ライフサイエンスコーパス: branchial arch

1 n, even when grafted directly into the first branchial arch.

2 the same spatial location within the fourth branchial arch.

3 arise in soft tissues derived from the first branchial arch.

4 eveloping anterior pituitary gland and first branchial arch.

5 a specific rhombomere and its corresponding branchial arch.

6 icles, the pharyngeal endoderm and the first branchial arch.

7 neural crest cells migrating into the third branchial arch.

8 but not mesenchymal expression in the first branchial arch.

9 oid arch take on the properties of the first branchial arch.

10 lates Msx1 expression in the growing, distal branchial arch.

11 interact with Hoxa-2 and Dlx-2 in the second branchial arch.

12 the epithelium of the non-odontogenic second branchial arch.

13 cells from r7 are observed within the third branchial arch.

14 rate along normal pathways toward the second branchial arch.

15 crest cells migrate primarily to the fourth branchial arch.

16 the depleted hindbrain region and the third branchial arch.

17 chial arch, but not in the limb or the first branchial arch.

18 mb bud or maintenance in the first or second branchial arch.

19 nto a distal-to-proximal invasion of the 2nd branchial arch.

20 downstream genes in each domain of the first branchial arch.

21 ut not in the maxillary process of the first branchial arch.

22 and proximal/distal domains within the first branchial arch.

23 NC cells in the proximal domain of the first branchial arch.

24 Tcf21, and Msc in the first, but not second, branchial arch.

25 ade the branchial arches, especially the 2nd branchial arch.

26 itx2 mutant descendents moved into the first branchial arch.

27 y pit, and mandibular component of the first branchial arch.

28 s expressed in the second and more posterior branchial arches.

29 tube and navigate over long distances to the branchial arches.

30 ls and are derived from the first and second branchial arches.

31 and is required for dHAND expression in the branchial arches.

32 on, are all active in the oral epithelium or branchial arches.

33 d hyomandibular and reduced third and fourth branchial arches.

34 control expression of dHAND in the heart and branchial arches.

35 ral crest cell migration into the developing branchial arches.

36 with defects of NCCs from the first to third branchial arches.

37 also causes apoptosis of neural crest in the branchial arches.

38 y elements that control transcription in the branchial arches.

39 of the neural tube, and neural crest derived branchial arches.

40 anglia, to their targets, the muscles of the branchial arches.

41 ndbrain neural crest cell migration into the branchial arches.

42 ence at the dorsal midline to entry into the branchial arches.

43 t cell migration streams bound for different branchial arches.

44 d close to the top of the clefts between the branchial arches.

45 m cells migrate to fill the core of specific branchial arches.

46 er it simply populates the nearest available branchial arches.

47 ain, eyes, somites, ventral blood island and branchial arches.

48 nes regulate proximodistal patterning of the branchial arches.

49 ximal regions of the murine first and second branchial arches.

50 ell populations and targets them to specific branchial arches.

51 ld faster doubling time after populating the branchial arches.

52 neurons, in the genital tubercle, and in the branchial arches.

53 cations, with at least five operating in the branchial arches.

54 embryonic vasculature and development of the branchial arches.

55 ugh different microenvironments and into the branchial arches.

56 ry routes to precise targets in the head and branchial arches.

57 ding open neural tubes and reductions in the branchial arches.

58 exploit neural crest streams to populate the branchial arches.

59 stinct functions in mandibular versus caudal branchial arches.

60 d expression pattern in developing visceral (branchial) arches.

61 laterally from their hyoid and gill-bearing (branchial) arches.

62 the rhombomere 4 (r4) migratory stream into branchial arch 2 (ba2), is due to chemoattraction throug

63 or absence of neural crest cells traversing branchial arches 3, 4 and 6, and entering the cardiac ou

64 e traced from the occipital neural tube, via branchial arches 3, 4 and 6, into the aortic sac and aor

65 apped binding of Meis, Pbx, and Hoxa2 in the branchial arches, a series of segments in the developing

66 signals in the vicinity of the hindbrain and branchial arches act on migrating myogenic cells to infl

67 gh muscles derived from the first and second branchial arches also share a clonal relationship with d

68 ssion in the mandibular portion of the first branchial arch and central nervous system.

