ライフサイエンスコーパス: brain

1 aques and tau neurofibrillary tangles in the brain.

2 oss species and extensively expressed in the brain.

3 me and the increasing size of the developing brain.

4 eenter systemic circulation, and seed in the brain.

5 d various barrier mechanisms surrounding the brain.

6 id (CSF) and a key barrier between blood and brain.

7 djusted to reproduce data collected from the brain.

8 of amyloid-like protein deposits within the brain.

9 nsequent serine and glycine elevation in the brain.

10 y because of its prevalent expression in the brain.

11 s to potentiate inhibitory signalling in the brain.

12 d improve synaptic dysfunction in 3xTg mouse brain.

13 totic surveillance pathway in the developing brain.

14 rodents and imaging-based analyses of human brains.

15 ferent types of uncertainty across mammalian brains.

16 y affected vessels of human CADASIL-affected brains.

17 o understand the mechanisms underlying these brain abnormalities and to explore interventions to miti

18 onstantly informed by internal priors in the brain acquired from past experiences, but the neural mec

19 uate and constrain computational models with brain activity and pushes our understanding of human bra

20 owever, previous studies focus on changes in brain activity related to motor execution.

21 nts in a group of healthy males and measured brain activity with positron emission tomography.

22 or ability, brain microstructure, functional brain activity, and alpha-syn pathology by longitudinall

23 han lower processing levels, as in the human brain, activity in low-level visual areas should encode

24 in the 21st century is to understand how the brain adapts with experience.

25 Brain administration of rIFN-beta resulted in microglial

26 tablishing a comprehensive cell-atlas of the brain, although its capacity for retrograde transport cu

27 Drug delivery to the brain always remains a challenging issue for scientists

28 Whole-brain analyses of cortical thickness were conducted both

29 spatial generalized linear mixed model whole-brain analysis identified left V3/V3A as the area with t

30 Tolls demarcate a map of brain anatomical domains.

31 tential functional corollaries of sex-biased brain anatomy in humans.

32 e predicted from parallel changes in overall brain anatomy.

33 s of the long-range traffic of DAT in intact brain and acute brain slices from the knock-in mouse exp

34 interact with synapses throughout the whole brain and are recognized as regulatory elements of excit

35 largest of which appeared to project to the brain and decorate the appendage neuromeres.

36 ling pathways from the gut microbiota to the brain and discuss direct effects that gut bacterial mole

37 to the rs6971 genetic polymorphism in human brain and heart samples.

38 pends on the developmental stage of the host brain and is limited by the migration time and the incre

39 hyde (alpha-AASA) and pipecolic acid both in brain and liver tissues, similar to the biochemical pict

40 Radiometabolites from brain and other tissues were measured ex vivo and in vit

41 nstrated significantly reduced uptake in the brain and periphery of lipopolysaccharide mice compared

42 led receptor that is highly expressed in the brain and represents a promising therapeutic target for

43 etworks (RSNs) are interconnected across the brain and spinal cord is unclear.

44 ce from multiple levels including molecular, brain, and behavioral indicates that these epigenetic bi

45 perform circuit tracing in the D. sechellia brain, and find that receptor adaptations are accompanie

46 this disease and provided new insights into brain angiogenesis by showing uncoupling of vessel morph

47 esentation in the mPFC and across the social brain appeared to cluster targets into three social cate

48 elations among these fluctuations across the brain are interpreted as "functional connections" for ma

49 evated levels of beta-amyloid (Abeta) in the brain are thought to contribute to the cognitive impairm

50 orders and neural circuit changes in several brain areas, but the cellular mechanisms that underlie t

51 B2/nesfatin-1 is expressed in reward-related brain areas, its role in regulating motivation and prefe

52 small adjustments of neural circuitry in key brain areas.

53 In A Randomized trial of Unruptured Brain Arteriovenous malformations (ARUBA), randomisation

54 However, the changes that occur in the brain as this learning takes place are poorly understood

55 might be more focal on frontal areas of the brain, as opposed to global differences.

