ライフサイエンスコーパス: bulbospinal

1 Bulbospinal A5 neurons, identified by juxtacellular labe

2 In summary, the loss of 84% of bulbospinal adrenergic neurones does not alter the abili

3 as evidence for short-range sprouting of the bulbospinal axons and the formation by them of new conne

4 lar recording and juxtacellular labelling of bulbospinal barosensitive neurones in the RVLM revealed

5 ogold-labeling for MOR1 was found in all RVL bulbospinal barosensitive neurons examined (9 of 9).

6 RVL bulbospinal barosensitive neurons were recorded in anest

7 ought to determine whether the barosensitive bulbospinal (BSBS) neurons of the RVLM express preproenk

8 Most bulbospinal C(1) cells with a putative sympathoexcitator

9 nerve activity (SNA) after the depletion of bulbospinal C1 adrenergic neurones.

10 olateral medulla (RVLM) region that contains bulbospinal C1 adrenergic neurons and is involved in blo

11 Within the RVLM, 79% of the bulbospinal C1 cells contained DNPI/VGLUT2 mRNA.

12 Bulbospinal C1 cells were destroyed ( approximately 84%

13 for GABA(Aalpha1) but a higher percentage of bulbospinal C1 neurons immunoreactive for GABA(Aalpha1)

14 s greater in more rostral versus more caudal bulbospinal C1 neurons, whereas, in physically active ra

15 nerve discharge owing to the destruction of bulbospinal C1 neurons.

16 neurons and also in approximately 20% of the bulbospinal C1 neurons.

17 s did not significantly affect the number of bulbospinal C1 or non-C1 neurons immunoreactive for GABA

18 extension (RVLM(RE) ), both of which contain bulbospinal catecholamine (C1) and non-C1 neurons.

19 ry for tyrosine hydroxylase (TH) to identify bulbospinal catecholaminergic (C1) neurons in sedentary

20 ction and Fast Blue to determine whether any bulbospinal catecholaminergic or serotonergic cell group

21 We sought to determine whether these bulbospinal cells are sensitive to Ang II.

22 In conclusion, RVLM bulbospinal cells express Ang II type-1 receptors whose

23 indeed adrenergic, a subset of barosensitive bulbospinal cells labeled with biotinamide were examined

24 GAD mRNA-positive bulbospinal cells were present medial to theA1 and C1 ca

25 lls project to medullary nuclei that contain bulbospinal cells which project to dorsal, intermediate,

26 activation of serotonergic and noradrenergic bulbospinal circuits.

27 erotonin is an important neurotransmitter in bulbospinal descending pathways, and 5-HT(1) receptors h

28 ible for diaphragm activation; PhMNs receive bulbospinal excitatory drive predominately from supraspi

29 oids elicit pain through tonic activation of bulbospinal facilitation from the RVM, (2) increased pai

30 tion of serotonin-containing axons and other bulbospinal fibres and remarkable recovery of diaphragma

31 A(2A)R mRNA traits, and (3) identify whether bulbospinal GABAergic neurons projecting to phrenic nucl

32 Thirty-eight bulbospinal I-AUG neurons were recorded in the rVRG and

33 tween segmental interneuronal and descending bulbospinal inputs, which results in the developmental r

34 crossed spinal synaptic pathways that convey bulbospinal inspiratory premotor drive to phrenic motone

35 cessfully elicit regeneration of sensory and bulbospinal motor axons but fail to elicit regeneration

36 For this group, EPSPs were found in 45/83 bulbospinal neurone/motoneurone pairs, with a mean ampli

37 ar spike-triggered averaging from expiratory bulbospinal neurones (EBSNs), with a view to revealing s

38 The activity pattern of the bulbospinal neurones and the L1 root consisted of two bu

39 Spike-triggered averaging from expiratory bulbospinal neurones in the caudal medulla revealed mono

40 ord lesions that transected the axons of the bulbospinal neurones in the segment below that under inv

41 is study, direct connections from expiratory bulbospinal neurones to identified motoneurones were inv

42 city in functional connections of expiratory bulbospinal neurones was investigated by measurement of

43 ory neurones projected to the area where the bulbospinal neurones were located.

44 We identified bulbospinal neurones with a firing pattern identical to

45 In both groups of operated animals bulbospinal neurones with firing properties and conducti

46 ncreased the spontaneous firing rate of most bulbospinal neurons (+250%, 28 of 39).

