-regulating multiple key hematopoietic an

159 While Mix represses Brachyury in Xenopus, it activates Brachyury in axolotl.

160 unction of no tail (ntl, homologous to mouse brachyury) in DFCs without affecting its expression in o

161 We also showed PGC induction by Brachyury, in the presence of BMP4.

162 on of the key notochord transcription factor Brachyury, indicating that Brachyury is not a notochord

163 C genes are likely to be indirect targets of Brachyury-induced signaling from the surrounding endoder

164 we show that the T-box transcription factor Brachyury induces in tumor cells epithelial-mesenchymal

165 nter in which the Notch and Wnt pathways and brachyury interact.

166 Brachyury is a direct target of canonical WNT signaling,

167 Brachyury is a member of the T-box gene family and is re

168 Brachyury is a sequence-specific transcriptional activat

169 Brachyury is a transcription activator, and its ability

170 Brachyury is a transcription factor that functions in ga

171 a overexpression of the transcription factor Brachyury is associated with enhanced secretion of multi

172 Since Brachyury is considered to have a major role in mesoderm

173 Brachyury is emerging as an exciting new drug target for

174 The T box transcription factor Brachyury is essential for the formation of the posterio

175 In ascidians, such as Ciona intestinalis, Brachyury is expressed exclusively in the notochord and

176 In vertebrates, Brachyury is expressed throughout the presumptive mesode

177 n embryos dissected between 5.5 and 6.5 dpc, Brachyury is first expressed in the distal extra-embryon

178 nscription factor Brachyury, indicating that Brachyury is not a notochord master regulator gene as st

179 the ascidian Ciona, in which the single-copy Brachyury is notochord-specific and CRMs are easily iden

180 Since Xenopus brachyury is proposed to regulate fgf expression, and FG

181 It is known that the transcription factor Brachyury is required for notochord formation in all cho

182 Here we show that Brachyury is specifically down-regulated in Wnt3a mutant

183 more, our functional analysis of the role of Brachyury is supportive of a Wnt-Brachyury feedback loop

184 Brachyury is the founder member of the T-box family of t

185 Our data confirm that Brachyury is the most ancient member of the T-box family

186 mpensation and the recent demonstration that Brachyury is the prototype for an evolutionarily conserv

187 In the embryo, Brachyury is transcribed during gastrulation in the futu

188 e associated with dorsal mesoderm formation, brachyury, is expressed normally in alpha6 integrin-pert

189 c differentiation-related factors, including Brachyury, KDR, SCL, GATA2, and PU.1.

190 - EBs, associated with delayed expression of Brachyury, Klf1, and Gata1.

191 movements during gastrulation [no tail (ntl)/brachyury, knypek (kny) and pipetail (ppt)/wnt5] interac

192 rd alters an amino acid within the conserved brachyury-like domain.

193 he green fluorescent protein targeted to the brachyury locus demonstrates that the haemangioblast is

194 uorescent protein (GFP) cDNA targeted to the brachyury locus, we demonstrate that endoderm develops f

195 the foxa2 locus in addition to GFP from the brachyury locus.

196 e in EMT and cancer progression suggest that Brachyury may be an attractive target for antitumor ther

197 esults thus chart a comprehensive map of the Brachyury-mediated gene-regulatory network and how it in

198 v/Xlefty)-mediated functional antagonism and Brachyury-mediated transcriptional suppression.

199 Both approaches induced BRACHYURY(+) mesoderm of distinct PS-like identities, wh

200 Analysis of the spatial distribution of brachyury(+) midline cells shows that the Cfl1 mutant mi

201 ur results suggest that Wnt3a, signaling via Brachyury, modulates a balance between mesodermal and ne

202 Brachyury mRNA expression in the primitive streak of RIa

203 Axin2, Fgf8 and Wnt3a, is down regulated in Brachyury mutant embryos and we demonstrate that they ar

204 as the spadetail mutant of zebrafish and the Brachyury mutant of the mouse, which both similarly exhi

205 fish tbx16/spadetail, nieuwkoid/bozozok, and Brachyury/no tail genes with dsRNA from the bacterial la

206 Our results reveal that neither Brachyury nor Wnt3 forms a ring of expression in the pro

207 Examination of the expression of brachyury, not, goosecoid, and papc indicated that conve

208 s targeting the zebrafish golden and no tail/Brachyury (ntl) genes and developed a budding yeast-base

209 FGF signaling represses the NMP markers brachyury (ntla) and sox2 through regulation of tbx16 an

210 ith severe mesodermal defects that phenocopy brachyury null mutants.

