ライフサイエンスコーパス: bulky

1 77% to 96%; P = .53) in subgroup C (classic bulky).

2 abeling, face structural constrains, and are bulky.

3 olidinones and several pyrrolidines carrying bulky 2-substituents, due to reversibility of the initia

4 trategies rely on either slow or tethered or bulky actuators (or a combination).

5 indirectly as toxicity and directly measured bulky adduct formation and removal from the genome by sl

6 cific restriction modification and repair of bulky adducts and interstrand crosslinks.

7 he effect of transcription factor binding on bulky adducts formation varies, depending on the specifi

8 Our data support that HR at bulky adducts in mammalian cells involves post-replicati

9 as model lesions, we show that HR induced by bulky adducts in mammalian cells predominantly occurs at

10 as EdU alone or coupled to Biotin and other bulky adducts in synthetic DNA templates.

11 resume DNA replication at forks stalled near bulky adducts on the DNA.

12 say does not detect potentially carcinogenic bulky adducts that can arise when metabolic enzymes conv

13 At bulky adducts, PrimPol promotes sister chromatid exchang

14 tion, and poorly reactive towards sterically bulky alkene substrates.

15 A number of amines with three bulky alkyl groups at the nitrogen, which surpass the st

16 While bulky alkyl substituents inhibit the switching behavior,

17 dy of the impact of small, medium-sized, and bulky alpha,beta-dehydroamino acids (DeltaAAs) on the st

18 X = Cl, Br, I, H) complexes supported by the bulky alpha-diimine chelate N, N'-bis(1 R,2 R,3 R,5 S)-(

19 with distinct steric effects by introducing bulky amido moieties to ortho- or para-positions of the

20 from benzylic amines, amides, and sterically bulky amines hitherto inaccessible and a comparison of t

21 y is especially useful for electron poor and bulky amines which are reluctant to react with aldehydes

22 This was subsequently blocked by a bulky amino acid substitution.

23 ng an extended cavity that might accommodate bulky amino acids and drugs.

24 sensitization processes, the introduction of bulky amino acids at the A-C interface produced a recept

25 metric sensor that inhibits the transport of bulky amino acids.

26 disappearance of this advantage when using a bulky ammonium ion, which cannot be complexed within the

27 increase in efficiency removes the need for bulky and costly amplified laser sources, and creates th

28 to metal/salt reference electrodes: they are bulky and difficult to miniaturize, leak electrolyte to

29 L mol(-1) s(-1) were accessible by combining bulky and electron-withdrawing substituents.

30 to structural scanning tools; however, these bulky and expensive instruments are accessible to traine

31 laboratories using single-plexed assays with bulky and expensive instruments.

32 hese detection limits, but they involve both bulky and expensive laboratory equipment or long and ted

33 be repurposed for better performance without bulky and expensive permanent magnets.

34 f-concept realizations of NZI media based on bulky and expensive platforms are not easily compatible

35 however, current analytical tools tend to be bulky and expensive.

36 ilters and detectors, which makes the sensor bulky and expensive.

37 tion difficult and leads to devices that are bulky and have limited mechanical flexibility, which is

38 MRI coil technology may reduce the need for bulky and heavy housing of coil electronics and may prov

39 Surprisingly, in all three structures, the bulky and hydrophobic BP pyrenyl residue is entirely sol

40 longed delivery of multiple drugs, are often bulky and lack multifunctionality, and employ custom con

41 quiring large magnetic fields that make them bulky and lossy, there has been significant interest in

42 dge nanomanufacturing transforms traditional bulky and low-value woods into advanced materials that h

43 These results suggest that both bulky and more accessible medium-sized DeltaAAs should b

44 been prepared by overcrowding the nodes with bulky and rigid substituents.

45 in freely-behaving animals, they tend to be bulky and stiff, causing damage to the tissue they are i

46 t robots with multiple degrees of freedom is bulky and unpractical.

47 s electromagnetic generators that are heavy, bulky, and become inefficient with low water supply.

48 during catalytic nitrogen fixation given the bulky anilinium acids employed.

49 xhibits a "key in a keyhole" pattern where a bulky aromatic residue from one clamp subunit is anchore

50 Sterically bulky aryl groups on the sulfenyl moiety prevented erosi

51 rve cell viability, and the usually required bulky, as well as expensive, laboratory equipment.

52 sensitivity to competitive inhibition via a bulky ATP analog.

53 d]pyrimidine-4-amine (PP) compounds that are bulky ATP mimetics.