56 his chemokine storm was also detected in the brain at day 6.

57 chanism and the effect of PEA-OXA on the gut-brain axis in rats subjected to experimental colitis ind

58 Chronic social stress alters blood-brain barrier (BBB) integrity through loss of tight junc

59 that pharmacologic restoration of the blood-brain barrier (BBB), 12 mo after murine TBI, is associat

60 ameliorate Plasmodium parasite growth, blood-brain barrier dysfunction, and mortality in a mouse mode

61 uncoupling of vessel morphogenesis and blood-brain barrier formation.

62 adipoRon (APN receptor agonist) was a blood-brain barrier penetrant.

63 ed in major cellular components of the blood-brain barrier, including endothelial cells and astrocyte

64 ty due to its ability to penetrate the blood-brain barrier.

65 singly dispensable for maintaining the blood-brain barrier.

66 We performed behavioral and brain-based experiments, with the latter employing elect

67 These results provide novel behavioral and brain-based targets for treatment of pediatric anxiety d

68 ate the approach, we investigated structural brain-behavior associations in an extensively phenotyped

69 that does not harmonize with the notion that brain-behavior relationships are flexible and may involv

70 ms to brain networks, providing insight into brain-behaviour relationships in patients with dementia.

71 e expression levels from 21 tissue datasets (brain; blood; thyroid, adrenal, and pituitary glands).

72 Keywords: Adults and Pediatrics, Brain/Brain Stem, CNS, Computer Aided Diagnosis (CAD), C

73 as necessary for angiogenic sprouting in the brain, but surprisingly dispensable for maintaining the

74 the characterization of N-glycans in rodent brains, but there is a lack of spatial resolution as eit

75 Glioblastoma is a devastating form of brain cancer.

76 oid tumors (ATRTs) are challenging pediatric brain cancers that are predominantly associated with ina

77 peutic strategies for these presently lethal brain cancers.

78 he mood disorders, particularly in the mouse brain cell types implicated by the expression patterns o

79 igate SARS-CoV-2 infection susceptibility of brain cells, mechanisms of virus-induced brain dysfuncti

80 al molecules are likely exerting on specific brain cells.

81 ovides powerful and persistent inhibition to brain centers involved in regulating sleep and activity.

82 Brain changes in response to binge EtOH treatment were m

83 How these structural and functional brain changes may relate to the cognitive and affective

84 these properties, but their relationship to brain circuits is unclear.

85 Within mammalian brain circuits, activity-dependent synaptic adaptations,

86 the same individuals and in two independent brain collections (BA10, N = 81 and 64).

87 ng, but also shed light on how the mammalian brain computes stereopsis.

88 Structural brain connectivity of the amygdala, fornix, uncinate fas

89 ry properties, and are well tolerated by the brain, D-serine, an endogenous amino acid, offers new ho

90 Using data from patients with focal brain damage, we demonstrate that there is a strong psyc

91 ithin subpopulations of neurons/glia for the brain data and granulocytes/T cells/B cells/monocytes fo

92 increase in younger HCV viremic donors after brain death being identified.

93 ltivariate pattern classification, and whole-brain decoding with L1 or L2 regularization-each have cr

94 beta mRNA expression in females, and reduced brain derived neurotrophic factor mRNA in males.

95 r (GR) and plasma corticosterone, as well as brain-derived neurotrophic factor (BDNF) and total perce

96 KB), while PNN component aggrecan attenuates brain-derived neurotrophic factor (BDNF)-induced pTRKB i

97 gs establish conserved aspects of sex-biased brain development in humans and mice, and shed light on

98 ete in the brain during childhood and affect brain development.

99 investigate the effect of PCE on early human brain development.

100 nity of pathogenic hallmarks of AD and other brain diseases.

101 MG2G method can be used in studying multiple brain disorders and injuries, e.g., in Parkinson's disea

102 Brain dopamine is critical for normal motor control, as

103 an aberrant functional reorganization of the brain during adolescence.

