ライフサイエンスコーパス: burden

1 estimate acute gastroenteritis (AGE) disease burden.

2 ng on multiple factors, including arrhythmic burden.

3 steeply in states with the highest COVID-19 burden.

4 beam for in vivo estimation of brain amyloid burden.

5 y cerebral white matter hyperintensity (WMH) burden.

6 lieved immune suppression and reduced br-met burden.

7 ility, resulting in a global annual economic burden.

8 oreover, it has a considerable socioeconomic burden.

9 atmospheric increases in the global methane burden.

10 es irrespective of age, sex, and risk factor burden.

11 unt for up to 20% of the total global cancer burden.

12 rial fibrillation ablation with low fibrosis burden.

13 Th17 cell differentiation, and higher fungal burden.

14 s and a decreased oligomeric alpha-synuclein burden.

15 en has added to the existing cervical cancer burden.

16 able host-directed therapy to reduce disease burden.

17 mbolism (VTE) is a significant public health burden.

18 sthma is associated with substantial disease burden.

19 ganglioneuroma effectively reduced the tumor burden.

20 inated population measure real-world disease burden.

21 lthcare providers to forecast future disease burden.

22 ld crops, inflicting a heavy global economic burden.

23 ts was correlated with a decrease in seizure burden.

24 r (BD), making this disease a major economic burden.

25 ased preventive therapies informed by plaque burden.

26 een associated with coronary atherosclerotic burden.

27 ted with a high personal health and economic burden.

28 L-1 Hypo mouse resulted in an increased lung burden.

29 e (HF) is a growing pandemic with increasing burden.

30 o benefit patients and reduce CKD's economic burden.

31 n ageing was associated with increased death burden.

32 ies a significant share of the global cancer burden.

33 y of life without a reduction in AML disease burden.

34 length of stay (LOS) and increase financial burden.

35 left ventricular diameter ratio and thrombus burden.

36 epsilon (POLE) have incredibly high mutation burdens.

37 ions can achieve large reductions in disease burden, a necessary step in the pathway towards eliminat

38 and controls were compared for rare variant burden across 56 cardiomyopathy genes utilizing a weight

39 ry tract infections (UTIs) represent a major burden across the population, although key facets of the

40 9 to 5.86) and added a significant emotional burden (adjusted OR 2.22, 95% CI 1.49 to 3.31).

41 3-year case-control study that measured the burden, aetiology, and consequences of moderate-to-sever

42 Pneumonia constitutes a substantial disease burden among adults overall and those who are elderly.

43 er disease (ESLD) suffer from a high symptom burden and a deteriorated quality of life (QOL), with un

44 We do not find any association between CNV burden and cognition.

45 reduces the later-stage extracellular Abeta burden and cognitive impairment, suggesting that preclin

46 ecessary for granulomas to control bacterial burden and disease pathology in M. tuberculosis infectio

47 ociated with a substantial loss in bacterial burden and diversity, particularly in the anaerobes.

48 dels were used to estimate the impact on IHD burden and health equity, as well as the cost-effectiven

49 erbations leading to significant health care burden and impaired quality of life.

50 nce and the need for policies to address the burden and improve outcomes in Ghana.

51 demonstrated that mothers with low parasite burden and in good body condition were more likely to ha

52 Data were analyzed to describe typhoid case burden and incidence from 2008 to 2019 by time, place, a

53 of cancers, resulting in reductions in tumor burden and increased long-term survival in subsets of pa

54 The cervical LNs had a greater tumor burden and infiltration of MDSC and M2 macrophages compa

55 , with a dramatic reduction in HCV infection burden and low reinfection rate among people living with

56 ion between lifetime systolic blood pressure burden and midlife cognitive function was accounted for

57 onal genomic markers (such as tumor mutation burden and neoantigen load) and the degree of CD8(+) T c

58 Increased bacterial burden and pathology was also found in lungs of TBI + Sp

59 sess the impact of IBS-D severity on patient burden and patient and healthcare professional attitudes

60 e for children <2 years could reduce disease burden and prevent drug-resistant infections.

