ライフサイエンスコーパス: by disrupting

1 (JAK2-JAK1) IFN-gamma signaling, potentially by disrupting a dimerization interface on JH2.

2 D mutation destabilizes prefusion F proteins by disrupting a hydrogen bond network at the base of the

3 186W mutant thermally destabilizes rhodopsin by disrupting a hydrogen bond network at the receptor's

4 numbers and morphology, and gene expression by disrupting a network of Ca(2+)-regulated genes.

5 which animals could gain a competitive edge by disrupting a rival bacterial community: "weeding," "s

6 It functions by disrupting a target gene, forming recessive lethal al

7 f the four giant planets in the Solar System by disrupting a theoretical initial resonant chain simil

8 the migration of human and mouse phagocytes by disrupting actin cytoskeletal dynamics via activation

9 trast, M5NF immobilized all the cancer lines by disrupting actin cytoskeleton.

10 s OB differentiation of IFT80-deficient OPCs by disrupting actin stress fibres and promoting cilia fo

11 cells (P < 0.01) and 3D tumoroids (P < 0.02) by disrupting AKT and ERK signaling through direct inter

12 dentify targets for therapeutic intervention by disrupting an essential RNA-protein interaction in pa

13 lts suggest that semaphorin activates plexin by disrupting an inhibitory plexin dimer and inducing th

14 methylation augments let-7 miRNA processing by disrupting an inhibitory secondary structure within t

15 at we suggest may promote channel activation by disrupting an interaction between IQ and the inhibito

16 TRIB1 promotes nuclear localization of COP1 by disrupting an intramolecular interaction between the

17 A risk allele contributes to type 2 diabetes by disrupting an islet enhancer, which results in reduce

18 By disrupting and retargeting Cdr1 localization, we show

19 ing CD8 T cell recognition of infected cells by disrupting antigen presentation pathways.

20 tin levels in cells, and this can be rescued by disrupting APC-mediated actin nucleation.

21 at the full spectrum of CPAs can be produced by disrupting AR at different developmental stages and i

22 that PSR causes paternal genome elimination by disrupting at least three histone marks following fer

23 ntal events such as infection or injury may, by disrupting B-cell anergy, dispose individuals toward

24 g inhibits BCR signaling and internalization by disrupting BCR-lipid raft coclustering and by inducin

25 1S) mouse induces functional retinal changes by disrupting BDNF signaling via the TrkB receptor.

26 shapes the protein's conformational dynamics by disrupting beta-sheet coupling between EF hands.

27 SPDEF induces a quiescent state in CRC cells by disrupting binding of beta-catenin to TCF1 and TCF3 a

28 80 inhibits Tat transactivation in microglia by disrupting binding of Tat to CDK9, a process key to H

29 functional NK deficits in patients with pDGS by disrupting both beta2-integrin activation and activat

30 ion at Ser61 plays key roles in FUS assembly by disrupting both intra- and intermolecular interaction

31 KZip(+) acts by disrupting both the formation and activity of Split G

32 lp1 may interfere with neuron survival in PD by disrupting Ca(2+)-coupled glutamate uptake.

33 y a monoclonal antibody directed at GFRAL or by disrupting CCK neuronal signalling.

34 ance angiogenesis, and improve wound healing by disrupting CCL28-activated CCR10-eNOS interaction.

35 unds which can overcome bacterial resistance by disrupting cell membranes and it is essential to dete

36 multidrug-resistant Gram-positive pathogens by disrupting cell wall biosynthesis in the presence of

37 ation confers a chronic proliferative signal by disrupting cellular iron signaling.

38 ration impairs context discrimination memory by disrupting cellular pattern separation processes with

39 adhesion but hinders migration, most likely by disrupting chemotactic gradients.

40 sts that IDH mutations promote gliomagenesis by disrupting chromosomal topology and allowing aberrant

41 omotes neurodegeneration and atherosclerosis by disrupting chromosome segregation and potentially oth

42 e risk of obesity and the metabolic syndrome by disrupting circadian and circannual rhythms.

