ライフサイエンスコーパス: broadly

1 ickly impacted neuroscience and biology more broadly.

2 awn from clinical trials can be applied more broadly.

3 stance exchanges among African foragers more broadly.

4 1 activation or influences immune cells more broadly.

5 fab1, and in chilling-sensitive plants more broadly.

6 ng of metagenomes and DNA sequence data more broadly.

7 ly impacts healthy regions of the brain more broadly.

8 ronic pain prevention and public health more broadly.

9 t innovative practices to reach faculty more broadly.

10 ay rate constants of short-tailed mRNAs vary broadly (1000-fold) and are larger for short-tailed mRNA

11 h hormones such as glucocorticoids have been broadly accepted in recent decades as general neuromodul

12 Thus, QMAP-Seq provides a broadly accessible and scalable strategy for chemical-ge

13 st several commercial platforms and controls broadly accessible to the research community to quantify

14 More broadly, across taxa, imperfect coordination of collecti

15 mmunities can be desirable over traditional, broadly acting antibacterials in several contexts.

16 and participates in valvulogenesis, was more broadly activated.

17 nes in N. colorata might support a similarly broadly active ancestral ABCE model of floral organ dete

18 This opens new opportunities to develop broadly active glycomimetic inhibitors of viral entry an

19 al phosphoproteome effects, PP2A modulations broadly affect responses to more than 200 drugs inhibiti

20 ched in NMD signals, and, accordingly, ZMAT3 broadly affects target transcript stability.

21 Higher-order visual thalamus communicates broadly and bi-directionally with primary and extrastria

22 he thermodynamics of catalytic intermediates broadly and for understanding how copper active sites ac

23 transcriptomic data, we show that NCKAP1 is broadly and highly expressed in both prenatal and postna

24 evoke sparse responses from a combination of broadly and narrowly tuned neurons.

25 Here, we discuss wearable technology broadly and provide specific examples of activity patter

26 B, and molecules which act on the CLR family broadly and which directly regulate acute CLR-signaling

27 p of the cancer-immunity cycle and propose a broadly applicable 'minimal combination' of therapies de

28 ed analysis and visualization techniques are broadly applicable across developmental and systems biol

29 targets and verification by sequencing) is a broadly applicable approach for unbiased CRISPR-Cas off-

30 esulting complex, providing an efficient and broadly applicable approach to early fragment developmen

31 Here we present a broadly applicable approach to quantification and classi

32 Here, we report an accurate and broadly applicable data-driven algorithm for dimensional

33 Cryoreduction-EPR is broadly applicable for the study of electron transfer in

34 on regulates cell signalling, which might be broadly applicable for understanding the signalling func

35 This work demonstrates LAMIMS as a broadly applicable high-throughput operando screening me

36 validity of this assumption, or consider how broadly applicable it may be to all genes that are in th

37 ts has not been studied in a prospective and broadly applicable manner.

38 extensive research, but highly effective and broadly applicable methods remain elusive.

39 shown promise in the field, but accurate and broadly applicable models are still lacking.

40 are provided open access; they constitute a broadly applicable neuroscience toolbox resource for res

41 elucidate carcinogenic mechanisms and inform broadly applicable risk assessment efforts.

42 These data reveal a broadly applicable strategy across tumor types for repro

43 of targeted therapy and Quisinostat may be a broadly applicable strategy to induce a prolonged respon

44 We introduce a new, broadly applicable technique for the precisely controlle

45 PIC-seq provides a direct and broadly applicable technology to characterize intercellu

46 In this review, we discuss general and broadly applicable themes that have emerged from this co

47 As a computational methodology, WIF is broadly applicable to any SMLM dataset, imaging system,

48 Our approach is broadly applicable to complex multimetallic systems and

49 Furthermore, our technique is broadly applicable to earlier image-based detection of m

50 resent an oligonucleotide MS method which is broadly applicable to monitor in vitro RNA (de-)modifica

51 etween monomers and dimers is expected to be broadly applicable to other biogenic and anthropogenic S

52 vity are shown, but the PIE-FLIM approach is broadly applicable to other signaling pathways.

