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1 ealed that Arg-65 is critical for activation by facilitating a conformational step that initiates che
3 patients leads to resistance to ER degraders by facilitating a switch from ER-dependent luminal cells
4 stems have revolutionized genome engineering by facilitating a wide range of targeted DNA perturbatio
6 tablish B cell fate and modulate cell growth by facilitating access of lineage-specific transcription
7 ammatory response within tumor-associated AT by facilitating accumulation of tumor-promoting alternat
8 transcription inhibition in human cells, and by facilitating accurate differential peak calling betwe
9 tred around the PAG supports decision-making by facilitating action preparation and highlight the rol
10 astuzumab links innate and adaptive immunity by facilitating activation of antigen-specific T cells.
11 ng potential to shape life history evolution by facilitating adaptation to fluctuating environments.
12 hat PE enhances excitatory synaptic strength by facilitating an anti-Hebbian form of long-term potent
13 oliferation of oncogene expressing SVZ cells by facilitating an antiproliferative expression profile.
14 in protecting mitochondrial genome stability by facilitating an efficient repair of oxidative DNA dam
15 llin4-Ring Finger E3 ubiquitin ligase (CRL4) by facilitating an interaction between SAMHD1 and the su
16 cerebellum for adaptive control of behavior by facilitating appropriate output in a broad temporal w
18 y directs enzalutamide-induced transcription by facilitating AR, Mediator and Pol II loading to enzal
19 ion (Ph-AH(+)-Np) to cucurbit[7]uril (CB[7]) by facilitating, at increased Na(+) concentrations, the
20 n contributes to ZIKV pathogenesis, possibly by facilitating attachment to and infection of lectin-ex
23 n, IL-10 production plays a detrimental role by facilitating bacterial persistence via the same mecha
25 ignaling at unattached kinetochores not only by facilitating binding of BubR1 but also by enhancing C
26 that H3K4me1 has an active role at enhancers by facilitating binding of the BAF complex and possibly
27 ubsequent specialization can drive evolution by facilitating biological innovation and developmental
29 r long axis preserves epithelial homeostasis by facilitating both stress relaxation and isotropic gro
30 at a number of scales assists coral recovery by facilitating both the delivery of coral larvae to the
31 tic growth at larval neuromuscular junctions by facilitating Ca(2+) release from the endoplasmic reti
35 portunities for the increase of biodiversity by facilitating challenging conditions for intraspecific
37 hannels and augments calcium current density by facilitating channel opening and increasing the numbe
38 d for the enhancement of electrical response by facilitating charge transfer processes of [Fe(CN)6](3
39 ponse to infection in several ways, that is, by facilitating clot formation, production of antimicrob
40 hronic HDM-induced allergic asthma pathology by facilitating clustering and cross-stimulation of diff
41 ce to CO(2) diffusion inside mesophyll cells by facilitating CO(2) transfer in both gas and liquid ph
42 cted the transcriptional activity of ERalpha by facilitating coactivator recruitment to the ERalpha t
43 unity diversity while increasing persistence by facilitating colonization and limiting competitive ex
44 ancestry within individual studies but also by facilitating combined analysis of genetic data from m
45 nal significance in renal health and disease by facilitating communication between cells and protecti
46 plying N to leaf tissues for acclimation and by facilitating compensatory growth following drought.
48 s a systems-level understanding of infection by facilitating comprehensive analysis of transcriptomes
49 binding of unfolded OMPs to chaperones and, by facilitating conformational selection after release f
50 in the eosinophil-mediated death of Colo-205 by facilitating contact between effector and target cell
51 mplemented fluorescence polarization imaging by facilitating cross-sectional inspection of tissue.
52 host defense against P. aeruginosa infection by facilitating crosstalk between macrophages and neutro
53 iates itself from other regulatory resources by facilitating crowd-sourced interpretation and annotat
54 nnate immune response to influenza infection by facilitating cytoprotective signals through c-Met sig
55 receptor antagonists, and is likely mediated by facilitating D(1)-mediated excitation in the nucleus
57 ilst auxin affects canonical ARFs indirectly by facilitating degradation of Aux/IAA repressors, direc
58 n of water accelerates the rate of catalysis by facilitating deprotonation of the hydrogen addition p
59 cess, completing the Streptomyces life cycle by facilitating dispersal of spores by soil arthropods.