54 ong alkyl or oligoethylene glycol spacers or bulky barriers in-between the binding stations, and a si

55 thod for capturing oligonucleotides carrying bulky base adducts, including UV-induced cyclobutane pyr

56 ions, including UV-induced photoproducts and bulky base adducts.

57 s a base excision repair enzyme that excises bulky base lesions from DNA.

58 ted, green energy from body-heat, overcoming bulky battery configurations that limit the wearable-tec

59 kyloxy-cytosine derivatives, especially with bulky benzyloxy substituents, showed increased potency.

60 Herein we show that by appending bulky beta-cyclodextrin (CD) groups onto sheet-forming p

61 Bulky beta-diketones have rarely exceeded dipivaloylmeth

62 (6)H(11), t-Bu, cyclopropylmethyl) bearing a bulky bidentate 2-[bis(adamant-1-yl)phosphino]phenoxide

63 nced reactivity of copper catalysts based on bulky bidentate phosphine ligands originates from the at

64 re P-chirogenic diphosphazanes incorporating bulky bisphenol and 1,1'-bi-2-naphthol-derived substitue

65 Employment of a pair of bulky Bronsted acid and base as additives is responsible

66 compounds, we suggest that lipophilic N6 and bulky C2 substituents can promote stable and long-lived

67 ell morphology are secondary consequences of bulky cargo retention.

68 ic reticulum (ER) exit sites, where it binds bulky cargo within the ER lumen and recruits membranes f

69 go1-depleted cells persist in the absence of bulky cargo, showing that they are due to a secretion-in

70 For the very bulky CF3 and iPr groups, constraints in the ground stat

71 are driven by the reagents' interaction with bulky chiral catalysts.

72 E-vinyldiazoacetates in the presence of the bulky chiral dirhodium tetracarboxylate catalyst, Rh(2)

73 ere, a 2D MHP is structurally tailored using bulky chiral organic cations to exhibit an unusual confl

74 e a transport intermediate for the export of bulky collagens.

75 development is still limited by inefficient bulky connections between functional modules, incompatib

76 f reactivity between arylazides N3 Ar with a bulky copper(I) beta-diketiminate.

77 ectrochemical method eliminates the need for bulky, costly and complex optical instrumentation that r

78 nese, iron or cobalt) sandwiched between two bulky Cp(ttt) ligands (where Cp(ttt) is {1,2,4-C(5)H(2)

79 Alkylation with a sterically bulky cyclopropylmethyl-derived acetoxymethyl ether rend

80 zyme and adduct that help to accommodate the bulky damages in a hydrophobic pocket to facilitate TLS.

81 diffusion controlled Zn(2+) intercalation in bulky delta-MnO(2) and control of H(+) conversion reacti

82 l (DeltaAla), medium-sized (Z-DeltaAbu), and bulky (DeltaVal) DeltaAAs exerting similar effects.

83 ors, designs have transitioned recently from bulky devices with an aqueous inner filling solution to

84 in the small fraction of kinases that harbor bulky DFG-1 residues offers a versatile selectivity filt

85 quence homology among unrelated kinases with bulky DFG-1 residues provides a new paradigm for selecti

86 cm in 96 (32%; subgroup B), whereas classic bulky (diameter > 10 cm) was detected in 99 (33%; subgro

87 The calculations have predicted that the bulky diol 1,4-Bis(2-hydroxy-2-propyl)benzene, which has

88 he estimated kinetic data point out that the bulky diol at 1 mol L(-1) in combination with 18-crown-6

89 used for designing a synergic combination of bulky diols with crown ethers able to accelerate this ki

90 The presence of bulky disease in Hodgkin lymphoma (HL), traditionally de

91 elated with younger age, higher frequency of bulky disease, lower hemoglobin levels, higher leukocyte

92 B, and IIA) and advanced stage (IIB-IV) with bulky disease.

93 affolds assemble at membrane surfaces, their bulky disordered domains become crowded, generating ster

94 Bulky DNA adducts are important replication-blocking les

95 In mammalian cells, bulky DNA adducts located in the template but not the co

96 a versatile mechanism to repair a variety of bulky DNA adducts.

97 broadly effective approach for detection of bulky DNA adducts.