69 reduction of Hoxa-3 expression in the third branchial arch and corresponding deficits in third arch-

70 t birth and display holoprosencephaly, first branchial arch and eye defects.

71 in the kidney and repression by Hoxa2 in the branchial arch and facial mesenchyme in vivo.

72 the developing mammalian kidney and Hoxa2 in branchial arch and facial mesenchyme.

73 ts including cleft face (involving the first branchial arch and frontonasal processes), incomplete he

74 First branchial arch and heart tissue from E10.5 embryos were

75 ral crest cells that migrate into the second branchial arch and is essential for proper patterning of

76 within the mandibular component of the first branchial arch and later in the primordia of middle ear-

77 Most notably, during first branchial arch and limb development, both YY1 and Msx2 w

78 tant mice show underdevelopment of the first branchial arch and midline fusion defects.

79 strict neural crest expression to the second branchial arch and more posterior regions.

80 Inactivation of Bmp4 in the caudal branchial arch and splanchnic mesoderm and OFT myocardiu

81 presumptive secondary heart field within the branchial arch and splanchnic mesoderm that contributes

82 sumptive secondary heart field, derived from branchial arch and splanchnic mesoderm, patterns the for

83 ogenesis in overlapping domains of the first branchial arch and the basal forebrain.

84 rphogenesis and differentiation in the first branchial arch and the basal forebrain.

85 rivatives of neural crest cells in the first branchial arch and the limb bud mesenchyme.

86 of the third and fourth neural crest-derived branchial arches and branchial arch arteries.

87 expression in epaxial and hypaxial somites, branchial arches and central nervous system, and argued

88 sively expressed in cranial placodes, in the branchial arches and CNS and in complementary or overlap

89 Eya3 is also expressed in the branchial arches and CNS, but lacks cranial placode expr

90 is expressed in the epithelial layer of the branchial arches and encodes for the endothelin-1 (ET-1)

91 in the ectodermal surfaces of the limb buds, branchial arches and epidermal appendages, which are all

92 narily distinct structures, for example, the branchial arches and eyes, respectively.

93 radation-1-like gene, expressed in embryonic branchial arches and in the conotruncus, appears to play

94 embryos, Ntan1 was strongly expressed in the branchial arches and in the tail and limb buds.

95 bryos, the Ubr1 expression is highest in the branchial arches and in the tail and limb buds.

96 erted from their migration pathways into the branchial arches and instead migrated around the otic ve

97 ression disrupts morphogenesis of the caudal branchial arches and leads to a failure to correctly ela

98 red for growth and development of the heart, branchial arches and limb buds.

99 e skeletal muscle precursors of the myotome, branchial arches and limbs as well as in the developing

100 pressed in midgestation mouse embryos in the branchial arches and limbs, consistent with the human ph

101 des paraxial presomitic mesoderm, notochord, branchial arches and neural crest derivatives.

102 f slow muscle, the photoreceptor cell layer, branchial arches and pectoral fins.

103 rk sheds light on the homology of vertebrate branchial arches and supports their common origin at the

104 2 isoforms have interchangeable functions in branchial arches and that Pitx2 target pathways respond

105 l elements derived from the first and second branchial arches and that there are heterogeneous popula

106 ctor dHAND is expressed in the mesenchyme of branchial arches and the developing heart.

107 Indeed, the size of branchial arches and the frontonasal mass of mutant embr

108 os exhibited an increased number of somites, branchial arches and the presence of forelimb buds; howe

109 l crest cells are directed in streams to the branchial arches and to the forelimb of the developing q

110 enotypes that are both more severe (head and branchial arches) and less severe (allantois growth) tha

111 ived from craniofacial mesenchyme, the first branchial arch, and the limb bud.