60 potential obstacles to replisome progression by facilitating DNA lesion bypass, extension of D-loops,
61 ular priming of lagging-strand DNA synthesis by facilitating DNA polymerase alpha function at replica
63 CN) channels plays an important role in pain by facilitating ectopic firing and hyperexcitability in
64 tions, it augments protein affinity strongly by facilitating efficient myristate insertion and PI(4,5
65 e (RSA) impacts plant fitness and crop yield by facilitating efficient nutrient and water uptake from
66 we show that PIMT improves stress tolerance by facilitating efficient reactive oxygen species (ROS)
69 that CaCCinh-A01 reduces ANO1 protein levels by facilitating endoplasmic reticulum-associated, protea
73 es house dust mite-induced airway remodeling by facilitating epithelial-to-mesenchymal transition and
75 onuclease activity on the lagging strand DNA by facilitating Exo1 loading onto a single strand gap at
76 tution p.Arg55His, but also affects splicing by facilitating exon 2 skipping, thus also being in effe
77 volved in regulation of LC-PUFA biosynthesis by facilitating fad expression, probably through targeti
78 or the normal function of the nervous system by facilitating fast conduction of action potentials.
80 doknot fluctuations disrupt the binding site by facilitating fluctuations in the 5'-end of helix P1.
81 ly by providing structural support, but also by facilitating force transmission, and by transducing k
83 marneffei admissions, and may drive exposure by facilitating fungal growth or spore release in the en
85 GHS-R1b expression inhibits GHS-R1a function by facilitating GHS-R1a trafficking to the plasma membra
86 protects against dietary insulin resistance by facilitating glucose disposal and mitochondrial funct
87 neage cells throughout their differentiation by facilitating growth factor release from resorbed matr
88 onsible for PK11195-mediated hCAR activation by facilitating hCAR interaction with coactivators and e
89 c histone modification and neuronal survival by facilitating HDAC3 activity and regulating its locali
90 up-regulation of key EGFR family members and by facilitating HGF-stimulated EGFR ligand secretion.
91 the bacterial CO(2)-concentrating mechanism by facilitating high CO(2) concentrations near the carbo
92 show that Baf200 plays an important function by facilitating homologous recombination-dependent proce
95 rimental role during C. pneumoniae infection by facilitating immune cell infiltration into the airspa
96 of-the-art technology to study gene function by facilitating inducible expression in a timed and reve
97 in some ways to human infection, for example by facilitating infection of cells with low levels of CD
99 its progress through the transcription cycle by facilitating initiation, elongation and termination.
100 ve shown that Kremen1 inhibits Wnt signaling by facilitating internalization of the Kremen1-Dkk-Lrp5/
101 s the potential to improve surgical outcomes by facilitating intraoperative nerve identification, red
102 strate that iron increases metastatic spread by facilitating invasion through expression of matrix me
103 ral anesthetics have revolutionized medicine by facilitating invasive procedures, and have thus becom
104 The low pH of endosomes activates fusion by facilitating irreversible conformational changes in t
105 on, pFUS was able to enhance the engraftment by facilitating islet revascularization and reducing inf
106 accelerates the degradation of TaSnRK1alpha by facilitating its association with the ubiquitin-26S p
107 d activation of TANK-binding kinase 1 (TBK1) by facilitating its dimerization and ability to phosphor
112 e repressors of plasma cell differentiation, by facilitating key transcriptional factor recruitment a
115 tentially make ensemble activity more sparse by facilitating lateral inhibition among MTs and/or enfo
116 t the same time, Plvap has roles in immunity by facilitating leukocyte diapedesis at inflammatory sit
117 hat LINC00305 promotes monocyte inflammation by facilitating LIMR and AHRR cooperation and the AHRR a
119 transport from the trans-Golgi network (TGN) by facilitating localized actin assembly at the TGN thro
120 ver, isoflurane affected neuronal plasticity by facilitating long-term potentiation in the hippocampu
122 Thus, NMT1 has tissue-protective functions by facilitating lysosomal recruitment of AMPK and dampen
123 The SINE promotes Malat1 nuclear retention by facilitating Malat1 binding to HNRNPK, a protein that
124 flammasomes regulate innate immune responses by facilitating maturation of inflammatory cytokines, in
125 functions during pre-TLR3 activation stages by facilitating maturation of TLR3 containing EE into LE
126 uptures in the nuclear membrane, potentially by facilitating membrane attachment to the rupture site.
