ライフサイエンスコーパス: breast milk

1 n not to affect their total concentration in breast milk.

2 ivered either across the placenta or through breast milk.

3 sychoactive drugs, and major metabolites, in breast milk.

4 als were comparable to those in mature human breast milk.

5 termination of phenolic compounds present in breast milk.

6 d result in the preferential uptake of FA in breast milk.

7 remainder acquired through modes other than breast milk.

8 ly dependent on the supply of vitamin D from breast milk.

9 OS) to exert similar effects to those of the breast milk.

10 et influences the nutritional composition of breast milk.

11 vestigated dietary effects on fatty acids in breast milk.

12 half by postnatal HIV exposure via maternal breast milk.

13 spectrum of other nutritional properties of breast milk.

14 s were exposed to consistent drug dosing via breast milk.

15 otentially attributed to anti-HIV factors in breast milk.

16 ission is likely due to antiviral factors in breast milk.

17 ory mechanism for maintaining the quality of breast milk.

18 V and the role of malaria in EBV shedding in breast milk.

19 ted the presence of major foods allergens in breast milk.

20 hreshold for exposure to maternal drugs from breast milk.

21 we show that cancer cells can be detected in breast milk.

22 tion of food allergy by OVA exposure through breast milk.

23 do-(L)-thyronine (TrT(3))] measured in human breast milk.

24 ime the presence of selenoprotein P in human breast milk.

25 d validated it on the glycoproteome of human breast milk.

26 100A8-A9, are found in high amounts in human breast milk.

27 lin G (IgG) antibody levels were measured in breast milk.

28 s important to infant HIV-1 infection, i.e., breast milk.

29 smission vehicles, including human feces and breast milk.

30 (101 days), cerebrospinal fluid (9 months), breast milk (16 months [preliminary data]), and semen (1

31 d as breast milk: median (IQR) proportion of breast milk, 92% (79%-98%) in the lower-protein group vs

32 re to Dermatophagoides pteronyssinus through breast milk affects gut mucosal immunity with long-term

33 ty of the three methods to detect changes in breast milk after storage.

34 n (SD) of 27.7% (15.2%) of the bacteria from breast milk and 10.3% (6.0%) from areolar skin.

35 consumption and high docosahexaenoic acid in breast milk and 2 studies that reported a positive corre

36 The method was validated in breast milk and also in various types of bovine milk, as

37 he association between exposure to PBDEs via breast milk and anthropometric measurements in early chi

38 ations between early-life PBDE exposures via breast milk and anthropometric measurements overall; how

39 termine the association between the maternal breast milk and areolar skin and infant gut bacterial co

40 was used to estimate the contribution of the breast milk and areolar skin microbiomes to the infant g

41 Studies in breast milk and cultured MECs confirmed expression of Zn

42 We estimated the relative contributions of breast milk and formula to arsenic exposure during early

43 eration given to combination feeding of both breast milk and formula.

44 models to estimate daily arsenic intake from breast milk and formula.

45 the partitioning of PBDEs between serum and breast milk and how this may affect infant exposure.

46 ic IgG reactivity in the mother's plasma and breast milk and in cord blood seemed to protect against

47 al IgG and OVA immune complexes (IgG-IC) via breast milk and induction of allergen-specific regulator

48 l IgA reduces risk of HIV-1 transmission via breast milk and into immune interventions aimed at enhan

49 iciency alters TRAIL protein levels in human breast milk and mammary epithelial cells.

50 the fine specificity and function of IgA in breast milk and plasma and compared these with the autol

51 While the envelope-specific breast milk and plasma IgA responses also did not reach

52 eding women, the estimated infant doses from breast milk and resultant infant plasma concentrations f

53 s but could detect EBV-2 in samples of their breast milk and saliva.

54 persist for months in saliva, urine, semen, breast milk and the central nervous system(8-12).

55 revealed persisting EBOV RNA in the mother's breast milk and the father's seminal fluid.