43 o ameliorate age-related myocardial fibrosis by disrupting collagen cross-linking through inhibition

44 nhibit the interaction of Efb with C3 partly by disrupting contacts essential for complex formation.

45 g in this repression mechanism was confirmed by disrupting COOLAIR production and mutating the COOLAI

46 Cytotoxic molecules can kill cancer cells by disrupting critical cellular processes or by inducing

47 ings indicate that titin mutations cause DCM by disrupting critical linkages between sarcomerogenesis

48 RPN13 can activate UCH37 by disrupting dimerization, although physiologically rel

49 f HDAC3 could be useful in treatment of CTCL by disrupting DNA replication of the rapidly cycling tum

50 t of individual microRNA-target interactions by disrupting each predicted miRNA-binding site by CRISP

51 ion of laminin alpha2 impedes male fertility by disrupting ectoplasmic specialization (ES; a testis-s

52 ymphocytes trigger oxidative bacterial death by disrupting electron transport, generating superoxide

53 PBDEs may be associated with obesity by disrupting endocrine systems.

54 secreted by reactive astrocytes open the BBB by disrupting endothelial tight junctions (TJs), but the

55 l METH exposure modulates offspring behavior by disrupting epigenetic programming of gene expression

56 deficiency may contribute to UC inflammation by disrupting epithelial barrier function.

57 ses contribute to allergic disorders in part by disrupting epithelial barrier function.

58 exposure affects cardiac development in fish by disrupting excitation-contraction (EC) coupling.

59 ally proposed to increase genome instability by disrupting exonucleolytic proofreading, the P286R var

60 ffinity of Abeta binding to the DMPC bilayer by disrupting favorable intrapeptide interactions upon b

61 d cardiomyocyte proliferation and maturation by disrupting fibronectin-integrin signaling, consistent

62 ional tuning of inhibitory inputs onto DSGCs by disrupting GABA release from the presynaptic interneu

63 estigated the homeostasis of GABA metabolism by disrupting genes related to GABA metabolism and signa

64 lencer at H-NS-repressed quorum sensing loci by disrupting H-NS nucleoprotein complexes that block tr

65 n their genomes (often virulence factors) or by disrupting host genes as a result of integration.

66 that contributes to periodontal pathogenesis by disrupting host-microbe homeostasis and promoting dys

67 inhibit cancerous Hsp90 chaperone activities by disrupting Hsp90/p23 interactions.

68 ed whether expansin exposes cellulose to HTG by disrupting hydrogen bonds.

69 ly increase atrial arrhythmia susceptibility by disrupting ID nanodomains and slowing atrial conducti

70 pairs mucosal immunity against this pathogen by disrupting IL-17 production or IL-17 receptor (IL-17R

71 ut also offer a new avenue to cancer therapy by disrupting immune components of the microenvironment

72 We addressed this problem by disrupting in vivo the interaction between miR-155 an

73 nflammation and that the disease is remitted by disrupting inflammatory and T-helper type 2 cytokine-

74 Our results indicate that PSMs function by disrupting interactions of biofilm matrix molecules,

75 e-related mutations enhance channel activity by disrupting interfacial interactions.

76 beta causes arcuate NPY neuronal dysfunction by disrupting intracellular Ca(2+) homeostasis.

77 t HCM mutations can modulate myosin activity by disrupting intramolecular interactions within the pro

78 dulation by bordetellae and demonstrate that by disrupting it much more robust protective immunity ca

79 Wnt signaling upregulated WBP2 by disrupting ITCH-WBP2 interactions via EGFR-mediated t

80 s in cells profoundly inhibits the WT enzyme by disrupting its ability to homotetramerize.

81 lation of RRM2 at K95 abrogates RNR activity by disrupting its homodimer assembly.

82 ase (NIK) and stabilizes it from degradation by disrupting its interaction with TRAF2.cIAP2 ubiquitin

83 e cell death pathway of invaded midgut cells by disrupting JNK signaling and prevents the activation

84 by knocking-down expression of Kv4 channels, by disrupting KChIP binding, by restoring TrkB receptor

85 xposure inhibits the granulopoietic response by disrupting key cell signaling for hematopoietic precu

86 se persistent deficits in cognitive function by disrupting key events in brain development.