61 s of APPs, and their contribution to disease burden and progression rates.

62 ogical patients, and their associated health burden and social and economic costs might be large.

63 positively correlated with both the amyloid burden and tau tangle density, and no other associations

64 g effective strategies to reduce the disease burden and transmission.

65 We assessed disease burden and treatment responses with a specially develope

66 100 CFU) that correlated with lung bacterial burdens and predicted Mtb infection outcomes across spec

67 ruction, MUC5B protein expression, bacterial burden, and neonatal mortality.

68 Patients with no or mild symptoms, a low PVC burden, and normal ventricular function may be best serv

69 bacteria-containing blood, quantify bacteria burden, and then calculate and unlock a selective drug d

70 probe to detect infection, assess infection burden, and visualize the effectiveness of antibiotic tr

71 od allergies have become a significant heath burden as prevalence continues to rise, affecting 6%-13%

72 diverse American population and the economic burden associated with chronic liver disease.

73 efficacy and safety while reducing treatment burden associated with regular IVT injections for patien

74 rtality, as well as the substantial economic burden, associated with the management of these diseases

75 The IHD burden attributable to TFA was calculated by comparing t

76 ative strategies is critical to address this burden but is predicated on a detailed understanding of

77 ors to initiate stepdown included medication burden, but not medication side effects.

78 e health care use and modestly lower symptom burden, but there was no significant difference in quali

79 nization of southeastern US salt marshes now burdened by rising sea levels.

80 To counter this burden, cells have evolved protein quality control (PQC)

81 our understanding of the infectious disease burden common to past populations from the Bronze Age to

82 Primary predictors were the bacterial burden, community diversity, and community composition o

83 ilar to that of FSTL-1 Hypo and reduced lung burden compared with the TCRdelta(-/-) controls.

84 to increase reporting of stillbirths in high burden contexts.

85 egrated management for both diseases in high burden countries is suggested.

86 in vivo, resulting in decreased target cell burden, decreased serum and tissue-bound autoantibodies,

87 tests were attributed to regional SARS-CoV-2 burden, demographic characteristics and obesity with a m

88 nide had no significant effect on arrhythmia burden, despite comparable sodium channel block.

89 gh blood-based measures of tumour mutational burden did not have predictive value in patients receivi

90 transmission correlated with high bacterial burdens during the acute symptomatic phase of the diseas

91 ch case, longitudinal assessment of pathogen burden elucidated the temporal sequence of events associ

92 Disease burden estimates should take into account the appropriat

93 Total burden (expressed as a percentage) and mean attenuation

94 itiating therapy in patients with high tumor burden FL.

95 xia constitutes a major global public health burden for millions of infants with a critical need for

96 age following cardiac arrest remains a major burden for modern resuscitation medicine.

97 the leading cancer-related cause of disease burden for women, affecting one in 20 globally and as ma

98 alyzed for associations among tumor mutation burden, frequency of mutations or copy number alteration

99 ives, and is the leading cause of the global burden from skin disease.

100 We investigated the global burden from the 5 major GI cancers, as well as geographi

101 reviously untreated patients with high tumor burden grade 1-3a FL received obinutuzumab- or rituximab

102 In patients with an ischemic burden >10%, the CAC-absent group was associated with re

103 3D CNN identified patients with a large scar burden (>15%) with 98% accuracy (202 of 207) (95% confid

104 substantial HIV-attributable cervical cancer burden has added to the existing cervical cancer burden.

105 A high tumour mutational burden (hypermutation) is observed in some gliomas(1-5);

106 At 12 months, AF burden in ablation patients averaged 6.3%, and in drug-t

107 on in the tissue, increases pro-oxidant iron burden in AD.

