ライフサイエンスコーパス: burdensome

1 nsome; 3, moderately burdensome; and 4, very burdensome).

2 e reliably induces histologic changes but is burdensome.

3 make their treatment more effective and less burdensome.

4 Atopic dermatitis (AD) is long term and burdensome.

5 d data collections are considered costly and burdensome.

6 sive labeled training data is experimentally burdensome.

7 EEs in PG is inefficient and environmentally burdensome.

8 n after kidney transplantation is costly and burdensome.

9 s usually limited in scope and operationally burdensome.

10 dgut neuroendocrine tumors (NETs) often find burdensome.

11 consequences of AF will become increasingly burdensome.

12 ralogy of Fallot is commonly required and is burdensome.

13 who did not perceive healthcare costs to be burdensome.

14 s measured on a 4-point scale (1, not at all burdensome; 2, slightly burdensome; 3, moderately burden

15 scale (1, not at all burdensome; 2, slightly burdensome; 3, moderately burdensome; and 4, very burden

16 tment options were limited to injectables, a burdensome administration route that has driven the need

17 oral semaglutide, with the prospect of less burdensome administration to achieve treatment goals in

18 cles, such as poor pharmacokinetics (PK) and burdensome administration, must be overcome to make bnAb

19 ents with asthma to prevent their costly and burdensome adverse effects.

20 ve of a registration process, along with non-burdensome adverse event reporting, to first understand

21 ies into more effective treatments with less burdensome adverse-effect profiles.

22 pants experienced dealing with presbyopia as burdensome, affecting quality of life to varying degrees

23 luster, is specific to Streptococcus suis, a burdensome agricultural pathogen and zoonotic agent.

24 P could lead to therapeutic targets for this burdensome airway disorder.

25 g the prosthesis to add prosthetic socks, is burdensome and can adversely affect users' function and

26 In addition, a gluten-free diet is highly burdensome and can profoundly affect patients and their

27 treatment, but the daily application can be burdensome and cause skin irritation.

28 Frequent intravenous injections are burdensome and costly for patients, consequently with po

29 forming dedicated post hoc image labeling is burdensome and costly.

30 e infection (SSTI) incidence, though this is burdensome and costly.

31 cterization of the isolates can be extremely burdensome and difficult.

32 governance approval has become increasingly burdensome and disproportionate to the conceivable risks

33 Treatment can be burdensome and have significant side effects, and new th

34 missing consent forms led to delayed cases, burdensome and inadequate consent by residents, and extr

35 zed to other practices in the US and if less burdensome and less costly approaches could result in si

36 mptomatic superficial-vein thrombosis a less burdensome and less expensive oral treatment option inst

37 Fatigue is recognized as one of the most burdensome and long-lasting adverse effects of cancer an

38 ially if adopted by more journals, is overly burdensome and may, in at least several applications of

39 of precision gene therapies to treat heavily burdensome and often deadly diseases.

40 ic foot ulcers (DFUs) represent a clinically burdensome and pathophysiologically distinct complicatio

41 ransitions in the last months of life can be burdensome and potentially of limited clinical benefit f

42 and urban canopy models, are computationally burdensome and require a high degree of expertise to emp

43 for an elderly individual with disability is burdensome and stressful to many family members and cont

44 However, current isolation approaches are burdensome and suffer from low speed, yield and purity,

45 ion science tools compared to more invasive, burdensome, and costly neuroimaging biomarkers.

46 ality disorder (BPD)-one of the most common, burdensome, and costly psychiatric conditions-is charact

47 Schizophrenia is one of the most common, burdensome, and costly psychiatric disorders in adults w

48 dard for diagnosis, oral food challenges are burdensome, and diagnostic tools based on specific IgE c

49 Pain is one of the most common, burdensome, and feared symptoms experienced by patients

50 development programs increasingly costly and burdensome, and many promising compounds fail before lau

51 igm of trials that are more accessible, less burdensome, and more inclusive.

52 telling subject (6%) said that the study was burdensome, and one control subject (8%) wished they had

53 g out on life; (2) health care for asthma is burdensome, and other things are more important; (3) the

54 (OAB) symptoms in Parkinson disease (PD) are burdensome, and the adverse effects of drug treatment ca

55 ce unit, several IACUC processes were deemed burdensome, and therefore there would be value in modify

56 nsome; 2, slightly burdensome; 3, moderately burdensome; and 4, very burdensome).

57 n region is among the most affected and most burdensome area in terms of tuberculosis cases.

