ライフサイエンスコーパス: bromination

1 elations increased with increasing degree of bromination.

2 further derivatized by core chlorination and bromination.

3 ydrogen bonding to catalyze their asymmetric bromination.

4 nto the biosynthetic timing of jamaicamide A bromination.

5 at relies on a new method for regioselective bromination.

6 yrromethane, (ii) 1-formylation, and (iii) 9-bromination.

7 served to detect and localize the tryptophan bromination.

8 was prepared via a highly selective aromatic bromination.

9 be preferential sites for posttranslational bromination.

10 played a critical role in downstream deboro-bromination.

11 n in a manner that allows site-selective C-H bromination.

12 hrough regioselective electrophilic aromatic bromination.

13 lving additional aromatic electrophilic ring bromination.

14 borylation-oxidation, and one electrophilic bromination.

15 toward the alkenes with only minor aromatic bromination.

16 ic aromatic substitution reactions involving bromination.

17 rbonylations, methylations, silylations, and brominations.

18 n of their performance in photocatalytic C-H brominations.

19 Reduction (19), bromination (20), and phenylselenenylation (21), followe

20 A regioselective bromination, a biaryl coupling, and an intramolecular cy

21 enzofuran (IBF) precursor 14 in three steps (bromination, acetalization, and halogen-metal exchange/h

22 n aldehyde to a methyl enone, regioselective bromination adjacent to the carbonyl, and phenoxide disp

23 ility with one-pot bromination/arylation and bromination/alkenylation procedures to deliver meta-aryl

24 oselective Rh(III)-catalyzed protocol for C8-bromination and amidation of quinoline N-oxide was devel

25 lectivity, as well as variants that catalyze bromination and azidation.

26 high enantioselectivity for atroposelective bromination and bromolactonization was demonstrated.

27 Both bromination and chlorination were highly efficient for p

28 olefins in gasoline that combines selective bromination and comprehensive two-dimensional (2D) gas c

29 The first enzymatic asymmetric bromination and cyclization of a terpene, producing mari

30 ajority of which are produced via sequential bromination and debromination steps.

31 e (7), which also was prepared by successive bromination and dehydrobromination of the 6'-bromohomovi

32 n promoting protein oxidative damage through bromination and demonstrate that protein tyrosine residu

33 ng a double Wittig condensation, followed by bromination and di-dehydrobromination, is reported.

34 Subsequent bromination and elimination of HBr yield a polymer with

35 We herein report the palladium(II)-catalyzed bromination and iodination of a variety of alpha-hydroge

36 component FDH AetF catalyzes site-selective bromination and iodination of a variety of aromatic subs

37 The Rh(III)-catalyzed selective bromination and iodination of electron-rich heterocycles

38 high-yielding, general, and practical ortho bromination and iodination reaction of different classes

39 Homodiamantane bromination and nitroxylation are accompanied by contrac

40 2-methylindole via Friedel-Crafts acylation, bromination and pivaloylation.

41 oxidation-condensation protocol, followed by bromination and Suzuki coupling in the imidazole ring to

42 (the C-4 arene ring is readily introduced by bromination and Suzuki coupling).

43 and 1.8-fold during free chlorination, free bromination, and chlorination in the presence of bromide

44 be extended to stereospecific chlorination, bromination, and iodination reactions.

45 f the DOPC double bonds by means of specific bromination, and molecular modeling of the perturbed lip

46 corresponding 5,5'-unsubstituted bipyrrole, bromination, and Stille or Suzuki coupling.

47 We demonstrate this utility with one-pot bromination/arylation and bromination/alkenylation proce

48 guanine is the preferred purine targeted for bromination as a free nucleobase, 8-bromoadenine is the

49 ng regioselective oxidative transformations (bromination at C1/C3, ketone directed Pd(II)-catalyzed h

50 ation of tyrosine occurred more readily than bromination at neutral pH, plasma levels of halides, and

51 yed a double role: (i) it allowed additional bromination at position 5 and (ii) it could afford the r

52 Zinc insertion, bromination at the 5-position, and Suzuki coupling with

53 at the 10-position undergoes regioselective bromination at the 8-position.