108 epilepsy patients, showed an increase in CNV burden in at least one tested category compared to contr

109 Bacterial burden in blood, lung, liver, and spleen was neither inc

110 y, Jiangxi province has had the largest HFRS burden in China.

111 hat correlate linearly with regional amyloid burden in congruent PET images.

112 s substantially to the psychological disease burden in dermatological patients, and the management of

113 agnosis) had significantly higher mutational burden in genes frequently mutated in ATL than did high-

114 lored autophagy as a mechanism to reduce tau burden in human neurons and, from a small-molecule scree

115 n exists between average gHFI and average sM burden in increasing age groups (r = -0.70, P = 0.017).

116 , malaria and diarrhoea have a large disease burden in India, especially among children.

117 The noncommunicable disease (NCD) burden in Kenya is not well characterized, despite estim

118 hose seen in patients with circulating tumor burden in leukemic phase disease.

119 al mortality, with a disproportionately high burden in low-income and middle-income countries.

120 ewly identified regulator of atherosclerotic burden in miR-144 knockout mice receiving a high fat die

121 We demonstrate high SARS-CoV-2 burden in nasal tissues and secretions, which coincided

122 The disease burden in older children, adults, and the elderly is und

123 oma cells and reduced the metastatic disease burden in patient-derived xenografts and in mouse melano

124 Series paper addresses the increased cancer burden in people with HIV, the increasing evidence for t

125 natures in whole exome, and tumor mutational burden in predicting NAC response.

126 the understanding of the neuropsychological burden in primary age-related tauopathy.

127 Unexpectedly, bacterial burden in prostates challenged with either UPEC or E. fa

128 Finally, we observed a DNV burden in RNA-binding-protein regulatory sites (OR = 1.1

129 sulting in significantly decreased bacterial burden in the FRT, accelerated Chlamydia clearance, and

130 Patients with tumour mutational burden in the lower two terciles seem to derive a substa

131 ds that permitted higher levels of bacterial burden in the lungs were more likely to have pathology.

132 Loss of ldh decreased bacterial burden in the nasopharynx and enhanced bacteremia in mic

133 ntial additional reductions in the influenza burden in the United States.

134 diseases remain the leading cause of disease burden in the world.

135 ividualized approaches to reduce the hypoxic burden in this delicate phase.

136 ivo target engagement and reduction of tumor burden in three mouse xenograft models driven by either

137 Real-life data confirm the high disease burden in uncontrolled CRS patients, clearly impacting q

138 In addition, the heterogeneous burdens in nursing homes and the variable reporting of d

139 upport reduced pathology and lower bacterial burdens in the lung, spleen, and liver.

140 d mice had improved survival, reduced fungal burden, increased lung concentrations of proinflammatory

141 Lipid core burden index (LCBI) was calculated as the fraction of pi

142 d T cell deficiency did not impact bacterial burden, indicating that B cells only enhance susceptibil

143 agement strategies based on COVID-19 disease burden, institutional preparedness for resumption of ele

144 Although low tumor mutational burden is a major hurdle for immune checkpoint inhibitor

145 In Africa, where malaria burden is highest, bednets treated with pyrethroid insec

146 nd for MSM in Southeast states where the STI burden is substantial.

147 ve been published and the true PeV infection burden is unknown.

148 edge of the authors the association with tau burden is unknown.

149 trolled asthma and its associated healthcare burden may account for important health-related adverse

150 Moreover, the influenza burden might have changed due to the emergence and circu

151 Tumour mutational burden might have some predictive value, although blood-

152 umber of DNA fragments restricts low-disease-burden monitoring through the prevailing deep targeted s

153 large proportion of the influenza-associated burden occurs among young infants and in low-income and

154 of clinical and CT parameters, consolidation burden (odds ratio [OR], 3.4; 95% confidence interval [C

155 ranslated to an individual lifetime economic burden of $274,921 and a societal burden of $88.8 billio

156 e economic burden of $274,921 and a societal burden of $88.8 billion.

157 cardial scar in three of 17 cases (18%, scar burden of 7% +/- 4).

