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1 azard ratio [aHR]: 2.493.494.89, P < 0.001), but a 62% lower mortality risk (aHR: 0.310.380.46, P < 0
2 are highly effective in many iMCD patients, but additional therapies are required for refractory cas
3 eukaryotic cells using different mechanisms, but all require the presence of cholesterol to pierce li
4 utant embryos display epidermal hyperplasia, but also apical cell extrusions, during which extruding
6 crops through fulfilling crops' water demand but also creates an evaporative cooling that mitigates c
8 standing of basic mechanisms of iron biology but also for the development of new pharmacologic agents
9 ot only in gathering terabytes of omics data but also in detailing the histologic-molecular correlati
10 elin not only influences insulin sensitivity but also is permissive for the normal CRR to insulin-ind
11 y direct observation of molecular structures but also local probe reactions, in which unstable short-
12 tructure defines not only tertiary geometry, but also maintains control in function and structural ev
13 one to coral collapse under fishing pressure but also more prone to recovery as fishing is reduced.
15 on the morphological structure of the heart, but also on its subcellular (ultrastructural) architectu
16 g plasmonic photochemistry in aqueous medium but also opens the door for nanoengineered, solar-based
17 atures are related to socio-economic factors but also provide favorable breeding conditions for mosqu
18 ole of Fam20C itself in OPN phosphorylation, but also revealed that phosphorylation was essential for
20 ng not only grammatical and statistical cues but also their prior knowledge of the form of language.
21 ted that the use of not only AiV-1 and PMMoV but also TMV as indicators of reductions in viral levels
22 nly to a nonspecific depletion of KIF1A mRNA but also to an accelerated proteasomal degradation of KI
23 sRNAs not only to control its own activities but also to trigger critical responses promoting homeost
24 the reaction centres and catalytic turnover, but also understanding degradation processes of the phot
26 cortex has been linked to voluntary action, but an explanation of why decisions to act emerge at par
28 enia and other neurodevelopmental disorders, but are also a contributing factor to impairment in cogn
33 model membranes at the coarse-grained level, but atomistic simulations remain computationally challen
35 nergy more available and affordable globally but brought environmental concerns, especially related t
36 are largely spared from respiratory illness but can develop a life-threatening multisystem inflammat
37 se from a single clone in the primary tumour but can exhibit subclonal heterogeneity at the genomic,
39 y in every nuclear waste-generating country, but carbonate rocks may serve as a potential alternative
40 d to be vulnerable to environmental changes, but cascading effects of organismal tolerances on the as
41 lar training and validation accuracy to nCV, but cnCV has much shorter run times because it does not
42 ich was markedly upregulated in tumorspheres but colocalized with and counteracted EZH2 and SOX2 duri
43 lta1 and alpha2delta3 subunits play distinct but complementary roles in driving formation of structur
44 l is enacted by the FPN and CON via distinct but complementary roles reflected in network dynamics.
47 E was fused with a thymidine-kinase promoter but could be restored by fusion with the 100 bp minimum
48 posure recapitulated the reduction in length but could not predict effects on development of the live
49 as the most toxic of the constituents tested but could not predict the AFFF phenotype in larval zebra
51 ased in vitro activities of RuBisCO and PPDK but decreased PEPc activity compared with warm-grown pla
53 vide high-quality two-dimensional materials, but despite improvements it is still limited in yield, l
57 de bond formation during reductive ER stress but did not bind to this protein during nonreductive ER
58 ms and offspring in a dose-dependent manner, but did not change TSH levels, weight, histology, or exp
59 elative to the level under static conditions but did not enhance intracellular cGMP accumulation.
