ライフサイエンスコーパス: bronchiseptica

1 ation in the lungs of mice than wild-type B. bronchiseptica.

2 a felis, Chlamydophila felis, and Bordetella bronchiseptica.

3 lis, 5 for FCV, 1 for C. felis, and 0 for B. bronchiseptica.

4 ludes B. pertussis, B. parapertussis, and B. bronchiseptica.

5 strains of Bordetella hinzii and Bordetella bronchiseptica.

6 n to be required for optimal virulence of B. bronchiseptica.

7 ndent gene regulation would also occur in B. bronchiseptica.

8 ur1, one of two fur homologues carried by B. bronchiseptica.

9 erved among multiple clinical isolates of B. bronchiseptica.

10 h CyaA is not critical for the success of B. bronchiseptica.

11 rge in-frame deletion relative to batB of B. bronchiseptica.

12 development of cell-free vaccines against B. bronchiseptica.

13 racts of mice more rapidly than wild-type B. bronchiseptica.

14 ned nasal tissues from mice infected with B. bronchiseptica.

15 em regulates biofilm formation in Bordetella bronchiseptica.

16 rongly support nosocomial transmission of B. bronchiseptica.

17 fectively reduced ciliary binding by Bvg+ B. bronchiseptica.

18 gens Bordetella parapertussis and Bordetella bronchiseptica.

19 pared with BMDCs treated with heat-killed B. bronchiseptica.

20 jority of the transcriptional response to B. bronchiseptica.

21 as shown in a previous study with Bordetella bronchiseptica.

22 al biofilm formation in the Bvgi phase in B. bronchiseptica.

23 synthesis of Bps and biofilm formation by B. bronchiseptica.

24 es, did not silence expression of bfrD in B. bronchiseptica.

25 ica or B. pertussis inhibited shedding of B. bronchiseptica.

26 ation in F. tularensis as well as Bordetella bronchiseptica.

27 In B. bronchiseptica, a remarkable spectrum of expression stat

28 In this study, we examined the effects of B. bronchiseptica ACT and TTSS on murine bone marrow-derive

29 Wild-type B. bronchiseptica activated the ERK 1/2 signaling pathway i

30 Previous studies indicate that B. bronchiseptica adenylate cyclase toxin (ACT) and the typ

31 B. bronchiseptica also infects humans, thereby demonstratin

32 athogens Bordetella pertussis and Bordetella bronchiseptica Although B. pertussis represents a pathog

33 gfp fusions in Escherichia coli, Bordetella bronchiseptica and Agrobacterium tumefaciens.

34 ion contributes to the in vivo fitness of B. bronchiseptica and B. pertussis.

35 Bordetella bronchiseptica and Bordetella pertussis form biofilms on

36 erric enterobactin utilization by Bordetella bronchiseptica and Bordetella pertussis requires the Bfe

37 ted cross-species protection against both B. bronchiseptica and Bordetella pertussis.

38 coding lipid A 3-O-deacylase from Bordetella bronchiseptica and by inactivation of the lgtB gene enco

39 nomes of Bordetella pertussis and Bordetella bronchiseptica and controls their infectious cycles.

40 to infection with relatively low doses of B. bronchiseptica and in vivo neutralization studies indica

41 ies to promote the growth of iron-starved B. bronchiseptica and induce bfeA transcription.

42 e 1beta-ADP pathways operative in Bordetella bronchiseptica and Mesorhizobium loti and by the GmhB of

43 e terminal trisaccharide, while wild-type B. bronchiseptica and mutants lacking only the palmitoyl tr

44 t information obtained studying FHA using B. bronchiseptica and natural-host animal models should app

45 ted the role of PRN in pathogenesis using B. bronchiseptica and natural-host animal models.

46 ding the successful zoonotic potential of B. bronchiseptica and other zoonotic bacteria.