158 ort was characterized by an average mutation burden of 85 somatic exonic mutations per tumor sample.

159 estimate include (a) the health and economic burden of AMR in humans,(b) the impact of AMU in animal

160 tudy, we quantified the global macroeconomic burden of breast cancer to underscore the critical impor

161 opulation as model predictors, the financial burden of cancer care was highest for Turkey (euro 25.18

162 Our analysis highlights the substantial burden of candidemia in the US.

163 There is a growing burden of cardiometabolic disease in many parts of the w

164 A substantial global burden of carotid atherosclerosis exists.

165 fore, our study aimed to assess the existing burden of cervical cancer as a baseline from which to as

166 stimulation (SCS) is needed to alleviate the burden of chronic pain and dependence on opioids.

167 This immune response may reduce the burden of circulating gametocytes.

168 ntions with strong evidence for reducing the burden of clinical malaria disease and examine their pot

169 Francophone Africa still carries a high burden of communicable and neonatal diseases, probably d

170 The prevalence and relative burden of comorbidities among hospitalized PLHIV is chan

171 ide a more reliable picture of the mortality burden of COVID-19 among patients on RRT.

172 ta to map projections of the cumulative case burden of COVID-19 and the subsequent burden on healthca

173 vulnerable to food insecurity, to reduce the burden of depression.

174 CTC and CPAD interventions in the six Global Burden of Disease (GBD) regions containing LMICs.

175 ART use was summarized within Global Burden of Disease (GBD) super-regions, with adjusted lin

176 The burden of disease and economic impact of breast cancer i

177 ver, regardless of the source or method, the burden of disease appears substantial, with estimates of

178 Risk Factors Study (GBD) 2017 to assess the burden of disease in francophone Africa and inform healt

179 t (unrelated), as a way of understanding the burden of disease in T2D.

180 Coronary artery disease is the main cause of burden of disease in the world.

181 Using data from the Global Burden of Disease Study 2017 (GBD 2017), this study deri

182 le Development Goals and the shifting global burden of disease, this systematic review analyses the e

183 CAS in accurately assessing the pathological burden of disease.

184 ling psychiatric disorder with a significant burden of disease.

185 however, it is important to first define the burden of disease.

186 We used results from the Global Burden of Diseases, Injuries, and Risk Factors Study (GB

187 eed for rehabilitation, data from the Global Burden of Diseases, Injuries, and Risk Factors Study 201

188 fundus imaging might aid in alleviating the burden of DR screening in low- and middle-income countri

189 Limited information exists regarding the burden of emergency department (ED) visits due to scabie

190 o 48), whereas the adjusted estimates of the burden of first recurrences and in-hospital deaths did n

191 as may be useful interventions to reduce the burden of GI cancers worldwide.

192 any resounding successes of VISION 2020, the burden of global blindness and vision impairment is set

193 This study suggests a high burden of HBV infection in PLWH, with disparities accord

194 available in low-resource settings where the burden of HIV is highest.

195 We estimated a high burden of hospitalization due to enteric fever among chi

196 The adjusted estimate of the burden of hospitalizations for C. difficile infection de

197 The burden of hypertension is escalating, and control rates

198 curately assess the prevalence and financial burden of hypertension worldwide.

199 The expected burden of IE among people who inject opioids in the U.S.

200 There is a paucity of data on the burden of in-stent restenosis (ISR) in the United States

201 articles (FAPs) can influence the biological burden of indoor air.

