ライフサイエンスコーパス: butyrylcholinesterase

1 ctivity toward human acetylcholinesterase or butyrylcholinesterase.

2 n inhibitor of human acetylcholinesterase or butyrylcholinesterase.

3 eased sensitivity to inactivation by PMSF of butyrylcholinesterase.

4 sembly of all detectable asymmetric AChE and butyrylcholinesterase.

5 cked asymmetric forms of the AChE homologue, butyrylcholinesterase.

6 serum acetylcholinesterase and equine serum butyrylcholinesterase.

7 replaced by aliphatic amino acid residues in butyrylcholinesterase.

8 y on alpha-amylase, acetylcholinesterase and butyrylcholinesterase.

9 se, alpha-amylase, acetylcholinesterase, and butyrylcholinesterase.

10 expression network immediately downstream of butyrylcholinesterase.

11 with human albumin, free tyrosine, and human butyrylcholinesterase.

12 mammalian CEs, as well as human acetyl- and butyrylcholinesterase.

13 tter acetylcholinesterase (55.57 +/- 0.83%), butyrylcholinesterase (49.59 +/- 1.09%), tyrosinase (44.

14 Acetylcholinesterase and butyrylcholinesterase accumulate with brain beta-amyloid

15 etylcholinesterase [(-)9] and of acetyl- and butyrylcholinesterase (AChE and BChE) [(-)10], respectiv

16 digitated electrode and acetylcholinesterase/butyrylcholinesterase (AChE/BChE) hydrolysis of their re

17 The volume of the butyrylcholinesterase active site gorge is approximately

18 Acetylcholinesterase and butyrylcholinesterase activities emerge in association w

19 agent that inhibits acetylcholinesterase and butyrylcholinesterase activities, to inhibit cholinester

20 aper to print electrodes able to measure the butyrylcholinesterase activity, delivering a reagent fre

21 Butyrylcholinesterase, administered in the plasma compar

22 rbicides, and triazine herbicide) to inhibit butyrylcholinesterase, alkaline phosphatase, and tyrosin

23 However, butyrylcholinesterase, an endogenous cocaine-hydrolyzing

24 ells modified to express an enhanced form of butyrylcholinesterase, an enzyme that hydrolyzes cocaine

25 expression system using genes encoding human butyrylcholinesterase and a proline-rich peptide under e

26 ists in cabin air may form adducts on plasma butyrylcholinesterase and albumin, detectable by mass sp

27 displayed considerable acetylcholinesterase, butyrylcholinesterase and alpha-glucosidase inhibitory a

28 echol dibenzoate, the latter inhibiting also butyrylcholinesterase and beta-glucosidase.

29 9), and ianthelline (7) moderately inhibited butyrylcholinesterase and Candida and Cryptococcus spp.

30 eins is either limited (e.g., plasma-derived butyrylcholinesterase and erythrocytic acetylcholinester

31 on DNA dendrimer scaffolds that incorporate butyrylcholinesterase and fluorescein in a nanoscale arr

32 In addition, butyrylcholinesterase and mouse AChE mutants F288L and F

33 re to combinations of chemicals that inhibit butyrylcholinesterase and neuropathy target esterase.

34 ed one major oligosaccharide for human serum butyrylcholinesterase and three or four major oligosacch

35 ives with inhibitory activity towards acetyl/butyrylcholinesterases and monoamine oxidases A/B as wel

36 (alpha-glucosidase, acetylcholinesterase and butyrylcholinesterase) and free radicals (DPPH, nitric o

37 Neuroligin, butyrylcholinesterase, and acetylcholinesterase are memb

38 tivities against human acetylcholinesterase, butyrylcholinesterase, and BACE-1, dual Abeta42 and tau

39 plasma levels of zinc-alpha-2-glycoprotein, butyrylcholinesterase, and increased levels of complemen

40 rum butyrylcholinesterase, recombinant human butyrylcholinesterase, and recombinant mouse acetylcholi

41 controls inhibited acetylcholinesterase and butyrylcholinesterase, and this effect was increased in

42 Transduction of another mutant butyrylcholinesterase, Applied Molecular Evolution mutan

43 inesterases, acetylcholinesterase (AChE) and butyrylcholinesterase, are primary targets of organophos

44 s Arg residues in neuroligin-3 (Arg-451), in butyrylcholinesterase (Arg-386), and in acetylcholineste

45 e detection of both acetylcholinesterase and butyrylcholinesterase, as well as their inhibition.

46 ith a gene transfer paradigm using a related butyrylcholinesterase-based cocaine hydrolase (CocH).

