ライフサイエンスコーパス: butyrolactone

1 c intermediate ultimately derived from gamma-butyrolactone.

2 ounterparts, gamma-hydroxybutyrate and gamma-butyrolactone.

3 7, was blocked by a Cdk5-specific inhibitor, butyrolactone.

4 ase than five-membered alpha-methylene-gamma-butyrolactone.

5 introduction of the required alpha-methylene butyrolactone.

6 tall the alpha-alkylidene-beta-hydroxy-gamma-butyrolactone.

7 s, gamma-hydroxycyclohexenones, and/or gamma-butyrolactones.

8 y streptomycetes produce extracellular gamma-butyrolactones.

9 to a variety of biologically important gamma-butyrolactones.

10 gh proportion of (E)-alpha-benzylidene-gamma-butyrolactones.

11 trifluoromethylated cis-fused bicyclic gamma-butyrolactones.

12 p synthesis of two naturally occurring gamma-butyrolactones.

13 h methyl-substituted olefinic azlactones and butyrolactones.

14 r methyl-substituted olefinic azlactones and butyrolactones.

15 l migrations delivering bridged, spiro-gamma-butyrolactones.

16 clization reactions to provide hydroxy-gamma-butyrolactones.

17 screened in the context of generating gamma-butyrolactones.

18 ine, ephedrine, gamma-hydroxybutyrate; gamma-butyrolactone, 1,4-butanediol, flunitrazepam, ketamine,

19 multigram scales beginning with inexpensive butyrolactone (10).

20 21 (10%) used gamma-hydroxybutyrate or gamma-butyrolactone, 175 (8%) used methamphetamine, and 162 (7

21 e, diketene (4-methyleneoxetan-2-one), gamma-butyrolactone, 2(5H)-furanone, and delta-valerolactone.

22 e, diketene (4-methyleneoxetan-2-one), gamma-butyrolactone, 2(5H)-furanone, and delta-valerolactone.

23 od includes access to tetrahydrofuran, gamma-butyrolactone, 2-isooxazoline, pyrrolidine, and thiolane

24 coelicolor A3(2) and S. griseus: (1) gamma -butyrolactones; (2) a complex cascade of mostly undefine

25 ched 5-substituted alpha-exo-methylene gamma-butyrolactones 3a-i.

26 , 1j, and 1l forms alpha-exo-methylene-gamma-butyrolactones 5b, 5f, 5j, and 5l in moderate to good yi

27 the disubstituted alpha-exo-methylene gamma-butyrolactones 6a and 6b with good to excellent levels o

28 sformed to the trans-4,5-disubstituted gamma-butyrolactones 7a, 7l, and 7p.

29 required for A-factor synthesis of the gamma-butyrolactone A-factor and consequently for streptomycin

30 ghly stereoselective one-pot approach to the butyrolactone, a challenging sp(2)-sp(3) Suzuki coupling

31 pyl carbinols to form alpha-alkylidene-gamma-butyrolactones (ABLs) is reported.

32 trasts with other reports that loss of gamma-butyrolactones abolishes antibiotic production.

33 (TGM/DBA) or without (TGM) a dimethyl-gamma-butyrolactone acrylate (DBA)-containing lactone ring tha

34 results in predominantly 5-substituted gamma-butyrolactones along with a small amount of butenolides

35 id, hydroxymethylfurfural, lipids, and gamma-butyrolactone also contributed to score and sensory qual

36 c acid, hydroxymethylfurfural, lipids, and y-butyrolactone also contributed to score and sensory qual

37 A variety of gamma-butyrolactone analogues also modulate GABA-induced curre

38 sis, and evaluation of alpha-methylene-gamma-butyrolactone analogues and their evaluation as anticanc

39 alpha-Methylene-gamma-butyrolactone and alpha-methylene-delta-valerolactone un

40 dration-translactonization to form the gamma-butyrolactone and an intramolecular aldol cyclization to

41 olved in the ring-opening reactions of gamma-butyrolactone and delta-valerolactone, the conformationa

42 Interestingly, 1-propanol, delta-butyrolactone and ethyl lactate concentrations, showed n

43 Novel 5-(1'-hydroxy)-gamma-butyrolactone and gamma-butyrolactam subunits were synth

44 Corroborating our previous results, butyrolactone and hexanoic acid, previously considered a

45 dable plastics, based on copolymers of gamma-butyrolactone and its ring-fused derivative, with compet

46 ted metabolomic approaches, two major (gamma-butyrolactone and methyl heptenone) and four minor (3-me

47 aldol addition of alpha,beta-dichloro gamma-butyrolactones and gamma-butyrolactams with aldehydes un

48 activated ketones and imines provides gamma-butyrolactones and lactams, respectively.