104 chain n-3 PUFAs (n-3 LCPUFAs) accrete in the brain during childhood and affect brain development.

105 of brain cells, mechanisms of virus-induced brain dysfunction, and treatment strategies.

106 o comprehensively characterize subclasses of brain endothelial cells (ECs) under both normal conditio

107 Clonal relatedness between the actor (brain fluke) and recipients (abdomen flukes) enables kin

108 tivity and pushes our understanding of human brain function further along the spectrum from strict mo

109 ting how cerebrospinal fluid (CSF) regulates brain function.

110 NT Brain tissue iron is essential to healthy brain function.

111 erature has examined social status-dependent brain gene expression profiles across vertebrates, yet s

112 rogression, but this approach did not reduce brain glycogen or LBs to levels below those at the time

113 ntly unavailable, major efforts in improving brain health need to focus on prevention, with emphasis

114 entical, in cell and synapse numbers between brain hemispheres.

115 ce of amyloid-beta and tau deposition in the brain, hippocampal atrophy and increased rates of hippoc

116 of synaptic changes and apply the method to brain homogenates from an Alzheimer's disease mouse mode

117 ine the role of peripheral ORs in triggering brain hypoxia, we used oxygen sensors in freely moving r

118 in rats shows that a specific circuit in the brain [i.e., neurons that project from the central amygd

119 red white matter integrity (p = 2.5x10-7) in brain images from 1,738 young healthy adults, providing

120 s were evaluated for their impact on the PET brain imaging data.

121 neurobiologically informed subtypes based on brain imaging data.

122 Field-based brain imaging research, including populations underrepre

123 temporary statistical methods for functional brain imaging-including univariate contrast, searchlight

124 homeostatic mechanisms in the intact central brain in vivo.

125 or the effect of an immunomodulatory drug on brain-infiltrating leukocytes.

126 f reactions leading to primary and secondary brain injuries and permanent neurological deficits.

127 and plays a protective role in ZIKV-mediated brain injuries.

128 s, e.g., in Parkinson's disease or traumatic brain injury (TBI), and hence it will be useful to the w

129 fections in the postacute phase of traumatic brain injury impede optimal recovery and contribute subs

130 Disparities in traumatic brain injury outcomes for ethnic minorities and the unin

131 ring brain tissue deformation from traumatic brain injury.

132 ession analyses, we examined associations of brain insulin signaling with diabetes, AD, and level of

133 istributed assemblies composed of individual brains, intragenerational and intergenerational interact

134 bralis (PI), a neuro-secretory center in the brain involved in homeostatic control, and express insul

135 point for creating mechanistic framework of brain IR in further development of personalized medicine

136 The brain is a critical target for developmental endocrine d

137 ctions, but how these are implemented in the brain is poorly understood.

138 pact on cognitive ageing in younger, healthy brains is less clear.

139 amniotes and may indicate an early origin of brain lateralization.

140 roach suboptimal for treatment of the global brain lesions present in most human neurogenetic disease

141 LASP1 and LASP2 are highly expressed in the brain, little is currently known about their function in

142 netrin-1 and DCC is maintained in the adult brain, little is known about their role in mature neuron

143 nal, virus was only isolated from some lung, brain, liver, and kidney samples that were ZsG and/or PC

144 Upon passive staining of mouse brain, lung or intestinal tissue surface with minute qua

145 h parenchymal microglia and extraparenchymal brain macrophages in homeostasis and during disease.

146 orm of rhombencephalosynapsis, a distinctive brain malformation characterized by partial or complete

147 Here, we investigate the basic brain mechanisms underlying the anxiogenic impact of sle

148 astuzumab emtansine, who had or did not have brain metastases, to receive either tucatinib or placebo

149 in patients with HER2-positive breast cancer brain metastases.

150 and brain microenvironment, thereby inducing brain metastatic competence.