47 The polymorphic K variant of the butyrylcholinesterase ( BCHE-K ) gene recently has been

48 developed for simultaneously measuring both butyrylcholinesterase (BChE) activity and the total amou

49 application, highly sensitive biosensing of butyrylcholinesterase (BChE) activity using the Fe-N-C S

50 S1) of cocaine hydrolysis catalyzed by human butyrylcholinesterase (BChE) and its mutants.

51 Inhibition of butyrylcholinesterase (BChE) and p38alpha mitogen-activa

52 Inhibitors showed that both butyrylcholinesterase (BChE) and PAFAH1b2 contribute to

53 njugates toward acetylcholinesterase (AChE), butyrylcholinesterase (BChE) and structurally close to t

54 s to investigate the biological functions of butyrylcholinesterase (BChE) and the mechanisms by which

55 hly potent and selective inhibitors of human butyrylcholinesterase (BChE) and will test the novel hyp

56 rdose, we undertook molecular engineering of butyrylcholinesterase (BChE) as a cocaine hydrolase so t

57 alization of acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) at the NMJ to bring out the

58 lectrochemical measurements, in parallel, of butyrylcholinesterase (BChE) enzyme activity towards but

59 the demonstration of Abeta immunoreactivity, butyrylcholinesterase (BChE) enzyme activity, and thiofl

60 gainst human acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) ex vivo.

61 Butyrylcholinesterase (BChE) has a major role in cocaine

62 Butyrylcholinesterase (BChE) hydrolyzes AG to des-acyl-g

63 f aprophen but also preferentially inhibited butyrylcholinesterase (BChE) in contrast to acetylcholin

64 thway [i.e., cocaine hydrolysis catalyzed by butyrylcholinesterase (BChE) in plasma].

65 Human butyrylcholinesterase (BChE) in serum is composed predom

66 The enzymatic activity of butyrylcholinesterase (BChE) in the brain increases with

67 Like acetylcholinesterase, butyrylcholinesterase (BChE) inactivates the neurotransm

68 Human plasma butyrylcholinesterase (BChE) inactivates these poisons b

69 ned by functionalizing a pseudo-irreversible butyrylcholinesterase (BChE) inhibitor.

70 e carbamate structure of pseudo-irreversible butyrylcholinesterase (BChE) inhibitors was optimized wi

71 Butyrylcholinesterase (BChE) is a promising target for t

72 Butyrylcholinesterase (BChE) is an enzyme with broad sub

73 Butyrylcholinesterase (BChE) is important in cocaine met

74 Butyrylcholinesterase (BChE) is regarded as a promising

75 Butyrylcholinesterase (BChE) is the most promising biosc

76 ocaine abuse based on viral gene transfer of butyrylcholinesterase (BChE) mutated for accelerated coc

77 hes brain reward centers using mutated human butyrylcholinesterase (BChE) or cocaine hydrolase (CocH)

78 a dried spot activity assay for quantifying butyrylcholinesterase (BChE) specific activity which is

79 well-established acetylcholinesterase (AChE)/butyrylcholinesterase (BChE) tacrine templates.

80 toward human acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) that retain or improve the

81 oducts (adducts) of the toxicant with, e.g., butyrylcholinesterase (BChE) typically by targeted analy

82 Butyrylcholinesterase (BChE) was chosen as a model enzym

83 osphorus nerve agent (OPNA) adducts to human butyrylcholinesterase (BChE) was developed.

84 ug/mL), while the highest inhibition towards butyrylcholinesterase (BChE) was observed for the extrac

85 ug/mL), while the highest inhibition towards butyrylcholinesterase (BChE) was observed for the extrac

86 o, and reactivation rates for OP-inactivated butyrylcholinesterase (BChE) were greater than those for

87 tion against acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) with IC(50) values of 0.070

88 e inactivation of recombinant (r) human (Hu) butyrylcholinesterase (BChE) with P(S)C(S)- and P(S)C(R)

89 otent inhibitors of either acetyl- (AChE) or butyrylcholinesterase (BChE) with specific compounds exh

90 m-based inhibitors were bound to pure equine butyrylcholinesterase (BChE), a 364 kDa homotetramer, an

91 all molecule and drug metabolism, especially butyrylcholinesterase (BCHE), a gene involved in the met

92 ant activities, acetylcholinesterase (AChE), butyrylcholinesterase (BChE), a-amylase, a-glucosidase,

93 ant activities, acetylcholinesterase (AChE), butyrylcholinesterase (BChE), alpha-amylase, alpha-gluco

94 te acetylcholinesterase (AChE), equine serum butyrylcholinesterase (BChE), and a structurally related

95 Torpedo AChE, fetal bovine serum AChE, human butyrylcholinesterase (BChE), and equine BChE.

96 nhibition of acetylcholinesterase (AChE) and butyrylcholinesterase (BChE), and tyrosinase (TYRO) by m