47 amplifying and disseminating vectors for B. bronchiseptica and reveal an important role for the Bvg-

48 ns with the respiratory bacterium Bordetella bronchiseptica and the gastrointestinal helminth Trichos

49 Both broad host range (e.g. Bordetella bronchiseptica) and human-adapted (e.g. Bordetella pertu

50 atory diseases in a long list of animals (B. bronchiseptica) and whooping cough in humans (B. pertuss

51 ive analysis of the Bordetella pertussis, B. bronchiseptica, and B. parapertussis genome assemblies p

52 t studies addressing virulence factors of B. bronchiseptica are based on isolates derived from hosts

53 rdetella pertussis, B. parapertussis, and B. bronchiseptica are closely related species associated wi

54 eport, the fhaB genes of B. pertussis and B. bronchiseptica are functionally interchangeable, at leas

55 with the idea that the O-antigen loci of B. bronchiseptica are horizontally transferred between stra

56 Bordetella pertussis and Bordetella bronchiseptica are the causative agents of whooping coug

57 line augmented transferrin utilization by B. bronchiseptica, as well as siderophore function in vitro

58 ecimens were identified as B. holmesii or B. bronchiseptica at CDC.

59 Ac by various Bordetella species (Bordetella bronchiseptica, B. pertussis, and B. parapertussis) and

60 ring analog to phage display, the Bordetella bronchiseptica bacteriophage (BP) employs a highly varia

61 tein (ZIP) metal transporter from Bordetella bronchiseptica (BbZIP) revealed an unprecedented binucle

62 Additionally, B. pertussis and B. bronchiseptica bfeR mutants exhibited impaired growth wi

63 t, bfeA transcription in B. pertussis and B. bronchiseptica bfeR mutants was completely unresponsive

64 fusion analyses found that expression of B. bronchiseptica bfrA was increased during iron starvation

65 ctional in B. bronchiseptica, but neither B. bronchiseptica bfrD nor bfrE imparted catecholamine util

66 These results suggest that B. bronchiseptica biofilm formation is growth phase depende

67 alyses of the extracellular components of B. bronchiseptica biofilm matrix revealed that the major su

68 the formation and complex architecture of B. bronchiseptica biofilms.

69 This study confirmed that Bordetella bronchiseptica, Bordetella pertussis and Bordetella para

70 espondingly, TLR4 is critical in limiting B. bronchiseptica but not B. pertussis or B. parapertussis

71 pertussis were shown to be functional in B. bronchiseptica, but neither B. bronchiseptica bfrD nor b

72 Further studies using a B. bronchiseptica bvgAS mutant expressing the B. pertussis

73 sis are predominantly differentiated from B. bronchiseptica by large, species-specific regions of dif

74 anti-BcfA serum enhances phagocytosis of B. bronchiseptica by murine macrophages.

75 In this report, we determine that Bordetella bronchiseptica can form biofilms in vitro and that the g

76 growth phase-dependent gene regulation in B. bronchiseptica can function independently from the BvgAS

77 We further demonstrate that B. bronchiseptica can modulate normal macrophage function a

78 Bordetella bronchiseptica can use catecholamines to obtain iron fro

79 rmones also induce bfeA transcription and B. bronchiseptica can use the catecholamine noradrenaline f

80 ly adapted to the human body temperature, B. bronchiseptica causes infection in a broad range of anim

81 While B. bronchiseptica causes lethal disease in TLR4-deficient m

82 irulence factors at 24 degrees C, whereas B. bronchiseptica cells resumed the production only upon te

83 in produced by all members of the Bordetella bronchiseptica cluster, which includes B. pertussis, B.