87 llular transformation and cancer progression by disrupting key metabolic signaling pathways.

88 reduction of neuronal activity and enhanced by disrupting L-type calcium channels or elevating cAMP.

89 upling with dominant negative connexin 43 or by disrupting lactate efflux was sufficient to mimic the

90 of cholesterol, which reduced IFNG signaling by disrupting lipid rafts, leading to reduced phosphoryl

91 othesized that BaP exerts anticancer effects by disrupting lipogenesis.

92 nt synaptogenesis phenotypes were suppressed by disrupting locomotion of the mutant animals, suggesti

93 eration of NPCs with the pathogenesis of ASD by disrupting long neural genes involved in cell-cell ad

94 ct-pathway SPNs in the on state, rather than by disrupting LTP induction.

95 el bacteremia and systemic infection, partly by disrupting lung epithelium through 12-LOX-dependent H

96 ell-known autophagy inhibitor that functions by disrupting lysosomal activity.

97 s help explain how reduced SIRT1 expression, by disrupting lysosomal function and generating a secret

98 n with PD0325901 mimics nutrient deprivation by disrupting lysosome organization and decreasing mTORC

99 may promote skeletal muscle weakness in CNM2 by disrupting machinery necessary for excitation-contrac

100 M10 overexpression elongated p53's half-life by disrupting MDM2-p53 interaction and subsequently repr

101 ) mediate gene silencing of a target protein by disrupting messenger RNAs in an efficient and sequenc

102 st that PBB153 exposure alters the epigenome by disrupting methyltransferase activity leading to defe

103 duces early apoptosis in innate immune cells by disrupting mitochondria membrane potential via its po

104 ating renal injury in the development of DKD by disrupting mitochondrial agility, thereby establishin

105 y animal models induce parkinsonian features by disrupting mitochondrial function.

106 odenine, mediate their antifungal activities by disrupting mitochondrial iron-sulfur (Fe-S) cluster s

107 H-L1 regulates the balance of mTOR signaling by disrupting mTORC1.

108 DPSi) treatment would induce PDAC cell death by disrupting mucin trafficking, thereby inducing the un

109 e a "clean" Chinese hamster ovary (CHO) cell by disrupting multiple genes to eliminate HCPs.

110 of exonic mutations altered splicing, mostly by disrupting multiple stages of spliceosome assembly.

111 t gltA mutation, which increases CS activity by disrupting NADH-inhibition of this enzyme, is benefic

112 uld be to protect against disease indirectly by disrupting nasopharyngeal carriage (e.g., herd protec

113 However, efforts to improve NK cell function by disrupting negative regulators that target proximal s

114 from information spreading to accessibility, by disrupting network paths.

115 Here, we tested this hypothesis by disrupting neural activity in SMA, in primary motor c

116 tribute to cognitive impairments in dementia by disrupting neuronal function in brain regions, includ

117 ing memory disturbances in preterm survivors by disrupting neuronal maturation with resultant functio

118 V-associated neurocognitive disorders (HAND) by disrupting neurotransmission including dopamine uptak

119 lts, we propose that EXPB1 loosens grass CWs by disrupting noncovalent junctions between highly subst

120 is relationship is comprehensively validated by disrupting nonfocal adhesion proteins (alpha-actinin,

121 ving cells has the potential to cause stress by disrupting normal metabolic processes.

122 that BPA exerts its effects on amelogenesis by disrupting normal protein removal from the enamel mat

123 ns responsible for inherited disease may act by disrupting normal transcriptional splicing.

124 Tumors generated by disrupting Notch signaling arose preferentially in th

125 es in the clonal raider ant, Ooceraea biroi, by disrupting orco, a gene required for the function of

126 e also demonstrate that the amnesia provoked by disrupting ORM reconsolidation through PKMzeta inhibi

127 ugh treatment with 1 can elicit side-effects by disrupting other RXR-heterodimer receptor pathways.