53 emonstrated that the present approach may be broadly applicable to proteins undergoing relatively sma

54 We anticipate that sci-fate will be broadly applicable to quantitatively characterize transc

55 Our APE-based method is easily computed and broadly applicable to statistically similar models found

56 The approach may be broadly applicable to the kinetic stabilization and char

57 catalytic system is practical, scalable, and broadly applicable to the reductive coupling of a wide r

58 he NADH photo-activation coupled with EPR is broadly applicable to trap reactive intermediates at low

59 This technology platform is broadly applicable to various diseases with well-known b

60 focused on minimizing alcohol intake may be broadly applicable.

61 nsive, enabling features that make CANs more broadly applicable.

62 of cells, indicating this approach could be broadly applicable.

63 ite solar cells which is in complimentary to broadly applied defect passivation techniques.

64 ylation has been thoroughly investigated and broadly applied in industry (>10(7) metric ton yearly).

65 Our optogenetic engineering approach can be broadly applied to aid the mechanistic dissection of cel

66 these challenges, machine learning has been broadly applied to analyze multiomics.

67 PRDD-seq can be broadly applied to characterize cell identity and lineag

68 ggests that urine diversion could be applied broadly as a strategy for both improving wastewater mana

69 m Spectrum Disorders (ASD) can be classified broadly as either synaptic or developmental.

70 vational studies suggest that prediabetes is broadly associated with diabetes complications, the caus

71 targeting sTNFalpha as a viable strategy to broadly attenuate sympathetic dysregulation, thereby imp

72 ic negative regulator of inflammation, which broadly attenuates pro-inflammatory gene programs in mac

73 The application of such methods to broadly available clinical samples such as formalin-fixe

74 ersity of bacteria and archaea by 44% and is broadly available for streamlined comparative analyses,

75 des and remains a robust, evidence-based and broadly available means for clinical workup and therapeu

76 HAL's components can broadly be classified into: on- and off-lattice agent co

77 E) in certain models of SCZ and discovered a broadly beneficial effect in preventing behavioral abnor

78 ockade of both IL-4 and IL-13 is required to broadly block type 2 inflammation, which translates to p

79 More broadly, by linking deep mutational scanning with engine

80 e we review the fundamental elements of four broadly categorized forms of synaptic plasticity and dis

81 w natural history collections can be used to broadly characterize trait responses to environment, rev

82 dentified shifts among symbiont classes that broadly coincided with the convergent evolution of phylo

83 ially separable subsets of CGRP(PBN) neurons broadly collateralize to their respective downstream par

84 While perovskite nanocrystals were broadly confined to only nanocubes, these new nanocrysta

85 higher animals; however, the enzyme appears broadly conserved across all kingdoms of life, which sug

86 chanisms for regulating critical periods are broadly conserved across evolution.

87 Here, we asked whether FXGs are a broadly conserved feature of the mammalian brain and sou

88 ne, thus, innexin/pannexin proteins may play broadly conserved roles in neuronal mechanotransduction.

89 n of NO(2) with water on diverse surfaces is broadly considered as a possible source of atmospheric H

90 LCRs) in protein sequences, with all of them broadly considering LCRs as regions with fewer amino aci

91 These results are broadly consistent with the canine surrogacy model as we

92 y to increase substrate contacts, others are broadly contractile, some polarize to facilitate migrati

93 e in the host-associated bacteria, which may broadly contribute to bacterial host adaptation and viru

94 ng approach to identify small molecules that broadly correct gene networks dysregulated in a human in

95 he origin and latitudinal spread of savannas broadly correspond with isotopic age estimates and encom

96 ness have renewed calls to develop improved, broadly cross-protective influenza vaccines.

97 that these differences may contribute to the broadly cross-reactive response elicited by HN13.

98 upport the use of LAIV in children to elicit broadly cross-reactive T cells, which are not induced by

99 ed DXR as a targeted inhibitor rather than a broadly cytotoxic chemotherapy.