151 ing the interaction between cancer cells and brain microenvironment, thereby inducing brain metastati

152 oral relationship between locomotor ability, brain microstructure, functional brain activity, and alp

153 Connections between the gut and brain monitor the intestinal tissue and its microbial an

154 lusion An artificial intelligence system for brain MRI approached overall top one, top two, and top t

155 The SI for up to eight brain MRI examinations per patient was measured, and rel

156 performed repeated structural and functional brain MRI in 108 Barcelona participants.

157 comparison was made with gadolinium-enhanced brain MRI performed approximately 9 years earlier (Figs

158 On brain MRI, within 1 year there was stabilization of T2/F

159 y, we performed metabolite profiling in both brain (n = 109) and matching serum samples (n = 566) to

160 In 3 collections of human postmortem brain (n = 206) and 1 collection of blood samples (N = 1

161 translocation into different regions of the brain, nanomaterials may induce neurotoxicity through mu

162 Therefore, predictive brains need abstract value representations.

163 ntation of temporal information in the human brain needed to form episodic memories.

164 establishing a firm link between macro-scale brain network organisation and conscious cognition requi

165 cognitive, and neuropsychiatric symptoms to brain networks, providing insight into brain-behaviour r

166 ze to syndrome-specific and symptom-specific brain networks.

167 ell as greater activity in attention-related brain networks.

168 This study revealed a total of 33 brain neuropils and 30 neuronal fiber tracts including s

169 In brain, neuroprotective pathways were identified as poten

170 analgetic agent with very high affinity for brain nicotinic acetylcholine receptors (nAChR).

171 Dysregulation of homeostatic and hedonic brain nuclei can lead to pathological feeding behaviors,

172 , dentatorubrothalamic tract, and other deep brain nuclei cannot be clearly identified.

173 ic CREs recombine in auditory and vestibular brain nuclei, making it difficult to ascribe resulting p

174 e Pax6 expression is maintained in the adult brain of lungfishes, in distinct regions of the telencep

175 ocessing of auditory information, within the brain of the African wild dog closely resembles that obs

176 bution has been much more limited within the brains of large animals compared to rodents, rendering t

177 Decreased TET enzymatic activities in the brains of persons who died with AD suggest that this red

178 The brains of young songbirds develop motor circuits that ac

179 How the brain orchestrates this integration process has been lar

180 l alterations provides information regarding brain organisation and its underlying biological propert

181 However, the current iterations of brain organoids also have limitations in faithfully reca

182 tropism and support the use of hiPSC-derived brain organoids as a platform to investigate SARS-CoV-2

183 acterization of non-tumor hemodynamics (e.g. brain), other preclinical disease models (e.g. stroke),

184 lieved to be peripherally restricted, affect brain oxygen responses induced by intravenous heroin at

185 g still powerfully attenuates heroin-induced brain oxygen responses.

186 ) followed by in vivo selection in mouse for brain parenchyma penetrating antibodies.

187 the tight extracellular migration tracts in brain parenchyma, allowed high-content time-resolved ima

188 reases with age and is a robust predictor of brain pathology including Alzheimer's and other dementia

189 n abnormalities in sleep and anxiety-related brain pathways is presented.

190 -1,3,4-oxadiazole analogues may have limited brain permeability.

191 We recently developed a brain-permeable EP2 antagonist 1 (TG6-10-1), which displ

192 These compounds emerge as interesting brain-permeable multitarget compounds, with a potential

193 luding neurodegeneration, dementia and other brain phenotypes.

194 roup consisted of patients with a history of brain radiation therapy or craniotomy who underwent 1.5-

195 arameters were obtained (i.e., mean tumor-to-brain ratios [TBR], time-to-peak values).

196 Global brain redistribution of contrast agent was heterogeneous

197 ecific GCN edges, we determined how well the brain region samples could be discriminated from each ot

198 ubecestat might cause hippocampal (and other brain region) volume loss by assessing its relationship

199 Using the expression profiles of brain region-specific GCN edges, we determined how well

200 lasts are transcriptionally distinct between brain regions and identify a regionally localized pial s

201 is known to process information from various brain regions and relay it to other brain regions, servi

202 Molecular disruptions within limbic brain regions and the periphery contribute to depression

203 computational phenotyping method that groups brain regions from MRI and subsets of neuropsychological

204 he results suggest collaboration of multiple brain regions in control of multistep behavior, with MD

205 peripheral inflammatory cells and networked brain regions involved in threat and reward processing.