58 t and handling of a contact lens would be so burdensome as to result in significant periods of uncorr

59 ning such consent is prohibitively costly or burdensome, as long as mechanisms are in place to ensure

60 ewer patients rated the insufflation as most burdensome aspect (56.1% vs. 18.6%; P = 0.001).

61 of CT colonography (5-point scale), the most burdensome aspect and side effects.

62 hyperarousal symptoms, a characteristic and burdensome aspect of the disorder.

63 am or at 5 pm or after) were considered very burdensome by 33 respondents (29.7%).

64 Asleep surgery was experienced as less burdensome by patients and was 26 minutes shorter than a

65 Peanut allergy (PA) is a common, burdensome childhood disease that in most patients conti

66 BM had better psychological well-being, less burdensome chronic GVHD symptoms, and were more likely t

67 Asthma is a common and burdensome chronic inflammatory airway disease that affe

68 Chronic itch represents a burdensome clinical problem that can originate from a va

69 Heart failure is a burdensome clinical syndrome, and patients and their car

70 st-thrombotic syndrome (PTS) is a common and burdensome complication of deep venous thrombosis (DVT).

71 pulmonary disease (COPD) is a prevalent and burdensome condition in low- and middle-income countries

72 CRS adds to the burden of an already highly burdensome condition, and suggests either that CRS promo

73 tates copy number tuning of an essential but burdensome construct through the action of a stably main

74 However, synthetic consortia often require burdensome control mechanisms to ensure that consortia m

75 ses owing to this mismatch translates into a burdensome cost for our patients.

76 at institutional review boards (IRBs) impose burdensome delays on research, little is known about the

77 ia of equal quality to traditional, but more burdensome, differential centrifugation.

78 tinguish preschool children at high risk for burdensome disease for further evaluation.

79 nderstanding and management of this chronic, burdensome disease.

80 Dementia is one of the most disabling and burdensome diseases.

81 ategy to understand the pathogenesis of this burdensome disorder.

82 tion methods is extremely time-consuming and burdensome due to the large volume and low signal-to-noi

83 including the risk of serious side-effects, burdensome duration of treatment, poor compliance and hi

84 h state-of-the-art classical methods without burdensome error mitigation.

85 However, colonoscopy is burdensome, expensive and invasive, and often has negati

86 an immediate fitness advantage from reducing burdensome expression of accessory genes.

87 thereby protecting against bleeding without burdensome factor IX replacement.

88 typhoidal Salmonella spp. represent the most burdensome foodborne illnesses worldwide, yet despite th

89 n process is particularly time consuming and burdensome for Black patients, who report more discrimin

90 e-of-the-art methods are too computationally burdensome for emerging large-scale data and all methods

91 requisite safety precautions are not overly burdensome for health care workers or for patients and t

92 aims data for quality measurement but can be burdensome for hospitals to collect.

93 g healthcare costs are becoming increasingly burdensome for Medicare.

94 However, the protocol is burdensome for nurses, disrupts the sleep of patients, a

95 tating frequent administration, which can be burdensome for patients and economically costly.

96 llowing live discharge from hospice care are burdensome for patients and families.

97 time-point SPECT/CT imaging for dosimetry is burdensome for patients and lacks statistical efficiency

98 Such monitoring is burdensome for patients and physicians and is costly for

99 ntial to improve BP but may be expensive and burdensome for patients, clinicians, health systems, and

100 n of CHO in a meal is prone to errors and is burdensome for patients.

101 aboratories; however, this approach would be burdensome for public health laboratories, since those l

102 mited, spatially aggregated, subjective, and burdensome for the patient to collect.

103 becoming increasingly complex, and thus more burdensome, for humans to handle.

104 Functional constipation is a prevalent, burdensome gastrointestinal disorder whose treatment rem

105 studies have examined the risk of incurring burdensome health care spending longitudinally among ind

106 r's disease is one of the most disabling and burdensome health conditions worldwide.

107 s one of the most prevalent and economically burdensome healthcare issues in the world.

108 This survey identified several perceived burdensome IACUC processes that would likely benefit ind

109 We defined patterns of transition as burdensome if they occurred in the last 3 days of life,

110 ation, some adults experience persistent and burdensome illness.

111 methods, though accurate, are expensive and burdensome, impeding the study of sufficiently large coh

112 recommend the use of the UAS7, which is less burdensome in administration and scoring.

113 reatment based on the symptoms that are most burdensome in an individual patient.