100 More broadly, DCA, LCA and their derivatives are major compon

101 thrombotic antiphospholipid syndrome can be broadly defined as breakthrough thrombosis while on stan

102 bstrate distance, whereas the phase angle is broadly defined by the local capacitive response of the

103 croenvironment, yet its cellular identity is broadly defined, and whether it comprises functionally d

104 nd control of vector-borne diseases has been broadly described in both the literature and the current

105 terrestrial sites in the Baltic region that broadly differed in vegetation type and nutritional trai

106 mune cells in the liver are considered to be broadly dispersed across the lobule.

107 rghum LOW GERMINATION STIMULANT 1 (LGS1) are broadly distributed among African landraces and geograph

108 ults show that the ability to proliferate is broadly distributed among hepatocytes rather than limite

109 e, we find DinJ-YafQ family TA systems to be broadly distributed amongst diverse phyla, consistent wi

110 , showing that penumbral discharges are more broadly distributed and less useful for seizure localiza

111 fenses against foreign invaders, including a broadly distributed bacteriophage defense system termed

112 nd seven analogues) in the essential oils, a broadly distributed class of natural flavours.

113 aracterised by increased connectivity of (a) broadly distributed delta networks, (b) left-hemispheric

114 t recent follow-up, 20.4 to 41.3%), with HbF broadly distributed in red cells (F-cells 58.9 to 93.6%

115 HPV16 integration sites were broadly distributed in the genome, but in one tumor, HPV

116 Both types involved a multitude of broadly distributed, weak brain connections as opposed t

117 th responses at later time-points being more broadly distributed-consistent with feedforward pathway

118 Extensive aberrant methylation of DNA is broadly documented in early UC, contributing to genetic

119 rtment budgeting, and the importance of more broadly documenting the cost of measles outbreaks.

120 The HepaCometChip thus provides a broadly effective approach for detection of bulky DNA ad

121 ct IFN-independent antiviral program that is broadly effective in limiting virus replication and in s

122 designed to elicit such antibodies could be broadly effective.

123 Our results demonstrate that SPM levels were broadly elevated in plasma collected from NOD/ShiLtJ fem

124 Rule identity is broadly encoded across decision-making circuits, but the

125 rimesters one to three (Epoch-1), one set of broadly expressed (the majority) and brain-specific risk

126 alyse ChIP-seq data from MEIS, TFs which are broadly expressed across mouse branchial arches, and HOX

127 Although ERs are broadly expressed by cells of the immune system, the mec

128 n human genetics is how sequence variants of broadly expressed genes produce tissue- and cell type-sp

129 +/- 1% of third instar larval neurons but is broadly expressed in adults.

130 CV 5' untranslated region (UTR), whereas the broadly expressed let-7 and miR-17 families bind two sit

131 AFFL-2 is a broadly expressed nuclear protein, and nuclear localizat

132 The C-C chemokine receptor 4 (CCR4) is broadly expressed on regulatory T cells (T(reg)) as well

133 brain regions and fall into two categories: broadly expressed regulatory genes that are expressed in

134 Since the majority of ASD risk genes are broadly expressed, many ASD individuals may benefit by b

135 express para, while in the adult CNS para is broadly expressed.

136 Here, I broadly frame our current knowledge of Brachypodium-viru

137 ude that these two histidines, and TM6b more broadly, help trigger the bulk rearrangement of DraNramp

138 tes varied between sampling areas, some were broadly homogeneous, others varied 80%.

139 It also shows, more broadly, how a nutritional constraint can drive predator

140 The COVID-19 pandemic has broadly impacted biomedical research and health care.

141 We show that beta-HPV E6 more broadly impairs cellular signaling, indicating that the

142 n arginine vasopressin and oxytocin that are broadly implicated in neural mechanisms of vertebrate so

143 g in vitro, while next generation sequencing broadly implicates TrkB.T1 in the PI3K signaling cascade

144 al study could have a significant impact for broadly improving quality of life of SCI individuals.

145 We found that HDAC3 is expressed broadly in embryonic epidermis and is required for its o

146 The C-terminal segment is found broadly in N4/N6-adenine DNA methyltransferases, some of

147 MALT-1 is expressed broadly in the C. elegans nervous system, and neuronal I

148 ive of glycosylation reactions and then more broadly in the context of partially acylated polyols.