206 l inputs to principle neurons of associative brain regions is established during development is unkno

207 tterns of resting-state connectivity between brain regions predict differential outcome to antidepres

208 fected rhesus macaques, we analyzed multiple brain regions through acute and chronic infection (90 da

209 first to investigate normal ageing in these brain regions using 7T (1)H-MRS and findings indicate th

210 various brain regions and relay it to other brain regions, serving an essential role in sensory perc

211 e networks connecting anterior and posterior brain regions.

212 ferences in afferent connectivity with other brain regions.

213 nd parameters for a wide range of probes and brain regions.

214 e of volumetric MRI changes for a variety of brain regions; and (ii) understand the mechanism through

215 ndings are crucial for understanding how the brain regulates information flow across senses to intera

216 complexities limit the explanatory power of brain-related expression quantitative trait loci (eQTL)

217 enesis remain elusive, mainly due to lack of brain-representative experimental systems to study HIV-C

218 We hypothesized that the brain represents possible future rewards not as a single

219 las provides a reference standard for canine brain research and will improve and standardize processi

220 and inhibitory (I) neurotransmitters in the brain, respectively.

221 spontaneous alpha band activity, a prominent brain rhythm known to influence perceptual reports in ge

222 which mediate complex interactions with the brain's cortical processing hierarchy.

223 The brain's endocannabinoid system, the primary target of ca

224 trating that cannabinoids can also alter the brain's initial molecular and epigenetic response to coc

225 es they are important for maintenance of the brain's physiology.

226 ral hierarchy that is thought to reflect the brain's response to cognitive demands.

227 In RNA-Seq analyses of human brain samples from the NYGC ALS cohort, truncated STMN2

228 A benchmark test based on the murine brain samples revealed a highly improved annotation qual

229 However, human brain sampling complexities limit the explanatory power

230 receptor class B type 1 (SR-B1) and CD15 on brain SHH MB cells in vitro, ex vivo, and in vivo.

231 er, the mechanistic basis of this microbiota-brain signalling and its physiological relevance are lar

232 lating and perivascular memory T cells, this brain signature was enriched and the surveilling propert

233 nge traffic of DAT in intact brain and acute brain slices from the knock-in mouse expressing epitope-

234 s performed on non-fixed coronal hemispheric brain slices of 23 patients with progressive multiple sc

235 striatal cell model and HD mouse organotypic brain slices we found that D(1)R-induced cell death sign

236 nerational and intergenerational interacting brains, social constructs, and artifacts.

237 In healthy brains, spatially tuned hippocampal place cells and ento

238 ature DG granule cells (GCs) or by prolonged brain-specific VEGF overexpression culminating in extens

239 We discovered that sleep-wake brain states and motor behaviors are coregulated by shar

240 Deep brain stimulation (DBS) is an effective treatment option

241 to these control nodes, it is theorized that brain stimulation is able to selectively target difficul

242 dystonia may respond differentially to deep brain stimulation of the globus pallidus pars interna (G

243 ta-burst stimulation (iTBS) is a noninvasive brain stimulation treatment that has been approved by th

244 ed the effects of early ketamine exposure on brain structure and function.

245 We obtained significant correlations between brain structure and markers of heart failure including e

246 ether genetic risk for MS is associated with brain structure during early neurodevelopment remains un

247 Brain structure in later life reflects both influences o

248 ng the effects of metformin on cognition and brain structure is feasible in long-term survivors of pe

249 does not require widespread modifications of brain structure, but might be achievable via small adjus

250 -driven motion estimation and correction for brain studies, abdominal studies in which respiratory an

251 Controlling unmodified serotonin levels in brain synapses is a primary objective when treating majo

252 erences in the refinement of borders between brain systems.

