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1 lycolysis/gluconeogenesis, and metabolism of branched chain amino acids.
2 biosynthetic enzymes for heme, cysteine, and branched chain amino acids.
3 proteins that is responsive to both GTP and branched chain amino acids.
4 olderia pseudomallei that is auxotrophic for branched chain amino acids.
5 ed esters arising from partial catabolism of branched chain amino-acids.
6 nd enhanced levels of volatiles derived from branched-chain amino acids.
7 or activation and for feedback inhibition by branched-chain amino acids.
8 lag in growth when nutritionally limited for branched-chain amino acids.
9 tin, C-reactive protein, acylcarnitines, and branched-chain amino acids.
10 protein, E1alpha phosphorylation, and plasma branched-chain amino acids.
11 anscriptional regulator that is activated by branched-chain amino acids.
12 known as yhdG) that encodes a transporter of branched-chain amino acids.
13 etabolites through its activation by GTP and branched-chain amino acids.
14 ain transporters that accumulate proline and branched-chain amino acids.
15 BkdR likely responds to the presence of branched-chain amino acids.
16 ently by altering the intracellular level of branched-chain amino acids.
17 nd sugars, and the genes for biosynthesis of branched-chain amino acids.
18 e availability of key nutrients like GTP and branched-chain amino acids.
19 , an essential enzyme in the biosynthesis of branched-chain amino acids.
20 by AMP deaminase 3 (Ampd3) and catabolism of branched-chain amino acids.
22 rved between patients who received high-dose branched-chain amino acids (222 mg/kg of body weight t.i
23 ncies and growth restriction associated with branched-chain amino acid accumulation and (ii) energy d
24 assic maple syrup urine disease pups reduced branched-chain amino acid accumulation in milk as well a
25 o repress transcription, suggesting that the branched-chain amino acids act as inducers rather than c
27 istently higher content of free amino acids (branched-chain amino acids, alanine, serine, glycine, pr
28 sult from alanine aminotransferase (ALT) and branched-chain amino acid aminotransferase (BcAT)'s high
29 (E. coli aspartate aminotransferase, E. coli branched-chain amino acid aminotransferase, and Bacillus
30 -well plate spectrophotometric assay for the branched-chain amino acid aminotransferases is described
31 In addition, (1)H MRS showed an increase in branched chain amino acid and alanine concentrations.
32 acid metabolism were evident from increased branched chain amino acid and asparagine levels and alte
33 ), and enrichment in metabolic pathways (eg, branched chain amino acids and arginine biosynthesis) an
34 r metabolite biomarkers of diabetes, such as branched chain amino acids and aromatic amino acids, sug
35 S. aureus CodY was activated in vitro by the branched chain amino acids and GTP, CodY appears to link
36 and proteins, including ones in pathways of branched-chain amino acid and fatty acid metabolism and
37 ystal structure of the GAF domain of CodY, a branched-chain amino acid and GTP-responsive regulator o
39 olutionary age analysis revealed that, while branched-chain amino acid and proline catabolism are ver
40 cumulation as well as circulating cytokines, branched-chain amino acids and acylcarnitines in the pat
43 tion, we prepared a series of 11 fluorinated branched-chain amino acids and evaluated them and their
44 to MS, we detected significant increases in branched-chain amino acids and intermediates of arginine
46 resulting in accumulation of fatty acids and branched-chain amino acids and oncogenic mTOR activation
49 n family are involved in the biosynthesis of branched-chain amino acids and/or in the Met chain elong
50 ysophosphatidylethanolamines, 5 ceramides, 3 branched chain amino acids, and 9 neurotransmitters).
51 Ceramides, lysolipids, aromatic amino acids, branched chain amino acids, and stress-induced amino aci
52 etic performance in this group are creatine, branched-chain amino acid, and beta-hydryoxy-beta-methyl
53 thesized that protein, essential amino acid, branched-chain amino acid, and leucine intakes are assoc
55 -density lipoprotein lipids, glucose levels, branched-chain amino acids, and inflammatory markers.