60 sed risk of hyperuricemia in Mexican adults, but diet soft drink consumption is not, which supports t
61 catalytic triad characteristic of proteases but differ in their configuration and protonation states
62 ammatory proteins and more severe depression but differed in terms of myeloid and lymphoid cell count
63 f precision-to populations of similar ethnic but different geographic background than the one the sco
64 mensionally reconstruct a virtually complete but disarticulated skull of the large morphotype, includ
65 hat protein stability varied within tissues, but discernible trends in the data suggest that cellular
67 ially reflects renal injury in RVD patients, but does not change in response to medical or interventi
68 table can have an FEV(1) >100% of predicted, but during an acute bronchospastic episode can experienc
69 ve been developed to address these problems, but each possesses limitations that constrain widespread
70 otential is crucial to ensure food security, but efforts are thwarted by an apparent trade-off betwee
71 membership and leadership positions, slower but encouraging signals for "Asian" and "Hispanic" membe
72 brillary tangle counts in entorhinal cortex, but entorhinal and meta-ROI SUVRs were not elevated in B
73 tion of a C(32-)A(38) cross-loop interaction but failed to fully explain the means by which s(2)C(32)
74 e become more common in the past five years, but few studies concern the factors that control the dis
75 e month 6 (mean, 20/41 vs. 20/49; P = 0.03), but final VA was similar (20/36 vs. 20/37; P = 0.68).
79 anscriptomic data commonly ignore non-coding but functional elements e.g. small RNAs, long antisense
80 the association (1.41 [95% CI, 1.14-1.73]), but further adjusting for pre-MI health status (1.25 [95
81 may need to adapt to declining productivity, but further research to support ongoing reforms in Queen
82 he SAT varied with phases of the gape cycle, but gape distance accounted for the majority of dynamic
83 gher glutamate levels in thalamus (p = .01), but Glx levels in dorsal ACC and thalamus did not differ
85 active in response to anxiogenic environment but had lower excitability and fewer presynaptic inputs
87 ers have nearly doubled global grain yields, but have also increased losses of reactive N to the envi
88 ic trees can mimic this transpiration cycle, but have been confined to pumping water across a single
89 itamin K status in patients on hemodialysis, but have no significant favorable effect on VC progressi
90 uspected celiac disease who are seronegative but have villous atrophy and genetic risk factors for ce
92 unknown function with low sequence homology but high structural homology to both yeast Get2 and mamm
95 ever, current protocols yield either complex but highly heterogeneous aggregates ('organoids') or 3D
96 ng transcription induce genomic instability, but how cells respond to the R loop-associated genomic s
97 o nucleoids within the mitochondrial matrix, but how mtDNA nucleoids are formed and regulated within
98 ants cause complete loss of NHE6 expression, but how subtler missense substitutions or nonsense mutat
99 wn to be central to suppressing aggregation, but how they affect substrate conformations remains poor
100 ce to escape from a sea lion-sized predator, but humpback whales could capture as much as 30-60% of a
101 estibulo-ocular reflex (VOR) gain adaptation but impaired eyeblink conditioning (EBC), which relies o
102 72 h 1) increases absolute insulin secretion but impairs beta-cell function, 2) causes insulin resist
103 n that neither binds the C terminus of Brd4, but in all other aspects the mutant behaves differently
104 are largely in the phases in crystallography but in both phases and amplitudes in cryo-EM, and that h
105 d HGF support beta cell growth and survival, but in people with type 2 diabetes the destructive effec
106 tly change measures of contrast sensitivity, but increased the speed at which participants responded
108 -PP1 enhanced eosinophil spreading on VCAM-1 but inhibited eotaxin-1 (CCL11)-mediated eosinophil migr
109 ossible future rewards not as a single mean, but instead as a probability distribution, effectively r
110 ion was not altered by changes in osmolarity but instead was induced by membrane-intercalating agents
111 rs have been used to identify these species, but insufficient phylogenetic signal was available.
112 m systems of any arbitrary finite dimension, but is attained exclusively by infinite-dimensional quan
114 tive cell transfer (ACT) therapy for cancer, but is limited by short exposure and high toxicities.
115 ential to yield commercially viable devices, but it also sharpens our understanding of the design pro
116 ications including passive building heating, but it can also drive secondary energy-conversion steps.
118 and sufficient to regulate lung inflammation but it has no direct antiviral activity against ECTV.