56 munoglobulin A (sIgA) capsular antibodies in breast milk and the occurrence of late-onset disease (LO

57 igher protein level in formula compared with breast milk and the removal of the milk fat and associat

58 enofovir and emtricitabine are excreted into breast milk and then absorbed by the breastfeeding infan

59 etabolites were detected between infants fed breast milk and those fed formula (P < 0.005) and betwee

60 Infants receiving only breast milk and those with introduction of other foods b

61 What lactating mothers eat flavors breast milk and, in turn, modifies their infants' accept

62 determine the total antioxidant capacity of breast milks and the results were compared with a common

63 Breast-milk and infant measures were obtained at 1 and 6

64 sive breastfeeding (EBF)-giving infants only breast-milk (and medications, oral rehydration salts and

65 antioxidant found in soil, enriched in human breast milk, and essential for development in mammals.

66 (DBP), in humans (fat tissues, serum, urine, breast milk, and fingernails).

67 somatic growth is influenced by fructose in breast milk, and fructose in breast milk is increased in

68 during pregnancy, in cord blood samples, in breast milk, and in infants in the first years of life w

69 efavirenz concentrations in maternal plasma, breast milk, and infant plasma (n = 134).

70 PFASs occur in breast milk, and the duration of breastfeeding is associ

71 turated fatty acids (PUFAs) and n-6 PUFAs in breast milk are associated with the development of aller

72 al for the maintenance of nutrient status in breast milk are unclear.

73 Bacterial composition in maternal breast milk, areolar skin, and infant stool by sequencin

74 sequencing of the 16S ribosomal RNA gene in breast milk, areolar skin, and infant stool samples of 1

75 To further establish the utility of breast milk as a tissue-specific biospecimen for investi

76 Incidence and dominance of skin and breast milk associated microbes were increased in the gu

77 Breast milk at 1, 3, and 6 months postpartum and midnasa

78 m infants who were fed solids in addition to breast milk at 4 mo postpartum achieved both standing [a

79 Whether the vitamin D content of breast milk at birth can be increased by supplementing t

80 mine and its three derivatives) was found in breast milk at concentrations that ranged from 0.176 to

81 clonal antibodies isolated from Env-specific breast milk B cells demonstrated diverse Env epitope spe

82 as identified between Env-specific blood and breast milk B cells, suggesting trafficking of that cell

83 ormula than for infants fed exclusively with breast milk (beta = 2.02; 95% CI: 1.21, 2.83; p < 0.0001

84 red cytomegalovirus (pCMV) infection through breast milk (BM) may cause severe illness and even death

85 sis of the type and amount of milk consumed: breast milk (BM), <600 mL formula milk/d (FMlow), >/=600

86 ing at the breast (DBF), pumping and feeding breast milk (BM), and formula (FF) in the first months"

87 spite the nutritional and health benefits of breast milk, breast milk can serve as a vector for mothe

88 irus is present in urine, saliva, tears, and breast milk, but the transmission risk associated with t

89 detect the presence of the food allergens in breast milk by microarray technology.

90 en maternal diet and a nutritive property of breast milk came from 3 studies that supported the link

91 lly on breast milk, paralleling reports that breast milk can be protective against viral infections(8

92 nt HIV-inhibitory activity and indicate that breast milk can prevent multiple routes of infection.

93 ritional and health benefits of breast milk, breast milk can serve as a vector for mother-to-child HI

94 ripheral blood mononuclear cells (PBMCs) and breast milk cells (BMCs) is increased for CD8+ T cells i

95 Approaches that reduce maternal cervical and breast milk CMV reactivation may help delay infant infec

96 hers during the third trimester, cord blood, breast milk collected 2 months after delivery, and plasm

97 -gamma/granzyme rB producers is increased in breast milk compared with PBMCs.

98 n addition, while significant differences in breast milk composition between transmitting and nontran

99 The increasing knowledge of breast milk composition led to the hypothesis that high

100 studies that reported a dietary influence on breast-milk composition did not assess diet directly, di

101 for emtricitabine, reflecting trough-to-peak breast milk concentration ratios of 1.0 for tenofovir an

102 We assessed the relationship between breast milk concentrations of five PBDE congeners-BDEs 2

103 Importantly, there was minimal variation in breast milk concentrations of tenofovir and emtricitabin

104 th associations between maternal intakes and breast-milk concentrations for 3 nutrients.