128 tochondrial Kac contributes to heart failure by disrupting oxidative metabolism.

129 of how cancer cells evade the immune system by disrupting phagocytic clearance and the effect of pha

130 onally regulated cell invasiveness, in part, by disrupting polarized cell motility under confinement

131 n response to chemoattractants fMLF and CCL2 by disrupting polarized distribution of F-actin and Gbet

132 s could accelerate mitochondrial dysfunction by disrupting protective metabolic adaptations.

133 fibrils could play a role in amyloid disease by disrupting protein degradation by lysosomes and traff

134 titute viable targets for efflux inhibition, by disrupting protein-protein interactions between helic

135 ffeine treatment can disrupt gene conversion by disrupting Rad51 filaments.

136 also impair its reactivation by CRAF, either by disrupting RAF-MEK complexes or by interacting with S

137 NJ), prevented OC development and activation by disrupting RANKL-induced localization of TRAF6 and c-

138 ease HSC activation and fibrogenesis in vivo by disrupting receptor tyrosine kinase endocytosis and s

139 g "Broca's area," the primary language area, by disrupting regional GPR56 expression and blocking RFX

140 ations can play functional roles in the cell by disrupting regulatory interactions between transcript

141 ests that rare CNVs increase the risk of MDD by disrupting regulatory regions.

142 which may impede song and speech development by disrupting reinforcement learning mechanisms.

143 mporal dementia syndrome in C9orf72 carriers by disrupting salience network connectivity.

144 rophic (HCM) or dilated (DCM) cardiomyopathy by disrupting sarcomere contraction and relaxation.

145 emperature-dependent sex determination (TSD) by disrupting sex ratios and other traits.

146 ease 9 to generate a cynomolgus monkey model by disrupting SHANK3 at exons 6 and 12.

147 mouse model for MSS was previously produced by disrupting Sil1 using gene-trap methodology.

148 ecific lncRNA that safeguards the hESC state by disrupting SIRT6 activity.

149 Sec18 functions by disrupting SNARE complexes formed in cis, on the same

150 ish EVC mutations causing EvC dwarfism do so by disrupting sonic hedgehog (Shh) signaling, our data i

151 Here we test this prediction by disrupting spatial sorting in replicated invasions of

152 ), receptors impairs firing rate homeostasis by disrupting synaptic homeostatic plasticity in hippoca

153 By disrupting synaptic stability at different times, we

154 nson's disease and dementia with Lewy bodies by disrupting synaptic vesicles.

155 Blocking CD28 was immunosuppressive by disrupting T-cell metabolic fitness; specifically, th

156 A components, underlie a number of EvC cases by disrupting targeting of both the EvC complex and SMO

157 es from stalling/collapsing at ALT telomeres by disrupting TERRA R-loops.

158 TAD3A steady state impairs mtDNA maintenance by disrupting TFAM/mtDNA binding.

159 ed meiotic checkpoint blocks Grk translation by disrupting the accumulation of grk mRNA in a translat

160 the effective stiffness of the cell membrane by disrupting the actin cytoskeleton using cytochalasin

161 at high intracellular calcium concentration by disrupting the actin-myosin ATPase pathway.

162 s contractility at high levels of activation by disrupting the acto-myosin ATPase cycle.

163 ariner transposase increase their activities by disrupting the allostery that normally serves to down

164 which inhibits insulin action in hepatocytes by disrupting the assembly of mTOR and rictor.

165 ced membrane deformation activates integrins by disrupting the association of the transmembrane domai

166 onic inflammation precedes hepatic steatosis by disrupting the balance between fatty acid synthesis a

167 ry response after MI and antagonizes healing by disrupting the balance between inflammation and repai

168 y developmental VDD impacts metabolic health by disrupting the balance between somatic growth and adi

169 rentially lead to repeat deletion during BER by disrupting the balance between the addition and remov

170 etes affect both functions of DCoH1, perhaps by disrupting the balance between the two DCoH complexes

171 Changes in chromosome number impair fitness by disrupting the balance of gene expression.

172 Oncogenes may drive carcinogenesis by disrupting the balanced control of cell cycle progres

173 preconditioning-induced autophagy, possibly by disrupting the Beclin 1/Bcl-2 interaction.