119 t on vision-related quality of life (VRQoL), but it is still unclear how this relationship varies wit
120 g burns remain sensitive to touch for weeks, but it is unknown whether calves experience ongoing, non
122 of courses of antibiotics (P-value > 0.05), but it was significantly associated with increased numbe
123 se to microbial infection and tissue damage, but its aberrant activation can lead to autoinflammatory
124 AAV) is a promising vector for gene therapy, but its broad tropism can be detrimental if the transgen
125 ediates VEGF-A and PDGF signalling in vitro, but its cardiovascular function in vivo remains relative
126 elenting, progressive cognitive impairments, but its course is heterogeneous, with a broad range of r
127 The degree of vesicle release at the fewer, but larger, individual remaining ribbon synapses colocal
128 e science with the broader natural sciences, but leave key elements of cognition and behaviour unexpl
129 letal muscle wasting is also common in COPD, but less is known about its contribution to LV size.
130 mpact development, homeostasis, and disease, but links between specific dietary fats and cell fates a
131 glial membrane to the extracellular matrix, but little is known about integrin's regulators in the g
132 ) are assembled into multiprotein complexes, but little is known about the mechanisms required for as
133 maintaining NPCs during kidney development, but little is known about the molecule(s) regulating FGF
135 ulin-sensitive C57BL/6J mice; hyperglycemic, but mildly insulin-resistant, KK mice; and hyperglycemic
136 BE-tolerant was similar with BE and egg OIT, but more frequent in participants who are BE-reactive.
138 more than 40 structurally related alkaloids, but most studies have focused on just two of these, mitr
139 sma-sources deliver both kinds of radiation, but mostly single modalities have been explored for appl
140 ng when a low-energy sensitizer is employed, but much lower KIEs are observed with higher-energy sens
141 ng, are well placed for analysing these data but must be applied with an understanding of the relevan
142 use an effect may be positive in one species but negative in another depending on the species' biolog
145 0.04, 0.48; P = 0.02) increase in hemoglobin but no effect on anthropometry or iron or vitamin A defi
146 the strongest associations with dysglycemia but none outperformed HbA1c (OR = 4.09 [2.81-5.94]).
151 ds in the therapeutic range lowered cell G6P but not ATP and decreased G6pc mRNA at high glucose.
153 -ATI plasma using macrophage-specific (CD14) but not CD4+ T cell-specific (CD3) antibodies, suggestin
154 e expression was rescued by re-expressing WT but not ChREBP that lacks hydroxylated prolines in ChREB
158 ed to higher active metabolite concentration but not greater IPA compared with integral prasugrel.
160 te signal transduction, a situation similar, but not identical, to the action of NAE endocannabinoids
163 turbations that eliminated caveolae in aECs, but not in neighbouring SMCs, impaired neurovascular cou
166 nsfected with FliI mutants, the LRR of FliI, but not its gelsolin-like domains, mediated association
167 extra-cellular stress conditions including, but not limited to, pathogen intrusion, oxygen or nutrie
171 In addition, in younger (4-6 years, n = 67), but not older (6-8 years, n = 70) children, habitual sle
175 ical conditions, purified Pol I and Pol III, but not Pol II, could transcribe nucleosomal templates.
176 d with SO2 (1.207 [1.154, 1.262; p < 0.001]) but not significantly associated with NO2 and PM10 (1.04
177 (IQR = 0-19) after indomethacin (P = 0.04), but not significantly associated with reductions in MCAv
178 (aOR, 6.49 [95% CI, 1.66-25.35], P = .007), but not significantly higher in women with positive anal
182 = .037), and total lung capacity (P = .013) but not their lung carbon monoxide diffusion capacity (P
183 correlates to surface phytoplankton biomass but not to physical mixing processes, which suggests a p
185 howed that the tubulogenic effect of GW0742, but not VEGF-A, was PPARbeta/delta- and sirtuin-1-depend
187 We further showed that ZmMC1 and ZmMC2, but not ZmMC9, are predominantly localized in a punctate
188 rd, in the Polynesian archaeological record, but nowhere else outside the pre-Columbian Americas(1-6)
189 g to high solubility and metabolic stability but occasionally at the cost of reduced permeability.