84 B. bronchiseptica colonization in IL-10(-/-) mice was signi

85 on model, mutation of arnT did not affect B. bronchiseptica colonization, growth, persistence through

86 cyaA promoter or in the bvgAS alleles of B. bronchiseptica compared to B. pertussis, but appears to

87 increased in mice infected with wild-type B. bronchiseptica compared with mice infected with TTSS mut

88 y loci indicated an increased capacity in B. bronchiseptica, compared to B. pertussis, for ex vivo ad

89 rica, Pseudomonas aeruginosa, and Bordetella bronchiseptica contain an outer membrane 3-O-deacylase (

90 Remarkably, B. bronchiseptica continues to be transferred with the amoe

91 conjugate vaccine composed of the Bordetella bronchiseptica core oligosaccharide with one terminal tr

92 B. pertussis and B. bronchiseptica core OS were bound to aminooxylated BSA v

93 iptome and CGH analysis, we report that a B. bronchiseptica cystic fibrosis isolate, T44625, contains

94 A mutant of B. bronchiseptica defective for hurP was incapable of regul

95 In vivo, a Bordetella bronchiseptica DeltabatB mutant was unable to overcome i

96 B. bronchiseptica DeltahurI mutant BRM23 was defective in h

97 Data presented here confirm that a B. bronchiseptica deltapagP mutant demonstrates defective p

98 zed that the defective persistence of the B. bronchiseptica deltapagP mutant was due to an increased

99 y, we identified an open reading frame in B. bronchiseptica, designated bcfA (encoding BcfA [bordetel

100 The deletion of btrS in B. bronchiseptica did not affect colonization or initial gr

101 ry phases, we found that the adherence of B. bronchiseptica did not decrease in these later phases of

102 d invasins, deletion of this protein from B. bronchiseptica did not result in any significant defect

103 A fourth protein, Bb2785 from B. bronchiseptica, did not have d-aminoacylase activity.

104 pressed during infection, confirming that B. bronchiseptica does not modulate to the Bvg(-) phase in

105 These data suggest that B. bronchiseptica drive DC into a semimature phenotype by a

106 d that <100 colony-forming units (CFU) of B. bronchiseptica efficiently infected mice and displaced c

107 Bordetella pertussis and Bordetella bronchiseptica establish respiratory infections with not

108 Bordetella bronchiseptica establishes asymptomatic and long-term to

109 Bordetella bronchiseptica establishes persistent infection of the m

110 eria that serve as an amoeba food source, B. bronchiseptica evades amoeba predation, survives within

111 DCs) from C57BL/6 mice infected with live B. bronchiseptica exhibited high surface expression of MHCI

112 omplement killing assay demonstrated that B. bronchiseptica exhibits pagP-dependent resistance to ant

113 eria Bordetella parapertussis and Bordetella bronchiseptica express a lipopolysaccharide O antigen co

114 In the virulent state (Bvg+), Bordetella bronchiseptica expresses adhesins and toxins that mediat

115 nonmotile human pathogens, while Bordetella bronchiseptica expresses flagellin and causes disease in

116 hese findings suggest that virulent-state B. bronchiseptica expresses multiple adhesins with overlapp

117 A(Bp) was able to substitute for FHA from B. bronchiseptica (FHA(Bb)) with regard to its ability to m

118 Our results show that B. bronchiseptica flagellin is a potent proinflammatory fac

119 Our results show that B. bronchiseptica flagellin is able to signal effectively t

120 ithelial cells, we studied the effects of B. bronchiseptica flagellin on host defense responses.

121 d receptor specificity in the response to B. bronchiseptica flagellin.

122 oducing cells and delays the clearance of B. bronchiseptica from the lungs.

123 onse led to phagocytosis and clearance of B. bronchiseptica from the lungs.

124 to 7.6, Bordetella pertussis and Bordetella bronchiseptica FtrABCD system mutants showed dramatic re

125 Using B. bronchiseptica genetically modified strains deficient in

126 The B. bronchiseptica genome encodes a total of 19 known and pr

127 The recently sequenced Bordetella bronchiseptica genome revealed the presence of a gene, f

128 In silico searches of the B. bronchiseptica genome to identify other genes that encod

129 sis of Neisseria meningitidis and Bordetella bronchiseptica genomes.