97 acetylthiocholine (ATC) by the hydrolysis of butyrylcholinesterase (BChE), could cause the aggregatio

98 rat contain acetylcholinesterase (AChE) and butyrylcholinesterase (BChE), enzymes implicated in neur

99 nhibit human acetylcholinesterase (AChE) and butyrylcholinesterase (BChE), ex vivo, demonstrated that

100 sfer of the acyl-ghrelin hydrolyzing enzyme, butyrylcholinesterase (BChE), in a mouse model of diet-i

101 The silent phenotype of human butyrylcholinesterase (BChE), present in most human popu

102 lacing a His near the oxyanion hole of human butyrylcholinesterase (BChE), we made an esterase (G117H

103 We engineer E30-6 from human butyrylcholinesterase (BChE), which is specific for coca

104 molecular mechanical (QM/MM) calculations on butyrylcholinesterase (BChE)-catalyzed hydrolysis of (-)

105 rate-determining transition state for human butyrylcholinesterase (BChE)-catalyzed hydrolysis of (-)

106 uncover the fundamental reaction pathway for butyrylcholinesterase (BChE)-catalyzed hydrolysis of ghr

107 found to be a substrate for nonenzymatic and butyrylcholinesterase (BChE)-catalyzed hydrolysis.

108 Butyrylcholinesterase (BChE)-cocaine binding and the fun

109 synthesis or decreased acetylcholinesterase-/butyrylcholinesterase (BChE)-mediated degradation.

110 gainst human acetylcholinesterase (AChE) and butyrylcholinesterase (BChE).

111 interleukin-1beta (IL-1beta), S100beta, and butyrylcholinesterase (BChE).

112 DMAPMA), MG) for the gentle incorporation of butyrylcholinesterase (BChE).

113 ligenin phosphate makes a covalent adduct on butyrylcholinesterase (BChE).

114 ic acid (MeP) product when adducted to human butyrylcholinesterase (BChE).

115 tabolized (bioconverted) into terbutaline by butyrylcholinesterase (BChE).

116 ocaine hydrolysis catalyzed by plasma enzyme butyrylcholinesterase (BChE).

117 ses, such as acetylcholinesterase (AChE) and butyrylcholinesterase (BChE).

118 st freshly prepared human acetyl- (AChE) and butyrylcholinesterase (BChE).

119 (1) against acetylcholinesterase (AChE) and butyrylcholinesterase (BChE); its absolute configuration

120 c frequency of the gene for the K variant of butyrylcholinesterase (BCHE-K) was 0.17 in 74 subjects w

121 e activities in vitro (acetylcholinesterase, butyrylcholinesterase, beta-site amyloid precursor prote

122 of all, these compounds selectively inhibit butyrylcholinesterase, block NMDA receptors containing N

123 A novel method for extracting butyrylcholinesterase (BuChE) from serum as a means of i

124 olinesterase inhibitor therapy should target butyrylcholinesterase (BuChE) in Alzheimer's disease (AD

125 potential as acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE) inhibitors was also assess

126 ested compounds inhibited the related enzyme butyrylcholinesterase (BuChE) up to their aqueous solubi

127 Butyrylcholinesterase (BuChE), an acetylcholine-degradin

128 e esterases, acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE), and several of their natu

129 The AChE and butyrylcholinesterase (BuChE), as measured by the method

130 tection of AChE and avoiding interference of butyrylcholinesterase (BuChE), the pseudocholinesterase.

131 fect on both acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE).

132 as based on the formation of OPNA adducts to butyrylcholinesterase (BuChE).

133 us mutations in the acetylcholinesterase and butyrylcholinesterase cDNAs.

134 serum acetylcholinesterase, and equine serum butyrylcholinesterase) clearly demonstrated a reduced he

135 action of these compounds with their target, butyrylcholinesterase, depends on the stereochemistry ar

136 olog (yeast, alpha-1,2-glucosyltransferase); butyrylcholinesterase; dipeptidyl-peptidase 4 (CD26, ade

137 The G117H mutant of human butyrylcholinesterase (EC 3.1.1.8) was expressed in Chin

138 on kinetics compared with wild-type AChE and butyrylcholinesterase (EC 3.1.1.8).

139 ganophosphorus toxicants (OP) for mutants of butyrylcholinesterase (EC 3.1.1.8; BChE) and acetylcholi

140 p-free optical platform for the detection of butyrylcholinesterase enzyme (BChE) activity in human se

141 d donepezil inhibition activities toward the butyrylcholinesterase enzyme were also measured in blood

142 zed probes (Prussian blue, carbon black, and butyrylcholinesterase), evaluating pesticides and reduci

143 xpression quantitative trait locus for BCHE (butyrylcholinesterase), expressed in thalamus tissue.