174 of a genetic variant deactivating enhancers by disrupting the binding of transcription factors (TFs)

175 ine 220 (K220), which inhibits PGK1 activity by disrupting the binding with its substrate, ADP.

176 90) and GyrA(D94) cause quinolone resistance by disrupting the bridge-enzyme interaction, thereby dec

177 exposed on the cancer cell surfaces and act by disrupting the cancer cell membranes.

178 ne perturbs the shape and functions of cells by disrupting the cell signaling pathways and the format

179 that the REO acts against F. verticillioides by disrupting the cell wall and causing the loss of cell

180 ne expression and reduced locomotor activity by disrupting the central and peripheral clocks and incr

181 involvement of Cep135 in centriole function by disrupting the Cep135 gene in the DT40 chicken B-cell

182 inversions in the susceptibility of diabetes by disrupting the cis-regulatory effect of SNPs from the

183 Land use change, by disrupting the co-evolved interactions between plants

184 surface to be regenerated after measurement by disrupting the complementary pairs above the oligonuc

185 By disrupting the conserved TAD border in one of the zeb

186 an pests, Musca domestica and Delia radicum, by disrupting the control of apoptosis.

187 vel decreases BDNF secretion from astrocytes by disrupting the conversion of GTP-Rab3a into GDP-Rab3a

188 approximate in vivo cable phenotypes caused by disrupting the corresponding genes.

189 substitutions trap the activation gate open by disrupting the coupling between the voltage-sensing u

190 is acid-base pair is initiated and preserved by disrupting the dative donation through protonation on

191 s, and externalizing problems in urban youth by disrupting the development of left hemisphere white m

192 n of uterine IGF1 signaling was not impaired by disrupting the distal enhancer or by deleting the cod

193 conformational dynamics and self-association by disrupting the disulfide bridge (Cys(3)-Cys(14)) in S

194 esults suggest MMPs increase HIV-1 infection by disrupting the endocervical epithelium, permitting tr

195 Heretofore, HumAb mice have been generated by disrupting the endogenous mouse Ig genes and simultan

196 rkB and p75 neurotrophin receptor (p75(NTR)) by disrupting the endosomal sorting, reducing lysosomal

197 y play a causal role in disease pathogenesis by disrupting the endosome-lysosome system.

198 7 by blocking the ubiquitin-binding site and by disrupting the enzyme active site.

199 ase the decay rate of the bis-Fe(IV) species by disrupting the equilibrium of the resonance structure

200 address the challenge of slow mass transfer by disrupting the external depletion layer around an in

201 HQNO induces specific self-poisoning by disrupting the flow of electrons through the respirat

202 itution in PKG1 increases its basal activity by disrupting the formation of an inactive conformation.

203 tes TGF-beta1-inducible activation of WT PFs by disrupting the formation of an inhibitory Thy-1-TGFbe

204 ycle progression and reduced DNA replication by disrupting the formation of the minichromosomal maint

205 cute infection contributes to immune control by disrupting the function of Nef.

206 viruses can block autophagosome degradation by disrupting the function of SNARE proteins.

207 y prevents nuclear collapse in lamin mutants by disrupting the function of the LINC complex.

208 activation, FXR trans-repressed these genes by disrupting the functional CREB-CRTC2 complex.