149 PRC2 binds RNAs broadly in vivo and in vitro.

150 significant expression changes, which could broadly influence quantitative trait variation.

151 We demonstrate that this small molecule broadly inhibits both viral and host protein synthesis a

152 g genetic variation for 14 traits classified broadly into four categories: biotic stress (cassava mos

153 n with a stable carbene other than NHC; more broadly, it drives further exploration of various carben

154 More broadly, its discovery demonstrates that targeting prote

155 the importance of the DNA entry-exit site in broadly maintaining the integrity of the transcriptome.

156 Broadly, MIGS can be categorized into surgeries that inc

157 from selective for a specific ion channel to broadly modulating cardiac ion channels from all three f

158 alide perovskite quantum dots (PQDs) or more broadly, nanocrystals possess advantageous features for

159 Broadly neutralizing antibodies (bnAbs) against HIV-1 pr

160 st blocking of viral infection by a class of broadly neutralizing antibodies (bnAbs) against human im

161 , ch.SOSIP trimers retained their binding to broadly neutralizing antibodies (bNAbs) and to their unm

162 The induction of broadly neutralizing antibodies (bNAbs) is a major goal

163 es of E2 complexes with front layer-specific broadly neutralizing antibodies (bNAbs) isolated from HC

164 apex mode of recognition like that of human broadly neutralizing antibodies (bNAbs) PGT145 and PCT64

165 Potent broadly neutralizing antibodies (bNAbs) represent a pote

166 Broadly neutralizing antibodies (bNAbs) represent a prom

167 patitis C virus (HCV) is the major target of broadly neutralizing antibodies (bNAbs) that are critica

168 d a focus for development of novel vaccines, broadly neutralizing antibodies (bnAbs), and therapeutic

169 o many diverse strains of the virus-known as broadly neutralizing antibodies (bnAbs)-could protect ag

170 been proposed to restrict the development of broadly neutralizing antibodies against HIV-1, but this

171 mised, passive immunization treatments using broadly neutralizing antibodies is a promising therapeut

172 tivating precursor B cell receptors of HIV-1 broadly neutralizing antibodies requires specifically de

173 Broadly neutralizing antibodies similar to the human V(H

174 Here, we show that older individuals make broadly neutralizing antibodies that have no hemagglutin

175 orts toward an HIV vaccine focus on inducing broadly neutralizing antibodies, but eliciting both neut

176 v conformation, preferentially recognized by broadly neutralizing antibodies, remains unknown.

177 nd serves as a target for some highly potent broadly neutralizing antibodies.

178 future efforts to design vaccines to induce broadly neutralizing antibodies.

179 tionally inferred germline sequences, to HIV broadly neutralizing antibodies.

180 loop bnAbs.IMPORTANCE The efficacy of HIV-1 broadly neutralizing antibody (bnAb) therapies may be co

181 evaluate TDF and FTC in combination with the broadly neutralizing antibody VRC01-N using a highly rep

182 Recently, numerous broadly neutralizing HIV-1 monoclonal antibodies (bNAbs)

183 g epitope in the head region recognized by a broadly neutralizing human antibody against a broad rang

184 RSV surface glycoprotein G in complex with a broadly neutralizing human monoclonal antibody.

185 viruses reveal a conserved footprint of the broadly neutralizing mAb RRV-12 in a region of the E2 gl

186 fe low-cost alternative is provided by using broadly neutralizing monoclonal antibodies (bnAbs).

187 More broadly, NucleaSeq enables rapid, quantitative and syste

188 mportantly, elevated anti-HAV Ig titers were broadly observed across plasma units obtained from the c

189 en by invertases in the epigenetic invertons broadly operate in the host-associated bacteria, which m

190 In this review, we address how a broadly operational RNA regulatory complex interfaces wi

191 her applications in battery design and, more broadly, other scientific domains that involve time-inte

192 More broadly our results call for caution in how we interpret

193 More broadly, our model provides a platform for understanding

194 More broadly, our results provide the necessary basis to inte

195 Broadly, our study presents a holistic account of how re

196 More broadly, our study reveals how fission-fusion dynamics a

197 ntext of Sox9(EGFP) populations, we classify broadly permissive and dynamic chromatin relative to TF

198 n the hippocampus, and the core network more broadly, play a causal role in episodic simulation and d

199 ance that ensures Xi integrity and may, more broadly, predict DNA repair outcome in malignant cells.