144 forms of plasma cholinesterases (human serum butyrylcholinesterase, fetal bovine serum acetylcholines

145 Twelve silent alleles of the human butyrylcholinesterase gene (BCHE) have been identified i

146 ngle locus immediately adjacent to the BCHE (butyrylcholinesterase) gene associated with plasma aspir

147 H-chromene hybrids inhibit human acetyl- and butyrylcholinesterase (h-AChE and h-BuChE), being more p

148 nesterase is found to decline in AD, whereas butyrylcholinesterase has been found to either increase

149 the rates differs for reactivation of human butyrylcholinesterase (hBChE) conjugates.

150 t into three efficient reactivators of human butyrylcholinesterase (hBChE) inhibited covalently by ne

151 nthesis and characterization of merged human butyrylcholinesterase (hBChE) inhibitor/cannabinoid rece

152 In human butyrylcholinesterase (hBChE), aging involves the residu

153 o-grafting procedure for both modified human butyrylcholinesterase (hBChE)- and GLP1-expressing cells

154 Human serum butyrylcholinesterase (Hu BChE) is a promising therapeut

155 Butyrylcholinesterase hydrolyses acetylcholine, which ex

156 alpha-glucosidase, acetylcholinesterase and butyrylcholinesterase (IC(50), 0.51, 13.5 and 58.0 mug m

157 astigmine resulted in complete inhibition of butyrylcholinesterase in all structures at 10(-5) M.

158 holinesterase and a more potent inhibitor of butyrylcholinesterase in plaques and tangles.

159 Dosing with CPF yielded an inhibition of 35% butyrylcholinesterase in plasma and 45% acetylcholineste

160 inhibitors of human acetylcholinesterase and butyrylcholinesterase in vitro and moderately potent Abe

161 The compound showed potent acetyl- and butyrylcholinesterase inhibition.

162 inhibitor BW284C51 and more potent than the butyrylcholinesterase inhibitors iso-OMPA and ethopropaz

163 esterase, which is replaced by A328 in human butyrylcholinesterase, is implicated in the binding of l

164 itory activity against acetylcholinesterase, butyrylcholinesterase, lipoxygenase, and tyrosinase; the

165 Human butyrylcholinesterase made a covalent bond with CBDP on

166 ld-type T. californica AChE, wild-type mouse butyrylcholinesterase, mouse Y330F, Y330A, F288L, and F2

167 MDE-FACS allowed the identification of human butyrylcholinesterase mutants that undergo self-reactiva

168 Inhibition studies of ethopropazine with butyrylcholinesterase mutants, where A328 (KI = 0.18 mic

169 bition studies of (-)-huperzine A with human butyrylcholinesterase mutants, where A328 (KI = 194.6 mi

170 The calibration curve of butyrylcholinesterase obtained in blood sample provided

171 Butyrylcholinesterase-positive plaques were more numerou

172 galactose residues on tetrameric human serum butyrylcholinesterase, recombinant human butyrylcholines

173 (-14)) and on chromosome 3 upstream of BCHE (butyrylcholinesterase) (rs509208, P=2.7 x 10(-8)) in a r

174 nt in vitro inhibitory activity toward human butyrylcholinesterase, self-induced Abeta aggregation, a

175 ocholine, while remaining insensitive to the butyrylcholinesterase-specific inhibitor iso-OMPA and di

176 stration of a quadruple mutant albumin-fused butyrylcholinesterase that efficiently catalyzes hydroly

177 identify a unique form of recombinant human butyrylcholinesterase that mimics the native enzyme asse

178 serum acetylcholinesterase, and equine serum butyrylcholinesterase, this ratio was approximately 0.5.

179 identical Cys substitution was reported for butyrylcholinesterase through genotyping patients with p

180 yme-inhibitory assays (acetylcholinesterase, butyrylcholinesterase, tyrosinase, amylase and glucosida

181 were screened against acetylcholinesterase, butyrylcholinesterase, urease, and tyrosinase enzymes.

182 ding potency toward acetylcholinesterase and butyrylcholinesterase using enzyme kinetic analysis.

183 Increased synaptic expression of butyrylcholinesterase was also observed, exposing the dy

184 Wild-type butyrylcholinesterase was irreversibly inhibited by echo

185 one major oligosaccharide from equine serum butyrylcholinesterase were determined.

186 y toxic, inhibiting acetylcholinesterase and butyrylcholinesterase, which causes neurotoxicity in ani

187 caine hydrolase (CocE) engineered from human butyrylcholinesterase will transiently accelerate cocain

188 17 with His to make the G117H mutant endowed butyrylcholinesterase with the ability to catalyze the h