190 the possible use of marijuana for glaucoma, but only 2.6% had used marijuana as a treatment for glau
192 le interval = 2.4-5.5), with a higher median but overlapping credible intervals compared with some ot
193 millipedes and centipedes, is a fascinating but poorly understood branch of life, including species
194 epleted energy stores (phosphocreatine/ATP), but potentially limiting greater ATP delivery during inc
197 graphy findings have pathognomonic features, but quantitative assessment reveals variability and a no
199 ntitatively describe the magnetism of CrI(3) but quantum rescaling corrections are required to reprod
201 n interaction with a single essential target but rather from the multilevel control of complex homeos
202 in state space (e.g points, lines, planes), but rather the stability of state trajectories which may
203 lence was not due to clonal spread in clinic but rather to an intermingling of distinct community tra
204 loop extrusion can achieve such compaction, but recent single-molecule studies (Golfier et al., 2020
205 al that were heavily enriched in development but reduced in adulthood, including the transcriptional
207 ave focused on activators such as enhancers, but regions that repress gene expression-silencers-have
210 in high-elevation streams, which include low but rising temperatures, low oxygen supply and increasin
211 2 reduces DNA damage repair gene expression, but selective inhibition of endogenous CDK12 is difficul
216 temperature had a small effect on recovery, but significant differences were observed for phlorizin
218 not induce significant hyperactivity itself, but significantly potentiated cocaine-induced hyperactiv
219 is dependent on the presence of darT(Mtb) , but simultaneous deletion of both darT(Mtb) -darG(Mtb) d
220 gic in aqueous solution and the DNA duplexes but slightly exoergic in the polymerase, with Arg517 and
221 of warming on VOC emissions were significant but smaller than the direct effects, during the 14-y mod
222 e and dynamics that are surprisingly subtle, but still sufficient to produce a large effect on CA-SP1
223 ly kills tumor cells by photodynamic therapy but stimulates the dimeric paclitaxel (PTX) generating m
224 o cholerae typically exists as a curved rod, but straight rods have been observed under certain condi
225 ystems or better has recently been proposed, but such a goal would require equitable translation to c
226 at various S(h) over its range of variation, but such calibrations are precluded because of lack of e
227 r cells from almost the entire blood volume, but such large numbers and concentrations of cells are i
228 s, treatment with an ARNI and baseline eGFR, but suggested treatment-by-subgroup interactions for sub
229 y is linked to T-bet in Ag-expCD4(+) T cells but that reduction in mTOR activity may not directly und
230 ly discriminate ICMS frequency up to ~200 Hz but that the sensory correlates of frequency were highly
231 le than typical metal or silicon electrodes, but the arrays described in previous reports had low cha
232 nclose substrates in the PHDs are conserved, but the C-terminal helix of the PHDs is strikingly absen
233 ural circuit changes in several brain areas, but the cellular mechanisms that underlie these defects
234 ffect of gene variants on phenotypic traits, but the Cre/loxP and Tet-On/Tet-Off systems can affect w
237 are linked to repression of gene expression, but the functions of repressive histone methylation dyna
238 oncogene has somewhat different surfaceomes, but the functions of these proteins are harmonized by co
239 Most bacteria have one pathway or the other, but the Gram-positive, facultative intracellular pathoge
240 mosomal structures in vertebrate cells(3-7), but the identical sequence of sister chromatids has made
241 essential to prevent OPC in mice and humans, but the individual roles of its ligands, IL-17A, IL-17F,
242 ions modify artery tone and tissue perfusion but the involved vascular-sensing mechanisms and disease
243 0 kb on both sides of the lesion within 1 h; but the kinetics and distribution of modification around
244 t underpin osmolyte synthesis and transport, but the main computational approach for predicting metab
246 ely linked to regulation of gene expression, but the mechanisms behind this directed movement have re
247 ed the Weibull model (0.96 <= R(2) <= 0.99), but the model overestimated inactivation by small-dose D
248 ogression through S phase of the cell cycle, but the molecular nature of this requirement has remaine
249 degeneration (AMD) and disease progression, but the precise biological function of HtrA1 in the eye
250 omics, crop improvement and crop protection, but the primary obstacle for the development of this tec
251 d in decades following forest establishment, but the role of climate in driving these trends has not
252 radical resembles both SOMOs of triangulene, but the spin density is distributed over the core in a n
253 f (*)OH was linearly correlated with a(440), but the steady-state concentration was best fit by a log
254 attentional modulation of underlying cortex, but the transformations that this circuit implements are
255 der the dependence of the small GTPase MglA, but the underlying molecular mechanisms remain elusive.