98 lisomes often encounter obstacles, including bulky DNA lesions caused by reactive metabolites and che

99 In nucleotide excision repair, bulky DNA lesions such as UV-induced cyclobutane pyrimid

100 duced thymine-thymine (T-T) dimers and other bulky DNA lesions, but pol eta also has other cellular r

101 r of chemically induced helix-distorting and bulky DNA lesions, such as cyclobutane pyrimidine dimers

102 topologically complex NLSs that lie next to bulky domains or are masked by quaternary structures.Imp

103 als with different rotamer conformations; b) bulky Dur-substituted phosphasilene forms two radicals (

104 cal MOFs exhibit superior adsorption for the bulky dye molecules and catalytic performance for the CO

105 an iridium(I) catalyst in conjunction with a bulky electron rich phosphine ligand (CataCXium A) which

106 ent variations in sweat composition requires bulky electronic systems and power sources, thereby cons

107 le electronics outperform existing rigid and bulky electronics and benefit a wide range of species, i

108 artifacts and discomfort caused by rigid and bulky electronics and mandatory device connection on act

109 nd all Smad2/3 cKO mice ultimately developed bulky endometrioid-type uterine cancers with 100% mortal

110 ean water from humid air without reliance on bulky equipment and high energy has been a substantial c

111 es are limited by multiplexing capabilities, bulky equipment, and cost.

112 methods are usually time-consuming, require bulky equipment, tedious sample preparation, a trained o

113 mation due to the strong steric hindrance of bulky ethylhexyl side chains.

114 merical-aperture objective lenses, which are bulky, expensive, and difficult to miniaturize.

115 ngs, sophisticated time-lapse microscopy, or bulky/expensive chemo-stat instrumentation for dynamic m

116 nt lab-on-chip approaches that still require bulky external instrumentation for their operation.

117 city, yet current methods are too complex or bulky for point-of-care (POC) use.

118 Consequently, the rigidity and bulky form factor of the existing devices are not suitab

119 e high computational loads or have rigid and bulky form factors that are unsuitable for use on the fa

120 subdivision of C. annuum separates large and bulky fruits from small ones.

121 tic molecules by the introduction of similar bulky functional groups at their periphery.

122 e 'HepaCometChip', enabling the detection of bulky genotoxic lesions that are missed by current genot

123 However, the consequences of appending the bulky GFP moiety to the protein of interest are rarely i

124 was also designed to encapsulate and release bulky globular proteins, such as mCherry, in a light-dep

125 Here we report that a bulky glycocalyx promotes the expansion of disseminated

126 steric arguments emphasizing the role of the bulky group of the catalyst that prevents the approach o

127 er and a linker [(L-(CH(3) )(6) )] with more bulky groups gives rise to a flu topology with a new 8-c

128 ere is increased evidence that the effect of bulky groups in organic, organometallic, and inorganic c

129 e amide nitrogen atom to be substituted with bulky groups, we developed quinazoline-based imaging too

130 Utilizing the bulky guanidinate ligand [L(Ar*)](-) (L(Ar*) = (Ar*N)2C(

131 coordination mode is exploited by sterically bulky HDAC6-selective phenylhydroxamate inhibitors.

132 rearranged spongian diterpenoid in which the bulky hydrocarbon fragment is joined via a quaternary ca

133 capitalizes on the remarkable discovery that bulky, hydrophilic trans-cyclooctene-containing primary

134 the replacement of breakpoint serine with a bulky hydrophobic amino acid is sufficient to completely

135 sed on rhodamine 110 and 6G dyes paired with bulky hydrophobic counterions, which prevent dye self-qu

136 recursors (6a, 6b, 6d, and 6e) with flexible bulky hydrophobic groups instead of the rigid polyhetero

137 chain (the "pEF head") confers a pronounced bulky hydrophobic nature to the AbetapE3 N terminus that

138 e very stable due to protection given by the bulky hydrophobic organic groups.

139 The conversion of these bulky hydrophobic side chains to smaller side chains is

140 e that cyclophellitol derivatives carrying a bulky hydrophobic substituent at C8 are potent and selec

141 es; most notably, compounds substituted with bulky hydrophobic substituents displace the Pf-M17 catal

142 ases and the mucosal projections become more bulky in the ampullary portion, with the projections les

143 configuration, allowing the accommodation of bulky inhibitor side chains.

144 Current WBC counting method relies on bulky instrument and trained personnel and is time consu

145 e transcription (RT-qPCR) typically involves bulky instrumentation in centralized laboratories and an

146 cids require many reagents and expensive and bulky instrumentation.

147 tep, time consuming, requiring expensive and bulky instruments with a constant need of electricity wh

148 trained personnel, laborious procedures, or bulky instruments, thereby decentralizing this important

149 hods are costly, labor-intensive and require bulky instruments.