130 Like E. coli GmhB, B. bronchiseptica GmhB and M. loti GmhB prefer the beta-ano

131 , in addition to the structure of Bordetella bronchiseptica GmhB bound to Mg(2+) and orthophosphate (

132 Bb3285 from Bordetella bronchiseptica, Gox1177 from Gluconobacter oxidans, and

133 sole NAD precursor, quinolinate promoted B. bronchiseptica growth, and the ability to use it require

134 While B. bronchiseptica has a wide host range, B. pertussis and B

135 fection, Bvg-regulated gene activation in B. bronchiseptica has not been investigated in vivo.

136 -Mulneix et al. demonstrates that Bordetella bronchiseptica has two different gene suites that are ac

137 We hypothesize that hemin is acquired by B. bronchiseptica in a BhuR-dependent manner after spontane

138 rotective immune response against Bordetella bronchiseptica in a mouse model of intranasal infection.

139 bin was not required to support growth of B. bronchiseptica in an Fe-limiting environment.

140 hrine could promote the growth of Bordetella bronchiseptica in iron-restricted medium containing seru

141 aprn mutant did not differ from wild-type B. bronchiseptica in its ability to adhere to epithelial an

142 ils (PMN) are critical for the control of B. bronchiseptica in mice, our data support the hypothesis

143 RP, the Aries BA did not cross-react with B. bronchiseptica in our study, although a larger sample se

144 (FHA(Bp)) and compared it with wild-type B. bronchiseptica in several natural-host infection models.

145 the bpsABCD locus to the pathogenesis of B. bronchiseptica in swine, the KM22Deltabps mutant was com

146 bution of the T3SS to the pathogenesis of B. bronchiseptica in swine, we compared the abilities of a

147 dependent contribution to pathogenesis of B. bronchiseptica in swine, we constructed a series of isog

148 nfection and host-to-host transmission of B. bronchiseptica in swine.

149 iliary binding, we used mutant strains of B. bronchiseptica in the binding assay.

150 that allow the persistent colonization of B. bronchiseptica in the host respiratory tract.

151 on of the pagP gene on the persistence of B. bronchiseptica in the lower respiratory tract of mice.

152 likely contributing to the persistence of B. bronchiseptica in the respiratory tract.

153 sive immunization led to the reduction of B. bronchiseptica in the tracheas and lungs.

154 were defective in reducing the numbers of B. bronchiseptica in the upper respiratory tract compared t

155 fhaS strain was out-competed by wild-type B. bronchiseptica, indicating that fhaS is expressed in viv

156 A strain isolated from a host with B. bronchiseptica-induced disease, strain 1289, was 60-fold

157 Interestingly, B. bronchiseptica induces a TLR4-dependent cytokine respons

158 and provided evidence that FHA-deficient B. bronchiseptica induces more inflammation in the lungs of

159 However, B. bronchiseptica-infected BMDCs did not exhibit significan

160 In this study, we show that B. bronchiseptica-infected macrophages can induce IL-17 pro

161 + splenocytes, and that lung tissues from B. bronchiseptica-infected mice exhibit a strong Th17 immun

162 contributes to pulmonary host defense in B. bronchiseptica infection by recruiting lymphocytes and N

163 of host cells are dephosphorylated during B. bronchiseptica infection in a TTSS-dependent manner.

164 gA response contributes to the control of B. bronchiseptica infection of the upper respiratory tract,

165 IgA induced by B. bronchiseptica infection predominantly recognized lipopo

166 ransplant center developed severe Bordetella bronchiseptica infections within 3 days of each other.

