ライフサイエンスコーパス: by altering

1 Climate change can shape evolution directly by altering abiotic conditions or indirectly by modifyin

2 h as NAE 12:0, that cause defoliation either by altering abscisic acid sensitivity, hormone disruptio

3 regulates class-switch recombination ex vivo by altering activation-induced cytidine deaminase expres

4 P-25b is important for cognitive performance by altering activity-dependent synaptic plasticity.

5 pressive-like behavior in male mice, perhaps by altering alpha-amino-3-hydroxy-5-methyl-4-isoxazolepr

6 Gradients could be reshaped by altering anchor density or by providing a source of c

7 ance of the clinical SAB assay was evaluated by altering Anti-HLA Ab concentration, subclass, and det

8 Deficiency in VPS35 by altering APP/Abeta metabolism has been linked to late

9 o test the hypothesis that ICP modulates IOP by altering aqueous humour dynamics.

10 ion of the conjugated backbone, for example, by altering aromatic cores or by varying the length of t

11 of vitamin C and phenolic content in acerola by altering ascorbic acid and phenolic metabolism throug

12 e medications may affect fetal drug exposure by altering BCRP expression in human placenta.

13 upon entry to mitosis) to regulate function by altering biomolecular complex concentrations.

14 ll membranes, halts liver cancer cell growth by altering both energy production and mammalian target

15 fts directly affect the thermal conductivity by altering both the phonon scattering phase space and t

16 ss of STIM2beta increased cell proliferation by altering Ca(2+) homeostasis and inhibited cell cycle

17 We suggest that the K15N mutation causes DCM by altering Ca(2+)-dependent thin-filament regulation an

18 hways to avoid IFN-beta-mediated restriction by altering capsid sequences and subsequent biological p

19 ejection fraction (HF-rEF) was then produced by altering cardiac parameters reflecting cardiac injury

20 RIPK signaling restricted viral replication by altering cellular metabolism via upregulation of the

21 d to the biomechanical demands of bipedalism by altering chondrocyte developmental programs.

22 ancer genomes, which perturb gene regulation by altering chromatin architecture.

23 ling enzymes that control gene accessibility by altering chromatin compaction or nucleosome positioni

24 suggests that CNVs may repress recombination by altering chromatin structure in meiosis.

25 mically regulates the expression of the gene by altering chromatin topology.

26 ng particles (INPs) influence global climate by altering cloud formation, lifetime, and precipitation

27 hange has affected downward carbon transport by altering copepod community structure and demonstrate

28 By altering crystallization lattice chaperones, we ident

29 utor to depressive-like behaviors in HD mice by altering DARPP-32/beta-adducin signaling and disrupti

30 so decreasing canonical transporter activity by altering DAT's conformational equilibrium.

31 they respond to chemotherapy-induced damage by altering daughter cell fates.

32 ate Gle1A and thereby coordinate SG dynamics by altering DDX3 function.

33 nisms often respond to changing environments by altering development of particular traits.

34 ated compounds affect growth and development by altering different mechanisms influencing plant devel

35 wavelength of a sodium-pump rhodopsin (KR2) by altering dipole moment of residues around the retinal

36 cate that CRGs mediate anthracycline benefit by altering DNA accessibility, with implications for the

37 n 1 (Chd1) remodeler repositions nucleosomes by altering DNA topology at its internal binding site on

38 tially diminishes several ecosystem services by altering ecosystem functioning and stability, especia

39 By altering embryonic cerebrospinal fluid pressure durin

40 xpression directly regulates Na(+) transport by altering ENaC activity in the apical membrane.

41 factor activation of endothelial NO synthase by altering endothelial NO synthase phosphorylation.

42 MSI2 influenced breast cancer cell growth by altering ESR1 function.

43 named SSO Ex5, that lowers the 607:558 ratio by altering exon 5 inclusion in SmgGDS pre-mRNA (messeng

44 aiotaomicron escapes bacteriophage predation by altering expression of eight distinct phase-variable

45 e to variation in HMA3 function, and respond by altering expression of genes related to Zn uptake, tr

46 rray analysis revealed FA affected FSK cells by altering expression of many genes including genes inv

47 bacterial products, through the epithelium, by altering expression of tight junctional components an

48 an responded similarly to different injuries by altering expression of tissue-specific gene sets.

