ライフサイエンスコーパス: broad substrate specificity

1 nd seedling growth, indicating that KAT2 has broad substrate specificity.

2 sented in the UM-BBD; they are known to have broad substrate specificity.

3 additional ATP-dependent proteases that have broad substrate specificity.

4 ymotrypsin, and elastase, exhibit relatively broad substrate specificity.

5 g as substrate for aldehyde dehydrogenase of broad substrate specificity.

6 ype 1 thymidine kinase exhibits a strikingly broad substrate specificity.

7 the advantages of increased sensitivity and broad substrate specificity.

8 ex type N-glycan intermediates with relative broad substrate specificity.

9 s for the c-type cytochrome biogenesis has a broad substrate specificity.

10 nd acts strictly as an aminopeptidase with a broad substrate specificity.

11 etic enzymes, lasso peptide isopeptidase has broad substrate specificity.

12 sis Acp (AcpA) is tartrate-resistant and has broad substrate specificity.

13 ly reusable for several cycles, and displays broad substrate specificity.

14 er understanding of how proteins can achieve broad substrate specificity.

15 a neutrophil-derived serine proteinase with broad substrate specificity.

16 on and translocation by SLC6 transporters of broad substrate specificity.

17 bers that mediate ATP-dependent transport of broad substrate specificity.

18 understand the molecular basis of its rather broad substrate specificity.

19 forms a major antibiotic efflux system with broad substrate specificity.

20 is a mitochondrial carotenoid-oxygenase with broad substrate specificity.

21 e-binding sites, which correlates with their broad substrate specificity.

22 ADPH-dependent polyol dehydrogenase exhibits broad substrate specificity.

23 sulfation of xenobiotic phenols and has very broad substrate specificity.

24 ecessary residues for catalytic activity and broad substrate specificity.

25 ng serine hydrolase that exhibits relatively broad substrate specificity.

26 e-limiting enzyme in lipolysis that displays broad substrate specificity.

27 drug-metabolizing enzyme of extraordinarily broad substrate specificity.

28 nerve agents with high-rate enhancements and broad substrate specificity.

29 secreted APase enzyme is a glycoprotein with broad substrate specificity.

30 ALDHs typically have very broad substrate specificities.

31 loned from humans and rodents appear to have broad substrate specificities.

32 in nature by evolving multiple enzymes with broad substrate specificities.

33 PhlD exhibits broad substrate specificity, accepting C4-C12 aliphatic

34 fied FATP1 and indicate that the enzyme is a broad substrate specificity acyl-CoA synthetase.

35 is a small secreted proteolytic enzyme with broad substrate specificity against ECM and non-ECM comp

36 The enzymes show broad substrate specificities and can employ acyl-CoAs,

37 thermore, the enzyme systems exhibit similar broad substrate specificities and can oxidize such compo

38 However, C. microcarpa ACS shows broad substrate specificities and produces not only acri

39 equires the use of endoglycoceramidases with broad substrate specificity and a robust workflow that e

40 oupled peptide transporter PepT1, displays a broad substrate specificity and accepts most charged and

41 cytochrome P-450 enzymes, many of which have broad substrate specificity and are inducible by hundred

42 XAT has broad substrate specificity and can esterify lutein, bet

43 The dioxygenases have a broad substrate specificity and catalyze enantiospecific

44 proteins, indicating that the rat HSD IV has broad substrate specificity and contributes to cholester

45 ther showed that the chimeric BCO2 displayed broad substrate specificity and converted carotenoids in

46 SsMTAP is unusual both for its broad substrate specificity and for its extreme thermal

47 (CBG) from mammalian liver is known for its broad substrate specificity and has been implicated in t

48 Aminoacylase showed broad substrate specificity and hydrolyzed nonpolar N-ac

49 Enzyme shows a broad substrate specificity and hydrolyzes both natural

50 The enzyme has a broad substrate specificity and includes mammalian cores

51 Csk orthologs, Corallochytrium Csk displays broad substrate specificity and inhibits Src in an activ

52 e (MMP-12) is a macrophage-specific MMP with broad substrate specificity and is capable of degrading

53 Human carboxylesterase 1 (hCE1) exhibits broad substrate specificity and is involved in xenobioti

54 indicate that ECE-1 possesses a surprisingly broad substrate specificity and is potentially involved

55 We show that KpsMT has broad substrate specificity and is sufficient for the tr

56 ent short chain dehydrogenase/reductase with broad substrate specificity and is thought to be respons

57 Together with complementing enzymes, the broad substrate specificity and kinetic characteristics

58 Because of its broad substrate specificity and lack of endogenous subst

59 esults suggest that Uve1p has a surprisingly broad substrate specificity and may function as a genera

