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4 f phosphoantigens leads to interactions with butyrophilin 2A1 and the subsequent activation of gammad
6 ound that the human and mouse genes encoding butyrophilin-2A2 (BTN2A2) are regulated by the class II
10 Evidence pointing to a role for the CD277/butyrophilin-3 (BTN3A) molecules in this response led us
14 Human Vgamma9Vdelta2 T cells recognize in a butyrophilin 3A/CD277-dependent way microbial (E)-4-hydr
15 Activation of Vgamma9Vdelta2 T cells with butyrophilin 3A1 (BTN3A1) agonists such as (E)-4-hydroxy
19 activation of Vgamma9Vdelta2 T cells is the butyrophilin 3A1 (BTN3A1) protein that contains an intra
22 2 T cell Ag-presenting transmembrane protein butyrophilin 3A1, providing information on critical resi
23 s, which bind to the intracellular domain of butyrophilin 3A1, triggering extracellular interactions
27 mology to the carboxyl-terminal sequences of butyrophilin and an additional group of zinc finger gene
28 ion of gammadelta T cells can be elicited by butyrophilin and butyrophilin-like molecules that are st
31 Recent studies have identified heterodimeric butyrophilin (BTN) 2A1 and BTN3A1 as the molecular entit
36 germline-encoded Vgamma-specific residues by butyrophilin (BTN) or BTN-like (BTNL) proteins that uniq
38 f phospho-antigen metabolites (pAgs) through Butyrophilin (BTN)-3A1 and BTN2A1 to the Vgamma9Vdelta2
40 cell PAg levels are specifically detected by butyrophilin (BTN)3A1, using its intracellular B30.2 dom
41 Vdelta1+Vgamma9- T cell lines to recombinant butyrophilin BTN2A1 and BTN3A1 demonstrated that both Vd
51 activation by intact iRBCs is independent of butyrophilin expression by the iRBC, and contact with an
53 a2 T cell activation by phosphoantigen-bound butyrophilin, facilitating immunotherapeutic drug design
55 mily molecules; however, the function of the butyrophilin family in the immune system has not been de
56 programmed death 1 ligand 2 (PD-L2), and the butyrophilin family member butyrophilin-like 2 (BTNL2) w
58 we characterize an MHC class II gene-linked butyrophilin family member, butyrophilin-like 2 (BTNL2),
59 flammation, and inhibitory members of the B7/butyrophilin family of ligands have evolved to balance t
62 TCRs likely coevolved with molecules of the butyrophilin family they interact with, whereas the semi
63 d mouse Skint1 and Btnl2, all members of the butyrophilin family, show greater structural and functio
71 , reveal structure-activity relationships of butyrophilin ligands, and support a negatively cooperati
72 sion of immune signaling molecules including butyrophilin-like (Btnl) 1, Btnl6, H2-T3, and Clec2e tha
73 The DETC repertoire is shaped by Skint1, a butyrophilin-like (Btnl) gene expressed specifically by
78 skin aligned with and depended on Skint1, a butyrophilin-like (BTNL) protein expressed by differenti
79 ltiple butyrophilin molecules and found that butyrophilin-like (BTNL)1 molecule functions to dampen T
83 s II gene-linked butyrophilin family member, butyrophilin-like 2 (BTNL2), the mutation of which has b
84 family of immune regulator genes, including butyrophilin-like 2 (BTNL2; OMIM, 606000), which is asso
85 r milk lipid secretion in lactation, whereas butyrophilin-like 2 is a coinhibitor of T cell activatio
91 1, BTN3A2, and BTN3A3, are members of the B7/butyrophilin-like group of Ig superfamily receptors, whi
92 of seven genes belonging to the expanding B7/butyrophilin-like group, a subset of the immunoglobulin
93 T cells can be elicited by butyrophilin and butyrophilin-like molecules that are structurally simila
97 do not agree with previous suggestions that butyrophilin may exist in cytoplasmic soluble forms, or
98 lts are discussed with reference to the role butyrophilin may play as the principal scaffold for the
101 er of the extended B7 superfamily related to butyrophilin, mimics PAg-induced Vgamma9Vdelta2 T-cell a
103 study, we performed an analysis on multiple butyrophilin molecules and found that butyrophilin-like
104 tification in an infant formula (IF) matrix: butyrophilin, mucin 1, xanthine dehydrogenase/oxidase, a
110 e gene HLA-H, we identified a family of five butyrophilin-related sequences, two genes with structura
111 revealed key features of phosphoantigens and butyrophilins required for gammadelta T cell activation.
113 nd C-terminal domains were used to show that butyrophilin retains a type I topology in plasma membran
114 , solute carrier family 3 member 2 (SLCA32), butyrophilin subfamily 2 member A1 (BTN2A1), katanin reg
118 a protein most closely related to mammalian butyrophilins, which are members of the immunoglobulin p
120 pid metabolism (n = 13, 59.10%) and included butyrophilin, xanthine dehydrogenase/oxidase, and lipid