49 how pathogenic mutations cause skin disease by altering filament assembly, we additionally determine

50 trations decreased feeding rates, presumably by altering food palatability or impairing the mayfly's

51 revealed that DHT/mAR-SLC39A9 might function by altering G(alphai) protein-mediated MAPK/MMP9 intrace

52 ation strategies can enhance nAb development by altering GCs and modulating the immunodominance of no

53 ional regulators in prokaryotes and function by altering gene expression in response to environmental

54 ancer cells to platinum drugs, in large part by altering gene expression patterns related to DNA repa

55 NaCl reabsorption via NCC over the long-term by altering gene expression.

56 sponds to deoxycholate, a component of bile, by altering global gene transcription in a manner consis

57 ncogene MYC promotes metabolic reprogramming by altering glutamine uptake and metabolism in cancer ce

58 Livestock grazing can affect insects by altering habitat quality; however, the effects of gra

59 lant species reduce the diversity of natives by altering habitats or disturbance regimes, but it is l

60 del in which FUT2 rs601338 influences holoHC by altering haptocorrin glycosylation, whereas B12 bound

61 esting that CBD may modulate gene expression by altering histone methylation.

62 lated by Ambra1-scaffolded complexes, likely by altering histone modifications and Atf2 activity.

63 dysbiosis enhances distal tumor progression by altering host cytokine levels, resulting in suppressi

64 holesterol increases lipid mixing efficiency by altering host membrane curvature.

65 ong-term consequences on CD8 T cell immunity by altering HPA axis activity.

66 pe with acceptor ionization energy of 42 meV by altering hydrogen incorporation in the lattice.

67 s) play important roles in tumor progression by altering immune surveillance, promoting vascular dysf

68 In summary, CSE exacerbates TB pathogenesis by altering immunometabolism in mice and inhibiting CSE

69 h resistance to immune checkpoint inhibitors by altering immunosuppressive environments in patients w

70 ailor appropriate responses to external cues by altering inflammatory gene expression.

71 in non alcoholic fatty liver disease (NAFLD) by altering inflammatory signalling in RSF.

72 of the stroma in shaping tumor architecture by altering inherent patterns of tumor glands in human P

73 uer entry, dauer recovery and adult lifespan by altering insulin sensitivity according to the prevail

74 impacts could extend to the community level by altering interactions between large carnivores and th

75 e cytoskeleton precisely tunes its mechanics by altering interactions between semiflexible actin fila

76 ing such sites can disrupt prion propagation by altering interactions with PQC factors.

77 assium depolarizes the postsynaptic afferent by altering ion permeation through hyperpolarization-act

78 ion also depolarized the postsynaptic neuron by altering ion permeation through hyperpolarization-act

79 at mutant p53 may exert its gain of function by altering iron metabolism.

80 e reported to disrupt translation repression by altering iron regulatory protein (IRP) interactions w

81 creatic Hhip gene inhibits insulin secretion by altering islet integrity and promoting Nox2 gene expr

82 gs indicate that PA regulates Sec18 function by altering its architecture and stabilizing membrane-bo

83 This alginate-AuNPs THI system is tunable by altering its composition to suit different time-tempe

84 ring to improve lignocellulose digestibility by altering its composition.

85 the stress caused to the original structure by altering its correlated bond environment.

86 deprivation reduces respiratory motor output by altering its cortical component with subsequent reduc

87 material for targeted delivery of probiotics by altering its digestion.

88 of and glycolysis in CRC cells was assessed by altering its expression in vitro and in vivo.

89 localization of ClC-2 and opens the channel by altering its gating.

90 The activity of a mechanophore can be tuned by altering its structure or the composition of the actu

91 inactivating individual IZs or occasionally by altering IZ firing time, demonstrating that IZs, rath

92 for improving K deficiency tolerance in rice by altering JA levels and JA responses.

93 droplets could modulate protein aggregation by altering kinetics of protein self-association, affect

94 n of levels of transcription factor activity by altering levels of ubiquitylation and subsequent prot

95 ere able to predictably tune burst magnitude by altering linker rigidity.