54 Strategic bromination at the indole C3 position greatly improved t

55 ivity; (iv) SgcC3 also efficiently catalyzes bromination but not fluorination or iodination; (v) SgcC

56 This is the first example of a regiospecific bromination by a vanadium haloperoxidase and further ext

57 avengers on yields of tyrosine nitration and bromination by EPO are examined.

58 In contrast, bromination by HOBr was independent of Br(-) and unaffec

59 ase-H2O2-Cl(-)-Br(-) system, indicating that bromination by myeloperoxidase involves the initial prod

60 experiments on the stoichiometric C(sp(2))-H bromination by Pd(OAc)2 and Br2 confirmed this predictio

61 l to install the isocyclic ring, after which bromination can be directed to the 7-position of ring B

62 gent N-alkylation/oxidative aminocyclization/bromination cascade that joins two key components, which

63 ations show that Rh plays a dual role in the bromination, catalyzing the directed halogenation and pr

64 ition with an OATB, which minimizes aromatic bromination caused by excess reagent.

65 The regioselectivity of anisole bromination changed with pH, consistent with the partici

66 The bromination chemistry was then applied to gasoline, foll

67 e formation and selective beta-halogenation (bromination, chlorination) with N-bromosuccinimide and P

68 for various organic transformations such as bromination, cohalogenation, oxidation, cyclization, rin

69 alomethanes under free chlorination and free bromination conditions.

70 Regiospecific bromination, conversion to the substituted benzoic acid,

71 e with primary amines, followed by a one-pot bromination/cyclization process.

72 C (91.7 ng/g of total PBDD/Fs) and a higher bromination degree with increasing temperature.

73 Bromination-dehydrobromination of the 5'-bromohomovinyl

74 second double bond was best introduced by a bromination-dehydrobromination sequence, the 2-fold loss

75 Rate comparisons of aromatic brominations demonstrate the reactivity enhancement avai

76 the seven-membered ring by a regioselective bromination-elimination protocol, introducing a bromo su

77 ic acid-directed Pd(II)-catalyzed C(sp(3))-H bromination, enabled by quinoline ligands.

78 nistic studies also suggest that the initial bromination event is stereodetermining, and the major mo

79 introduced at the free meso-position of 7 by bromination followed by palladium-catalyzed cross-coupli

80 and is found to involve double-electrophilic bromination followed by thermal elimination of dibromine

81 was demonstrated by the example of enzymatic brominations, for which only a minute amount of a specia

82 Free bromination generally resulted in greater haloacetonitri

83 ted, and further combination with an in situ bromination gives access to polyfunctional pyrrole scaff

84 nslational modifications, such as tryptophan bromination, glutamic acid carboxylation, and threonine

85 Bromination had a larger effect on potency than chlorina

86 Specifically, selective C3 and C6 bromination has been achieved as well as C8 borylation.

87 ee of posttranslational processing including bromination, hydroxylation, and glycosylation define a f

88 etric increase in the level of tyrosine ring bromination (i.e., carbon-bromine bonds).

89 The final two steps involved bromination in liquid bromine and proper 2-fold dehydrob

90 The ability to suppress bromination in ring B (under acidic media) has been expl

91 tand the molecular basis for decarboxylative bromination in the biosynthesis of 1, we sequenced two P

92 Selective bromination in the fully aromatic skeleton is accomplish

93 The pattern of posttranslational bromination in the light sleeper peptide suggests that t

94 Results indicate that, degree and pattern of bromination, in the vicinity of the ether oxygen bridge,

95 between DM iodination versus chlorination or bromination include a more pronounced role for the hypoh

96 Sequential regioselective bromination, intramolecular ring cyclization, and aromat

97 Aryl group bromination is accomplished with such reagents as molecu

98 The regioselectivity of bromination is controlled by the presence of a carbocati

99 The capability for preferential 15-bromination is essential to install the isocyclic ring,

100 Bromination is one of the most important transformations

101 In addition, a complementary bromination is reported, which also establishes the seco

102 ps (Cl-DOM) are reacting with HOBr by direct bromination leading to Br-Cl-DOM and by bromine substitu

103 NBS bromination, lithium halogen exchange, and alkylation ga

104 version suggested that the initial catalytic bromination may be regioselective and stereochemistry-de

105 A mild, metal-free bromination method of arenes has been developed using th

106 hemistry textbooks as electrophilic aromatic bromination, nitrosation, and nitration, respectively.