211 rate functional conservation of a homolog of Brachyury of the protist Capsaspora owczarzaki in Xenopu

212 the T-box-containing transcription factors, Brachyury or Tbx6, also lack paraxial mesoderm.

213 The Brachyury, or T, gene is required for notochord developm

214 We have identified a second zebrafish Brachyury ortholog (Bra), and show that a combined loss

215 ranscription factors spadetail (spt) and the brachyury ortholog no tail (ntl) are together essential

216 mbryo, represses expression of the zebrafish brachyury ortholog no tail (ntl), causing a failure to s

217 es the expression of an ectopic patch of the brachyury ortholog no tail and leads to the formation of

218 studies of mouse Brachyury and the zebrafish Brachyury ortholog Ntl indicated that Brachyury plays a

219 The chick Brachyury orthologue and two related chick T-box genes t

220 of the mesenchymal and invasive features of Brachyury-overexpressing tumor cells and show that IL-8

221 Brachyury overexpression also repressed E-cadherin trans

222 ed the importance of HS for the induction of Brachyury(+) pan-mesoderm as well as normal gene express

223 rafish Brachyury ortholog Ntl indicated that Brachyury plays a more significant role in higher verteb

224 p is a direct target gene of Ci-Bra and that Brachyury plays an immediate role in the cellular morpho

225 we demonstrate that endoderm develops from a brachyury(+) population that also displays mesoderm pote

226 in supporting hematopoiesis after specifying brachyury-positive mesoderm.

227 in the mouse arise in the early embryo from Brachyury-positive multipotent cells in the posterior-pr

228 To explore ancestral roles of brachyury prior to the evolution of definitive mesoderm,

229 UTX and UTY bind directly to Brachyury promoter and are required for Wnt/beta-catenin

230 Jmjd3 reduces H3K27me3 marks at the Brachyury promoter and facilitates the recruitment of be

231 We further show that ntl and Brachyury promoter regions contain functional kappa B si

232 tration-dependent downregulation of cellular brachyury protein levels in all models tested.

233 notably the muscle specifier Macho-1 and 50 Brachyury-regulated notochord genes, as well as several

234 ta significantly change the understanding of Brachyury regulation in Xenopus, implying the existence

235 osterior development, functioning in the FGF-brachyury regulatory loop.

236 ntage of the system to provide evidence that Brachyury represses neural differentiation and that sign

237 Conversely, inhibition of Brachyury resulted in downregulation of mesenchymal mark

238 the binding preferences of the C. owczarzaki Brachyury results in a similar motif to that of metazoan

239 homozygous mutants, indicating that loss of brachyury results in stochastic fate transformation.

240 transcription activator of both Myc-Max and Brachyury site-containing reporters in a Max-dependent m

241 vity and expression of the mesodermal marker brachyury, suggesting that ERK1 can compensate for ERK2

242 g a syndromic ASD model, e.g., Black and Tan BRachyury T(+)Itpr3(tf)/J (BTBR) mice, we revealed that

243 p1, Ncdn and Nrp-1), transcriptional factor (Brachyury T), and cell surface receptors (CD24, CD90, CD

244 ebrate 'mesodermal' genes, such as nodal and brachyury T, are likely to ancestrally have been involve

245 Bmp-4), and the transcription factors of the Brachyury T-Box family (Tbx2-Tbx5) and Lung Kruppel-like

246 afish spadetail (spt)/VegT and no tail (ntl)/Brachyury T-box genes are semi-redundantly and cell-auto

247 be detected during the transitory phase from Brachyury (T) (+) mesendoderm toward a CXCR4 (+) DE stat

248 Mesodermal markers mox-1, Notch-1, Brachyury (T) and Sonic hedgehog (Shh) were expressed in

249 notably, upregulation of mesendoderm genes, Brachyury (T) and Sox17.