112 res 4 and 5, the selective loss of the 2(nd) branchial arch, and the loss of most, but not all, 2(nd)

113 and the mandible bone derive from the first branchial arch, and their development depends upon the c

114 i3 mutants are able to migrate, populate the branchial arches, and display some elements of correct p

115 nt to the even-numbered rhombomeres into the branchial arches, and each stream contains contributions

116 In the olfactory pathway, as in the limbs, branchial arches, and heart, mesenchymal/epithelial indu

117 her sites of induction, including the limbs, branchial arches, and heart.

118 TFs which are broadly expressed across mouse branchial arches, and HOXA2, which is expressed in the s

119 dition, foxi1 is expressed in the developing branchial arches, and jaw formation is disrupted in hear

120 notochord, somites, heart, pronephric ducts, branchial arches, and jaw muscles in embryos and larvae.

121 mbryonic forebrain as well as aortic arches, branchial arches, and limb buds.

122 rtebrate primordia such as sensory placodes, branchial arches, and limb buds.

123 was found localized to the brain, eye, ear, branchial arches, and spinal cord.

124 ofound abnormalities in the first and second branchial arches, and the early remodeling of blood vess

125 and Hand2 transcription factor genes in the branchial arches, and we identify a branchial arch-speci

126 n factors required to initiate myogenesis in branchial arch- and somite-derived muscles are known, bu

127 f the neural-crest-derived components of the branchial arch are expressed in dHAND-null embryos, sugg

128 es and of the maxillary process of the first branchial arch are integral to lip and primary palate de

129 ral crest cell migration and invasion of the branchial arches are separable processes.

130 erge from the neural tube or en route to the branchial arches, areas where cell-cell interactions typ

131 aorta, as well as variable narrowing of the branchial arch arteries and proximal dorsal aorta.

132 ilure to establish the initial complement of branchial arch arteries in the caudal pharyngeal region.

133 -31, shows that the initial formation of the branchial arch arteries is not disturbed in ETA-/- or EC

134 cts that includes abnormal patterning of the branchial arch arteries, double-outlet right ventricle,

135 rentiation of smooth muscle cells within the branchial arch arteries, which are derived from the neur

136 derm near the junction of the aortic sac and branchial arch arteries.

137 chymal cells of the distal outflow tract and branchial arch arteries.

138 th neural crest-derived branchial arches and branchial arch arteries.

139 ferentiation markers in the dorsal aorta and branchial arch arteries.

140 allele resulted in abnormal morphogenesis of branchial-arch arteries (BAAs) and defective OFT septati

141 n mice impairs asymmetric remodelling of the branchial arch artery (BAA) system, resulting in randomi

142 ayed micropthalmia and the loss of the first branchial arch, as detected by the expression of pax-6,

143 itiation of MyoD expression in limb buds and branchial arches, as enhancer deletion delayed MyoD acti

144 prior to fusion, and also in the developing branchial arches at the times of critical morphogenetic

145 suggested to control patterning of the first branchial arch (BA1) and odontogenesis.

146 In mammals, the first branchial arch (BA1) develops into a number of craniofac

147 yclopia, as well as alterations in the first branchial arch (BA1) leading to lack of jaw (agnathia).

148 he mandible, which is derived from the first branchial arch (BA1).

149 gnaling and gene expression within the first branchial arch (BA1).

150 Although the initial formation of branchial arches (BAs) is normal, expression of several

151 n the CNC resulted in enlarged, hemorrhaging branchial arch blood vessels and hydrocephalus.

152 undetectable in the mesenchyme of dHAND-null branchial arches but unaffected in the limb bud, consist

153 t signaling in the epaxial somite and second branchial arch, but not in the limb or the first branchi

154 organisation of structures derived from the branchial arches, but that exposure to increasingly nove

155 the development of the embryonic pharyngeal (branchial) arches, but its effects on innervation of the

156 eptiles developed a neck fold from the hyoid branchial arch by preventing it to fully fuse with poste

157 2 is also expressed in Xenopus neural folds, branchial arches, cardiac outflow tract, inflow tract, a

158 y fail to form neurons in cranial ganglia or branchial arch cartilage, illustrating that they are at

159 s, including cornea, trigeminal ganglion and branchial arch cartilage.