114 ary incontinence being relatively common and burdensome in men worldwide and strongly associated with

115 k and cognitive impairment are prevalent and burdensome in Parkinson disease (PD), requiring efficaci

116 Conventional self-reporting method is burdensome, inaccurate, and often biased.

117 chnology to address the most challenging and burdensome infectious diseases confronting global popula

118 as acne inversa, is a chronic, painful, and burdensome inflammatory disease manifesting in nodules a

119 costs, increasing complexity and length, and burdensome institutional and regulatory requirements.

120 e, 40.7% of residents underwent at least one burdensome intervention (hospitalization, emergency room

121 Distressing symptoms and burdensome interventions are also common among such pati

122 anced dementia were much less likely to have burdensome interventions in the last 3 months of life th

123 Although many older adults prefer to avoid burdensome interventions with limited ability to preserv

124 nts in comparison with more administratively burdensome interviewer-based 24-hour recalls.

125 imilar to those of the more administratively burdensome interviewer-based recall.

126 s), while initially convenient, often become burdensome, leading to errors, poor traceability, and co

127 gs or vaccines, adjunctive to or replacing a burdensome life-long gluten-free diet for coeliac diseas

128 for global efforts to tackle this common and burdensome liver condition.

129 dalities are utilized in costly fashion with burdensome logistics and decreased accessibility.

130 agement strategies are imperfect and involve burdensome long-term dietary exclusions, or drug treatme

131 Agitation is a prevalent, distressing, and burdensome manifestation of Alzheimer dementia in need o

132 tients with GD, preventive measures for this burdensome manifestation of GD may become a reality.

133 Acute and chronic itch are burdensome manifestations of skin pathologies including

134 ly on energy-inefficient and environmentally burdensome manufacturing methods.

135 Insomnia is one of the most prevalent and burdensome mental disorders worldwide, affecting between

136 abetes control is poor globally and leads to burdensome microvascular and macrovascular complications

137 at all disease stages report widespread and burdensome multidimensional problems at HIV diagnosis.

138 ity by improving regeneration in diverse and burdensome muscle disorders.

139 opular choice for gene delivery, despite the burdensome need for multiple plaque purifications to iso

140 ined the NHGRI-EBI GWAS Catalog for the most burdensome non-communicable causes of death worldwide.

141 tic, physiologic, and metabolic) influencing burdensome non-communicable disease outcomes, including

142 such models can be used widely to reduce the burdensome number of ROP screening examinations.

143 Salmonella enterica is among the most burdensome of foodborne disease agents.

144 e conditions receive health care that may be burdensome, of uncertain benefit, and not focused on wha

145 nt-reported measures exist, but most are too burdensome or imprecise to be useful in clinical practic

146 drawbacks as they are either computationally burdensome or provide inaccurate estimates in the tail o

147 , limited hours at important facilities, and burdensome paperwork sometimes requiring access to photo

148 from class III to class II, providing a less burdensome pathway to market for diagnostic companies.

149 dings suggest missed opportunities to reduce burdensome polypharmacy by deprescribing long-term medic

150 a coli growth and found that 59 (19.6%) were burdensome, primarily because they depleted the limited

151 Fractures are a common and burdensome problem among kidney transplant recipients (K

152 is a clear opportunity to finally solve this burdensome problem.

153 bipolar disorder are three of the four most burdensome problems in people aged under 25 years.

154 ch to educate families about this, at times, burdensome procedure.

155 nts with end-stage dementia received as many burdensome procedures as cognitively intact patients and

156 or treatment were absent per person-year and burdensome procedures used to manage these episodes (bla

157 rting ART in many countries is a lengthy and burdensome process, imposing long waits and multiple cli

158 Pediatric severe sepsis remains a burdensome public health problem, with prevalence, morbi

159 l disease, tonsillectomy (TE), may involve a burdensome recovery.

160 nded to be used for 24 hours per day, a more burdensome regimen.

161 isease to be completed in the current era of burdensome regulation and escalating research costs.

162 owever, these advances are under threat from burdensome regulatory oversight that can compromise, at

163 educe the resource intensive, expensive, and burdensome sequelae of device failure.

164 itis C is expensive, is often accompanied by burdensome side effects, and, sadly, fails in almost hal

165 tative and intervention strategies for these burdensome side effects.

166 trum of core symptoms as well as their often burdensome side-effect profiles and poor tolerability.