107 roxy group was introduced by an NBS-mediated bromination-nucleophilic substitution sequence.

108 A in CH(2)Cl(2)), ring B is deactivated, and bromination occurs preferentially at the 15-position (87

109 Direct bromination of 1-formyldipyrromethane with 2 mol equiv o

110 ed in yields of 30 and 15%, respectively, by bromination of 2,2'-bipyrimidine, prepared from 2-chloro

111 The bromination of 2,3-diarylcyclopent-2-en-1-ones under var

112 here a biocatalytic scheme for the enzymatic bromination of 2-aminothiazoles using a marine macroalga

113 obenzimidazole (10) was obtained by a direct bromination of 2-chlorobenzimidazole (9) with bromine-wa

114 NBS bromination of 24 followed by lactone formation gave 26

115 erivative (2e) was obtained in high yield by bromination of 2d with NBS.

116 An improved and efficient bromination of 3,5-bis(trifluoromethyl)benzene was devel

117 Regioselective bromination of 4 and 2-methoxy-9,10-dihydro-9,10-[1,2]be

118 Bromination of 4 and 6 is also reported.

119 Compound 4a was prepared via selective bromination of 6-(furan-2-yl)nicotinonitrile (2a) with N

120 The second approach entails regioselective 7-bromination of a 10,15-diarylchlorin that lacks a substi

121 Electrophilic iodination or bromination of a 5,10-diaryl-substituted chlorin proceed

122 lf) was prepared by sequential acylation and bromination of a 5-substituted dipyrromethane followed b

123 Iodination or bromination of a free base 5,10-diaryloxochlorin gave a

124 idinium salts were efficiently prepared from bromination of a series of backbone substituted N,N-bisu

125 alutamide were labeled through electrophilic bromination of a tributylstannane precursor.

126 15-, 20-, and beta-pyrrolic positions, while bromination of a zinc 5,10-diaryloxochlorin selectively

127 catalytic, asymmetric process for the alpha-bromination of acid chlorides to produce synthetically v

128 de (DMF) and tetrabromomethane (CBr4) in the bromination of alcohols.

129 enantioselective transformations, the alpha-bromination of aldehydes remains a challenging reaction.

130 Alternatively, bromination of alpha-ketoesters with CuBr2 provided 3-br

131 e development of an unprecedented C(sp(3))-H bromination of alpha-tertiary and alpha-quaternary free

132 synthesis of a 7-aryl-imidazotriazinone via bromination of an unsubstituted imidazotriazinone follow

133 econd-order rate constant determined for net bromination of anisole by HOBr is up to 3000-times less

134 e and reductive transformations, such as the bromination of anisole or the reductive dechlorination o

135 l, Br2O, and HOBr toward rates of sequential bromination of anisole was quantified.

136 Nuclear bromination of anthracene, 9-methylanthracene, and diben

137 extended to a palladium-catalyzed ortho C-H bromination of aryl-O-carbamates even at 5 mol % loading

138 roach based on palladium-catalyzed C-H ortho bromination of azobenzenes, followed by copper-catalyzed

139 The first was uncovered during the bromination of benzodiazocine 8 in dichloromethane at 0

140 A continuous-flow protocol for the bromination of benzylic compounds with N-bromosuccinimid

141 metal catalysis, dimerization of acetylenes, bromination of benzylic substrates, and A(3)-couplings a

142 Electrophilic bromination of BN anthracene 1 with Br2, however, occurs

143 reactivity behavior and regioselectivity of bromination of BN anthracenes are consistent with the el

144 the large "dendrimer effect" observed in the bromination of cyclohexene with H(2)O(2) and NaBr cataly

145 Bromination of cytosine and formation of a piperidine-la

146 Bromination of DDR at carbon-5 abolished growth-inhibito

147 -)-8 was accomplished by the stereoselective bromination of dibromonorbornene (+)-4 guided by anchime

148 ) formation is observed, which competes with bromination of DOM (i.e., THM and HAA formation).