160 In addition, the migratory ability of branchial arch cells from normal explants could be reduc

161 of Ph/Ph cells to PDGF-A treatment of normal branchial arch cells in vitro with recombinant PDGF-AA s

162 it would in normal development, resulting in branchial arches containing mixed cell populations not o

163 Pitx2 was expressed in branchial arch core mesoderm and both Pitx2 null and Pit

164 ntal disorder characterized by hearing loss, branchial arch defects, and renal anomalies.

165 disorder characterized by the association of branchial arch defects, hearing loss, and renal anomalie

166 , including external ear anomalies, abnormal branchial arch derivatives, heart malformations, diaphra

167 while partial disruption leads to defects of branchial arch derivatives, similar to those seen in CAT

168 hindbrain and for the formation of adjacent branchial arch derivatives.

169 patterning and the subsequent development of branchial arch derivatives.

170 ssing their differentiation, while a further branchial arch derived signal, namely Bmp7, is an overal

171 Moreover, we identified Fgf8 as the branchial arch derived signal.

172 ET-1/ECE-1/ETA pathway results in defects in branchial arch- derived craniofacial tissues, as well as

173 s of neural crest-derived tissues, including branchial arch-derived craniofacial structures, aortic a

174 utant mice are not viable and display severe branchial arch-derived facial skeleton defects, includin

175 mesoderm of the second heart field (SHF) and branchial arch-derived head muscles.

176 stablishing a baseline molecular bauplan for branchial arch-derived jaw development and further valid

177 ch, and the loss of most, but not all, 2(nd) branchial arch-derived tissues.

178 ssed by myogenic cells that migrate into the branchial arches despite its expression in migrating pre

179 in derivatives of neurogenic placodes and in branchial arches, despite the fact that cephalochordates

180 In mouse embryos, mutation of Prdm1 affects branchial arch development and leads to persistent trunc

181 To determine the potential role of dHAND in branchial arch development and to assess the role of the

182 1 reveals that it is essential for posterior branchial arch development, although the mandibular arch

183 g analysis of the potential role of dHAND in branchial arch development.

184 or HAND2 is required during limb, heart, and branchial arch development.

185 aniofacial cartilage deposition and impaired branchial arch development.

186 ted in cardiac hypoplasia but with preserved branchial arch development.

187 located distal to the neural tube and in the branchial arches did not express Pax3.

188 yoid arch is strongly reduced and subsets of branchial arches do not develop.

189 te host peripheral structures, including the branchial arches, dorsal root and sympathetic ganglia.

190 expressed in the differentiating somites and branchial arches during embryogenesis and is skeletal mu

191 ing expression of AKAP95 and fidgetin in the branchial arches during mouse embryogenesis.

192 later in development and is characterized by branchial arch dysplasia and aberrant segmental boundari

193 elates with a delay in expression of Fgf8 in branchial arch ectoderm and a failure of neural crest ce

194 egulated by an interplay between a specified branchial arch ectoderm and a plastic mesenchyme.

195 Zebrafish foxi1 is also expressed in branchial arch ectoderm and endoderm, and morpholino kno

196 ent, and Bmp4 expression was expanded in the branchial-arch ectoderm.

197 polarity is first established in mandibular branchial arch ectomesenchymal cells by a signal, Fgf-8,

198 riants most likely perturb the patterning of branchial arches, either through excessive activity (und

199 Jaws are principally derived from the branchial arches, embryonic structures that exhibit prox

200 Endothelin-1 (ET-1) signaling regulates the branchial arch enhancer and is required for dHAND expres

201 Mice lacking the dHAND branchial arch enhancer died perinatally and exhibited a

202 cells stop and collapse filopodia at the 2nd branchial arch entrances, but do not die.

203 odontogenesis, which are not found in other branchial arch epithelia.

204 Sema3A mRNA is concentrated in branchial arch epithelium at the appropriate time to med

205 s expressed in the mesenchyme underlying the branchial arch epithelium.

206 neural crest cells fail to fully invade the branchial arches, especially the 2nd branchial arch.