202 Transmission reducing immunity, reducing the burden of infection in mosquitoes, is a well-acknowledge

203 Moreover, auranofin reduced the burden of intracellular N. gonorrhoeae by over 99% outpe

204 Our findings help to quantify the burden of IRD attributable to each gene.

205 rs have mixed effects on the overall disease burden of JAK2-mutated clones(6,7), prompting us to inve

206 e are large inter-country differences in the burden of kidney cancer and it is generally higher in co

207 The burden of malaria is heavily concentrated in sub-Saharan

208 is providing a high level of protection, the burden of malaria remains substantial in the 2 study are

209 nts receiving NCRS were younger, had a lower burden of medical comorbidities, lower proportion of squ

210 and related initiatives strive to reduce the burden of mental disorders by developing precision medic

211 tistical power by substantially reducing the burden of multiple comparison correction; (ii) employ br

212 veloped nations and accounts for the largest burden of non-communicable diseases worldwide.

213 d norovirus in US Veterans, highlighting the burden of norovirus disease in this adult population.

214 model to quantify the clinical and economic burden of norovirus in the United States.

215 The burden of nosocomial Pneumocystis infections in transpla

216 or AMPK is necessary to offset the metabolic burden of overnutrition was tested using chow-fed and hi

217 ria infections related strongly to the total burden of P. falciparum parasites.

218 of highly hazardous pesticides to reduce the burden of pesticide suicides.

219 Maternal burden of pre-pregnancy hypertension has nearly doubled

220 uman development index (HDI) faced a greater burden of premenopausal breast cancer for both new cases

221 We sought to explore the burden of psychosocial risk factors among patients with

222 ight Cardio sequencing panel to evaluate the burden of rare variants in 56 putative DCM genes in 1040

223 However, the overall burden of readmissions associated with adhesions remains

224 comparable to decompensated HF, and a major burden of rehospitalization caused by recurrent episodes

225 a novel mechanism of action will relieve the burden of resistance.

226 We aim to characterize the burden of respiratory syncytial virus (RSV) and human me

227 of procedures account for a disproportionate burden of revisit-associated resource utilization in ped

228 The epidemiology and disease burden of rotavirus has been altered by rotavirus vaccin

229 the impact of maternal HIV infection on the burden of RSV among mothers and their infants in western

230 studies worldwide investigating the disease burden of RSV-ARI in this population.

231 Accurate estimates of the burden of SARS-CoV-2 infection are critical to informing

232 ause of health loss, but data for the global burden of sepsis are limited.

233 The burden of stroke is higher in low-income and middle-inco

234 In this study, we observed a burden of TB in IDP populations of Northeast Nigeria man

235 es, deaths, and costs and the total economic burden of TB in the United States.

236 ury in 2017, three survived, living with the burden of their injury.

237 h to find effective strategies to reduce the burden of this disease.

238 enes (25 newly reported) showing significant burden of ultra-rare (MAF < 0.01%) gene-disruptive mutat

239 The burden of untreated eye disease is very high among the R

240 onger will mean spending more years with the burdens of chronic diseases such as Alzheimer's disease,

241 e characterized the health care use and cost burdens of HDV in the United States using real-world cla

242 ing, this condition is causing a substantial burden on health care costs.

243 e case burden of COVID-19 and the subsequent burden on healthcare resources.

244 ectotherms and may place a greater metabolic burden on larger individuals, impairing their physiologi

245 ric fever can impose a considerable economic burden on patients, caregivers, and health facilities in

246 End-stage liver disease (ESLD) is a major burden on public health, particularly in sub-Saharan Afr

247 and has been found to place a large economic burden on society.

248 to confer a major oxidative and inflammatory burden on the brain, but it does markedly increase the c

249 ent's quality of life, and are a substantial burden on the healthcare system.

250 tes alone and place an estimated $20 billion burden on the healthcare system.

251 ; (3) minimize administrative and regulatory burdens on research sites; (4) recruit, retain, and supp

252 Currently most assays require high bacterial burdens or prolonged enrichment to achieve acceptable pe

253 s and OOP expenses to minimize the financial burden placed on patients.