209 guingly, Bcl2 directly inhibits RNR activity by disrupting the functional hRRM1/hRRM2 complex via its

210 (exp)) RNA produces a toxic gain of function by disrupting the functions of RNA splicing factors, suc

211 op (AUSL) element, "flipping" the RNA switch by disrupting the GAIT (interferon-gamma-activated inhib

212 tosynthetic arsenite oxidation was confirmed by disrupting the gene in a representative photoarsenotr

213 ng can easily generate knockout mouse models by disrupting the gene sequence, but its efficiency for

214 ed form of MDP in Mycobacterium tuberculosis by disrupting the gene, namH, responsible for this modif

215 pproaches, we test the specificity of TALENs by disrupting the H2A.B multi-copy gene family using onl

216 taining calcium-responsive alternative exons by disrupting the histone deacetylase-to-histone acetylt

217 n alters the properties of the bulk material by disrupting the hydrogen bonds, but obstructs detailed

218 o act as a novel immune checkpoint inhibitor by disrupting the hypoxia-adenosine-A2aR pathway.

219 istically, SMURF2 regulates RANKL expression by disrupting the interaction between SMAD3 and vitamin

220 GTP-bound Rho activates mDia family members by disrupting the interaction between the DID and DAD au

221 MW05, with SARS-CoV-2 neutralizing activity by disrupting the interaction of receptor binding domain

222 eported to suppress STING-mediated signaling by disrupting the interaction of STING and TBK1 and/or M

223 tivation of TRPA1 were selectively prevented by disrupting the interaction of the carboxy-lobe of cal

224 with non-phosphorylated NBD1, suggests that by disrupting the interaction of the NBD core with the N

225 rylation negatively regulates Sec4p function by disrupting the interaction with the exocyst complex v

226 ydrogen bonding and remodeled mature fibrils by disrupting the intermolecular salt bridge Asp23-Lys28

227 macrophages and diverse nonphagocytic cells by disrupting the internalization vesicle, releasing the

228 MORC3 autoinhibition is released by disrupting the intramolecular ATPase:CW coupling thro

229 ed when host circadian rhythms are abolished by disrupting the key clock gene transcription factor Bm

230 r cell or ejects the drug into its cytoplasm by disrupting the liposome and endosome.

231 ease progression could potentially be slowed by disrupting the machinery of cell migration.

232 adolescent cognitive and emotional outcomes by disrupting the maturation of the underlying brain net

233 expression to subvert the host immune system by disrupting the MHC-II enhanceosome through binding wi

234 t crocin inhibited cell proliferation mainly by disrupting the microtubule network.

235 knockdown of hspb7 causes laterality defects by disrupting the motility of these cilia.

236 amics interferes with neurite outgrowth, not by disrupting the net assembly of MTs at the growth cone

237 d the hypothesis that PB alters gut function by disrupting the neural and immune systems of the intes

238 of analog and digital transmission, possibly by disrupting the normal stoichiometry of presynaptic po

239 trategy that interferes with Notch signaling by disrupting the Notch transcription complex and shows

240 g protein, but not repeat RNA, is pathogenic by disrupting the nuclear lamina.

241 PUMA inhibits mitochondrial pyruvate uptake by disrupting the oligomerization and function of mitoch

242 and excessive worry about everyday problems by disrupting the online updating ("reality check") of t

243 By disrupting the ORF MXAN7041 in two different sublines

244 rimental evidence to support that ovulation, by disrupting the ovarian surface epithelium and releasi

245 role in neuroprotection, during the insult, by disrupting the p38 MAPK pathway.

246 Recovery of p53 function by disrupting the p53-MDM2/MDMX interaction using small-

247 protein A55 dysregulates NF-kappaB signaling by disrupting the p65-importin interaction, thus prevent

248 o constrain intracellular parasite infection by disrupting the parasitophorous vacuole membrane.

249 nfluenza A vRNPs and inhibits their activity by disrupting the PB2-NP interaction.

250 hat can suppress influenza virus replication by disrupting the polymerase assembly.

251 We manipulated PcG clusters by disrupting the polymerization activity of the sterile

252 unities to interfere with herpes replication by disrupting the precise force balance between the enca

253 tions lead to increased self-oligomerization by disrupting the PYD and LRR domains, which are essenti

254 nally, we show that this mutation impairs HR by disrupting the RAD51D-XRCC2 interaction and confers P

255 in A cleavage mimics the effects of progerin by disrupting the Ran gradient, but the effects on Ran a

256 protein that protects host genome integrity by disrupting the retroviral capsid as it transports vir

257 TRIM27 protein levels were restored by disrupting the RING domain of ICP0 or by inhibiting t

258 ng csgD (agfD), the master biofilm regulator by disrupting the silenced, H-NS-bound promoter.