207 In addition, some branchial arch explants and untransfected COS7 cells rep

208 ealed that geniculate axons were repelled by branchial arch explants that were previously shown to be

209 mesenchymal cells, cell migration from Ph/Ph branchial arch explants was compared to migration from n

210 e Hand2 allele or deleting the ventrolateral branchial arch expression of Hand2 led to a novel phenot

211 eodomain binding sites that are required for branchial arch expression.

212 comparing protein binding to these sites in branchial arch extracts from endothelin receptor A (Ednr

213 r element that drives Myf5 expression in the branchial arches from 9.5 days post-coitum and show that

214 lar pathway results in growth failure of the branchial arches from apoptosis, while partial disruptio

215 this conclusion, Dlx6 was down-regulated in branchial arches from EdnrA mutant mice.

216 Crest cells of the second branchial arch generate few facial ganglion neurons and

217 c ganglion neurons, but crest cells in other branchial arches generate many sensory neurons.

218 that HAND2 is involved in development of the branchial arches, heart, limb, vasculature, and nervous

219 s, including the craniofacial skeleton, ear, branchial arches, heart, lungs, diaphragm, gut, kidneys,

220 , including the lateral neural folds, caudal branchial arch, hindbrain, and optic cup.

221 there is a tight link between the resulting branchial arch Hox code and a particular skeletal morpho

222 resulting in the persistence of an abnormal branchial arch Hox code and extensive defects in the hyo

223 sulting in the reestablishment of the normal branchial arch Hox code.

224 ne for these facial prominences in the first branchial arch in mice.

225 rtage of the CNC contribution into the first branchial arch in the Lef1 mutant.

226 ventolateral regions of the first and second branchial arches in these mutant mice, but expression wa

227 and defects in the derivatives of the first branchial arch, including cleft palate, suggesting a pro

228 T-1) mutant embryos, dHAND expression in the branchial arches is down-regulated, implicating it as a

229 reveals that crest does not migrate into the branchial arch it would have colonised in normal develop

230 s, cranial nerve ganglia, hindbrain, retina, branchial arches, jaw, and fin buds.

231 Overexpression of Hoxa2 in the chick first branchial arch leads to a transformation of first arch c

232 hed during development and patterning of the branchial arches may set up signals that the neural plat

233 ocyte Growth Factor, although a component of branchial arch-mediated growth promotion and chemoattrac

234 Proliferation was reduced in the branchial arch mesenchyme of Yap and Taz CNC conditional

235 Explants of branchial arch mesenchyme were strongly growth-promoting

236 c sac mesothelium and in left splanchnic and branchial arch mesoderm near the junction of the aortic

237 ic progression in the first, but not second, branchial arch mesoderm.

238 nomous function in expansion and survival of branchial arch mesoderm.

239 ecule is expressed in ventral splanchnic and branchial-arch mesoderm and outflow-tract (OFT) myocardi

240 of migrating and were incorporated into the branchial arch muscle mass.

241 re the lateral rectus and the proximal first branchial arch muscle primordia arise.

242 rs Myf5, MyoD and myogenin were expressed in branchial arch muscle, but at comparatively late stages

243 ted to the lateral rectus and proximal first branchial arch muscles; many also contributed to the dor

244 ing has been implicated in somite, limb, and branchial arch myogenesis but the mechanisms and roles a

245 llary and mandibular components of the first branchial arch, nasal processes, eyelid, midbrain, medul

246 culating disc of temporomandibular joint and branchial arch nerve ganglia.

247 Using molecular markers of branchial arch neural crest (Barx1) and commitment to ch

248 dHAND is also expressed in the branchial arch neural crest, which contributes to cranio

249 eral neural crest sublineages, including the branchial arch neural crest.

250 The diminutive first branchial arch of mutants could not be explained by loss

251 Migration into the presumptive caudal branchial arches of the lamprey involves both rostral an

252 o detection of DRR activity in limb buds and branchial arches of transgenic mice.

253 the outgrowth and orientation effects of the branchial arch on motor axons.