149 Bromination of either syn-4 or anti-4 gave anti-oriented

150 escribe the investigation of electrochemical bromination of electron-rich arenes in a 200% cell.

151 ated DBPs are primarily attributable to dark bromination of electron-rich formulas.

152 - and diastereoselective electrophilic alpha-bromination of enecarbamates to provide an atom-economic

153 ly developed method for the one-pot beta-C-H bromination of enones, which allows for rapid constructi

154 Selective bromination of gamma-methylene C(sp(3) )-H bonds of alip

155 ained with a radical-mediated regioselective bromination of indoline 12 serving as a key step.

156 We report herein the bromination of integral alkyne units in a pair of Zr(4+)

157 Regioselective stepwise bromination of meso-tetraaryl [14]triphyrins(2.1.1) was

158 The chemistry of sulfo-bromination of metals leading to dual-tapered 2D-shaped

159 h this compound class, including the aerobic bromination of methoxyaryls, oxygenation of 1,1,2,2-tetr

160 -) and H(2)O(2) at acidic pH results in both bromination of monochlorodimedone and modification of th

161 round-state selectivity of the electrophilic bromination of nitrobenzene can be fundamentally changed

162 Bromination of nucleobases was inhibited by scavengers o

163 route, including (i) CuBr(2)-mediated alpha-bromination of o-arylacetophenone, (ii) sequential nucle

164 Bromination of oak and pine litter is limited primarily

165 ethoxysilane/tetraethoxysilane catalyzes the bromination of organic substrates (4-pentenoic acid, 3,5

166 an average overall yield of 65% or by direct bromination of oxindoles (yield of 65-86%).

167 l and soil humus, we have shown that abiotic bromination of particulate organic matter occurs in the

168 As the first evidence of abiotic bromination of particulate SOM, this study identifies a

169 n peptide that catalyzes the atroposelective bromination of pharmaceutically relevant 3-arylquinazoli

170 For the bromination of phenylacetone as a model, a productivity

171 Subsequent regioselective bromination of phthalazin-1(2H)-ones 3 with benzyltrimet

172 studies on the nucleophilic chlorination and bromination of readily available six-membered cyclic nit

173 We describe the enzymatic bromination of ribosomally synthesized peptides and deve

174 Bromination of ring-B and tripropyl functionalization of

175 Specifically, this method demonstrated the bromination of several aromatic and heteroaromatic compo

176 e subject to abiotic oxidations resulting in bromination of SOM.

177 a greatly improved yield from the selective bromination of tetraphenylporphyrin (TPP) by NBS.

178 ia successive nucleophilic and electrophilic bromination of the 2-oxidocyclopentenyl cation and its r

179 hydrocupration of an alkyne, followed by the bromination of the alkenyl copper intermediate.

180 nd cleavage but rather in selective multiple bromination of the anthracenyl ligand.

181 Controlled bromination of the aromatic ring gave the monobromo oxim

182 itution, whereas viral PDI increased through bromination of the flavin.

183 Bromination of the methylene butyrolactone products foll

184 The NBS-mediated radical bromination of the N,N-di-tert-butoxycarbonyl protected

185 Bromination of the polycyclic oxetane 2,4-oxytwistane (r

186 urencia, Plocamium, Corallina) catalyzes the bromination of the sesquiterpene (E)-(+)-nerolidol produ

187 3), with Br(2) results in diastereoselective bromination of the stilbene units.