60 ation-division (RND) family, often show very broad substrate specificity and play a major role both i

61 eals several novel features that explain the broad substrate specificity and preference for nearby ba

62 ype multidrug transporters have an extremely broad substrate specificity and protect bacterial cells

63 tite nuclear localization signals to provide broad substrate specificity and rapid evolution in nucle

64 led that one of these proteins (Ph-4CL1) has broad substrate specificity and represents a bona fide 4

65 These data suggest that ACER2 has broad substrate specificity and requires Ca(2+) for its

66 posed D-amino acid dehydrogenase activity of broad substrate specificity and the physiological functi

67 important detoxification enzymes due to its broad substrate specificity and wide distribution throug

68 first reported aminopeptidase to demonstrate broad substrate specificity and yet release glycine and

69 ERAAP has a broad substrate specificity, and its expression is stron

70 el LPMOs, the molecular determinants driving broad substrate specificity are still not easily predict

71 Nmu-pdg I and Nmu-pdg II were found to have broad substrate specificities, as evidenced by their abi

72 bstrate binding pockets, consistent with the broad substrate specificity, as determined by degradomic

73 ubstrate: large variation in reaction rates, broad substrate specificity; (b) rigid enzyme-rigid subs

74 rate-selective inhibition of a protease with broad substrate specificity based on direct binding of a

75 t this enzyme is characterized by relatively broad substrate specificity, being able to oxidize posit

76 Translocation of protein kinases with broad substrate specificities between different subcellu

77 aperone involved in protein homeostasis with broad substrate specificity but also elucidate the origi

78 l homoserine lactone hydrolase that displays broad substrate specificity but shows a preference for s

79 This would explain not only their broad substrate specificity, but also their unusual evol

80 lt1473 is a multifunctional PL that exhibits broad substrate specificity, but utilizes pH as a mechan

81 emonstrated that both ACX1;1 and ACX1;2 have broad substrate specificities (C8-C18).

82 chia coli beta-ketoacyl-ACP reductase with a broad substrate specificity, can enhance or reduce activ

83 rotein kinase IV (CaMKIV) is a member of the broad substrate specificity class of Ca(2+)/calmodulin (

84 ic role in the mandelate pathway, BFDC shows broad substrate specificity coupled with tight stereo co

85 NA base excision repair N-glycosylase with a broad substrate specificity directed primarily against o

86 coli as well as from higher eukaryotes has a broad substrate specificity displaying dual enzymatic fu

87 dehydrogenase (coded for by raldH1 gene) and broad substrate specificity E1 (a member of EC 1.2.1.3 a

88 xidoreductase whose salient features include broad substrate specificity, encompassing 3-hydroxyacyl-

89 The human alkyladenine DNA glycosylase has a broad substrate specificity, excising a structurally div

90 nd Delta13ARF1, i.e. it lacks the relatively broad substrate specificity exhibited by ARF GAP.

91 This most likely explains the broad substrate specificity exhibited by phosphotriester

92 ive biosynthetic alanine racemase Alr showed broad substrate specificity, exhibiting measurable racem

93 bundant cytosolic lipid-binding protein with broad substrate specificity, expressed in mammalian ente

94 erlie a low affinity for glucose but generic broad substrate specificity for aldose sugars.

95 In contrast, ATB[Formula: see text] exhibits broad substrate specificity for all neutral and cationic

96 icin and doxorubicin biosynthesis that has a broad substrate specificity for anthracycline glycone su

97 SbCYP82D1.1 has broad substrate specificity for flavones such as chrysin

98 Endo III or Nth) is a DNA glycosylase with a broad substrate specificity for oxidized or reduced pyri

99 their analogs indicate that PfNT1 exhibits a broad substrate specificity for purine and pyrimidine nu

100 ndonuclease III) is a DNA glycosylase with a broad substrate specificity for pyrimidine derivatives.

101 lear whether and how 4CL proteins with their broad substrate specificities fulfill the specific hydro

102 We address the molecular basis of their broad substrate specificity gleaned from structural info

103 work presented here, the enzyme's unusually broad substrate specificity has allowed us to extend the

104 knowledge of the structural basis for their broad substrate specificity has been limited.

105 t, possesses a single 4CL protein exhibiting broad substrate specificity in mixed-substrate assays.

106 Here we show that pPAF-AH has broad substrate specificity in that it hydrolyzes short-

107 P1A2) is a drug uptake transporter known for broad substrate specificity, including many drugs in cli

108 This enzyme has been found to have broad substrate specificity, including the phosphorylati

109 Broad substrate specificity is also observed for the str

110 cessive accumulation of carotenoids, and its broad substrate specificity is consistent with this.

