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1 cally bind to Holliday junctions and promote branch migration.
2 ed, the acceptor accessed the cDNA 3' end by branch migration.
3 ical approach to analyze the mechanism of HJ branch migration.
4 exchange of base pairs known as spontaneous branch migration.
5 n, and then recruits two RuvB pumps to power branch migration.
6 s around the junction remain parallel during branch migration.
7 , presumably by blocking strand exchange and branch migration.
8 DNA, promoting DNA annealing, and promoting branch migration.
9 en propagates towards the primer terminus by branch migration.
10 er by promoting strand exchange invasion and branch migration.
11 accomplish additional activities such as DNA branch migration.
12 day junctions, using ATP hydrolysis to drive branch migration.
13 DnaB binds to just one DNA strand during branch migration.
14 cooperate to promote homologous pairing and branch migration.
15 ese joint molecules to promote ATP-dependent branch migration.
16 tails that equilibrate to many structures by branch migration.
17 on, because a symmetric junction can undergo branch migration.
18 ining protein required for specific tracheal branch migration.
19 evidence that RuvA has a mechanistic role in branch migration.
20 e found that the crosslink failed to inhibit branch migration.
21 y, possibly by Rqh1 catalysing their reverse branch migration.
22 strand annealing, and Holliday junction (HJ) branch migration.
23 ating joint molecules and in the polarity of branch migration.
24 s based on the inhibition of spontaneous DNA branch migration.
25 esolution occurs as the resolvasome promotes branch migration.
26 ancing and receding duplexes of an HJ during branch migration.
27 ng specificity and RuvB drives ATP-dependent branch migration.
28 sed the role of DNA unwinding in relation to branch migration.
29 g over by interfering with Holliday junction branch migration.
30 n relocate through an isomerization known as branch migration.
31 ence heterology to estimate the step size of branch migration.
32 junction such that RuvBC complexes catalysed branch migration.
33 defines the boundaries of Holliday junction branch migration.
34 ge of a Holliday junction during spontaneous branch migration.
35 omologous DNA molecules and subsequent polar branch migration.
36 investigate the thermodynamics of three-way branch migration.
37 lacement, strand separation (unwinding), and branch migration.
38 A strands, effectively halting RecA-mediated branch migration.
39 increase its energy barrier through four-way branch migration.
40 so mismatches almost terminate a spontaneous branch migration.
41 Unfolding of the HJ is required for branch migration.
42 cation fork regression and Holliday junction branch migration.
43 ere that the enzyme efficiently promotes DNA branch migration.
44 as little as a single base stalls catalysed branch migration.
45 e conformational changes in SisPINA to drive branch migration.
46 of the significance of hybrid propagation by branch migration.
47 late-guided alignment proceeding through DNA branch migration.
48 141R, is unable to promote Holliday junction branch migration.
49 ly replaced by a distinct mode of migration: branched migration.
51 e of this mutant reveals that the ATPase and branch migration activities of RecA are not necessarily
53 However, only RPA robustly stimulates WRN branch migration activity and increases the percentage o
56 ts demonstrate a functional link between the branch migration activity of hRad54 and the structure-sp
60 collar at Holliday junctions, promoting DNA branch migration activity while blocking other DNA remod
61 ation of model replication forks through its branch migration activity, but shows strong bias toward
62 rmine whether RPA and POT1 also modulate WRN branch migration activity, we examined biologically rele
67 41 helicase has been shown to catalyze polar branch migration after the T4 gene 59 helicase assembly
71 ion flips between conformations favorable to branch migration and conformations unfavorable to it.
72 del in which Sgs1 helicase catalyzes reverse branch migration and convergence of double HJs for noncr
74 gle base pair mismatch in the invader stalls branch migration and displacement occurs via direct diss
75 which UvsW is a DNA helicase that catalyzes branch migration and dissociation of RNA-DNA hybrids.
79 fication of a protein complex that catalyses branch migration and Holliday junction resolution argues
80 s generally proceed by three-way or four-way branch migration and initially were investigated for the
81 k, the trachea, and show that dVHL regulates branch migration and lumen formation via its endocytic f
82 section of the nascent DNA by RecJ and RecQ, branch migration and processing of the fork DNA surround
83 substitution, deletion or insertion inhibits branch migration and produces stable cruciform structure
84 fractionated human extracts caused a loss of branch migration and resolution activity, but these func
85 enetic and biochemical studies indicate that branch migration and resolution are coupled by direct in
86 al experiments suggest that the processes of branch migration and resolution are linked, coimmunoprec
87 ey also provide insight into the coupling of branch migration and resolution by the RuvABC resolvasom
88 vABC complex that is capable of facilitating branch migration and resolution of Holliday junctions vi
94 on by degrading the displaced strands during branch migration and thereby causing strand exchange to
95 models using a Holliday junction undergoing branch migration and time-lapse atomic force microscopy,
96 those that can undergo a number of steps of branch migration, and confirm that the enzyme exhibits a
97 volving RNase H cleavage, acceptor invasion, branch migration, and finally primer terminus transfer.