96 Nod1 may exert its restrictive role by altering macrophage polarization, leading to immune e

97 ication influences bone metastasis formation by altering melanoma cell repulsion/adhesion to bone end

98 witch to stationary phase, conserving energy by altering metabolism and stopping motility.

99 ssociated angiogenesis and immunosuppression by altering metabolism in breast cancer cells.

100 e to the adverse effects of DEHP on the host by altering metabolites sensed by both intestinal and im

101 t MYC mediates its oncogenic effects in part by altering mevalonate metabolism in glioma cells, sugge

102 n aged mouse brain impedes cognitive ability by altering microglia transcriptome and limiting Mef2C,

103 fects in mouse models of Alzheimer's disease by altering microglial cell activation.

104 They affect multiple cancer phenotypes by altering miRNA and mRNA expression and stability, as

105 sustained increase in intracellular Ca(2+), by altering mitochondrial function and impairing beta-ce

106 art mediated centrally and can be alleviated by altering motor cortex function.

107 RNA can regulate physiologic gene expression by altering mRNA levels and tuning protein translation.

108 in knee joint injury and modulation of such by altering muscular strength.

109 e rather than regulating splicing indirectly by altering MyD88 transcription.

110 roids modify the course of brain development by altering neurogenesis, cell death, migration, differe

111 at has been shown to improve stroke recovery by altering neuronal activity of the target area.

112 CP-1 or PDE-1 activity promotes CO(2) escape by altering neuropeptide expression in the BAG CO(2) sen

113 able to tackle splicing-associated diseases by altering/obstructing information-exchange paths.

114 and ZZ (male) cells in gonadal chimeras, or by altering oestrogen levels of ZW and ZZ embryos.

115 (+4 degrees C), sea level changes (simulated by altering of the inundation duration to 0, 2, and 6 hr

116 s of the extraction procedure were optimized by altering one parameter while keeping the other parame

117 , act as senolytics and impact the epigenome by altering one-carbon metabolism.

118 (2+) signaling in cells and can be modulated by altering or occluding the hydrophobic pocket of NCS1.

119 reprogramming efficiency when overexpressed by altering OSK targeting, somatic-enhancer inactivation

120 present a method to control output dynamics by altering output mRNA decay rates.

121 roduction directly through embryotoxicity or by altering parental care behaviors.

122 ations may negatively influence reproduction by altering parental nesting behaviors of wild songbirds

123 ecosystem processes, such as decomposition, by altering patterns of cascading effects propagating th

124 -PB contact and PB biogenesis were modulated by altering PB composition, ER shape, or ER translationa

125 impact the strength of the immune responses by altering peptide repertoire size.

126 mprove cerebellar patients' movement control by altering (phase advancing) the visual feedback they r

127 8-independent protection of respiration, not by altering physical properties of the membrane.

128 s to be done next, and then restores balance by altering physiological processes and ingestive drives

129 es the trajectory of early T-cell activation by altering PI3K activity and PtdIns levels.

130 By altering PKA activity PKI can act as a molecular swit

131 ce or manipulate insect behavior and fitness by altering plant quality and defense.

132 rates in the low-diversity plant communities by altering plant species composition and community-wide

133 ow climate change could influence vegetation by altering PPT periods.

134 nsuming prey according to their abilities or by altering prey behavior as they avoid being consumed.

135 ators can shape genetic correlations in prey by altering prey perception of risk.

136 nthase, which regulates Treg differentiation by altering proinflammatory cytokine secretion by T and

137 HIV-1 enters the brain by altering properties of the blood-brain barrier (BBB).

138 By altering protease specificities but continuing to deg

139 ential roles in plant and animal development by altering protein function in spatially and temporally

140 hotspots regulate multiple RecBCD activities by altering RecBCD's conformation, which is proposed to

141 t N-glycosylation can modulate GPCR function by altering receptor dynamics.

142 il phase and allows concentrating the solute by altering relative lengths of the sender and receiver

143 seases, not by driving initial symptoms, but by altering repair mechanisms.

144 limate change poses a new and growing threat by altering resource phenology and diminishing the forag

145 g survival and reproduction, and indirectly, by altering resources.