49 ion mutant of scbR also failed to make gamma-butyrolactones and showed delayed Red production.

50 lon-caprolactone, delta-butyrolactone, gamma-butyrolactone, and D, L, meso, and racemic lactides has

51 hat negatively regulates metabolism of gamma-butyrolactone, and its repressing function is relieved b

52 tion reactions to provide butenolides, gamma-butyrolactone, and/or beta,gamma-epoxycyclohexanones.

53 federal government, 1,4-butanediol and gamma-butyrolactone, another precursor of gamma-hydroxybutyrat

54 es of enantiopure (R,R)-alpha-alkylated-beta-butyrolactones are obtained from (R)-P3HB and then subje

55 nantioenriched, densely functionalized gamma-butyrolactones are of high synthetic utility, as highlig

56 alpha-Alkylidene-gamma-butyrolactones are readily prepared by the palladium-cat

57 ne) (PVL), poly(lactic acid), and poly(gamma-butyrolactone), are elucidated.

58 grees of ring-opening with methanol of gamma-butyrolactone-based monomers provided a model to predict

59 Polymerization of beta-butyrolactone (BBL) and beta-valerolactone (BVL) using t

60 Terpolymerizations of (rac)-beta-butyrolactone (BBL), cyclohexene oxide (CHO), and carbon

61 for ring-opening polymerization of rac-beta-butyrolactone (beta-BL) to isotactic poly(3-hydroxybutyr

62 opening polymerization (ROP) of racemic beta-butyrolactone (beta-BL) using in situ-generated catalyst

63 te, methyl formate, beta-propiolactone, beta-butyrolactone, beta-isovalerolactone, diketene (4-methyl

64 and methyl formate, beta-propiolactone, beta-butyrolactone, beta-isovalerolactone, diketene (4-methyl

65 versatile latent carbonyls from which gamma-butyrolactones, beta-hydroxy methyl ketones, and beta-hy

66 ranscribed gene, scbR, which encodes a gamma-butyrolactone binding protein.

67 genes, which are related to genes for gamma-butyrolactone-binding proteins.

68 Polyketide, non-ribosomal peptide, and gamma-butyrolactone biosynthetic enzymes are primarily strain

69 tetrahydrofuran (THF) to exclusively afford butyrolactone (BTL), likely a result of prolonging the r

70 n of renewable alpha-methylene-gamma-(methyl)butyrolactones by chiral C(2)-symmetric zirconocene cata

71 clic poly(gamma-methyl-alpha-methylene-gamma-butyrolactone) (c-PMMBL), from the bio-based monomer MMB

72 ethod of preparing enantiopure hydroxy-gamma-butyrolactones containing multiple contiguous stereocent

73 Butenolides and gamma-butyrolactones control the production of pharmaceuticall

74 lvolysis, the poly(oxanorbornene-fused gamma-butyrolactone) could be cleanly chemically recycled back

75 - 2.4 kcal/mol for beta-propiolactone, gamma-butyrolactone, delta-valerolactone, and epsilon-caprolac

76 tion with alkene to afford diverse new gamma-butyrolactone derivatives in very good yields.

77 amates, as well as tetrahydrofuran and gamma-butyrolactone derivatives, without erosion of enantiomer

78 ioselective allylic alkylation using a gamma-butyrolactone-derived silyl ketene acetal.

79 n and trapping the generated 17-radical with butyrolactone disulfides.

80 tonization to afford the corresponding gamma-butyrolactones, each as a single isomer.

81 y functionalized spiro alpha-methylene-gamma-butyrolactones, efficiently prepared from (R)-4-amino-Uh

82 raw and roasted defective seeds in general), butyrolactone (for raw defective seeds in general), and

83 y selective NHC-catalyzed synthesis of gamma-butyrolactones from the fusion of enals and alpha-ketoph

84 es has been explored for the access of gamma-butyrolactone-fused 1-pyrrolines.

85 The [3+2] annulation of gamma-butyrolactone-fused donor-acceptor cyclopropanes with ni

86 ing/cyclization to give the respective gamma-butyrolactone-fused gamma-butyrolactams in good yields.

87 However, the bioderived five-membered gamma-butyrolactone (gamma-BL) is commonly referred as 'non-po

88 f the biorenewable "non-polymerizable" gamma-butyrolactone (gamma-BL) to a high-molecular-weight meta

89 ow-ceiling-temperature (LCT) monomers, gamma-butyrolactone (gamma-BL) toward ring-opening polymerizat

90 ctones including epsilon-caprolactone, delta-butyrolactone, gamma-butyrolactone, and D, L, meso, and

91 gamma-butyrolactone (GBL) (750 mg/kg i.p.) increased DOPA leve

92 d triiodide (FAPbI(3)) in a mixture of gamma-butyrolactone (GBL) and 2-methoxyethanol (2ME), a phenom

93 ese processes are under the control of gamma-butyrolactone (GBL) autoregulatory systems.