254 Accurately estimating its burden requires cumulative incidence data from longitudi

255 A mitochondrial antioxidant reduced AF burden, restored I(Na), I(Ca,L), I(Kur), action potentia

256 , the functional impact of the high mutation burden resulting from this phenotype remains poorly expl

257 owever, patients with high tumour mutational burden seem to have a less pronounced benefit with targe

258 In high-burden settings, deaths due to HIV, tuberculosis, and ma

259 FSTL-1 Hypo/TCRdelta(-/-) displayed a lung burden similar to that of FSTL-1 Hypo and reduced lung b

260 ed patients were categorized into safety-net burden (SNB) quartiles.

261 rs resulted in a small benefit for caregiver burden (standardized mean difference, -0.24 [95% CI, -0.

262 the IL-10 + M3 group showed lower microglial burden, suggesting that M3 can successfully lower microg

263 ts were associated with low tumor mutational burden/T cell-inflamed gene expression signature (GES) o

264 56 cardiomyopathy genes utilizing a weighted burden test approach, accounting for multiple testing us

265 tions in cases versus controls, rare variant burden testing of 56 genes revealed enrichment in MYH6 (

266 (for example, the face) had a lower mutation burden than melanocytes from intermittently sun-exposed

267 s Appalachian region harbors a higher cancer burden than the rest of the nation, with disparate incid

268 to the neuronal iron elevation and oxidative burden that feature in AD pathology.

269 but overaccumulation results in an oxidative burden that, if unchecked, would lead to cell death.

270 while IL-10 expression increased microglial burden, the IL-10 + M3 group showed lower microglial bur

271 ion about the bifurcation anatomy and plaque burden, thereby enabling planning, education, and decisi

272 arly pterosaurs by imposing a high energetic burden, thus requiring flight to provide some offsetting

273 S) was associated with a high tumor mutation burden (TMB) and a dominant ultraviolet damage mutationa

274 Tumor Mutational Burden (TMB) is a measure of the abundance of somatic mu

275 Tumor mutational burden (TMB) was similar to muscle-invasive disease and

276 technology in colorectal surgery, there is a burden to demonstrate these benefits.

277 networks lead to dysbiosis and considerable burden to the host prior to systemic impact that extends

278 The WGS approach enabled dynamic tumor burden tracking and postoperative residual disease detec

279 mTOR inhibitor, everolimus, on residual HIV burden, transcriptional gene expression profiles, and im

280 IFN-I production and better control of viral burden upon LCMV infection but show exacerbated HSC acti

281 nfrared spectroscopy-IVUS, the median plaque burden was 73.7%, the median MLA was 2.9 mm(2), and the

282 Furthermore, AF burden was also significantly reduced in catheter ablati

283 and activation were impaired, and metastatic burden was increased in E2 (-/-)mice.

284 However, a significant reduction in VUS burden was observed after the addition of phenotypic cri

285 agocytophilum The bacterial peripheral blood burden was pronouncedly reduced in immunized mice compar

286 iographically mild lesions with large plaque burden was safe, substantially enlarged the follow-up ML

287 Low-attenuation plaque burden was the strongest predictor of myocardial infarct

288 decline after adjustment for neuropathologic burden was weakly related to age at death; it occurred i

289 reflects total left ventricular hemodynamic burden, was lower with TAVR than SAVR at 1 year (3.7+/-0

290 d tumor gene expression to control for tumor burden, we identified a subgroup of patients with an adv

291 ov identifier NCT00782067]), QOL and symptom burden were assessed during treatment with midostaurin b

292 and cavitary disease, correlates of disease burden, were associated with detection via buccal swab.

293 al morbidity and constitutes a public health burden, which increases with asthma severity.

294 ft-tissue infection and endocarditis disease burden with related IDU or substance use disorder terms

295 ating regional neo-epitope and viral antigen burden with the regional adaptive immune response.

296 tion, but migration can also reduce parasite burdens within host populations via migratory escape fro

297 Alcohol use disorder (AUD) is a major health burden worldwide.

298 rs are at the leading edge of global disease burden worldwide.

299 r diseases, which are a major socio-economic burden worldwide.

300 articular remain a major health and economic burden worldwide.