105 In this study, we investigated whether breast milk contained infectious EBV and the role of mal

106 Human breast milk containing OVA-IgG-IC induced tolerance in h

107 Breast milk contains a diverse population of bacteria, b

108 tors necessary for infant development, human breast milk contains bacteria that contribute to the est

109 g experiments and micronutrient profiling of breast milk demonstrated that the defects observed were

110 Breast milk-derived cells with NF1 mutations also carrie

111 as the presence of bioactive molecules from breast milk dictate gut microbial growth and survival.

112 rred repeat element methylation was lower in breast milk DNA from cases compared to controls, and cas

113 ing of osmolality of infant milks, including breast milk, during enzymatic hydrolysis of lactose by s

114 h 17 predictive equations; measured TEE plus breast milk energy output (ERWBC) was compared with the

115 Breast milk enhances the predominance of Bifidobacterium

116 eding period is still a limiting factor, and breast milk exposure to HIV accounts for up to 44% of MT

117 Breast milk exposure to HIV accounts for up to 44% of MT

118 umeric associations between concentration of breast milk fatty acids and allergic disease outcomes we

119 from validated 24-h diet recall surveys and breast milk fatty acids.

120 d feeding method, and the supplementation of breast milk feeding with formula is associated with a mi

121 ransfer of leukocytes and their products via breast milk feeding, greatly assists the newborn's immun

122 gnancy and lactation, amniotic fluid flavor, breast-milk flavor, and children's food acceptability an

123 eed to better understand the determinants of breast-milk folate and the impact they might have on mil

124 folate-dependent enzymes are associated with breast-milk folate content in a cohort of mothers enroll

125 We found that total breast-milk folate content was not associated with any o

126 None of the SNPs were associated with total breast-milk folate.

127 OR 1.4, CI 1.3-1.6, p < 0.001), feeding only breast milk for the first 3 d (90% of 7,557 versus 79% o

128 A. africanus infants predominantly consumed breast milk for the first year after birth.

129 The antibody microarray was incubated with breast milk from 14 women collected from Fundacion Jimen

130 nalyzing urine from Austrian individuals and breast milk from Austrian and Nigerian individuals.

131 present in sera, cervicovaginal lavages, and breast milk from HIV-1-infected individuals.

132 Breast milk from HIV-infected women contains multiple HC

133 ements (LNSs) on B vitamin concentrations in breast milk from HIV-infected women in Malawi.

134 od, saliva, urine, aqueous humor, semen, and breast milk from infected or convalescent patients.

135 urine from 6-week-old infants (n = 72), and breast milk from mothers (n = 9) enrolled in the New Ham

136 Breast milk from mothers of preterm infants was monitore

137 tribution of melamine and its derivatives in breast milk from the United States.

138 , we measured genome-wide DNA methylation in breast milk from women with and without a diagnosis of b

139 paucity of information on the association of breast milk GBS serotype-specific capsular antibodies an

140 d with a placebo) results in a higher VDA of breast milk >/=2 mo postpartum.

141 Breast milk has a faster GE than formula milk.

142 n risk, the HIV-inhibitory activity of their breast milk has not been compared.

143 Breast milk has utility as a biospecimen for prospective

144 The bioactive components in breast milk have been primarily studied in the context o

145 Consumption of human breast milk (HBM) attenuates the incidence of necrotizin

146 The complex nature of human breast milk (HBM) makes samples difficult to analyze, re

147 therefore could potentially protect against breast milk HIV MTCT.

148 ity in HIV-infected infants, or with odds of breast-milk HIV transmission in HIV-exposed infants.

149 In contrast, the magnitudes of the breast milk IgA and secretory IgA responses against HIV-

150 We found that neither plasma nor breast milk IgG antibody responses were associated with

151 lyptus, garlic, mint) transmit to and flavor breast milk in a time-dependent manner.