146 reshape RNA-protein and RNA-RNA interactions by altering RNA structure mainly by destabilizing base p

147 latory elements that control gene expression by altering RNA structure upon the binding of specific m

148 R enzymes that diversifies the transcriptome by altering selected nucleotides in RNA molecules.

149 egulated the fabrication process of graphene by altering self-assembly layers and modification area,

150 lated regenerative and cognitive impairments by altering signaling cascades downstream of GPI-anchore

151 raction between SMAD3 and vitamin D receptor by altering SMAD3 ubiquitination.

152 impacting water movement at the land surface by altering soil hydrologic properties, land cover, and

153 ning fluid (ALF) may increase susceptibility by altering soluble mediators of innate immunity.

154 adduction, and pelvic list during bipedalism by altering step widths and pelvic motions in humans in

155 tiffness, and regeneration can be controlled by altering stiffness.

156 n acted as an inhibitor of tumor progression by altering stress to the endoplasmic reticulum, down-re

157 ycling and thus surface temperature directly by altering surface physical properties (e.g., albedo an

158 ling that contributes to behavioral deficits by altering synaptic connections, and RhoA-ROCK inhibiti

159 in turn creates an immune-suppressive milieu by altering T cell subpopulations.

160 hat induce an immune response against tumors by altering T-cell regulation have increased survival ti

161 ne-cue memory reconsolidation and extinction by altering T-LA synaptic strength.

162 the progression of AD-related Tau pathology by altering Tau clearance and promoting release of Tau-e

163 C proliferation and neuronal differentiation by altering TGF-beta signaling.

164 ilencing in plants and impede plant defenses by altering the abundance of small RNAs that serve as de

165 how dietary factors may affect tumour growth by altering the access to and utilization of nutrients b

166 LI repression complex regulates target genes by altering the acetylation status at enhancers.

167 logical processes that promote tumorigenesis by altering the activity of oncogenic and tumor suppress

168 ase and the stimulation of protein secretion by altering the activity of signal peptidase IB.

169 where causal variants affect gene expression by altering the activity of transcription factors and th

170 Attention is believed to enhance perception by altering the activity-level correlations between pair

171 o HCN channels and influences channel gating by altering the affinity of TRIP8b for the HCN cytoplasm

172 trength of this plasma gel could be tailored by altering the amount of crosslinkers for any desired b

173 ty of SCCs in V1 can be directly manipulated by altering the amount of high-order structure in synthe

174 g site on the capsid protein (CP), and works by altering the angle between capsomers.

175 ipulated forearm arterial perfusion pressure by altering the arm position above or below the level of

176 n of BSH activity should enhance weight gain by altering the BA pool, host signalling and lipid metab

177 late macrophage-mediated inflammation events by altering the balance between angiotensin II, which ac

178 nce inflorescence architecture and fecundity by altering the balance of hormonal regulators.

179 dulates spatial integration in visual cortex by altering the balance of inputs that generate neuronal

180 ructures, such as lamellipodia or filopodia, by altering the balance of these assembly factors' activ

181 oosts willingness to expend cognitive effort by altering the benefit-to-cost ratio of cognitive work.

182 By altering the beta-sheet peptide graft density and con

183 Our results suggest FOXL2(C134W) drives AGCT by altering the binding affinity of FOXL2-containing com

184 ses the K(m) for GTP hydrolysis, potentially by altering the binding mechanism between these proteins

185 rcQTL SNPs might influence circRNA formation by altering the canonical splicing site or the reverse c

186 hicken embryos disrupted somite segmentation by altering the CDH2-dependent epithelialization of PSM

187 n challenge affects subsequent lung immunity by altering the cellular composition of cells in the lun

188 n cells, namely inhibiting HIV-1 replication by altering the cellular milieu through targeting factor

189 atures of microbial communities, for example by altering the character and pace of molecular evolutio

190 We propose that MVCs activate Ddl by altering the charge distribution of its active site.

191 directly or indirectly regulate their influx by altering the chemotactic milieu in the islets.

192 e apoptosis in the developing nervous system by altering the chromatin landscape.