127 ec7 to activate Arf1 on the membrane surface by facilitating membrane insertion of the Arf1 amphipath
131 fected with Mycobacterium tuberculosis (Mtb) by facilitating mitogen-activated protein kinase phospha
132 e bilateral cortical computational resources by facilitating movement-related desynchronization.
133 nt manner, thereby promoting mTORC1 activity by facilitating mTORC1 dimerization and mTORC1-Rag inter
134 igurations that could enhance MMR efficiency by facilitating MutLalpha nicking the DNA at multiple si
135 served in animals and regulates neurogenesis by facilitating neural differentiation, yet its role in
136 s mRNA function--it changes the genetic code by facilitating non-canonical base pairing in the riboso
137 s an important role during viral replication by facilitating NS5A's interaction with the SH2 domain o
138 f PGAM5 promotes the expression of cytokines by facilitating nuclear translocation of NFAT and dephos
139 sumed a new significance because they might, by facilitating ongoing transmission, be a threat to the
140 netic protein 2 (BMP2) promotes PF formation by facilitating oocyte and granulosa cell development.
142 domains, has a central role in gene control by facilitating or constraining interactions between gen
144 ontribute to the development of liver cancer by facilitating persistent HBV replication, augmenting t
146 Annexin A2 helps reseal the plasma membrane by facilitating polymerization of cortical F-actin and e
147 an important role in targeted gene silencing by facilitating posttranscriptional and translational re
150 gically inert material, it confers virulence by facilitating proper formation of the A. fumigatus con
151 ocin system reduce the effects of xenophobia by facilitating prosocial behavior toward refugees.
152 e, STUB1, could influence metformin response by facilitating proteasome-mediated degradation of cycli
153 f redox stress-induced mutagenesis, possibly by facilitating protection through modification of chrom
154 t contributes to the robustness of the clock by facilitating protein complex formation and synchroniz
155 rmone auxin activates primary response genes by facilitating proteolytic removal of auxin/indole-3-ac
156 ty of ASS1 in cancers supports proliferation by facilitating pyrimidine synthesis via CAD (carbamoyl-
157 role in initiating homologous recombination by facilitating RAD51 filament formation on single-stran
159 d the scope of carbonyl and iminyl chemistry by facilitating reactions with non-nucleophilic reagents
160 ssion of angiotensin II (Ang II)-induced AAA by facilitating reactive oxygen species (ROS) formation.
161 ion-independent interstrand crosslink repair by facilitating recruitment of lesion incision activitie
162 esponse to various cellular stresses in part by facilitating recruitment of the transcription machine
163 RAF3 dampened interleukin 2 (IL-2) signaling by facilitating recruitment of the tyrosine phosphatase
164 at enhances nucleotide excision repair (NER) by facilitating recruitment of the XPA protein to sites
166 onse to genotoxic stress and iron deficiency by facilitating redistribution of its small heterodimeri
167 , can contribute to informed decision making by facilitating reflection and discussion of personal co
169 in degradation of MARCH5 substrates, likely by facilitating release of ubiquitinated proteins from t
170 phase of inflammatory responses and does so by facilitating removal of inflammatory CC chemokines.
171 romatin integrity during polymerase passage, by facilitating removal of the H2A-H2B dimer, stabilizin
172 ations such as bioseparations and biosensors by facilitating reorganization of adsorbed protein, acce
173 nces the outcome of an infection, presumably by facilitating replication and egress depending on the
174 ential for ensuring distal ureter maturation by facilitating retinoic acid signaling, Ret expression,
175 NA synthesis but enhances genome replication by facilitating RNA encapsidation.IMPORTANCE All NNS RNA
176 ortant for Cbfb-MYH11-induced leukemogenesis by facilitating RUNX1 regulation of transcription and ce
177 candidate hiPSC seed stocks for clinical use by facilitating safety and potential risk evaluation.
178 ity is that cholesterol promotes myelination by facilitating signal transduction within the cell, bec
180 gest that the cSMAC enhances early signaling by facilitating signaling interactions and attenuates si
181 f breast cancers and promotes transformation by facilitating silencing of tumour suppressors and othe
182 w that CDK8 regulates p27 protein expression by facilitating Skp2-mediated p27 ubiquitination and deg
184 small footprint optimize imaging throughput by facilitating spatial registration and enabling minima
185 ssing, governs access to the MVC capsid gene by facilitating splicing and suppressing internal polyad
186 the proximal polyadenylation (pA)p site, and by facilitating splicing of an upstream adjacent intron.