150 In the N139L mutant, the bulky L139 side chain inhibits timely reprotonation of E

151 ery and several types of DNA damage, such as bulky lesions and DNA double-strand breaks.

152 In this way, comet-undetectable bulky lesions are converted into comet-detectable single

153 -flipping mechanism that enables excision of bulky lesions more commonly associated with nucleotide e

154 DNA-protein crosslinks (DPCs) are bulky lesions that interfere with DNA metabolism and the

155 DPCs are bulky lesions that interfere with the progression of rep

156 ide excision repair, which primarily removes bulky lesions.

157 led-coil domains through introduction of the bulky leucine surrogate homoisoleucine.

158 ted Lewis pairs': unquenched combinations of bulky Lewis acids and bases whose dual reactivity can be

159 The use of bulky Lewis acids, aluminum tris(2,6-diphenylphenoxide)

160 c conditions with Pd2(dba)3 (2.5 mol%) and a bulky ligand (JackiePhos, 10 mol%) controlling the beta-

161 e bulky ligands with small ligands or remove bulky ligands from NPs after NP deposition.

162 tive site support its binding to anionic and bulky ligands like glucuronides.

163 al catalysts, taking advantage of sterically bulky ligands on the metal that serve as surrogate suppo

164 f such complexes often requires polydentate, bulky ligands to stabilize the catalytically active Co(I

165 g unique surface chemistry that can exchange bulky ligands with small ligands or remove bulky ligands

166 The compound with a bulky lipophilic substituent (SnBu(3)) exhibits a relati

167 heless, fibrils with parallel molecules show bulky loops formed by residues 1 to 7 located on the sam

168 oing waves-that is, mirrors, which are often bulky, lossy and difficult to fabricate.

169 In multiple regression analyses, bulky lymphadenopathy (>=5 cm) and refractoriness to B-c

170 Patients without bulky lymphadenopathy, BCRi-refractory CLL, or an advers

171 Each presented with persistent fevers, bulky lymphadenopathy, massive hepatosplenomegaly, and s

172 uthors analyzed 61 untreated patients with a bulky lymphoma (at least one tumor mass >/=7 cm in diame

173 s(beta-diketiminato) ligand [L(Ph)](3-) with bulky m-terphenyl substituents that can host two Ni-H un

174 f nutrients without the burden of fermenting bulky masses of dietary fiber.

175 ent dye leakage support for the formation of bulky, membrane-disruptive supramolecular amphiphiles du

176 Treatment of the bulky metallocene hydride Cp*2Zr(H)OMes (Cp* = pentameth

177 Introduction of bulky methionine for glycine at two points on this surfa

178 We employ a bulky methylcyclopropylacetoxymethyl ether to diminish t

179 hly toxic interstrand cross-links (ICLs) and bulky minor groove adducts normally recognized by Fancon

180 dination of the carboxylic acid group to the bulky Mn complex ensures the rigidity needed for high en

181 er group (Bpin) is generally thought of as a bulky moiety because of the two adjacent quaternary sp(3

182 exceptional activity in the hydrogenation of bulky molecules ( approximately 2 nm).

183 area of 2D materials allows for reactions of bulky molecules too large to access interior pores.

184 different acid-catalyzed reactions involving bulky molecules, as in the synthesis of fine chemicals a

185 nct HDF mechanisms for L(2)CuH (bidentate or bulky monodentate phosphines) and L(3)CuH (small cone an

186 readily available copper catalyst bearing a bulky monodentate phosphoramidite ligand, which is essen

187 that pendant carboxylic acids, combined with bulky monophospine ligands on palladium, can direct the

188 The use of ditopic and bulky monotopic subcomponents, respectively, allows a he

189 of AOPCP without the necessity of additional bulky N(6)-substituents.

190 he interaction is undiminished by sterically bulky N-alkyl groups.

191 disease due to the destabilizing effect of a bulky N-glycan.

192 Our study suggests that the bulky N-glycans influence the large-scale conformational

193 ovel cyclometalated ruthenium catalysts with bulky N-heterocyclic carbene (NHC) ligands.

194 actors, including patient age, contralateral/bulky neck disease, increasing number of positive lymph

195 The prognosis of patients with bulky nodal and metastatic PSCC is dismal and new manage

196 rbitrap MS(n) with online trapping to enrich bulky, nonpolar adducts.