250 onal analysis has demonstrated that Fgf8 and Brachyury (T) are required for normal mesoderm and left-

251 Because brachyury (T) denotes mesoderm specification, a mouse ES

252 ouse conceptuses homozygous for mutations in brachyury (T) exhibit a short, misshapen allantois that

253 he domain of expression of the streak marker Brachyury (T) expands more than 3-fold, from a narrow st

254 In addition, CD protein (CD24 and CD90) and Brachyury (T) expression in immature disc cells were als

255 putative transcription factors including the Brachyury (T) gene product.

256 ions of the notochordal transcription factor brachyury (T) in up to 27% of cases.

257 The T-box transcription factor Brachyury (T) is essential for formation of the posterio

258 Brachyury (T) is the founding member of this T-box trans

259 ications in notochordal transcription factor brachyury (T), PI3K signalling mutations, and mutations

260 econd (T2) gene is 15 kb away from classical Brachyury (T).

261 The transcription factor brachyury (T, BRA) is one of the first markers of gastru

262 d and the onset of gastrulation, marked by T/Brachyury (T/Bra) at the posterior of the embryo.

263 of mesodermal markers prior to expression of Brachyury/T and acceleration of the mesodermal developme

264 This leads to a graded repression of the Brachyury/T transcription factor, reducing mesoderm ingr

265 s essential for its biological function, but Brachyury target genes have proved difficult to identify

266 factor binding in the regulatory regions of Brachyury target genes in rodents.

267 uence 5'-TCACACCT-3' in the vicinity of most Brachyury target genes.

268 leotide to generate a differential probe for brachyury target genes.

269 mbryos and we demonstrate that they are also Brachyury targets in the human.

270 gets of Brachyury, but little is known about Brachyury targets in the mouse.

271 Expression of the transcription factor brachyury (TBXT) is normally restricted to the embryo, a

272 at the developmental transcription factor T (brachyury; TBXT) is the top selectively essential gene i

273 The mouse Brachyury the Second (T2) gene is 15 kb away from classi

274 ryo and consequently tail length: Brachyury, Brachyury the second, and the t-complex tail interaction

275 We previously noted that the chick T gene (Brachyury), the prototypical T-box transcription factor,

276 brachyury, the founding member of the T-box gene family,

277 ectopic domains of the gastrulation marker, BRACHYURY This phenotype, and increased epiblast prolife

278 The ability of Brachyury to activate transcription is essential for its

279 n concert with the niche-establishing factor Brachyury to allow mesoderm formation.

280 Furthermore, we found Brachyury to be overexpressed in various human tumor tis

281 network that directly links the function of Brachyury to diverse developmental pathways and cellular

282 data demonstrate small-molecule targeting of brachyury transcription factor addiction in chordoma, id

283 analyses of the expression of HNF-3beta and Brachyury, two molecular markers for gastrulation, showe

284 The interaction between Mix and Brachyury, two transcription factors involved in the est

285 of FGF/Erk signalling mediates this loss of Brachyury upstream of Wnt signalling, while high-level F

286 oup, they reveal the evolutionary history of Brachyury utilization in deuterostomes.

287 ue of the T-box family transcription factor, Brachyury, was cloned through a candidate gene approach.

288 regulation of the T-box transcription factor brachyury We find in zebrafish that FGF is continuously

289 nd the amount of nascent mesoderm expressing Brachyury were both severely reduced.

290 ucts has come mainly from the prototypical T/Brachyury, which is a transcription activator.

291 e find that the genes caudal, orthopedia and brachyury-which are expressed in various bilaterian hind

292 age of immature NP cells expressing CD24 and Brachyury, while higher percentage of immature AF cells

293 ing the molecular phenotype of C. owczarzaki Brachyury with that of homologs of early branching metaz

294 d interaction of the family members Tbx3 and Brachyury with the CRM1 exporter, suggesting general sig

295 of the early vertebrate embryo depends on a Brachyury/Wnt autoregulatory loop within the posterior m

296 the polarized expression domains of Xenopus brachyury (Xbra) and Xenopus nodal-related factor 2 (Xnr

297 pression of Sox17 in vegetal blastomeres and Brachyury (Xbra) in marginal blastomeres.

298 expression of the general mesodermal marker Brachyury (Xbra) requires a zygotic, ligand-dependent Wn

299 at confers mesodermal identity in Xenopus is Brachyury (Xbra), which is required for normal gastrulat

300 The Xenopus homologue of Brachyury, Xbra, is expressed in the presumptive mesoder