254 shown to function as brain, olfactory bulb, branchial arch, otic vesicle and fin enhancers, recapitu

255 showed comparable expression patterns in the branchial arch, otic vesicle, forebrain and/or limb at e

256 the mesenchyme and endothelial cells of the branchial arches, outflow tract, and heart suggest that

257 mus alters Hoxa2 expression and consequently branchial arch patterning, demonstrating that neural cre

258 heir nested expression patterns in the first branchial arch (primordium for jaw) and mutant phenotype

259 -less gene family, is expressed in the first branchial arch, prior to the initiation of tooth develop

260 erentiation of the cartilage elements in the branchial arches, rather than during crest migration, im

261 The branchial arch regulatory element is particularly robust

262 supports internal to the gills--the visceral branchial arches--represents one of the key events in ea

263 position of origin after migration into the branchial arches, resulting in skeletal abnormalities.

264 so lacked the early defects in growth of the branchial arches seen in Hand2 null embryos and survived

265 es mix along migration routes and within the branchial arches, separate groups of premigratory neural

266 Isolated E9.5 +/+ first branchial arches showed normal outgrowth of mouse ERG-po

267 ing the development of the allantois, heart, branchial arches, somites and forebrain.

268 mal lineage, including craniofacial regions, branchial arches, somites, vibrissal and hair follicles,

269 late mesoderm cells did not migrate into the branchial arches, somitic cells were capable of migratin

270 A specific deletion of the Hand2 branchial arch-specific enhancer also leads to a hypopla

271 s in the branchial arches, and we identify a branchial arch-specific enhancer in the Dlx5/6 locus, wh

272 onistic signals from the neural tube and the branchial arches specify extraocular versus branchiomeri

273 reduction in head size after 1 day, loss of branchial arch structures after 2 days, and embryos with

274 Shh null mice have cyclopia and loss of branchial arch structures.

275 ral crest and the mesenchyme of the head and branchial arch structures.

276 d defective angiogenesis of the yolk sac and branchial arches, stunted development and embryo wasting

277 s from adjoining rhombomeres within a single branchial arch support the notion that the pattern of hi

278 ed region contributes to a greater number of branchial arches than it would in normal development, re

279 ebrate face develop from transient embryonic branchial arches that are populated by cranial neural cr

280 he establishment of signaling centers in the branchial arches that are required for neural crest surv

281 re heterogeneous populations of cells in the branchial arches that rely on different cis-regulatory e

282 the chondrogenic regions of first and second branchial arches, the appendicular skeleton, and the der

283 f the somites, the ventromedial pathway, the branchial arches, the gut, the sensory ganglia, and the

284 a from both human fetal ear and mouse second branchial arch tissue confirmed that genes located among

285 Branchial arch tissue may thus act as a target-derived f

286 d from the neural tube that migrate into the branchial arches to generate the distinctive bone, conne

287 mbryo, including paraxial mesoderm, somites, branchial arches, vibrissae, developing central nervous

288 tic activity during NC cell migration to the branchial arches was altered when premigratory cells wer

289 al cues in driving neural crest cells to the branchial arches, we isochronically transplanted small s

290 Muscles derived from the first branchial arch were absent, whereas muscles derived from

291 ent, whereas muscles derived from the second branchial arch were merely distorted in Pitx2 mutants at

292 ll-derived skeletal structures of the second branchial arch were morphologically transformed into ele

293 om locations close to the hindbrain into the branchial arches where they undergo muscle differentiati

294 migrate from hindbrain segments to specific branchial arches, where they differentiate into distinct

295 d crest-derived prechondrocytes in posterior branchial arches, whereas a third paralogue is expressed

296 xpressed in the distal (ventral) zone of the branchial arches, whereas the Hand2 expression domain ex

297 C development in the third, fourth and sixth branchial arches, while the bone malformations present i

298 HGF was expressed in the branchial arches, whilst Met, which encodes an HGF recep

299 maintain a spatially-ordered invasion of the branchial arches with differences in cell proliferation

300 in the head, optic vesicles, spinal cord and branchial arches with weaker expression in the somites.