94 diffusible signaling molecules of the gamma-butyrolactone (GBL) family.

95 ronal impulse flow and DA release with gamma-butyrolactone (GBL) increased DA concentrations in the s

96 rsal striatum of rats submitted to the gamma-butyrolactone (GBL) model of absence epilepsy, amygdala

97 In the gamma-butyrolactone (GBL) model of DA autoreceptor function, m

98 abolition of DA neuronal activity [by gamma-butyrolactone (GBL) treatment or transection of the nigr

99 forebrain, absence seizures evoked by gamma-butyrolactone (GBL), and audiogenic seizures in genetica

100 mide (DMF), dimethyl sulfoxide (DMSO), gamma-butyrolactone (GBL), and water.

101 with the nerve impulse flow inhibitor gamma-butyrolactone (GBL).

102 g a sulfur atom in the alpha-position of the butyrolactone group, whereas carbon-linked lactones were

103 3-Hydroxy-gamma-butyrolactone has been identified as one such chemical;

104 opropyl ring to access fused tricyclic gamma-butyrolactones has been described.

105 The stereochemistry of these hydroxy-gamma-butyrolactones has been established using NOE spectrosco

106 he application of the CDK inhibitors p21 and butyrolactone I but not p16.

107 Butyrolactone I, a cdk5 inhibitor, had an additional pro

108 e gave access to a naturally occurring gamma-butyrolactone in good yield, with excellent diastereo- a

109 from culture fluids, but differed from gamma-butyrolactones in being alkali resistant.

110 ence of an organocatalyst yields trans-fused butyrolactones in high yield and enantioselectivities.

111 he need to isolate and purify the toxic beta-butyrolactone intermediate.

112 in-derived spirocyclic alpha-methylene-gamma-butyrolactone is a suitable core for optimization to ide

113 cyclization of nonracemic benzylidene gamma-butyrolactone is studied toward the asymmetric synthesis

114 ivity were ethyl hexanoate, ethyl octanoate, butyrolactone, isoamyl alcohols, acetaldehyde, ethyl ace

115 imit the synthesis of ethyl esters and gamma-butyrolactone, keeping the accumulation of off-flavours

116 rein-butyrolactone-like, ladderane-like, and butyrolactone-ladderane-like hybrid (BL-BGC)-have not be

117 of the cluster directs synthesis of a gamma-butyrolactone-like autoregulator.

118 Three types of BGCs identified herein-butyrolactone-like, ladderane-like, and butyrolactone-la

119 The butyrolactones linked to the steroidal nucleus via the b

120 That putative gamma-butyrolactone material was not produced when orf18 * was

121 alpha-Methylene-gamma-butyrolactone (MBL), a naturally occurring and biomass-s

122 sults indicate a complex mechanism for gamma-butyrolactone-mediated regulation of antibiotic biosynth

123 renewable gamma-methyl-alpha-methylene-gamma-butyrolactone (MMBL).

124 e intermediate with an alpha-methylene gamma-butyrolactone moiety was identified as a promising lead

125 biobased tricyclic oxanorbornene-fused gamma-butyrolactone monomer (M1).

126 solution of CH(3)NH(3)I and PbI(2) in gamma-butyrolactone on a 400 nm thick film of TiO(2) (anatase)

127 This enhancement was eliminated by either butyrolactone or CK1-7 and was absent in DARPP-32 knocko

128 ate and its subsequent monomer (l-lactide, B-butyrolactone, or cyclohexene oxide) selectivity in one

129 The chemical synthesis of poly(gamma-butyrolactone) (PgammaBL) through the ROP process has be

130 Biobased poly(y-methyl-a-methylene-y-butyrolactone) (PMMBL), an acrylic polymer bearing a cyc

131 s of a novel series of 17beta-glucocorticoid butyrolactones possessing either a 16alpha,17alpha-isopr

132 Additionally, they show that the gamma-butyrolactones probably interact at two different sites

133 ator in addition to being required for gamma-butyrolactone production.

134 monosuccionate, diethyl succinate and gamma-butyrolactone production.

135 Bromination of the methylene butyrolactone products followed by zinc-mediated reducti

136 gent desaturation of 4,5-disubstituted gamma-butyrolactones (Quercus-like lactones), funneling all fo

137 of three further bld genes and several gamma-butyrolactone receptor genes have led to new ideas about

138 vidans, we showed that TylP, a deduced gamma-butyrolactone receptor, downregulated reporter gene expr

139 , similar to the targets for authentic gamma-butyrolactone receptors, in the promoters of tylP, tylQ

140 Peripherally, C75, an alpha-methylene-gamma-butyrolactone, reduces adipose tissue and fatty liver, d

141 Gamma-butyrolactones regulate secondary metabolism and, someti

142 treptomyces homologue CprB, which is a gamma-butyrolactone regulator.