111 ic, the model of multisubstrate enzymes with broad substrate specificity is proposed as a paradigm fo

112 s the beta-alanine carrier which, due to its broad substrate specificity, is likely to play an import

113 te the proposed enzymatic activity with very broad substrate specificity; it utilizes all D-amino aci

114 Although the GS52 enzyme exhibited broad substrate specificity, its activity on pyrimidine

115 ility to cause pericellular degradation, its broad substrate specificity, its synthesis in an active

116 sess at least one of three phosphatases with broad substrate specificity, known as PhoA, PhoX, and Ph

117 The broad substrate specificity of acyltransferase CT775 pro

118 lexible hinges that may be essential for the broad substrate specificity of BCRP.

119 This study reveals a broad substrate specificity of Endo-A for transglycosyla

120 The broad substrate specificity of FabZ coupled with the ina

121 Broad substrate specificity of human P-glycoprotein (ABC

122 de variety of substrates and may explain the broad substrate specificity of MerB.

123 The broad substrate specificity of MRP was confirmed by the

124 The similarly broad substrate specificity of multidrug transporters ca

125 Our work provides insights into the broad substrate specificity of Nln and may aid in the fu

126 usion and offer a simple explanation for the broad substrate specificity of phage resolvase.

127 e-67, and asparagine-176 may account for the broad substrate specificity of PviPRX9.

128 patibility with various target proteins, the broad substrate specificity of Sfp for labeling the ybbR

129 The broad substrate specificity of SsMTAPII may be due to th

130 rowth on anthranilate, suggesting relatively broad substrate specificity of the BenC reductase, which

131 The broad substrate specificity of the cytochrome P450 (P450

132 These complex structures delineate the broad substrate specificity of the enzyme toward both NM

133 Analysis of the structure explains the broad substrate specificity of the enzyme, and provides

134 In line with the broad substrate specificity of the GH3 family of enzymes

135 These results show that the broad substrate specificity of the mammalian enzyme is n

136 A significant determinant for the broad substrate specificity of the metallo-beta-lactamas

137 from unnatural amino acids by exploiting the broad substrate specificity of the ribosome.

138 polarity is likely to be responsible for the broad substrate specificity of these mammalian P450s.

139 However, the broad substrate specificity of Uve1p suggests a more gen

140 Together with the broad-substrate specificity of an aldehyde reductase or

141 l molecule kinase inhibitors with inherently broad substrate specificities, precluding detailed exami

142 t here that the existence of the potentially broad substrate specificity protease Lon (also called La

143 iples are demonstrated: (i) For enzymes with broad substrate specificity, such as HIV-1 protease, res

144 on in the oil-rich cotyledon tissue, and the broad substrate specificities suggest that the two acyl-

145 This oxidase/reductase pair has broad substrate specificity, suggesting that this pathwa

146 The strong lipase activity of PDAT with broad substrate specificity suggests that this enzyme co

147 alactosaminidases (O-glycanases, GH101) with broad substrate specificities, termed Peptide:O-Glycosid

148 1 (MMP-3) is a matrix metalloproteinase with broad substrate specificity that has been linked to join

149 e betaine, a low affinity for choline, and a broad substrate specificity that included acetylcholine,

150 -20 expression pattern was associated with a broad substrate specificity that might preclude its expr

151 Consistent with broad substrate specificity, the drug glutathione conjug

152 ermining allelic variation: (1) Enzymes with broad substrate specificity: The observed polymorphism i

153 Despite their broad substrate specificity, their reactivity is very sp

154 Although the enzyme exhibits broad substrate specificity, there is a trend for peptid

155 Thanks to their broad substrate specificity, these chymotrypsin-like pro

156 icrodomain for proline-directed kinases with broad substrate specificity to phosphorylate mGluR and t

157 vity of the Sec residue is thought to confer broad substrate specificity to the enzyme.

158 gnition sites of the ribosomes, which confer broad substrate specificity to the system.

159 Moreover, Vv2KGR exhibited broad substrate specificity toward glyoxylate, pyruvate,

160 ficient organophosphate hydrolase (OPH) with broad substrate specificity using rational and random mu

161 levated levels of chemoprotective P450s with broad substrate specificity, which could influence chlor

162 These transporters demonstrate a remarkably broad substrate specificity, which seemingly contradicts

163 omal GH9 (Cel9W) is a cellulase displaying a broad substrate specificity, whose engineered form beari

164 synthetic pathways, suggesting that ZhuC has broad substrate specificity with respect to the holo-ACP

165 The Ch FatB1 has a broad substrate specificity with strong preference for 1

166 In addition, SetA has broad substrate specificity, with preferences for glucos

167 GghA has broad substrate specificity, with specific activities of

168 (II)-dependent 2,3-catechol dioxygenase with broad substrate specificity, YwnB is an NAD(P)H-dependen