256 e the likelihood of dementia in older people but their impact on cognitive ageing in younger, healthy
257 ve been explored, including green materials, but their performances have not yet reached the level of
258 tors elegantly account for these properties, but their relationship to brain circuits is unclear.
259 o the striatum can trigger dopamine signals, but their release properties are not well understood.
260 for optimal bacterial entry into host cells, but their relevance to infection in vivo is undefined.
261 important feature of predator-prey ecology, but their significance has had little impact on the conc
262 ng nephrogenic systemic fibrosis (NSF) risk, but there are few if any unconfounded cases of NSF.
263 racterization of N-glycans in rodent brains, but there is a lack of spatial resolution as either the
265 and found no difference in the speed prior, but there was heightened variability in the ASD group.
266 ed with untreated control nonhuman primates, but there were immunological changes in granulomas and l
267 ed with patients who had fewer risk factors, but these cells showed impaired IFN-gamma production.
268 frequently used in heterogeneous catalysis, but they are expensive, rare and the ability to tailor t
270 e (0.22 SD; 95% CI, 0.05 to 0.38; P = 0.03), but this could not be attributed conclusively to a chang
271 from lethal exposure to lipopolysaccharides, but this protection is not conferred upon genetic or pha
272 tion, may reduce cardiovascular risk in CKD, but this requires testing in prospective randomised tria
274 beta accumulation in Alzheimer disease (AD), but to the knowledge of the authors the association with
275 hat the ORS is composed of two intermingling but transcriptionally distinct cell types with differing
276 d to convey a high risk of recurrent stroke, but two previous trials (SAMMPRIS and VISSIT) did not sh
277 ogical function of most SMs remains obscure, but understanding of both the activation of silent gene
278 D8(+) T cells, which represent a challenging but valuable model to gain insight into CTL biology.
279 major pathological response rate (TRG1 = 8%) but was associated with a significant pathological regre
281 or multicomponent clinic-based interventions but was low or very low for other intervention types.
282 aling from many immune receptors in mammals, but was not previously implicated in IL-17 signaling or
283 monstrated potent antitumor activity in vivo but was poorly tolerated, which was hypothesized to be t
284 mutant interacted with zDHHC17 more strongly but was S-acylated with reduced efficiency in HEK293T ce
285 rences in acute and chronic pain mechanisms, but we are only beginning to understand their mechanisti
286 uman gene catalogue is essentially complete, but we lack an equivalently vetted inventory of bona fid
288 hazard ratio [HR], 0.92 [95% CI, 0.80-1.06]) but were associated with significant reductions in total
289 sity when compared to no-CCY (all P > 0.05), but were less likely to have a previous C-section, gesta
290 ich had presented with recession at baseline but were not treated showed a significantly more apical
291 .6 +/- 2.8 vs 18.8 +/- 3.0 g CO(2)e MJ(-1)), but were notably lower under sorghum for sites in the so
292 of cartilage makes it a unique tissue(1-4), but whether and how the absence of nutrient supply regul
293 opioids, to elicit pseudoallergic reactions, but whether it represents the main opiate receptor of sk
294 ch the Y site is similar to that in Y-SiO(2) but which lacks adjacent hydroxyl groups, and are 7 time
295 opped markedly during Younger Dryas cooling, but while plant diversity recovered in the early Holocen
296 continued to be on the rise in recent years, but who is diagnosed changed during the study period.
297 t between patients with R0 versus R1 margins but wider resection margins do not confer a survival ben
299 ic region) and seven were declining strongly but with less certainty (mostly reptile and amphibian gr