167 The TTSS of B. bronchiseptica inhibits the generation of IFN-gamma-prod

168 monstrate that norepinephrine facilitates B. bronchiseptica iron acquisition from the iron carrier pr

169 from the Gram-negative bacterium, Bordetella bronchiseptica Irradiating ZIPB by microsecond X-ray pul

170 Bordetella bronchiseptica is a Gram-negative bacterium equipped wit

171 Bordetella bronchiseptica is a Gram-negative bacterium that infects

172 Bordetella bronchiseptica is a gram-negative respiratory pathogen t

173 Bordetella bronchiseptica is a gram-negative respiratory pathogen t

174 Bordetella bronchiseptica is a gram-negative respiratory pathogen t

175 Bordetella bronchiseptica is a pathogen that can acquire iron using

176 Bordetella bronchiseptica is an etiologic agent of respiratory dise

177 Additionally, B. bronchiseptica is capable of establishing long-term or c

178 st inflammatory response to FHA-deficient B. bronchiseptica is characterized by the early and sustain

179 The Bvg- phase of B. bronchiseptica is characterized by the expression of fla

180 huRSTUV heme utilization locus in Bordetella bronchiseptica is coordinately controlled by the global

181 athogens Bordetella pertussis and Bordetella bronchiseptica is dependent on the BfeA outer membrane r

182 Bordetella bronchiseptica is pervasive in swine populations and pla

183 including those required for motility in B. bronchiseptica, is activated and genes encoding virulenc

184 hooping cough), whereas their progenitor, B. bronchiseptica, is of variable virulence in a wide varie

185 An extensive characterization of human B. bronchiseptica isolates is needed to better understand t

186 Cross-reactivity was found only with 5 B. bronchiseptica isolates, which were positive with IS1001

187 nes, BteA is secreted through the TTSS of B. bronchiseptica, it is required for cytotoxicity towards

188 is thought to have derived from a Bordetella bronchiseptica-like ancestor, we hypothesized that growt

189 . parapertussis evolved separately from a B. bronchiseptica-like progenitor to naturally infect only

190 e model that BhuR is a hemin receptor and B. bronchiseptica likely acquires heme during infection aft

191 involved in the increased virulence of a B. bronchiseptica lineage which appears to be disproportion

192 e to the increased virulence of a Bordetella bronchiseptica lineage.

193 se data are consistent with the view that B. bronchiseptica lineages can have different levels of vir

194 red for addition of glucosamine (GlcN) to B. bronchiseptica lipid A.

195 endotoxins using RAW cells suggests that B. bronchiseptica lipopolysaccharide (LPS) is 10- and 100-f

196 palmitoyl group to the lipid A region of B. bronchiseptica lipopolysaccharide.

197 Disruption of the Bordetella bronchiseptica locus (BB4268) revealed that ArnT is requ

198 Bordetella bronchiseptica LPS has the same structure, but lipid A i

199 stigated Bordetella pertussis and Bordetella bronchiseptica LPS-derived core oligosaccharide (OS) pro

200 indicate that persistent colonization by B. bronchiseptica may rely on the ability of the bacteria t

201 ature adaptation between B. pertussis and B. bronchiseptica may result from selective adaptation of B

202 This investigation characterizes a new B. bronchiseptica mechanism for iron uptake from transferri

203 sults indicate a critical role for FHA in B. bronchiseptica-mediated immunomodulation, and they sugge

204 We recently developed a Bordetella bronchiseptica mouse model to study transmission and hav

205 For successful colonization, B. bronchiseptica must acquire iron (Fe) from the infected

206 A B. bronchiseptica mutant lacking ACT produced more biofilm

207 was found to aggregate and permeabilize a B. bronchiseptica mutant lacking the terminal trisaccharide

208 B. bronchiseptica naturally infects a variety of animal hos

209 This study specifically shows that B. bronchiseptica not only inhabits amoebas but can persist

210 We report the prevalence in Bordetella bronchiseptica of IS481, a frequent target for diagnosis

211 Vaccination with heat-killed whole-cell B. bronchiseptica or B. pertussis inhibited shedding of B.

212 Bordetella bronchiseptica PagP (PagPBB) is a lipid A palmitoyl tran

213 ract (LRT) sensor], which is required for B. bronchiseptica persistence in the LRT.

214 he O antigen and palmitoylated lipid A of B. bronchiseptica play no role in this resistance.