152 ave measured micronutrient concentrations in breast milk in light of maternal diet and subsequent inf

153 Mean iron intake, from sources other than breast milk, in the last 24 hours was 0.29 (0.286-0.294)

154 Thus, pathogen-specific IgG in breast milk induced during maternal infection or immuniz

155 ) wk to measure maternal stress and anxiety, breast milk intake and milk cortisol, and infant behavio

156 were associated with the proportion of daily breast milk intake in a dose-dependent manner, even afte

157 ntervention on maternal psychological state, breast milk intake, milk cortisol levels, and infant beh

158 Volume of breast-milk intake via the deuterium dose-to-mother tech

159 In Zambia, breast milk is a key route for transmitting HCMV and car

160 ination to induce anti-HIV immune factors in breast milk is a potential intervention to prevent postn

161 by fructose in breast milk, and fructose in breast milk is increased in response to maternal sugar-s

162 The supply of vitamin D from breast milk is limited.

163 Breast milk is rich in PUFA, and it has been hypothesize

164 Breast milk is the sole source of nutrition for exclusiv

165 small amount of iron that is contributed by breast milk, make them iron sufficient until >/=6 mo of

166 It has been hypothesized that n-3 PUFA in breast milk may assist immune and lung development.

167 For breastfeeding infants, breast milk may be an important exposure pathway.

168 Our results also suggest multiple factors in breast milk may contribute to its HIV-inhibitory activit

169 nt formula so it is closer to that of mature breast milk may reduce long-term risk of overweight or o

170 ive total enteral feeding volume provided as breast milk: median (IQR) proportion of breast milk, 92%

171 ants have been reported as components of the breast milk microbiome in other studies.

172 extraction methodologies for analysis of the breast milk microbiome, and exercising caution interpret

173 This study shows that human breast milk might be an appropriate specimen to evaluate

174 Despite daily exposure to virus in breast milk, most infants breastfed by HIV-positive wome

175 d on protein and fat content of administered breast milk (n = 15).

176 ier adding 1.8 g of bovine protein/100 mL of breast milk [n = 15]) or individualized high-protein sup

177 l nutrition and genetics are determinants of breast-milk nutrient composition and, as such, are deter

178 luate the in vivo HIV-inhibitory activity of breast milk obtained from HIV-positive transmitting and

179 y assesses the presence of SARS-CoV-2 in the breast milk of 18 US women infected with SARS-CoV-2.

180 Among cells derived from breast milk of additional ten women not known to have br

181 between levels of n-3 PUFAs and n-6 PUFAs in breast milk of allergic- and nonallergic mothers and ast

182 nance of IgG isotype Env-specific B cells in breast milk of chronically HIV-infected women.

183 alovirus (HCMV)-specific T-cell responses in breast milk of HCMV-seropositive mothers is not well def

184 This suggests that immune factors in breast milk of HIV-1-infected mothers help to limit vert

185 Breast milk of HIV-negative women can inhibit HIV infect

186 It is well documented that breast milk of HIV-negative women can inhibit HIV infect

187 re, we demonstrate, for the first time, that breast milk of HIV-positive mothers (nontransmitters and

188 Our results demonstrate that breast milk of HIV-positive mothers has potent HIV-inhib

189 bird eggs, fish, dolphin blubber, and in the breast milk of humans that consume seafood.

190 The aim of our study was to discern whether breast milk of ITP mothers contained antiplatelet antibo

191 edians (IQRs) of infant daily intake through breast milk of vitamin D and 25(OH)D were 0.10 mug (0.02

192 that in most current formulas and closer to breast milk) on infant growth by comparing against WHO g

193 breast milk only; age 12 years: beta = 2.10 mm Hg (95% C

194 ot differ by feeding mode (predominantly fed breast milk or not).

195 cluded the lack of maternal antibody status (breast milk or plasma) or prevaccination antibody measur

196 tion of other foods or drinks in addition to breast-milk or replacement-milk substitutes before 4-6 w

197 5% confidence interval [CI], 1.69-15.61) and breast milk (OR, 7.93; 95% CI, 3.81-17.14).

198 ompared with those fed partially or fully on breast milk, paralleling reports that breast milk can be

199 ervational study, we investigated plasma and breast milk pharmacokinetics of efavirenz and breastfed

200 its safety requires an understanding of its breast milk pharmacokinetics, level of breastfed infants

201 icient evidence to suggest that colostrum or breast milk polyunsaturated fatty acids influence the ri

202 We investigate protection of breast milk pre-F antibodies against RSV acute respirato

203 Low breast milk pre-F IgG antibodies before RSV ARI support

204 The median breast milk pre-F IgG antibody concentration before illn

205 Induction of breast milk pre-F IgG may be a mechanism of protection f

206 Certain bioactive breast milk proteins and HMOs are associated with infant

207 n milk oligosaccharides (HMOs) and bioactive breast milk proteins have many beneficial properties.