167 Given burdensome side-effects and long latency for efficacy wi

168 iscovered drugs often with limited efficacy, burdensome side-effects, and unclear mechanisms of actio

169 Eczema is the most burdensome skin condition worldwide and topical anti-inf

170 Atopic dermatitis (AD), the most burdensome skin condition worldwide, is influenced by cl

171 onstruction methods can exclude the usage of burdensome spectral camera hardware while keeping a high

172 imiting illness compared with room air, less burdensome strategies should be considered after brief a

173 oteins at high concentrations to enable less burdensome subcutaneous injection, preferably with an au

174 Pruritus is the most common and burdensome symptom of atopic dermatitis (AD).

175 ary and secondary), are recognized for their burdensome symptom profiles, life-threatening complicati

176 Despite burdensome symptoms and poor outcomes, limitation of suc

177 multidrug-resistant tuberculosis experience burdensome symptoms, clinical uncertainty, and high mort

178 , and maintenance of all these packages is a burdensome task.

179 nts, illustrating their potential to replace burdensome tests.

180 e-related macular degeneration would be less burdensome than repeated intravitreous injections.

181 Sjogren-related dry eye is more burdensome than systemic manifestations of the disease.

182 with required standards without becoming so burdensome that they cannot reasonably be completed.

183 committee (IACUC) processes were considered burdensome, the perceived value of some suggested modifi

184 tances in which patients continue to request burdensome therapy that is unlikely to help.

185 st question of the SF-12, which is the least burdensome to administer, may be sufficient to identify

186 ne screening because they are generally less burdensome to administer, results are directly actionabl

187 alculations that may have otherwise been too burdensome to attempt.

188 and communication requirements and would be burdensome to complete given their busy schedules.

189 apons are especially beneficial to males and burdensome to females, which could explain why males hav

190 ethod is not easily accessible; it's costly, burdensome to patients, and requires specialized facilit

191 ated with other aspects of care and could be burdensome to patients.

192 to the use of aids and devices) and somewhat burdensome to score, has some floor effects, and has psy

193 times and pain associated with treatment are burdensome to the patient and a hindrance to widespread

194 ysiological time that is accurate, minimally burdensome to the patient, and readily generalizable to

195 Cancer treatment can result in burdensome toxic effects that profoundly affect patient

196 es with high computing resource consumption, burdensome training data gathering, and restricted scala

197 rsing home decedents, 19.0% had at least one burdensome transition (range, 2.1% in Alaska to 37.5% in

198 381 individuals (9.0%) experienced a type 1 burdensome transition and 3144 individuals (2.7%) experi

199 was an association between regional rates of burdensome transition and the likelihood of feeding-tube

200 2 575 of all decedents (20.2%) experienced a burdensome transition at the EOL.

201 3144 individuals (2.7%) experienced a type 2 burdensome transition.

202 ssociated with higher odds of experiencing a burdensome transition.

203 ctors explaining variation in these rates of burdensome transition.

204 idents in regions in the highest quintile of burdensome transitions (as compared with those in the lo

205 n, and organizational characteristics with 2 burdensome transitions after live hospice discharge (out

206 strative claims data to describe potentially burdensome transitions among assisted living residents a

207 ative 20% sample of beneficiaries to examine burdensome transitions among NH decedents at the EOL fro

208 Burdensome transitions are common, vary according to sta

209 Factors contributing to risk of burdensome transitions following hospice discharge are u

210 This retrospective cohort study of burdensome transitions following live hospice discharge

211 are associated with a reduced likelihood of burdensome transitions in the last 90 days of life for r

212 dels, factors associated with higher odds of burdensome transitions included identifying as non-Hispa

213 with advanced cancer experience potentially burdensome transitions of care after hospitalizations.

214 l practice and policy may reduce the risk of burdensome transitions, such as hospice discharge planni

215 .52-0.69) were associated with lower odds of burdensome transitions.

216 red to needs of patients at greater risk for burdensome transitions.

217 Main outcomes included 4 measures of burdensome transitions: (1) hospital transfer in the las

218 U personnel, but are frequently dismissed as burdensome, unreasonable, and even counter to good-quali

219 oes are the sole vector of malaria, the most burdensome vector-borne disease worldwide.

220 s in order to recognise and mitigate against burdensome work.

221 l use disorder (AUD) is highly heritable and burdensome worldwide.

222 f a once-weekly basal injection that is less burdensome, yet equally safe and efficacious as conventi

223 Medical driving restrictions are burdensome, yet syncope recurrence while driving can cau