56 luding diacylglycerols and triacylglycerols, branched-chain amino acids, and markers reflecting metab
58 s subtilis operon (ilvB) for biosynthesis of branched-chain amino acids are subject to multiple mecha
59 sted the effects of a genetic determinant of branched-chain amino acid/aromatic amino acid ratio on c
61 Individuals carrying the C allele of the branched-chain amino acid/aromatic amino acid ratio-asso
63 holipids and amino acids (Trp, Met, and Cys, branched-chain amino acids), as well as carnitine shuttl
64 nvolved with biosynthesis and degradation of branched-chain amino acids, as well as in the production
66 convergence of microRNAs and TFs within the branched chain amino acid (BCAA) metabolic pathway, poss
67 electrophoresis (MD-CE) assay for monitoring branched chain amino acid (BCAA) uptake/release dynamics
69 rsity includes: inflammation, degradation of branched chain amino acids (BCAA), and regulation of per
70 ta are currently available on the effects of branched-chain amino acid (BCAA) and branched-chain keto
72 synthase (AHAS) catalyzes the first step of branched-chain amino acid (BCAA) biosynthesis, a pathway
75 e (BCKDH) catalyzes the critical step in the branched-chain amino acid (BCAA) catabolic pathway and h
76 We previously described abnormalities in the branched-chain amino acid (BCAA) catabolic pathway as a
78 ways involved in inflammation, fibrosis, and branched-chain amino acid (BCAA) catabolism; systemic ma
79 augment BCKDC flux have been shown to reduce branched-chain amino acid (BCAA) concentrations in vivo.
80 enylbutyrate administration decreases plasma branched-chain amino acid (BCAA) concentrations, and pre
82 d correlations among metabolites involved in branched-chain amino acid (BCAA) degradation, trimethyla
85 production, while it does not contribute to branched-chain amino acid (BCAA)-derived aldehyde biosyn
88 posed cells are either supplemented with the branched-chain amino acids (BCAA) anaerobically or retur
89 its and enzymes involved in the oxidation of branched-chain amino acids (BCAA) and fatty acids (e.g.,
91 ldup of branched-chain keto-acids (BCKA) and branched-chain amino acids (BCAA) in body fluids (e.g. k
92 een associated with a selective reduction in branched-chain amino acids (BCAA) in spite of adequate d
93 does not grow in minimal medium lacking the branched-chain amino acids (BCAA) leucine or valine but
95 are enzymes that initiate the catabolism of branched-chain amino acids (BCAA), such as leucine, ther
98 fat, or high-fat diet supplemented with 1.5X branched chain amino acids (BCAAs) by replacing carbohyd
99 ith varying doses of leucine or a mixture of branched chain amino acids (BCAAs) on myofibrillar prote
101 High-protein diets, rich in methionine and branched chain amino acids (BCAAs), apparently reduce li
102 reductions were seen in the concentration of branched chain amino acids (BCAAs), which are key precur
105 -1.kg-1.180 min; P = 0.04; eta2p = 0.31] and branched-chain amino acids (BCAAs) [between-group differ
106 esized that a greater decline in circulating branched-chain amino acids (BCAAs) after weight loss ind
109 emonstrated, while it is yet unclear whether branched-chain amino acids (BCAAs) are a primary input o
111 tudies have shown that increased circulating branched-chain amino acids (BCAAs) are associated with i
112 Recent studies have shown that circulating branched-chain amino acids (BCAAs) are elevated in obese
117 mportant for acid adaptation, as turnover of branched-chain amino acids (bcAAs) could provide importa
120 demiological and experimental data implicate branched-chain amino acids (BCAAs) in the development of
121 have previously shown that the limitation of branched-chain amino acids (BCAAs) is a cue that induces
122 the pools of specific metabolites, i.e., the branched-chain amino acids (BCAAs) isoleucine, leucine,
126 Based on evidence that dysregulation of branched-chain amino acids (BCAAs) may contribute to the
131 bs (n = 24) were enterally supplemented with branched-chain amino acids (BCAAs), carbohydrate (maltod
134 that BCAT1, a cytosolic aminotransferase for branched-chain amino acids (BCAAs), is aberrantly activa
137 ed in the oxidation of fatty acids (FAs) and branched-chain amino acids (BCAAs), senses nutrients and
138 ccompanied by elevated circulating levels of branched-chain amino acids (BCAAs), whereas both paramet
139 g healthy mice a diet with reduced levels of branched-chain amino acids (BCAAs), which are associated
147 insulin were to reduce plasma levels of the branched chain amino acids (BCAs) leucine/isoleucine and
148 t differences in the amounts of aromatic and branched chain amino acids between the groups as well as
149 ed a significant difference in the levels of branched-chain amino acids between the wild type and Del
151 onal yeast mitochondrial enzyme required for branched chain amino acid biosynthesis and for the stabi