215 identification of a novel gene in Bordetella bronchiseptica, plrS, the product of which shares sequen

216 tranasal inoculation of mice with Bordetella bronchiseptica produces a transient pneumonia that is cl

217 losely related zoonotic pathogen, Bordetella bronchiseptica, raising important questions about the co

218 Bordetella pertussis and Bordetella bronchiseptica rely on the global two-component regulato

219 iderably lesser extent when compared with B. bronchiseptica Remarkably, B. pertussis maintained the p

220 nd myoglobin as sources of nutrient Fe by B. bronchiseptica requires expression of BhuR, an outer mem

221 sing cloned alcS genes of B. pertussis or B. bronchiseptica restored the wild-type phenotype to the a

222 Norepinephrine treatment of B. bronchiseptica resulted in BfeR-dependent bfeA transcrip

223 phase-dependent gene regulation occurs in B. bronchiseptica, resulting in prominent temporal shifts i

224 Colonization by Bordetella bronchiseptica results in a variety of inflammatory resp

225 Discordant results included five Bordetella bronchiseptica results that were incorrectly identified

226 sis of Bvg regulation in B. pertussis and B. bronchiseptica revealed a relatively conserved Bvg(+) ph

227 immunization strategies aimed at inducing B. bronchiseptica-specific IgA may be beneficial to prevent

228 ion of vaccines, we constructed a Bordetella bronchiseptica strain (LPaV) that does not express the a

229 A B. bronchiseptica strain deficient in adenylate cyclase-hem

230 versus chronic disease, we constructed a B. bronchiseptica strain expressing FHA from B. pertussis (

231 chicine and provided protection against a B. bronchiseptica strain isolated from a dog with kennel co

232 B. pertussis strain Tohama I and Bordetella bronchiseptica strain RB50.

233 CVs) from the lungs of mice infected with B. bronchiseptica strain RBX9, which contains an in-frame d

234 A B. bronchiseptica strain that was missing dermonecrotic tox

235 tected against challenge with a prototype B. bronchiseptica strain.

236 Other B. bronchiseptica strains from the same phylogenetic lineag

237 eady-state manner by constructing Bordetella bronchiseptica strains in which the bvgAS promoter was r

238 Multilocus sequence typing analysis of 49 B. bronchiseptica strains was used to build a phylogenetic

239 When 18 additional B. bronchiseptica strains were serotyped, all were found to

240 infection, we found that the virulence of B. bronchiseptica strains, as measured by the mean lethal d

241 t are protective against highly divergent B. bronchiseptica strains, preventing colonization in the l

242 Here we show that two Bordetella bronchiseptica strains, RB50 and 1289, express two antig

243 hen compared to Bvg+ or Bvg- phase-locked B. bronchiseptica strains, single-knockout strains lacking

244 loci are horizontally transferred between B. bronchiseptica strains.

245 pneumonia after inoculation with Bordetella bronchiseptica, suggesting that TLR4 is required for exp

246 -gamma production by the TTSS facilitates B. bronchiseptica survival in the lower respiratory tract.

247 series of isogenic mutants in a virulent B. bronchiseptica swine isolate and compared each mutant to

248 or the PRN structural gene in a virulent B. bronchiseptica swine isolate.

249 ne, is activated substantially earlier in B. bronchiseptica than B. pertussis following a switch from

250 The prolonged persistence of B. bronchiseptica that was observed in gamma interferon (IF

251 Unlike wild-type B. bronchiseptica, the Deltaprn mutant was unable to cause

252 Bordetella bronchiseptica, the etiologic agent of upper respiratory

253 lar characterization of ZIPB from Bordetella bronchiseptica, the first ZIP homolog to be purified and

254 In Bordetella bronchiseptica, the functional type III secretion system

255 When applied to B. bronchiseptica, the screen identified the first TTSS cha

256 3SS, self-polymerizes to form the Bordetella bronchiseptica tip complex.