188 Methods were developed for the bromination of the vinyl groups of protoporphyin IX dime

189 Bromination of these BN-PAHs proceeds with complete regi

190 The first regioselective, mild bromination of thieno[2,3-b]pyridine is described herein

191 Bromination of trioxatricornan afforded a C(1)-symmetric

192 phy, and the analysis revealed the effect of bromination of triphyrin(2.1.1) on the structural framew

193 mediated oxidative damage of proteins (e.g., bromination of tyrosine residues) recovered in bronchoal

194 ults in oxidative damage of proteins through bromination of tyrosine residues, a heretofore unrecogni

195 tive modifications of proteins, particularly bromination of tyrosine residues, in peroxidasin-express

196 oxidation and chlorination of tryptophan and bromination of tyrosine residues.

197 We report the site-selective bromination of vancomycin to produce, with substantial e

198 By the use of a high-yielding bromination of various 2,1-borazaronaphthalenes to gener

199 d in four steps starting with two successive brominations of 2-acetylfuran first with N-bromosuccinim

200 Nitration (and bromination) of the 4-methyl, 7-methyl, 7-ethyl, 3,9-dim

201 synthetic utilities such as chalcogenation, bromination, olefination, and arylation are potential ad

202 emperature was developed to promote aromatic bromination on a variety of arene substrates with comple

203 f positioning and degree of chlorination and bromination on potency relative to an unsubstituted PAH

204 ynthesized TRAMs were proven by carrying out bromination on the -OH-containing aryl part and followed

205 or of a duplex with no modifications such as bromination or methylation on cytosine bases.

206 d by alternating (dGdC) polymers modified by bromination or methylation, as well as for (dGdC)13 inse

207 stabilized in the Z-conformation by means of bromination or supercoiling, but not to B-DNA.

208 htly and specifically to Z-DNA stabilized by bromination or supercoiling.

209 form and dibromoacetic acid formation (i.e., bromination pathway).

210 actic acid affect the efficiency of aromatic brominations, presumably via Lewis acid/base halogen-bon

211 ansition-metal-catalyzed, meta-selective C-H bromination procedure is reported.

212 A standard ortho-lithiation/bromination procedure, when applied to bromoarenes, resu

213 Fourth, subsequent bromination proceeded regioselectively at the 15-positio

214 roved to enhance the regioselectivity of the bromination process for O- and N-substituted arenes cons

215 The sulfo-bromination process is initially nucleated on the metal(

216 of 2,3-bis(thiosulfanyl)-but-2-enedinitrile, bromination products of 1-bromo-2,3-dimethylbenzene, and

217 s investigated by exploring the chlorination/bromination products of 3-indolepropionic acid using liq

218 The bromination protocol can also be performed with equal ef

219 st via an in situ halogenation (chlorination/bromination) protocol.

220 chlorinated drinking water, contributions to bromination rates decreased as BrCl > BrOCl > HOBr > Br2

221 That bromination rates increased with increasing [Cl(-)], [FA

222 as LED NMR kinetic analysis of photochemical bromination rates of different boronic esters further th

223 hese additional brominating agents influence bromination rates of disinfection byproduct precursors i

224 e that species other than HOBr can influence bromination rates under conditions typical of drinking w

225 synthetic pathways as demonstrated using the bromination reaction found on the jamaicamide biosynthet

226 formed experiments, the mechanism behind the bromination reaction was also proposed.

227 tic details of the isoselenazolone-catalyzed bromination reaction were revealed by (77)Se NMR spectro

228 of the isoselenazolone as a catalyst for the bromination reaction.

229 for catalytic activity in an atroposelective bromination reaction.

230 s can be used as generic bromine sources for bromination reactions giving improved yields and selecti

231 oselectivities observed in the nitration and bromination reactions in representative cases are the sa

232 ytic phosphorus(V)-mediated chlorination and bromination reactions of alcohols have been developed.