154 ein in Saccharomyces cerevisiae required for branched-chain amino acid biosynthesis and for the stabi
155 halts bacterial growth via inhibition of the branched-chain amino acid biosynthesis enzyme dihydroxya
156 and raised the root and shoot levels of the branched-chain amino acid biosynthesis intermediate 2-ox
159 l was based, demonstrated the involvement of branched-chain amino acid biosynthesis, ascorbate and al
160 ctively catalyze the first committed step of branched-chain amino acid biosynthesis, but ilvG is uniq
161 A-B27-negative AAU, including an increase of branched-chain amino acid biosynthesis, that reflects di
163 yme reactions and regulatory circuits of the branched chain amino acid biosynthetic pathways, includi
164 pA have been shown to regulate expression of branched-chain amino acid biosynthetic genes, suggesting
165 2 skeletal muscle had increased oxidation of branched chain amino acids but decreased oxidation of fa
166 ues essential for full activation of CodY by branched-chain amino acids, but these residues are not c
167 These data led to the discovery of impaired branched chain amino acid catabolic enzyme isovaleryl-Co
169 by metformin exposure, including changes in branched-chain amino acid catabolism and cuticle mainten
170 Collectively, these results indicate that branched-chain amino acid catabolism contributes to TAG
171 yl-CoA (HMG-CoA) lyase (HMGL) is involved in branched-chain amino acid catabolism leading to acetyl-C
172 hat several Arabidopsis mutants deficient in branched-chain amino acid catabolism or fatty acid metab
173 It also increases our knowledge of the role branched-chain amino acid catabolism plays in seed devel
177 the identification and characterization of a branched-chain amino acid decarboxylase, which would app
178 detection of the major CoA-intermediates of branched chain amino acid degradation in biological samp
180 rior to this study, the relationship between branched-chain amino acid degradation (named for leucine
181 Furthermore, the Hadza GM is equipped for branched-chain amino acid degradation and aromatic amino
182 oteins: the H-protein and the E2 subunits of branched chain amino acid dehydrogenase (BCDH) and alpha
183 The metabolite 3-MOB along with related branched-chain amino acids demonstrated strong predictab
184 amino acids for colonization, acquisition of branched-chain amino acids does not appear to be a deter
187 r very-low-density lipoprotein measures, and branched-chain amino acids (e.g., leucine OR = 2.94, 2.5
188 erprints of severe obesity were aromatic and branched-chain amino acids (elevated), metabolites relat
189 a 10 gene cluster responsible for increased branched chain amino acid fermentation in the co-culture
190 d redirect metabolism for the utilization of branched-chain amino acids for energy, carbon, and perha
191 sted that Ca. C. thermophilum may synthesize branched-chain amino acids from an intermediate(s) of th
192 lude testosterone analogues, growth hormone, branched chain amino acid, glutamine, arginine, creatine
193 le genome-wide association studies (GWAS) on branched-chain amino acids have identified some regulato
196 lysis revealed a defect in the catabolism of branched-chain amino acids in bkdE1alpha Furthermore, th
198 reported to confer transport of proline and branched-chain amino acids in in vitro expression system
199 und reduced concentrations of vitamin B6 and branched-chain amino acids in PSC (P < .0001), which str
201 genotype and diet, with a unique increase in branched-chain amino acids in the Glyco(Hi) HFD group.
202 f the authors, that focus on the role of the branched-chain amino acids in the regulation of mRNA tra
204 to GTP in vitro but also responded poorly to branched-chain amino acids in vitro unless GTP was simul
206 yme inhibitors and the rich concentration of branched-chain amino acids in whey, which act synergisti
209 zyme's substrate and stereospecificity for L-branched chain amino acids is a group of hydrophobic res
210 Accumulation of free isoleucine and other branched-chain amino acids is greatly elevated in respon
211 hypothesis that raised plasma levels of the branched-chain amino acids isoleucine, leucine, and vali
212 reased in presymptomatic HD sheep, including branched chain amino acids (isoleucine, leucine and vali
213 l transcriptional regulator that responds to branched-chain amino acids (isoleucine, leucine, and val
214 metabolic precursors (i.e., fatty acids and branched-chain amino acids), isotope labeling analyses s
215 ficits in enzymes required for catabolism of branched chain amino acids, ketones, and lactate, along
216 gulated pathways for the biosynthesis of the branched chain amino acids L-isoleucine, L-valine, and L
218 ave been the subject of great scrutiny, as a branched-chain amino acid, Leu can be catabolized within
219 l amino acid phenylalanine and the essential branched chain amino acids leucine, isoleucine, and vali
222 the ability of nutrients, in particular the branched-chain amino acid leucine, to activate mTOR inde