193 Our findings suggest that by altering the composition of microbial communities on

194 cate that SERINC5 inhibits HIV-1 infectivity by altering the conformation of gp120 on virions and/or

195 nd prevents alphaSyn-mediated vesicle fusion by altering the conformational properties of the protein

196 By altering the contractile mechanics of the cardiomyocy

197 g some that appear to affect gene expression by altering the copy number of intergenic regulatory reg

198 These modifications act by altering the direction in which the dynein linker swi

199 inverted topology of a transmembrane protein by altering the direction of its translocation across me

200 ily member 20) through topological inversion by altering the direction through which the protein is t

201 environmental clues, and respond plastically by altering the dispersal rates?

202 r a polypeptide conformation can be achieved by altering the donor-acceptor properties of side-chain

203 tribute to the genetic predisposition to CTS by altering the environment through which the median ner

204 the channel enhances PF-05089771 inhibition by altering the equilibrium between resting states (with

205 BE, we found that an HFD promoted dysplasia by altering the esophageal microenvironment and gut micr

206 eishmanial drugs have an impact on monocytes by altering the expression of IL-12 induced by LPS, wher

207 breast cancer in MCF-7 and 4T1-bearing mice by altering the expression of MMP2, MMP9, VEGF, Occludin

208 cts cellular response to bile acid treatment by altering the expression of multiple bile transporters

209 s-eQTLs regulate expression of distant genes by altering the expression of nearby genes (cis-eGenes).

210 QTLs may regulate expression of remote genes by altering the expression of nearby genes.

211 , proliferation, and differentiation of OPCs by altering the expression of regulatory cytoplasmic and

212 OFs) amenable to significant property tuning by altering the functional groups on the imidazolate lin

213 o tune the onset of the crumpling transition by altering the geometry and topology of the sheet itsel

214 able bacteria to respond to external stimuli by altering the global transcriptome.

215 n TET2 may confer risk for neurodegeneration by altering the homeostasis of key aging-related process

216 HSC self-renewal leading to AML-like disease by altering the homeotic/hematopoietic gene-associated c

217 also affect the antigenicity of cancer cells by altering the immunopeptidome.

218 using only a single polymer (M(n) = 290 kDa) by altering the initial emulsification conditions.

219 By altering the initial treatment we could potentially i

220 By altering the initial treatment, we could potentially

221 in each burst influenced the metabolic cost by altering the interactions of inward and outward curre

222 gested to affect the sleep/wake architecture by altering the intestinal balance of neurotransmitters.

223 ogical processes, including brain functions, by altering the intestinal metabolism.

224 pothesis that NH(4)Cl augments VacA toxicity by altering the intracellular trafficking of VacA or inh

225 L binding but instead stabilized the complex by altering the kinetic binding.

226 d using different cyclic enals and enones or by altering the length of the carbon tether.

227 ol A relieves restriction of LV transduction by altering the levels of interferon-induced transmembra

228 that checkpoint blockade might work in part by altering the limits of T cell phenotypes.

229 inated individuals, may be markedly enhanced by altering the lipid composition of the viral membrane.

230 rDNA loci, thereby increasing rRNA synthesis by altering the local acetylation status of histone H3 a

231 mportant predator-prey interactions, in part by altering the location and size of spatial refugia for

232 ences global weather and climate variability by altering the location of tropical heating in a warmer

233 By altering the macromolecular concentration surrounding

234 t ion channel function in an indirect manner by altering the mechanical properties of the surrounding

235 ation of other transition metal SACs, simply by altering the metal precursors used in the metalation

236 tion of pollutants and nutrients rather than by altering the microbial community composition of the w

237 CR2 chemokine signaling in tumor progression by altering the microenvironment.

238 of low-salinity brine enhances oil recovery by altering the mineral wettability in carbonate reservo

239 By altering the mode of aggregation, colloidal gels show

240 pectra of dual-aptamer mixtures can be tuned by altering the molar ratio of these bioreceptors.

241 he initiation and progression of the cancers by altering the molecular and cell biological processes

242 findings has enabled us to hypothesize that, by altering the morphology and surface electrostatics of

243 By altering the N-glycosylation machinery in the endopla

244 El Tor biotype isolates gain CAMP resistance by altering the net charge of their cell surface through

245 piro-epoxyoxindoles has been reported simply by altering the nucleophilic fluoride reagents.