257 family sensor kinases and is required for B. bronchiseptica to colonize and persist in the lower, but

258 ically, FHA(Bb), but not FHA(Bp), allowed B. bronchiseptica to colonize the lower respiratory tracts

259 , FhaS was unable to mediate adherence of B. bronchiseptica to epithelial cell lines in vitro and was

260 trating a stable relationship that allows B. bronchiseptica to expand and disperse geographically via

261 es are involved in the ability of Bordetella bronchiseptica to grow and disseminate via the complex l

262 of Paraburkholderia phytofirmans allowed B. bronchiseptica to grow in the absence of supplied pyridi

263 results suggest that pagP is required for B. bronchiseptica to resist antibody-mediated complement ly

264 y its catalytic activity, is required for B. bronchiseptica to resist phagocytic clearance but is nei

265 hypothesized that the ability of Bordetella bronchiseptica to undergo phenotypic modulation is requi

266 o mouse studies, we hypothesized that the B. bronchiseptica type III secretion system (T3SS) would be

267 The B. bronchiseptica type III secretion system (TTSS) mediated

268 an immunomodulation involving the Bordetella bronchiseptica type III secretion system (TTSS) which co

269 These findings suggest that B. bronchiseptica use the TTSS to rapidly drive respiratory

270 Bordetella bronchiseptica uses a type III secretion system (TTSS) t

271 t studies addressing virulence factors of B. bronchiseptica utilize isolates derived from hosts other

272 Bordetella bronchiseptica utilizes a type III secretion system (TTS

273 Bordetella bronchiseptica utilizes a type III secretion system (TTS

274 This novel B. bronchiseptica vaccine candidate induces strong local im

275 Furthermore, human B. bronchiseptica vaccines are not available.

276 tion factor A (BcfA) to develop acellular B. bronchiseptica vaccines in the absence of an additional

277 Despite the widespread use of veterinary B. bronchiseptica vaccines, there is limited information on

278 usly for B. pertussis, bfrD expression in B. bronchiseptica was also dependent on the BvgAS virulence

279 to demonstrate that the rate of growth of B. bronchiseptica was directly correlated with the rate at

280 -type and LPS mutants of B. pertussis and B. bronchiseptica was examined.

281 Expression of nadC in B. bronchiseptica was influenced by nicotinic acid and by a

282 B. bronchiseptica was investigated because it is easier to

283 While wild-type B. bronchiseptica was shed from colonized mice and efficien

284 In this study, B. bronchiseptica was shown to use catecholamines to obtain

285 med by the sequenced laboratory strain of B. bronchiseptica We hypothesized that swine isolates would

286 ing the broad host range pathogen Bordetella bronchiseptica We recently discovered an additional sens

287 g mice that are natural host's of Bordetella bronchiseptica, we determined the effects of vaccination

288 ng the mouse respiratory pathogen Bordetella bronchiseptica, we examined the mechanisms of Ab-mediate

289 ll death, type III-secreted proteins from B. bronchiseptica were analyzed using matrix-assisted laser

290 Wild-type B. pertussis and B. bronchiseptica were both resistant to SP-D; however, LPS

291 nal regulators that were Bvg regulated in B. bronchiseptica were deleted, inactivated, or unregulated

292 Bordetella pertussis and Bordetella bronchiseptica, which are respiratory mucosal pathogens

293 gh, is a human-adapted variant of Bordetella bronchiseptica, which displays a broad host range and ty

294 w that the cyaA genes of B. pertussis and B. bronchiseptica, which encode adenylate cyclase toxin (AC

295 d that the fhaB genes of B. pertussis and B. bronchiseptica, which encode filamentous hemagglutinin (

296 a genetically engineered double mutant of B. bronchiseptica, which lacks adenylate cyclase and type I

297 Using B. bronchiseptica, which naturally infects mice, we show th

298 4 (TLR4) in immunity to B. pertussis and B. bronchiseptica, while no role for TLR4 during B. paraper

299 Furthermore, B. bronchiseptica within the sori can efficiently infect mi

300 ructure of a prokaryotic homolog, Bordetella bronchiseptica ZrT/Irt-like protein (bbZIP), and in sili