253 s enriched and the surveilling properties of brain T(RM) cells was revealed by intravital imaging.

254 minobutyric acid (GABA) at non-image-forming brain targets.

255 led the gradients and regional variations in brain temperatures reported in the literature for awake

256 n tissues and organs, including the ear, the brain, the blood, and the lung, and thus in highly diver

257 ral information is commonly processed in the brain through generation of antagonistic responses to di

258 h the same direction of effect in the second brain tissue (BA25, N = 60) from the same individuals an

259 at greater risk of mechanical damage during brain tissue deformation from traumatic brain injury.

260 ring late adolescence.SIGNIFICANCE STATEMENT Brain tissue iron is essential to healthy brain function

261 e lack of cell-specific targeting methods in brain tissue or living animals.

262 ents that previously went undetected in bulk brain tissue samples.

263 mg/kg; at which naloxone was undetectable in brain tissue) and found that this drug still powerfully

264 racterized by rapid cellular infiltration of brain tissue, raising the possibility that disease progr

265 on the rigidity and the permeability of the brain tissue.

266 s as well as in mitochondria from postmortem brain tissues of unaffected individuals and HD patients,

267 es extracted from cell cultures and human AD brain tissues, demonstrating the ability of the Hsp70 ma

268 cell types with a focus on neurogenesis and brain tissues.

269 and histone acetylation from ASD and control brains to identify a convergent molecular subtype of ASD

270 trajectory of LOAD disease progression from brain transcriptomic data.

271 The aggressive brain tumor glioblastoma (GBM) is characterized by rapid

272 identification revealed deleted in malignant brain tumors 1 (DMBT1) (also known by the aliases GP340

273 feasible in long-term survivors of pediatric brain tumors and that metformin is safe to use and toler

274 Glioblastomas are aggressive primary brain tumors known for their inter- and intratumor heter

275 r, however, its efficacy in highly malignant brain-tumors, glioblastomas (GBM), is limited.

276 ) is a highly aggressive, difficult to treat brain tumour.

277 Primate brains typically have regions within the ventral visual

278 PCR demonstrated viral replication in salmon brains up to 15 days postinjection.

279 ults: Each radioligand gave high early whole-brain uptake of radioactivity, followed by a brief fast

280 Our data suggest that the brain uses theta power and synchronization for flexibly

281 emporal profiles of NT and NM release in the brain using genetically encoded sensors for in vivo stud

282 any NR2B-specific binding of radioligand in brain, various preblocking or displacing agents were eva

283 In the adult brain, vascular endothelial growth factor D (VEGFD) is r

284 sion of the cerebrospinal fluid (CSF)-filled brain ventricles.

285 nt of cilia beat in multiciliated cells from brain ventricles.

286 the difficulties involved studying the human brain via electron microscope techniques.

287 ) characterize the effect of verubecestat on brain volume by evaluating the time course of volumetric

288 e examined studies that reported measures of brain volume using MRI in PubMed, Web of Science, Scopus

289 ave demonstrated reduced global and regional brain volumes in infants with congenital heart disease (

290 lated (34) groups each had generally smaller brain volumes than the optimal controls (71).

291 f visually responsive neurons in the central brain was blocked by transient dFB activation, confirmin

292 lectron microscopic (EM) image of the female brain, we map all inputs and outputs to both pC1d and pC

293 (iPSC)-derived neurons that model developing brains, we identified thousands of genetic variants exhi

294 wave induces a steady streaming to/from the brain which strongly depends on the rigidity and the per

295 etecting pain perception and reaction in the brain, which successfully classified three different sti

296 ow these regions and their interactions with brain-wide activity drive action selection is less under

297 ciative, but concurrently increased sensory, brain-wide connectivity.

298 sponsiveness contrasts strongly with intense brain-wide neural network dynamics.

299 s nutrient absorption and motility(2,3), and brain-wired feeding behaviour(2).

300 tructures of the intact V-ATPase from bovine brain with all the subunits including the subunit H, whi