208 g body of evidence, the associations between breast milk PUFA and allergic disease have not previousl

209 o exclusive soy formula, cow milk formula or breast milk regimens.

210 ve shown tumor suppressor DNA methylation in breast milk related with history of breast biopsy, an es

211 , and 0.03 to 4.6 mug/L in urine, serum, and breast milk, respectively.

212 variety of clinical specimens (blood, urine, breast milk, respiratory samples, biopsies, and vitreous

213 ttle is known about the protective effect of breast milk RSV-specific antibodies.

214 five widely employed methodologies to a mock breast milk sample and four individual human breast milk

215 ed method showed the presence of caffeine in breast milk samples (12-179ng/mL).

216 and OVA levels were determined in 100 human breast milk samples and the association with prevalence

217 nalyses, we extracted and measured HMOs from breast milk samples and then correlated their levels wit

218 at bacterial DNA extraction methodology from breast milk samples are a substantial contributor to the

219 These parabens were also measured in breast milk samples collected at approximately 3 months

220 atasets were generated from 28 HCMV-positive breast milk samples donated by 22 mothers (15 HIV-infect

221 rum samples and in 118 three-month expressed breast milk samples from mothers of children enrolled in

222 Breast milk samples had >50% detection for MP, PP, and E

223 Breast milk samples obtained at 3 months postpartum were

224 ing activity in sera of infants and serum or breast milk samples of mothers were measured using enzym

225 m for determination of the parabens in human breast milk samples using micro solid phase extraction b

226 Breast milk samples were analyzed at 6 mo (n = 659) for

227 Breast milk samples were available for 31 LOD cases (8 s

228 Ninety-nine breast milk samples were collected from the LUPE cohort

229 Breast milk samples were collected on cases and controls

230 The relative recovery values for the spiked breast milk samples were in the acceptable range of 87.2

231 Peak blood and breast milk samples were obtained 1-2 h after the matern

232 Breast milk samples were obtained from Kenyan mothers at

233 Maternal serum and breast milk samples were obtained prior to administratio

234 etermine whether viral DNA was encapsidated, breast milk samples were treated with DNAse before DNA e

235 supplemented infant formulas and three human breast milk samples were used to apply alumina hollow fi

236 ed using Illumina HumanMethylation450k in 87 breast milk samples.

237 breast milk sample and four individual human breast milk samples.

238 A total of 75 women provided breast-milk samples (44 women provided breast-milk sampl

239 vided breast-milk samples (44 women provided breast-milk samples at both 2 wk and 2 mo postpartum).

240 o were breastfeeding were invited to provide breast-milk samples for VDA measurement [concentration o

241 Breast-milk samples were obtained from women who were en

242 The role of breast milk secretor status on oral live-attenuated rota

243 his study indicate that bacteria in mother's breast milk seed the infant gut, underscoring the import

244 Breast milk sIgA capsular antibodies were associated wit

245 Yu and Dilbaz et al. identify how a class of breast milk-specific lipid mediators referred to as alky

246 content that more closely resembles that of breast milk supports healthy growth comparable to the WH

247 t Research on Environmental Chemicals) study.Breast-milk tetrahydrofolate (THF), 5-methyl-THF, 5-form

248 O) are a diverse range of sugars secreted in breast milk that have direct and indirect effects on imm

249 nsidered variation in specific components of breast milk that may affect early development.

250 Secondary outcomes, breast milk thiamine concentration and infant eTDP, were

251 ancy and early lactation had higher eTDP and breast milk thiamine concentrations and their infants ha

252 ctating women and newborn infants and higher breast milk thiamine concentrations compared with a cont

253 Low maternal thiamine intake reduces breast milk thiamine concentrations, placing breastfed i

254 tein (adding 1 g of bovine protein/100 mL of breast milk through a commercial human milk fortifier; n

255 ogenous estrogens in human urine, serum, and breast milk to enable proper exposure and risk assessmen

256 ition from passively acquired IgA present in breast milk to host-derived IgA.