99 ion unfolding, which accelerates spontaneous branch migration, and individual time traces reveal comp
100 nded DNA structure is capable of spontaneous branch migration, and is lost during standard DNA extrac
101 tion, displacement-loop (D-loop) processing, branch migration, and resolution of double Holliday junc
102 RuvA and RuvB proteins, which together drive branch migration, and RuvC endonuclease, which resolves
104 nferred rates for hybridization, fraying and branch migration, and they provide a biophysical explana
105 ated using a sensitive assay for spontaneous branch migration, and was shown to preserve both artific
106 e that RecA, recombinational DNA repair, and branch migration are all important for H(2)O(2) resistan
107 theless, the mechanistic models proposed for branch migration are all predicated on a parallel alignm
108 this assay, alterations in end processing or branch migration are reflected by the frequency of co-co
109 lecule FRET experiments led to the model for branch migration as a stepwise stochastic process in whi
110 f p53 on both spontaneous and RuvAB promoted branch migration as well as the effect on resolution of
111 re, we present a single-molecule spontaneous branch migration assay with single-base pair resolution
112 ase has a defined substrate specificity: the branch migration-associated resolvase is highly specific
113 ce dependence of crossover isomerization and branch migration at symmetric sites has been established
116 nge mediated by spontaneous renaturation and branch migration; beta imposed a polarity on the strand
117 eins are known to bind HJs and promote their branch migration (BM) by translocating along DNA at the
118 xample, the combination between toeholds and branch migration (BM) domains is 'hard wired' during DNA
119 Several proteins have been shown to catalyze branch migration (BM) of the Holliday junction, a key in
121 a critical role in modulating its helicase, branch migration (BM), or strand annealing [18, 19].
122 opy data show that the nick does not prevent branch migration, but it does decrease the probability t
124 Holliday junction when the DNA is undergoing branch migration, but RuvA is immobile at the same junct
125 the limits of a previous approach to thwart branch migration, but the design of the 12-arm junction
126 lliday junctions and catalyses ATP-dependent branch migration, but the equivalent proteins in archaea
127 rate that the stimulation of hRad54-promoted branch migration by hRad51 is driven by specific protein
129 Furthermore, we show that TWINKLE catalyzes branch migration by resolving homologous four-way juncti
130 ing binding to duplex DNA and also constrain branch migration by RuvAB in a manner critical for junct
132 chastic process of the junction dynamics and branch migration by the variability of the time that the
133 and those of hRad54 are to promote efficient branch migration, bypass potential mismatches and facili
134 uble crossover molecules to demonstrate that branch migration can occur in antiparallel Holliday junc
135 Our kinetic studies of Holliday junction branch migration catalysed by a ring-shaped helicase, T7
137 vestigated the interaction between the RuvAB branch migration complex and the Topo IV.quinolone.DNA t
141 tion with EcRuvB, it was unable to stimulate branch-migration-dependent resolution in a RuvABC comple
142 ons; these are junctions that cannot undergo branch migration, despite the fact that they are flanked
145 a DNA structure that brings a toehold and a branch-migration domain into close proximity can catalyz
146 ellular data that support RPA enhancement of branch migration during HR repair and, conversely, POT1
147 nt with approximately 0-1, 1-2 and 2-3 bp of branch migration during recombination reactions involvin
149 r, MlRuvA formed functional DNA helicase and branch-migration enzymes with EcRuvB, although the heter
151 -cDNA hybrid is thought to then propagate by branch-migration, eventually catching up with the primer
153 tic Holliday junction was used as substrate, branch migration facilitated by Sep1 could not be detect
155 ons stabilize folded conformations and stall branch migration for a period considerably longer than t
158 All attempts at modeling the kinetics of branch migration have relied on the assumption that bran
159 The data obtained support the model for branch migration having the extended conformation of the
160 s a stepwise stochastic process in which the branch migration hop is terminated by the folding of the
163 model system has been developed for studying branch migration in a small synthetic four-arm junction.
168 the fully exchanged molecules resulted from branch migration in either direction depending on which
169 ese results, we conclude that Rad51-promoted branch migration in either direction occurs fundamentall
170 e we report that the rates of Rad51-mediated branch migration in either the 5'- to 3'- or 3'- to 5'-d
177 e basis of these data, we propose a model of branch migration in which the propensity of the junction
179 ch-migration subunit.Whereas MlRuvA promoted branch-migration in combination with EcRuvB, it was unab
180 is not required for RuvA mobilization during branch migration, in contrast to previous proposals.