187 ed in an increase of the sampling throughput by facilitating stable atmospheric-pressure optical trap
188 aine exerts its behavioral stimulant effects by facilitating synaptic actions of neurotransmitters su
191 functions as a pioneer transcription factor by facilitating the access to chromatin for steroid horm
192 promotes atherosclerotic lesion development by facilitating the accumulation of oxidized low-density
193 isms include those that promote plant growth by facilitating the acquisition of limiting nutrients su
194 es in PDAC cell extravasation and metastasis by facilitating the adhesion to endothelial cells and tr
195 P335A mutation promotes its priming function by facilitating the alpha-helix to adopt an extended con
196 has revolutionised natural product chemistry by facilitating the analysis of novel biosynthetic steps
198 WD40 domain in PALB2, and drives DNA repair by facilitating the assembly of PALB2-containing HR comp
199 persensitivity underlies abuse vulnerability by facilitating the behavioral responses to repeated coc
200 in regulating IL-10 production in Th2 cells by facilitating the binding of IL-10-inducing transcript
201 ble to overcome stable epigenetic resistance by facilitating the binding of the pioneer factor, Pu.1
203 tions in drug discovery and cellular biology by facilitating the characterization of phenotypic diffe
204 odegenerative conditions may protect neurons by facilitating the clearance of accumulated sphingolipi
206 e for postimplantation embryonic development by facilitating the conversion from naive to primed stat
208 date the contribution of genetics to disease by facilitating the creation of more accurate cellular a
209 f the complement cascade on its cell surface by facilitating the degradation of C3b, an opsonin, to a
210 sential for evading the host's immune system by facilitating the degradation of interferon regulatory
211 was previously implicated in APP processing by facilitating the degradation of the APP-cleaving beta
213 important inland and estuarine water bodies by facilitating the detection of point- and nonpoint-sou
214 GSTP protects the heart from I/R injury by facilitating the detoxification of cytotoxic aldehyde
215 profoundly altering the course of evolution by facilitating the development of aerobic respiration a
216 tions that allow intercellular communication by facilitating the diffusion of small molecules from ce
217 timulates the maximum rate of ATP hydrolysis by facilitating the dimerization of nucleotide-binding d
218 lysosome contacts serve additional functions by facilitating the direct transfer of metabolites or io
219 the specificity of T-cell effector function by facilitating the directional release of cytokines and
220 on framework that addresses these challenges by facilitating the discovery of both data and models co
221 promotes STAT5 accessibility at promoter DNA by facilitating the dissociation of the linker histone H
222 cooperates with PKC to drive LTD expression by facilitating the effect of PKC on the dissociation of
223 that CTCF promotes HSV-1 lytic transcription by facilitating the elongation of RNA Pol II and prevent
224 n the removal of carbon dioxide from tissues by facilitating the exchange of chloride and bicarbonate
225 ibutes to intracellular pH (pHi ) regulation by facilitating the exchange of extracellular Cl(-) for
226 ibutes to intracellular pH (pHi ) regulation by facilitating the exchange of extracellular Cl(-) for
227 es the hypermutator effect of Poldelta-R696W by facilitating the extension of mismatched primer termi
228 ic epithelium, where it dehydrates the stool by facilitating the final step of chloride and fluid abs
229 -magnitude increase in membrane permeability by facilitating the formation of larger transmembrane po
230 hus, Foxp3 poises its targets for repression by facilitating the formation of repressive chromatin in
232 e is found to greatly enhance ice nucleation by facilitating the formation of special topological def
233 ependent checkpoint signaling in human cells by facilitating the generation of RPA-bound single-stran
234 ys a critical role in postsynapse maturation by facilitating the GluN2 subunit switch and proteostasi
236 resolved questions about microbial pathogens by facilitating the identification of genes underlying e
237 s techniques can help to accelerate breeding by facilitating the identification of genetic markers fo
238 genome has contributed to post-GWAS studies by facilitating the identification of the functional tar
239 tivity of hyperthermophilic proteins, likely by facilitating the increasing flexibility required for
240 ontribute to immunological memory in T cells by facilitating the induction of nearby inducible regula
241 RECQ5 helicase promotes TOP1 SUMOylation by facilitating the interaction between PIAS1, SRSF1 and
242 ta targets the E3 ligase RNF8 to DNA lesions by facilitating the interaction between RNF8 and its ups
243 regulating the stability of PDE transcripts by facilitating the interaction between the exoribonucle
244 how that WIZ regulates global H3K9me2 levels by facilitating the interaction of G9a with chromatin.