47 T(1A)R on serotonergic and catecholaminergic bulbospinal neurons and for their potential role in dire

48 for the sympathoinhibitory effects of SST on bulbospinal neurons and to identify likely sources of RV

49 trogens can modulate the function of RVLM C1 bulbospinal neurons either directly, through extranuclea

50 Thus, we conclude that bulbospinal neurons express MOR1 and DOR1; moreover, MOR

51 atomical studies have demonstrated that many bulbospinal neurons in the medial medullary reticular fo

52 teral medulla (RVLM) contains barosensitive, bulbospinal neurons that provide the main supraspinal ex

53 Most (33 of 46) histologically recovered bulbospinal neurons were C1 cells (immunoreactive for ty

54 GABAergic bulbospinal neurons were located in the caudal part of t

55 ological analysis revealed that ~21% of RVLM bulbospinal neurons were retrogradely labelled by both v

56 al pre-I pattern in retroambigual expiratory bulbospinal neurons, but this pattern is not elicited in

57 This population included bulbospinal neurons.

58 ophysiological methods, we showed that these bulbospinal NK1R-ir neurons are slowly discharging inspi

59 le-label immunofluorescence identified fewer bulbospinal non-C1 neurons immunoreactive for GABA(Aalph

60 gic neurons and two physiological classes of bulbospinal nonserotonergic cells interact to modulate p

61 Bulbospinal noradrenergic A5 neurons did not contain DNP

62 peptides and GABA are not co-transmitters of bulbospinal noradrenergic axons in the rat.

63 hese NK1R-ir cells make and whether they are bulbospinal or propriomedullary.

64 Anterograde tracing from RAm defined a bulbospinal pathway, terminations of which overlapped th

65 inociception produced by activation of these bulbospinal pathways is predominantly mediated by spinal

66 ulated by different types of neurons and the bulbospinal pathways regulating sympathetic outflow to t

67 This activity is derived from bulbospinal pathways that cross the spinal midline cauda

68 t most are also at the origin of descending, bulbospinal pathways.

69 nsiderable independence of the monoaminergic bulbospinal pathways.

70 In the RVLM, 54% of bulbospinal PPE(+) neurons were Fos-ir, whereas such cel

71 We determined whether the bulbospinal PPE(+) RVLM neurons are barosensitive in two

72 At the most rostral RVLM level, 29% of bulbospinal PPE+ cells were tyrosine hydroxylase-immunor

73 the thoracic spinal cord (T1) revealed that bulbospinal PPG(+) neurons are present in the rVRG (n =

74 stimulation is largely due to activation of bulbospinal presympathetic neurons within the RVLM.

75 Although monosynaptic bulbospinal projections to phrenic motoneurons have been

76 l GABAergic and glutamatergic nature of some bulbospinal raphe neurons was suggested by the presence

77 ngata, with the major outflow terminating in bulbospinal regions of the rostral ventromedial medulla.

78 ticity may relate to the unmasking of latent bulbospinal respiratory connections which restore functi

79 The neurotransmission of bulbospinal respiratory drive is believed to involve pri

80 Because some bulbospinal respiratory premotor neurons have bilateral

81 Retrogradely labeled bulbospinal RVLM neurons (N = 125) were recorded in thin

82 Patch clamp recordings were made from bulbospinal RVLM neurons (n = 31) in brainstem slices pr

83 d into the spinal cord to specifically label bulbospinal RVLM neurons in sedentary and active rats.

84 Fourteen bulbospinal RVLM neurons were recovered for immunohistoc

85 Bulbospinal RVLM neurons were spontaneously active (2.7

86 The majority of barosensitive bulbospinal RVLM neurons were tyrosine hydroxylase immun

87 All of the barosensitive bulbospinal RVLM neurons with axonal conduction velociti

88 ly fill spontaneously active, barosensitive, bulbospinal RVLM neurons with biotinamide following elec

89 These results indicate that the majority of bulbospinal RVLM neurons with putative sympathoexcitator

90 le-cell patch clamp recordings from isolated bulbospinal RVLM neurons, 17beta-estradiol dose-dependen

91 Bulbospinal serotonergic neurons and two physiological c

92 These results indicate that the bulbospinal serotonergic system(s) provide a significant

93 c continuum, and the contribution of altered bulbospinal sympathetic control to the decline in cardia

94 al cord injury is underpinned by interrupted bulbospinal sympathetic control.

95 her, our findings demonstrate that disrupted bulbospinal sympathetic pathways contribute directly to

96 Whether interrupted bulbospinal sympathetic projections contribute to cardia

97 is well recognized that the interruption in bulbospinal sympathetic projections is the main cause of

98 aneous neuroanatomical plasticity of severed bulbospinal systems and propriospinal neurons was invest

99 ls evoked from segmental, propriospinal, and bulbospinal systems in motor neurons were compared acros

100 -ir) and the latter constituted 19.4% of the bulbospinal TH-ir cells.

101 inct populations of pre-BotC and inspiratory bulbospinal ventral respiratory group (ibsVRG) neurons.