246 icts a stiffness optimum that can be shifted by altering the number of active molecular motors and cl

247 crystal size controls structural flexibility by altering the number of repeating units, which eventua

248 climate to changes in substrate availability by altering the number of transporters on the cell surfa

249 ter Tpm binding and thin filament activation by altering the overlap structure.

250 partially enhances P450 17A1 lyase activity by altering the P450 17A1 conformation but did not measu

251 site of secondary envelopment of VZV capsids by altering the pH of the trans-Golgi network and thereb

252 By altering the physical capacity and outlook of fishers

253 ng-term changes in coastal plant communities by altering the physical conditions that affect ecosyste

254 roup.) Conclusions: AnxA1 affords protection by altering the platelet phenotype in cerebral I/RI from

255 mational change in the way care is delivered by altering the process of interaction between patient a

256 may affect the biology of primary consumers by altering the processing of two critical nutrients ass

257 By altering the properties of the lipid membrane and the

258 ed cell cycle arrest, apoptosis of ATC cells by altering the protein expression of cancer-related gen

259 By altering the protonation state of the titratable grou

260 We demonstrate that, by altering the ratio of attractive to repulsive interac

261 late population-level granule cell responses by altering the ratios of excitation and inhibition at t

262 fluence phylogenetic accuracy of the methods by altering the relative weight of the evolutionary hist

263 annels control conduction velocity primarily by altering the resting membrane potential and are assoc

264 hin genes and impair splicing recognition or by altering the RNA-binding preferences of individual sp

265 tion promotes oxidative stress in the retina by altering the selection of mRNAs for translation.

266 substantially controlled and even maximized by altering the side-on orientation of the quantum state

267 e, the local refractive indices may be tuned by altering the size, shape, and spacing of the nanopart

268 lum (ER) homeostasis and cell wall integrity by altering the sorting of glycosylphosphatidylinositol

269 These abnormalities can be triggered by altering the specialized centromeric histone 3, the e

270 ng sequence impacts its regulatory functions by altering the speed of uORF translation.

271 sense gene are known, most cis-NATs function by altering the steady-state level or structure of mRNA

272 between 1 and 30 kDa can be targeted simply by altering the stoichiometry of the reaction.

273 Thus, by altering the stringency and partially impairing negat

274 By altering the strings of the bow, the degree of bendin

275 tion of cell migration over the wounded area by altering the subcellular distribution of F-actin.

276 promote cell proliferation and tumorigenesis by altering the subcellular localization of an essential

277 By altering the superhelical density, gyrase may regulat

278 The phenotypic variation could be prevented by altering the temperature for growth.

279 otor features, and odors modulate locomotion by altering the time a fly spends performing different l

280 hat indirectly affect termination efficiency by altering the time window in which termination can occ

281 ic release from sediment beds can be managed by altering the timing and magnitude of releases in flow

282 vide new ways to address ecological problems by altering the traits of wild organisms, but the potent

283 sion to steatohepatitis and hepatic fibrosis by altering the transcription and phenotype of hepatic m

284 nges directly affect the global carbon cycle by altering the transport of organic material from the s

285 f TRIM25 and the inhibited expression of PML by altering the ubiquitination level of TRIM25.

286 that duplicate genes evolve new functions is by altering their expression patterns.

287 n conditional stress survival to be inferred by altering their expression.

288 ons of nucleoid and cytoplasmic localization by altering their length and/or translation.

289 s and leavening agents only was investigated by altering their location or content in flour.

290 approaches were proposed to kill persisters by altering their metabolism, obviating the need to targ

291 spond to changes in subendothelial stiffness by altering their migration and mechanics, but whether t

292 Fs contributed to blood vessel abnormalities by altering their secretion of various pro- and anti-ang

293 colonies can adjust to environmental changes by altering their social network.

294 re increasingly degrading fluvial ecosystems by altering their streamflows.

295 n each end of the bridge and can be modified by altering these charges.

296 istone modifications promotes carcinogenesis by altering transcription.

297 de novo lipogenesis via numerous mechanisms: by altering transcriptional and allosteric regulation, i

298 ion may contribute to metastasis suppression by altering tumor endocytic and motility phenotypes.

299 have a critical role in asthma pathogenesis by altering type 17 inflammation, and thus interfering w

300 1-42 oligomers may impair vascular functions by altering VEGFR-1 expression and causing ECs to enter