259 ans and human mesenchymal stem cells (hMSCs) by disrupting the SKN-1/Nrf2-mediated oxidative stress r

260 he striatal representation of value, perhaps by disrupting the striatal population that normally repr

261 By disrupting the substrate-binding proteins from each i

262 cline of coral reef ecosystems, particularly by disrupting the symbioses between reef-building corals

263 variants affect normal embryonic development by disrupting the synthesis of NAD, a key factor in mult

264 By disrupting the Tbsnm1 gene, we demonstrate that TbSNM

265 ive ligands indirectly inhibited TCR binding by disrupting the TCR-CD1a contact zone.

266 ding protein, which enhanced ASK1 activation by disrupting the thioredoxin-ASK1 complexes.

267 We generated HAT-L4 knockout mice by disrupting the Tmprss11f gene encoding HAT-L4.

268 linking canonical and non-canonical pathways by disrupting the TRAF2-cIAP2 ubiquitin ligase complex.

269 ng that alpha-syn impairs lysosomal function by disrupting the trafficking of lysosomal hydrolases.

270 disrupted performance following a reversal, by disrupting the use of negative outcomes to guide subs

271 ties to fine-tuning in a controllable manner by disrupting the weak halogen bonds between the molecul

272 Rendering adult nephrocytes dysfunctional by disrupting their endocytic function or temporally con

273 tions in ANXA11 impair RNA granule transport by disrupting their interactions with lysosomes.

274 R-1 and miR-206, but not the miR-133 family, by disrupting their RISC association.

275 o constrain intracellular parasite infection by disrupting their vacuole membranes.

276 By disrupting these hydrogen bonds, we are able to gener

277 d thus improvements in ZT are still possible by disrupting these modes.

278 ns can cause loss of function in the nucleus by disrupting this assembly and chromatin binding.

279 nhibits VEGFR2 phosphorylation and signaling by disrupting this association.

280 Pheromone exposure inhibits learning by disrupting this balance: it activates ADL and increas

281 By disrupting this PAR4 calcium/beta-arrestin signaling

282 By disrupting this pathway, we develop an effective comb

283 primary immunodeficiencies may cause disease by disrupting transcription factor binding.

284 pithelial enhancers and alter their activity by disrupting transcription factor motifs that overlap t

285 ly rearranged structure of the gibbon genome by disrupting transcription of cell cycle genes.

286 n diminished accessibility at targeted sites by disrupting transcription of EWSR1-FLI1.

287 h these diseases: loss of function typically by disrupting transcription of the mutated gene, RNA tox

288 ide abolished TRPC3-regulated ROS production by disrupting TRPC3-Nox2 interaction, without affecting

289 nalogues maintain their mechanisms of action by disrupting tubulin polymerization, similar to their p

290 ing apoptosis and/or necrosis and indirectly by disrupting tumor vasculature and increasing tumor imm

291 for xylose metabolism in E. coli was blocked by disrupting two genes (xylA and EcxylB) encoding xylos

292 moving RPE miRNA regulatory activity in mice by disrupting two independent and essential steps of miR

293 une system may confer risk for schizophrenia by disrupting typical synaptic pruning in late adolescen

294 can acutely promote ventricular arrhythmias by disrupting ventricular myocyte intercalated disk (ID)

295 bed to prevent myofibroblast differentiation by disrupting, via distinct mechanisms, the actions of b

296 membranes early in the replication cycle and by disrupting viral particle egress in the late stage of

297 515) can inhibit influenza virus replication by disrupting viral RNA promoter binding activity of pol

298 By disrupting WASP autoinhibition, mycolactone leads to

299 ion 1 likely affects affinity of DNA binding by disrupting water-mediated interactions with the DNA m

300 vironment and constraint of dendritic growth by disrupting Wnt signaling led to increased branch addi