197 ic effect of pHIFU and thermal parameters in bulky normal muscle tissues based on a rabbit model and

198 Following the study in bulky normal muscle tissues, we further created bulky tu

199 yield), and crowded beta-diketones featuring bulky o-biphenyl or m-terphenyl fragments were prepared

200 pendant carboxymethyl side chain cis to the bulky octahydronapthalene substituent was pivotal in fas

201 However, most present filters are bulky, opaque, and show low-efficiency PM(0.3) /pathogen

202 s are performed using free-space optics with bulky optical components.

203 am generation are either severely limited by bulky optical setups or by restricted channel capacity w

204 Patients with bulky or deep-seated soft-tissue malignancies not amenab

205 any potentially useful substrates, including bulky or electron-deficient indoles, are poorly accepted

206 V-1 Env residue 375 mutations that mimic the bulky or hydrophobic residues typically found in simian

207 Current designs are either bulky or use planar films that cause problems in crackin

208 e discrete metal halide centers, isolated by bulky organic cations.

209 Because labeling in bulky organs, such as fruits, is difficult, we developed

210 Two new YPhos ligands with bulky ortho-tolyl (pinkYPhos) and mesityl (mesYPhos) sub

211 abeling technology, probes are tagged with a bulky Osmium tag (Osmium tetroxide 2,2'-bipyridine), in

212 Due to the presence of the bulky Osmium tag, probes traverse more slowly, produce m

213 More electronegative and less bulky oxygen of OTIs compared to the sulfur of the origi

214 , respectively, while employing sufficiently bulky P(t)Bu3 and terphenyl phosphine ligands.

215 hine ligands, revealing the critical role of bulky P-aryl groups in facilitating this process.

216 Steric shielding due to the bulky P-substituent gives marked different reactivities

217 in the cross-coupling of sterically hindered bulky PAHs.

218 application is limited by complex protocols, bulky peripherals, and slow operation.

219 dynamics simulation data suggested that the bulky Phe acts as a pawl that stabilizes the downward ra

220 (2) as a monoligated complex L->C(2) using a bulky phosphine ligand bearing two imidazolidin-2-iminat

221 The resulting bulky phosphines formed complexes with IrCp*Cl(2), RuCl(

222 w years, the use of suitable ligands such as bulky phosphines or N-heterocyclic carbenes (NHCs) has e

223 k of the phosphine ligands: derivatives with bulky phosphines that shield the oxo ligand are stable e

224 Bulky photolabile masked alkyne equivalents (MAEs) are n

225 lumn efficiencies in TRLC despite the use of bulky polymers as stationary phases in HPLC.

226 results from steric interactions between the bulky porphyrin ligand and the intermediate substrate ra

227 without employing higher drift voltages and bulky power supplies.

228 o a transport intermediate commensurate with bulky procollagens is then facilitated by two complement

229 noblasts were elongated and displayed large, bulky pseudopods with dynamic actin bursts.

230 nditions and are driven by high voltages, no bulky pumping systems are needed, neither for the hydrod

231 ds to (+/-)-CF(3)-SOX with the use of a less bulky quinone oxidant, the kinetic syn-1,3 amino alcohol

232 subpopulations without the need of labels or bulky readout optical equipment.

233 posed by the relatively rigid and sterically bulky repeating units.

234 Only 15% of human kinases carry a bulky residue at the DFG-1 position, providing an opport

235 In resistant RVs and EVs, bulky residues in this pocket prevent their binding.

236 Here we identify that bulky residues located N-terminal to the DFG motif (DFG-

237 We hypothesized that the bulky residues should destabilize the closed conformatio

238 lexes, extended the sampling times for large bulky residues, incorporated the modeling of glycans on

239 The bulky rhodium carbenes led to highly site-selective func

240 -film bioelectronic system avoids the use of bulky, rigid sensors, while providing negligible mechani

241 in the form of an RNA:DNA hybrid segment or bulky secondary structures, indicating a dsRNA scanning

242 ne mixing during TANGO1-mediated transfer of bulky secretory cargos from the ER to the ERGIC/Golgi vi

243 arious limitations such as a small eyebox, a bulky setup and a high cost.

244 en interfaced with energy harvesters through bulky Si-based rectifiers that are difficult to integrat

245 ture wherein a surface residue with a single bulky side chain forms the end of the substrate binding

246 to test the hypothesis that eliminating this bulky side chain would create an opening and permit the

247 ain amount of alkyl side-chains with compact bulky side-chains (CBS).

248 nner helix suggest an important role for its bulky sidechain in the allosteric mechanism; we show tha

249 he Mn centers and prevent energy transfer, a bulky singly protonated cation that avoids H-bonding is

250 In addition, the bulky size limits their implementation in a wearable set

251 rmation acoustics-based designs need to have bulky sizes in terms of working wavelength.