233 system can be used in both chlorination and bromination reactions of allyl amides with a variety of

234 nation, hydrofluorination, chlorination, and bromination reactions to produce saturated ROMP resins w

235 of Suzuki coupling, reduction, and Sandmeyer bromination reactions, starting from halogenated nitrobe

236 as well as the development of the analogous bromination reactions.

237 oups, was also observed in the nitration and bromination reactions.

238 ected to peptide-catalyzed, enantioselective bromination reactions.

239 in Suzuki-Miyaura coupling, methylation, and bromination reactions.

240 aromatic substitution reaction using simple bromination reagents.

241 A two-step, bromination-reductive Heck reaction protocol was also ef

242 oefficients are consistent with the observed bromination regioselectivity.

243 to the corresponding diketone and subsequent bromination resulted in an unexpected rearrangement to a

244 an arylzinc species with ZnCl2, followed by bromination, resulted in dramatically improved yields of

245 lternative attack at the enol carbon center (bromination, selenation) have also been defined.

246 a domino oxa-Michael addition/aldol reaction/bromination sequence that constructs both a fused five-m

247 d N(2) sorption studies suggest that partial bromination serves to increase the stability of this int

248 aminopyridine/CBrCl3 system acts as an alpha-bromination shuttle by transferring Br from CBrCl3 to th

249 es, which indicate the kinetically preferred bromination site for all products.

250 stribution, which in turn leads to different bromination sites directly dependent on the cavity condi

251 not activate the AhR2, but chlorination and bromination strongly affected potency in a position-depe

252 e EPO-H2O2-Br- system enhanced phenolic ring bromination, suggesting N-bromoamines are preferred brom

253 Fresh plant material is more susceptible to bromination than decayed litter and soil humus, due to a

254 Contrary to C-H chlorination and bromination, the direct iodination of alkanes represents

255 Free radical bromination then provided this hypercrosslinked monolith

256 erages an unusual heterocyclic N-oxide alpha-bromination to functionalize a critical C-H bond, enabli

257 by N-alkylation to improve the solubility or bromination to yield precursors for further derivatizati

258 olvent-grade mild reagent for site-selective bromination, to achieve the other photoredox cycle (II).

259 The bromination tolerates a broad range of functional groups

260 at the 13-position, (iii) regioselective 15-bromination under acidic conditions, and (iv) one-flask

261 alkenes to 1,2-dibromo alkanes via oxidative bromination using HBr paired with dimethyl sulfoxide, wh

262 ort a new method for regioselective aromatic bromination using lactic acid derivatives as halogen bon

263 rt an approach to unactivated, aliphatic C-H bromination using readily available N-bromoamide reagent

264 umber of olefins were subjected to oxidative bromination using Selectfluor/KBr.

265 but its regioselectivity of chlorination and bromination was almost completely switched from C6 to C7

266 upporting electrolyte (Bu(4)NBr) on chemical bromination was investigated.

267 The kinetics of polyamide bromination were first order with respect to the concent

268 ematically varied, and rates of dimethenamid bromination were measured.

269 eriochlorins with NBS gave regioselective 15-bromination when no pyrrolic substituents were present o

270 effectiveness of hydroxide for nitromethane bromination while respecting its incompatibility with th

271 s dimethyl sulfide and triethylamine and the bromination with Br(-).

272 ene (4) with ethyl diazoacetate, which after bromination with Br2 gave two isomeric monobromides (11

273 y(dG-d5meC) and binds to Z-DNA stabilized by bromination with high affinity and specificity.

274 Bromination with lithium bromide proceeds under simple,

275 O-BC) undergoes regioselective electrophilic bromination with NBS to give the 15-bromo analogue (MeO-

276 p-toluenesulfonic acid, and nuclear aromatic bromination with NBS).

277 or photochemical C(sp(3))-H chlorination and bromination with selectivity for primary and secondary C

278 10-mesitylchlorin (FbC-M(10)A(13)) undergoes bromination (with 1 molar equiv of NBS in THF) both in r

279 the 6-formyl derivative 19 by reduction and bromination) with the appropriate N-alkylaniline.