245 e and orientation of enzymatic components or by facilitating the interface between enzymes/cofactors
246 lation and normal meiotic progress, possibly by facilitating the linking between PRDM9-bound hotspots
247 d a role during the infancy of the RNA world by facilitating the nonenzymatic replication of genomic
248 is protein plays a key role in HIV infection by facilitating the nuclear import of the pre-integratio
249 tions contribute to the spliceosome dynamics by facilitating the physical rearrangements of the splic
250 ion of Ena1 expression after cationic stress by facilitating the plasma membrane recruitment of the m
251 linked to tumor progression in breast cancer by facilitating the processes of invasion, migration, an
252 e dark adaptation of cones, first, directly, by facilitating the processing of chromophore in cones,
253 igh folate intake may promote carcinogenesis by facilitating the progression of established neoplasia
254 ence and inhibiting worker reproduction, and by facilitating the recognition and policing of worker-l
255 ture and ecosystem functioning post-drought, by facilitating the recovery of sensitive species via di
256 pivotal role in maintaining genome integrity by facilitating the recruitment of kinetochore and siste
257 on of the phagophore into the autophagosome, by facilitating the recruitment of the Atg12-5-16L1 comp
258 , both by accelerating fibrin generation and by facilitating the regulatory anticoagulation mechanism
259 us by Blimp-1, downregulates PD-1 expression by facilitating the removal of activating histone marks,
261 e possibility of genetic improvement, either by facilitating the selection of candidate genes for hyp
262 ion, can also improve perceptual performance by facilitating the selective processing of relevant ove
263 m might operate in the plant stress response by facilitating the stress-induced transcription of gene
264 contribute to the comparative genomics field by facilitating the study of the origin of new genes and
267 plays a central role in ribosome biogenesis by facilitating the transcription and processing of nasc
269 lanktonic to the biofilm mode of growth, and by facilitating the transition of biofilm cells to a hig
270 planktonic to the biofilm mode of growth and by facilitating the transition of biofilm cells to a hig
271 role in the allosteric regulation of TbGMPR by facilitating the transition of its oligomeric state d
272 e expression during myogenic differentiation by facilitating the transition of promoter sequences fro
273 ays a vital role in maintaining lens clarity by facilitating the transport of water across lens fiber
274 am from the sound source improves efficiency by facilitating the tuning between fundamental frequency
275 s shown to modulate the chemotactic response by facilitating the uptake of 4-hydroxybenzoate, which l
278 of Reelin signaling that acts predominantly by facilitating the VLDLR-Dab1 axis to direct neuronal m
279 species' detoxification benefited the others by facilitating their survival, such that they could gro
280 ation and minimizes their cytoplasmic levels by facilitating their ubiquitination by the E3 ligase SC
281 ppresses Ras-induced cellular transformation by facilitating Tip60-mediated degradation of Dmnt1 and
284 stocyst formation rate in human SCNT embryos by facilitating transcriptional reprogramming, allowing
285 tating the Na2 site potentiated K(+) binding by facilitating transition to the inward-facing state.
286 antiproliferative and prosurvival properties by facilitating translation of mRNAs encoding for the cy
287 endosome contact sites promote cell invasion by facilitating translocation of MT1-MMP-laden endosomes
288 ulates NMDAR subunit composition at synapses by facilitating transport of GluN2B from the ER to synap
289 rticipates in endosomal receptor trafficking by facilitating tubule fission via activation of the ubi
290 promotes histone pre-mRNA 3'-end processing by facilitating U7-snRNP recruitment through physical in
291 to transform autologous T cell immunotherapy by facilitating universal, off-the-shelf cell products.
293 ead to increased organ utilization per donor by facilitating viability testing, improving transplant
294 y of factors that may favor HIV transmission by facilitating viral entry into host cells, eliciting t
295 e SINV replication in differentiated neurons by facilitating viral structural protein translation.IMP
296 tively in human airway cells and mouse lungs by facilitating virus survival in the extracellular envi
297 essin (AVP) has a key role in osmoregulation by facilitating water transport in the collecting duct.
299 flammatory cells multitask at the wound site by facilitating wound debridement and producing chemokin
300 021-HA can compensate for the loss of F13-HA by facilitating wrapping to produce EV and further delin