143 nalogous functions to the better known gamma-butyrolactone regulatory molecules.

144 phenylbutyraldehyde, and alpha-hydroxy-gamma-butyrolactone, relying on cyanoborohydride for coupling

145 nd 3,4-dihydroxybutyric acid+3-hydroxy-gamma-butyrolactone, respectively, molecules with potential us

146 a nitrogen analogue of alpha-methylene-gamma-butyrolactone resulted in a total loss of the reaction a

147 as the stereoselective attachment of a gamma-butyrolactone ring to a tetracycle core structure by use

148 bond and a highly stable five-membered gamma-butyrolactone ring.

149 Addition of the gamma-butyrolactone SCB1 of S. coelicolor resulted in loss of

150 s and in the synthesis of a diffusible gamma-butyrolactone, SCB1, that can elicit precocious Act and

151 The resultant butyrolactone serves as a handle for a radical polar cro

152 ne-gamma-butyrolactone to alpha-methyl-gamma-butyrolactone, Sharpless kinetic resolution, Sharpless a

153 e that the lack of polymerizability of gamma-butyrolactone should be attributed to the low strain of

154 ma factors, antibiotic biosynthesis, a gamma-butyrolactone signalling system, members of the actinomy

155 relevant polycyclic products bearing a gamma-butyrolactone structural motif, thus broadening the synt

156 These led to a revised gamma-butyrolactone structure for the metabolite.

157 d (N55) with a new N-linoleoyl-2-amino-gamma-butyrolactone structure was purified from fenugreek seed

158 ted toward elaboration of the characteristic butyrolactone substituent.

159 unsaturated amido ester to form various C(3)-butyrolactone-substituted oxindole derivatives in very g

160 es for the respective gene products in gamma-butyrolactone synthesis.

161 one (template I) and 4,4-disubstituted gamma-butyrolactone (template II), with the latter producing p

162 roducts to various compounds such as epoxy y-butyrolactone, tertiary B-hydroxy ketone and epoxy diest

163 anenitrile, ethyl bromoacetate, and 2-acetyl butyrolactone, the synthetic sequence afforded the A. ne

164 the synthesis of biologically relevant gamma-butyrolactones through dual activation under ambient rea

165 lective hydrogenation of exo-methylene-gamma-butyrolactone to alpha-methyl-gamma-butyrolactone, Sharp

166 light-mediated cyclization of an O-arylated butyrolactone to form a tricyclic cis-fused benzofuran a

167 tK, AttL, and AttM collectively covert gamma-butyrolactone to succinate.

168 n developed that allows functionalized gamma-butyrolactones to be prepared in one step from simple te

169 rmal total synthesis of a known marine gamma-butyrolactone-type metabolite.

170 These gamma-butyrolactones underwent intramolecular radical cyclizat

171 gamma-Butyrolactone, unlike delta-valerolactone, does not poly

172 ribes an enantioselective synthesis of gamma-butyrolactones, using the N-tolyl-substituted oxazolidin

173 nthetic strategy to cis-fused bicyclic gamma-butyrolactones via the retro-Diels-Alder reaction/intram

174 d for the stereoselective synthesis of gamma-butyrolactones via the sequence of N-acylation, C(alpha)

175 the diethyl phosphonate derivative of gamma-butyrolactone was treated with potassium hexamethyldisil

176 or homoalkynyl-alpha,beta-unsaturated gamma-butyrolactones was found to accelerate the rate of the i

177 l-2-ene (C(5)-1), the enol tautomer of gamma-butyrolactone, was generated in the gas phase as the fir

178 alpha-Heteroaromatic-gamma-butyrolactones were engaged in a highly regio-, diastere

179 The glucocorticoid butyrolactones were hydrolyzed in human plasma by the en

180 Mono- and multi-functionalised gamma-butyrolactones were synthesised through exo-cyclisation

181 ive the corresponding tetracyclic cage gamma-butyrolactones, which were employed as precursors for th

182 e reaction of optically pure 3-hydroxy-gamma-butyrolactone with a primary amine to give an amide, whi

183 rized to chiral alpha,alpha-dialkylated-beta-butyrolactones with high stereoselectivity.

184 to racemic alpha-keto esters, forming gamma-butyrolactones with three contiguous stereocenters.

185 A scbA mutant produced no gamma-butyrolactones, yet overproduced two antibiotics, actino