1 reveal the complex architecture of ecDNA, a
breakage-fusion-bridge and other complex rearrangements.
2 lication (WGD) with frequent chromothripsis,
breakage-fusion-bridges and extra-chromosomal DNA.
3 ult in sister chromatid fusion and prolonged
breakage/fusion/bridge (
B/F/B) cycles, leading to extens
4 duplication such as tandem duplications and
breakage/fusion/bridge (
B/F/B) cycles.
5 Both
breakage fusion bridge (
BFB) cycles and extrachromosomal
6 The
breakage-fusion-bridge (
BFB) cycle has been proposed to
7 The chromosome
breakage-fusion-bridge (
BFB) cycle is a mutational proce
8 Breakage-fusion-bridge (
BFB) cycle is a series of chromo
9 DNA amplification, most notably seen in the
breakage-fusion-bridge (
BFB) cycle.
10 mechanism of DNA amplification involves the
breakage-fusion-bridge (
BFB) cycle.
11 rbara McClintock's pioneering article on the
breakage-fusion-bridge (
BFB) cycle.
12 lution, yet only a subset of cancers display
breakage-fusion-bridge (
BFB) cycles and chromothripsis,
13 seen in tumor cell lines that have undergone
breakage-fusion-bridge (
BFB) cycles leading to gene ampl
14 mation of double minute (DM) chromosomes and
breakage-fusion-bridge (
BFB) cycles, have been repeatedl
15 riety of mechanisms such as micronucleation,
breakage-fusion-bridge (
BFB) cycles, or chain-like trans
16 te, which subsequently undergoes a series of
breakage-fusion-bridge (
BFB) cycles.
17 ssociated with DNA inversions resulting from
breakage-fusion-bridge (
BFB) cycles.
18 Breakage-fusion-bridge (
BFB) is a mechanism of genomic i
19 It is thought to arise through a
breakage-fusion-bridge (
BFB) mechanism.
20 tive information on the relationship between
breakage fusion bridge cycle, chromothripsis, seismic am
21 new dicentric undergoes the chromosome-type
breakage-fusion-bridge cycle and produces double bridges
22 Dicentric chromosomes undergo a
breakage-fusion-bridge cycle as a consequence of having
23 hase spindle elongation is delayed and a DNA
breakage-fusion-bridge cycle ensues that is dependent on
24 logical analyses supports a model in which a
breakage-fusion-bridge cycle followed by chromothripsis-
25 ms initiating focal amplifications, with the
breakage-fusion-bridge cycle prevalent in some and the t
26 chromosomes derived from the chromosome type
breakage-fusion-bridge cycle was examined for the presen
27 n chromosomes undergoing the chromosome type
breakage-fusion-bridge cycle were examined by FISH.
28 usion, perhaps through the initiation of the
breakage-fusion-bridge cycle.
29 ric chromosomes, thus starting a devastating
breakage-fusion-bridge cycle.
30 that subsequently initiates a chromatid-type
breakage-fusion-bridge cycle.
31 We resolve complex extrachromosomal DNA and
breakage-fusion-bridge cycles amplicons by integrating o
32 alterations display signatures of successive
breakage-fusion-bridge cycles and chromothripsis of unst
33 CK-AML characterized by linear and circular
breakage-fusion-bridge cycles and chromothripsis.
34 plex chromosomal rearrangements initiated by
breakage-fusion-bridge cycles and completed by simultane
35 mechanisms leading to amplicons that involve
breakage-fusion-bridge cycles and extrachromosomal DNA a
36 ic complexity, together with the presence of
breakage-fusion-bridge cycles and high DNA methylation c
37 induced by telomere crisis primarily involve
breakage-fusion-bridge cycles and simple genome rearrang
38 Breakage-fusion-bridge cycles and translocations activat
39 In sporadic iAMP21,
breakage-fusion-bridge cycles are typically the initiati
40 Breakage-fusion-bridge cycles contribute to chromosome i
41 Breakage-fusion-bridge cycles followed by chromothripsis
42 15;21)c to be constitutionally dicentric and
breakage-fusion-bridge cycles generate dicentric chromos
43 Perpetuation of
breakage-fusion-bridge cycles in CML progenitors was med
44 chromosomes that protect against chromosomal
breakage-fusion-bridge cycles in dividing cells.
45 nds, which initiate McClintock's chromosomal
breakage-fusion-bridge cycles in maize.
46 wed by chromosome instability resulting from
breakage-fusion-bridge cycles involving the sister chrom
47 equent than fragments in the second mitosis,
breakage-fusion-bridge cycles possibly occurred during g
48 via a dicentric chromosome intermediate and
breakage-fusion-bridge cycles that are repaired using mu
49 a subset of AR amplifications arise through
breakage-fusion-bridge cycles with associated Xq loss.
50 s, mitotic errors, spindle multipolarity and
breakage-fusion-bridge cycles, among others, which may l
51 result in fusions which initiate chromosomal
breakage-fusion-bridge cycles, causing genomic instabili
52 ow-level drug selection underwent continuing
breakage-fusion-bridge cycles, generating amplicons more
53 Formation of long palindromes, through
breakage-fusion-bridge cycles, is thought to play an ear
54 omatic retrotranspositions can also initiate
breakage-fusion-bridge cycles, leading to high-level amp
55 epeatedly generates palindromic DNA, such as
Breakage-Fusion-Bridge cycles.
56 of telomeric fusions indicative of multiple
breakage-fusion-bridge cycles.
57 rearranged, and corroded through hundreds of
breakage-fusion-bridge cycles.
58 they generate new DSBs downstream of IgH via
breakage-fusion-bridge cycles.
59 a rapid increase in DNA content and trigger
breakage-fusion-bridge cycles.
60 t seal end-to-end fusions, in the absence of
breakage-fusion-bridge cycles.
61 duplications have been attributed solely to
breakage-fusion-bridge cycles.
62 by de novo telomere synthesis, or multistep
breakage-fusion-bridge cycles.
63 e amplification, suggested the occurrence of
breakage-fusion-bridge cycles.
64 ht be the result of cytoskeletal defects and
breakage-fusion-bridge cycles.
65 original stocks developed in the 1940s, via
breakage-fusion-bridge cycles.
66 c duplication of the ERBB2 locus and trigger
Breakage-Fusion-Bridge cycles.
67 ctivation and oncogene amplification through
breakage-fusion-bridge cycles.
68 ls, it may allow cancer cells to escape from
breakage-fusion-bridge cycles.
69 mplification in these regions reminiscent of
breakage/fusion/bridge cycles.
70 trisomy, and evidence of chromothripsis and
breakage-fusion bridge cycling.
71 es centromere-proximal, which can arise from
breakage-fusion-bridge events.
72 ated with: high levels of chromothripsis and
breakage-fusion-bridge events; increased expression of g
73 inute chromosome formation (MYC and MDM2) or
breakage-fusion-bridge (
KRAS, MDM2 and RFC3).
74 ases of amplifications are compatible with a
breakage-fusion-bridge mechanism.
75 ic chromosomes and c-myc amplification via a
breakage-fusion-bridge mechanism.
76 omosome damage, repair, and damage through a
breakage-fusion-bridge mechanism.
77 in (IgH)/c-myc coamplification mediated by a
breakage-fusion-bridge mechanism.
78 -myc through an intra- or interchromosome 12
breakage-fusion-bridge mechanism.
79 Cycles of
breakage-fusion-bridge result in amplification of IgH/c-
80 g that the terminal deletions may occur by a
breakage-fusion-bridge type mechanism.
81 Mechanistically,
breakage-fusion-bridges were the source of 8p11-p12 ampl