224 icantly raised the circulating levels of the branched-chain amino acids leucine, isoleucine, and vali
226 4.1, 95% CI [-7.0; -1.1], p = 0.007) and the branched-chain amino acids (leucine: beta = -6.0, 95% CI
227 e disease (MSUD) is an inherited disorder of branched chain amino acid metabolism presenting with neo
229 F1F0-ATPase system, fatty acid biosynthesis, branched chain amino acids metabolism), and molecular ch
231 pts surrounding the current understanding of branched-chain amino acid metabolism and its role in can
234 e disease (MSUD) is an inherited disorder of branched-chain amino acid metabolism presenting with lif
235 nning on page 434) defined a new disorder of branched-chain amino acid metabolism resembling human ma
236 deregulated in many cancers, with changes in branched-chain amino acid metabolism specifically affect
237 spiration, an ornithine-glutamine shunt, and branched-chain amino acid metabolism were hypothesized a
238 zed the condensation of two intermediates in branched-chain amino acid metabolism, isovaleryl-Coenzym
242 ex and formation of a metabolic unit (termed branched-chain amino acid metabolon) that can be influen
243 ained before and 7 hours after a single oral branched chain amino acid mixture enriched with leucine
244 nsulin resulted in increased plasma glucose, branched chain amino acids, nonesterified fatty acids, b
247 ociated with multiple metabolites, including branched-chain amino acids, other hydrophobic amino acid
248 of the BCKDC, promotes metabolon formation, branched-chain amino acid oxidation, and cycling of nitr
250 arget of rapamycin (mTOR), through which the branched-chain amino acids, particularly leucine, act to
252 he general amino acid permease (Aap) and the branched-chain amino acid permease (Bra) of Rhizobium le
253 solute transport systems: PA1971 (braZ) for branched-chain amino acids permease; PA2042 for a putati
254 t-chain dicarboxylacylcarnitines (SCDA), and branched-chain amino acid plasma biomarkers were indepen
255 er biochemical inhibition of biosynthesis of branched-chain amino acids (precursors to branched-chain
258 es of cardiovascular disease risk (including branched-chain amino acids, select unsaturated lipid spe
260 gion was enhanced in the presence of GTP and branched-chain amino acids, suggesting a link between nu
263 th microbial function; 13 pathways including branched chain amino acid synthesis were significantly e
264 of genes related to vitamin B6 synthesis and branched-chain amino acid synthesis (Q(fdr) < .05).
265 ctional gene classes, including aromatic and branched-chain amino acid synthesis, ribosomal proteins,
267 talyses the transfer of the amino group from branched-chain amino acids to alpha-ketoglutarate (alpha
269 IDH1 mutation and decreased activity of the branched-chain amino acid transaminase 1 (BCAT1) enzyme.
270 how that glioblastoma express high levels of branched-chain amino acid transaminase 1 (BCAT1), the en
272 s well as single-nucleotide polymorphisms in branched-chain amino-acid transaminase 1 (BCAT1) and phe
273 ic glucosinolate biosynthesis in tandem with BRANCHED-CHAIN AMINO ACID TRANSAMINASE4, which is involv
274 was identified as a potential biomarker for branched chain amino acid transferase inhibitor activity
275 scovered a potential causal link between the branched-chain amino acid transferase BCAT-1 and the neu
276 uced miR-276-5p fine-tunes the expression of branched-chain amino acid transferase to terminate the r
277 n with a chromosomal interval containing two branched-chain amino acid transferases, BCAT1 and BCAT2.
278 of the leucine, isoleucine, and valine (LIV) branched-chain amino acid transport system, reduced the
279 Despite each LIV protein being required for branched-chain amino acid transport, only the LivJ and L
280 ase in acetate, lactate, succinate, alanine, branched chain amino acids, trimethylamine and a progres
281 t-activity rhythm) and metabolic parameters (branched-chain amino acids, tryptophan pathway, phenylal
282 ultivariate analyses identified preoperative branched-chain amino acid/tyrosine ratio (BTR) <5, alani
283 howed severe disturbance in the synthesis of branched-chain amino acids upon treatment with imazapyr.
287 abolic disorder, affecting the metabolism of branched chain amino-acids (Valine, Leukine, Isoleukine)
289 posure to PFAS and increased serum levels of branched-chain amino acids (valine, leucine, and isoleuc
292 g to the intracellular levels of GTP and the branched-chain amino acids, was previously shown to be a
293 of CodY with various levels of activation by branched-chain amino acids, we concluded that unliganded
296 i produced leucine, isoleucine and valine as branched chain amino acids when grown on LBG hydrolysate
297 coneogenesis and oxidations of glutamine and branched chain amino acids, which together sustain the n
299 Metformin reduced levels of circulating branched-chain amino acids, which regulate tryptophan up