257 IgG, but not IgA or IgM, transferred through breast milk to the intestinal lumen of suckling offsprin

258 dologies demonstrated that the magnitudes of breast milk total and secretory IgA responses against a

259 Breast milk total thiamine concentrations were 14.4 mug/

260 containing supplement.We sought to determine breast-milk total folate and unmetabolized folic acid (U

261 Breast-milk total folate was 18% higher (P < 0.001) in s

262 ment use was associated with modestly higher breast-milk total folate.

263 reased with maternal antiretroviral therapy, breast milk transmission accounts for most of the 180 00

264 reased with maternal antiretroviral therapy, breast milk transmission accounts for most of the 180,00

265 iled analysis of virus persistence following breast milk transmission of HIV-1 and ART has not been p

266 er, the MTHFR 677C>T SNP was associated with breast-milk UMFA (R2 = 0.01; unadjusted P = 0.004), expl

267 Detectable breast-milk UMFA was nearly ubiquitous, including in wom

268 Breast-milk UMFA was proportionally higher than 5-methyl

269 association between the MTHFR 677C>T SNP and breast-milk UMFA, albeit modest, highlights the need to

270 A linear mixed model was used to compare breast-milk VDA between the 3 study groups.

271 itamin D supplementation during pregnancy on breast-milk VDA in the first 2 mo of lactation.

272 , we observed a positive correlation between breast milk viral load and the CD8 pp65-specific respons

273 Mean +/- SD intake of breast-milk volume was 787 +/- 148 mL/d.

274 pment, and delivery mode and feeding method (breast milk vs formula) are determinants of its composit

275 Breast milk was collected from 537 women recruited withi

276 ficient dams, we found that IgG derived from breast milk was crucial for protection against mucosal d

277 resistant, suggesting that the viral DNA in breast milk was encapsidated.

278 n) on the volatile compound profile of human breast milk was evaluated, in order to compare both pres

279 entional formula (control, n = 117) whenever breast milk was not available during the first 6-8 month

280 in these families, although specific IgA in breast milk was not proportionally up-regulated.

281 Breast milk was sampled ~1 mo postpartum, and tetrahydro

282 the presence of Der p 1 and/or OVA in human breast milk, we identified groups of lactating mothers,

283 uoroalkyl substance (PFAS) concentrations in breast milk, we measured perfluorooctane sulfonic (PFOS)

284 n (IQR) time-averaged peak concentrations in breast milk were 3.2 ng/mL (2.3 to 4.7) for tenofovir an

285 (IQR) time-averaged trough concentrations in breast milk were 3.3 ng/mL (2.3 to 4.4) for tenofovir an

286 t superinfections with distinct strains from breast milk were captured during follow-up.

287 Early enteral feeding and, in particular, breast milk were correlated with an increase in lactate-

288 ctivity profiles in mothers, cord blood, and breast milk were highly correlated.

289 -elicited Env-specific B cells isolated from breast milk were IgA isotype, in stark contrast to the o

290 Overall, PBDE exposures via breast milk were not associated with early-life anthropo

291 ak and trough samples of maternal plasma and breast milk were obtained at drug concentration steady s

292 fruit intake and unsaturated fatty acids in breast milk were positively correlated with an increased

293 myelination in newborn pups via secretion in breast milk, whereas genetically blocking N-glycan branc

294 lergy, that is, D pteronyssinus allergens in breast milk, which disrupt gut immune homeostasis and pr

295 tus in mothers modulates TRAIL expression in breast milk, which may have implications for both mother

296 of n-3 and n-6 PUFA levels in colostrum and breast milk with allergic disease and lung function at a

297 nt in children of allergic mothers receiving breast milk with higher levels of n-3 long chain polyuns

298 in children of nonallergic mothers receiving breast milk with higher levels of n-6LCP (OR 1.86; 95% C

299 aternal serum/plasma during pregnancy, or in breast milk, with different timing of sample collection

300 fants can detect diet-transmitted flavors in breast milk within hours of a single maternal ingestion