252 velengths constrain current spectrometers to bulky sizes, our nano-3D printed prototypes demonstrate

253 However, the rigid bulky SnSe cannot satisfy the applications for flexible

254 ance imaging (MRI), which revealed bilateral bulky solid adnexal masses.

255 ; activation can release chemotherapy within bulky solid tumors and can enhance response when combine

256 process of metal release from the BMC to the bulky solvent.

257 Eligible patients were aged 60-80 years with bulky stage 2-3 or stage 3-4 CD20-positive diffuse large

258 ad ECOG performance status of 2 or less; had bulky stage I or stage II-IV disease requiring full-cour

259 n-between the binding stations, and a single bulky stopper at one end were synthesized.

260 [2]rotaxanes are obtained by introduction of bulky stoppering ("capping") units at the tethers and su

261 Systematic incorporation of bulky substituents at the 6-position of the fulvene ring

262 Second, tetrazines with bulky substituents form stable imine conjugates even wit

263 Bulky substituents on the terminal alkene exclusively ge

264 sensitive to ATP-competitive inhibitors with bulky substituents that complement this expanded binding

265 e pyrimidine dimers, even in the presence of bulky substituents.

266 A bulky substituted stannane Ar*SnH3 (Ar*=2,6-(2',4',6'-tr

267 a macrocyclic phosphinite pincer ligand and bulky substrate substituents, we demonstrate how the mec

268 l features, which identify enzymes acting on bulky substrates as a distinct subgroup of the BVMO clas

269 is of 4-nitrophenyl benzoate, and tolerating bulky substrates.

270 nalog computing in the spatial domain uses a bulky system of lenses and filters.

271 vision and biomedical engineering; however, bulky system size and slow switching speed have hindered

272 beam generated by the traditional method of bulky systems cannot be maintained in an optical fiber d

273 log computing: migrating from free-space and bulky systems into conceptually wavelength-sized element

274 ion-depletion (STED) systems were lens-based bulky systems.

275 auben"-like compartmentalized structure with bulky terminal specializations and are proposed here as

276 ivity are maintained upon replacement of the bulky tert-butyl substituents on the ligands with methyl

277 ed 2-O-glycosylated glucosyl donors carrying bulky tert-butyldimethylsilyl groups to different extent

278 found that NEIL1 but not TDG was active with bulky TET-oxidation products.

279 hout the need for complex on-board valves or bulky tethers.

280 Now it is shown that bulky tetrazine substituents accelerate this cycloadditi

281 pound 3 acts as a phosphine ligand bearing a bulky tetrel Zintl cluster moiety.

282 ring were extensively controlled by a remote bulky TIPS group.

283 ich are accessible to molecules that are too bulky to benefit from traditional confinement within mic

284 ocation and release involve movements of the bulky transport domain through the lipid bilayer.

285 ) rotators axially linked by triple bonds to bulky trialkylsilyl groups of different sizes.

286 d arsenido (ThAsTh) linkages stabilized by a bulky triamidoamine ligand.

287 tractive dispersion interactions between the bulky trimethylgermanyl groups on the ancillary ligand a

288 lly bound Fe-N(2)(-) species, supported by a bulky trisphosphinoborane ligand ((Ar)P(3)(B)), generate

289 The RAG1 mutation, R401W, places a bulky tryptophan opposite the binding site for HMG Box A

290 ky normal muscle tissues, we further created bulky tumor model with VX2 tumors implanted on both hind

291 The study reported that patients with bulky tumors, a known high-risk feature defined as great

292 High-risk features were defined by bulky tumors, variant histology, lymphovascular invasion

293 residues flanking the SP motif, such as the bulky Tyr(1) next to Ser(2), prevent the formation of su

294 re was applied to the synthesis of (a)chiral bulky unsymmetrical unsaturated 2,6-diisopropylphenyl N-

295 and cellular disorganization, which leads to bulky valves that are unable to coapt correctly during v

296 feasibility to enhance tumor permeability in bulky VX2 tumors in a rabbit model using pHIFU technique

297 ingle-photon spectrometers either consist of bulky wavelength-scanning components or have limited det

298 adiation imaging systems have been large and bulky with significant portions of volume occupied by ph

299 When examined in a bulky xenograft model of MM, single-dose 211At-CD38 at 1

300 n of the rigid macrocyclic scaffold with the bulky, yet conformationally flexible isonitrile.