200 gh the pathway structure of the epitopes was broadly preserved across the clinical groups, there were

201 We showed that irreversible BTKis broadly prevented IgE-mediated degranulation and cytokin

202 prehensively determine the wiring logic of a broadly projecting serotonergic neuron (the CSDn) that s

203 However, similarly broadly protective antibodies against IBV NA have not be

204 y vaccines targeting rare B cells capable of broadly protective antibody responses are not hindered b

205 and consensus H1 as stem was shown to elicit broadly protective CD4(+) and CD8(+) T cell responses.

206 s toward design and implementation of a more broadly protective influenza vaccine.

207 disease progression and the need to develop broadly protective interventions to prevent future coron

208 Broadly protective vaccines against known and preemergen

209 To develop better, more broadly protective vaccines, a more thorough understandi

210 Although broadly protective, stem-targeted Abs against the influe

211 Defined broadly, psychiatric epigenomics seeks to understand the

212 However, it is unknown how broadly RBPs and ERV transcripts directly interact to pr

213 lls (antibodies, cellular therapies) or more broadly reactivate antileukemia immunity (vaccines, chec

214 Computationally optimized broadly reactive Ags (COBRA) targeting H1 elicit a broad

215 A molecule enhanced the elicitation of these broadly reactive antibodies.

216 that were important in elicitation of these broadly reactive antibodies.

217 the development of computationally optimized broadly reactive antigens (COBRA) for hemagglutinin (HA)

218 rom a single strain-specific clone, a single broadly reactive clone or both clones.

219 We report three broadly reactive human MAbs targeting N1 NA.

220 Some antiviral drugs and broadly reactive influenza vaccines that target the HA p

221 versions of adult T cells but instead are a broadly reactive layer of T cells poised to quickly deve

222 cognition, ranging from narrowly reactive to broadly reactive mAbs.

223 differentiating between strain-specific and broadly reactive plasma cell production during infection

224 limited information is available on Abs that broadly recognize the head domain.

225 lements regarding major predictor variables, broadly reflecting known sources.

226 st-spreading virus, Akkermansia muciniphila, broadly regarded as a beneficial commensal, bloomed upon

227 We distil genetic loci that are broadly relevant for many cognitive traits (g) from loci

228 e morphogen signaling strength, a conclusion broadly relevant for the many human diseases in which ol

229 , DNA repair, mutations, and cytotoxicity is broadly relevant to health.

230 This work is broadly relevant to studies of structure-function in rib

231 These results may be broadly relevant to the physiologic function of S100A4 i

232 e composite measure was valid in that it was broadly representative of the component measures and was

233 l ribose-utilization systems (RUSs) that are broadly represented in Bacteroidetes and appear to have

234 WAGO-class 22G-RNAs are also broadly required for transposon silencing, whereas piRNA

235 We hypothesise that this signal, broadly resembling that of other mid-latitudes proxies,

236 Numerous studies have broadly revealed a link suggesting that as years of form

237 emical biosensors for pathogen detection are broadly reviewed in terms of transduction elements, bior

238 t diverse intracellular pathogens and can be broadly segregated into distinct circulating and tissue-

239 ogenous tumor antigens generated in situ may broadly serve as a facile platform to modulate the suppr

240 ecies that are highly reactive and footprint broadly several amino acid residue side chains on the ti

241 uring the thermal annealing process has been broadly shown to induce deep-level defects, incur nonrad

242 The quality of life (QOL) of both arms was broadly similar at 12 months.

243 This principle applies more broadly since genomic analysis indicates suboptimal cano

244 These observations suggest that, broadly speaking, the systems-level anatomy of the audit

245 More broadly speaking, this work could provide a potential fr

246 ent-wide rates of alluvium accumulation were broadly stable for ~40,000 years, but increased 10-fold

247 enes, whereas the WT and DUBmut viruses more broadly stimulate upregulation of over 2,800 genes, incl

248 Peptidase inhibitors (PIs) have been broadly studied due to their wide therapeutic potential

249 Although they have been broadly studied in different areas of diagnostics, they

250 of national vector control programs or more broadly support local healthcare systems.