181 ng of a single base pair and (ii) initiating branch migration incurs a thermodynamic penalty, not cap
182 displacement processes (toehold-binding and branch migration) independently, and information can be
185 ce studies led to a model according to which branch migration is a stepwise process consisting of con
188 The free energy landscape of spontaneous branch migration is found to be highly nonuniform and go
189 e heterology suggests that the inhibition of branch migration is largely attributable to a thermodyna
190 pendently, we conclude that the step size of branch migration is quite small, of the order of one or
192 ase activity in vitro [12], the mechanism of branch migration is thought to involve DNA opening withi
194 ns interact at Holliday junctions to promote branch migration leading to the formation of heteroduple
196 a junction along DNA, by a process known as branch migration, leads to heteroduplex formation, where
197 The replication fork helicase DnaB catalyzes branch migration like RuvB but, unlike RuvB, is not depe
199 tides unwind an RNA duplex through a toehold/branch migration mechanism, allowing non-enzymatic prime
200 Results suggest that both proximity and branch migration mechanisms contribute to transfers, wit
203 of wild-type NDEL1 levels displayed diverse branched migration modes with multiple leading processes
204 sequence heterologies exert their effects on branch migration more or less independently, we conclude
205 resolvase does not interact directly with a branch migration motor, which simplifies analysis of its
208 e physical process by which a single step of branch migration occurs is significantly slower than the
211 nd that RuvA does not inhibit DnaB-catalyzed branch migration of a homologous junction, even at high
212 e encircling two DNA strands, DnaB can drive branch migration of a synthetic Holliday junction with h
213 or 2D agarose gel analysis are favorable for branch migration of asymmetrically replicating nascent s
216 a junction-specific DNA helicase that drives branch migration of Holliday intermediates in genetic re
218 chia coli RuvA and RuvB proteins promote the branch migration of Holliday junctions during the late s
219 , we also demonstrate that UvsW promotes the branch migration of Holliday junctions efficiently throu
221 ons, but the controversy on the mechanism of branch migration of Holliday junctions remains unsolved.
222 ults strongly support a role for UvsW in the branch migration of Holliday junctions that form during
234 core complex component FANCM also catalyzes branch migration of model Holliday junctions and replica
235 NA), the MmsA protein appears to promote the branch migration of partially exchanged intermediates in
239 The E. coli RuvAB protein complex promotes branch migration of the Holliday junction recombination
240 as molecular motor proteins responsible for branch migration of the Holliday junction(s) and reversa
243 acetyllactosamine (LacNAc) epitopes, induces branching migration of mammary epithelia in vivo, ex viv
248 a DNA-binding protein and can stimulate the branch migration phase of RecA-mediated strand transfer
250 cules from any type of ends on the dsDNA and branch migration proceeds exclusively in the 5'- to 3'-d
253 n initiated with a 3' or 5' overhanging end, branch migration proceeds more rapidly when it is initia
254 iation of double D-loop DNA hybrids is a DNA branch migration process involving the rotation of both
255 ompetitive displacement technique mimics the branch migration process that occurs during DNA recombin
258 These findings suggest that p53 can block branch migration promoted by proteins such as RuvAB and
265 ularly, the concept of "toehold-mediated DNA branch migration reactions" has attracted considerable a
266 be used for subsequent toehold-mediated DNA branch migration reactions, e.g., DNA hybridization chai
268 ions suggest that following invader binding, branch migration results in a 2:3 partition of the templ
271 on Holliday junction DNA that drives coupled branch migration (RuvAB) and resolution (RuvC) reactions
272 re recombination intermediates--and promotes branch migration; RuvC is a junction-specific endonuclea
275 RuvA homologue of M. leprae is a functional branch-migration subunit.Whereas MlRuvA promoted branch-
276 ation, strand-annealing, strand-exchange and branch migration suggest a dual role of TWINKLE in mitoc
280 ctions adopt an unfolded conformation during branch migration that is retained despite a broad range
281 ecules to undergo an isomerization, known as branch migration, that relocates the site of the branch
282 which an invader strand can bind to initiate branch migration, the rate with which strand displacemen
286 s that breathless and pointed control dorsal branch migration through transcriptional regulation of t
287 rimer and acceptor strands then propagate by branch migration to catch the advancing primer terminus.
288 tween homologous DNA molecules but can drive branch migration to extend the region of heteroduplex DN
289 nor RNA, the cDNA-acceptor hybrid expands by branch migration until transfer of the primer terminus i
292 tudies have shown that RuvA and RuvB promote branch migration whereas RuvC resolves junctions by endo
293 54 and hRad51 during DNA strand exchange and branch migration, which are two core steps of homologous
294 tif harbouring a toehold triggers successive branch migration, which autonomously propagates to form
295 ergo a conformational isomerization known as branch migration, which relocates the site of branching.
298 strates that simultaneously exploit four-way branch migration, with a high-energy barrier to minimize
299 y barrier to minimize leakage, and three-way branch migration, with a low-energy barrier to maximize
300 tion factors RecG and RuvAB, RadA stimulates branch migration within the context of the RecA filament