251 n, a reverse-phase protein array was used to broadly survey cellular signaling pathway activation fol

252 e sufficient performance to be deployed more broadly than in HIV care.

253 More broadly, the alpine cryosphere is an example of a system

254 More broadly, the MG2G method can be used in studying multipl

255 More broadly, the underlying incidence and demographic data,

256 More broadly, these data highlight factors determining dispar

257 More broadly, these datasets will facilitate interpretation o

258 Broadly, these strategies have fallen into two categorie

259 fer to the glycolysis pathway and that, more broadly, they show strong pleiotropy and epistasis.

260 e expense of what is already known, and more broadly, they suggest that environments that induce grea

261 More broadly, this approach of identifying robust changes in

262 More broadly, this research demonstrates a proof of concept f

263 More broadly, this study highlights the importance of underst

264 More broadly, this work is a step toward a detailed mechanist

265 ve gene regulators, both of which contribute broadly to morc1 de-repressed gene expression.

266 We hypothesize that this pattern will apply broadly to species that have extensive carbohydrate need

267 Medial SMCs proliferate broadly to thicken the media, after which a small number

268 this article, we discuss cultural competence broadly, to include not only the knowledge and the skill

269 elf-renewal and lineage commitment and, more broadly, to study and characterize the hematopoietic and

270 enetic and functional reprogramming, but how broadly trained immunity protects from infections is unk

271 ess the operation of mnemonic processes more broadly, triggering windows of anterograde and retrograd

272 ero"), showing that it is possible to obtain broadly tunable effective magnetic responses by introduc

273 optics, which has enabled the generation of broadly tunable light pulses with duration down to a few

274 rimary visual cortex: inhibitory neurons are broadly tuned in vivo and show non-specific connectivity

275 LNs expressing 5-HT7Rs are broadly tuned to odors and target every glomerulus in th

276 consistent with the initial recruitment of a broadly-tuned face detection mechanism which privileges

277 reported that gustatory cortical neurons are broadly-tuned to multiple tastes, and tastes are not rep

278 work further suggests that butyrate could be broadly used as a tool to increase growth of virus stock

279 There are few materials that are broadly used for fabricating optical metasurfaces for vi

280 efSaCas9 can be broadly used in genome-editing applications that require

281 a key element in the synthesis of molecules broadly used in medicine, agriculture and materials.

282 Thus, it can be broadly used to identify disease-related microbial organ

283 ensitive than previous methods and should be broadly useful as additional transcriptome datasets beco

284 We anticipate DeCoDe to be broadly useful for a variety of library generation probl

285 re unique to each patient, and therefore not broadly useful for ACT, some are shared.

286 n of previous work by the MDWG to identify a broadly useful gene panel based on whole transcriptome t

287 in C. elegans, here we derive a general and broadly useful model that matches stimulus history to od

288 We now introduce a new class of broadly useful small-molecule probes and a relay sensing

289 This inhibition assay may be broadly useful to quantify the functional antibody respo

290 The presented method has the potential to be broadly utilized for other whole blood biomolecule analy

291 ivation of carbonyl-containing substrates is broadly utilized in organic synthesis.

292 More broadly, we conclude that CRISPR mutagenesis in corals s

293 More broadly, we demonstrate that oligonucleotide-based thera

294 More broadly, we found that sequence patterns that lead to mo

295 More broadly, we hope that our approach will provide the blue

296 More broadly, we identified widespread genomic signatures of

297 More broadly, we see experimental evolution of digital organi

298 DNA enhancers in NSCs, where it colocalizes broadly with NSC regulator SOX2.

299 vely with increased rates of origination and broadly with total species diversity.

300 stem provides a rapid and effective means to broadly yet selectively mobilize chromatin sites.