ライフサイエンスコーパス: by introducing

1 resistance and potency of therapeutic siRNAs by introducing 4'-C-methoxy (4'-OMe) as the alpha (C4'al

2 sed the complexity of the molecular scaffold by introducing a bicyclic core.

3 xcitable Pdots with narrow-band NIR emission by introducing a BODIPY-based assistant polymer donor as

4 phila Dys, Trio, and Shot were downregulated by introducing a C-terminal truncated mutant DISC1.

5 rolase with pH-switchable activity, achieved by introducing a catalytic histidine residue at the term

6 mperatures, we herein design a novel pathway by introducing a certain amount of CoO to the supported

7 een 5hmU and base J, we also map base J loci by introducing a chemical tagging strategy for the gluco

8 By introducing a compatible reducing agent (2-ethylimida

9 Here, we overcome such difficulty by introducing a configuration where the light-emitting

10 Meanwhile, it has been shown that by introducing a contact barrier, in a specific transist

11 Here, it is demonstrated that, by introducing a crosslinking agent, it is possible to d

12 By introducing a deep-subwavelength dielectric ridge bet

13 Slc7a7Bay/Bay) using CRISPR/Cas9 technology by introducing a deletion of exons 3 and 4.

14 then eliminate these defects from the system by introducing a density gradient to create a configurat

15 ining dietary diversity and flexibility, and by introducing a dependency on fortification and supplem

16 the protease cleavage site (R508S/R511S) or by introducing a disulfide bridge between gp120 and gp41

17 By introducing a governing force in the assembly process

18 of vibration attenuation in such structures by introducing a gradient profile for the considered uni

19 Here, we addressed the former by introducing a homogeneous quenching resonance energy

20 ent an innovative solution to this key issue by introducing a hurdle model, which is a mixture betwee

21 Here, we circumvent this problem by introducing a lateral flow plasmonic biosensor (LFPB)

22 ving reactivity of 1 can be further enhanced by introducing a Lewis base X, affording faster kinetic

23 , a thermally activated system was developed by introducing a linker between HNPs and gemcitabine.

24 n wild-type mice, increasing task difficulty by introducing a long delay or by optogenetically interf

25 he sensor can be regenerated within a minute by introducing a low-pH chemistry that elutes the antibo

26 the compositional space of the MXene family by introducing a material with site-isolated cobalt cent

27 ling of internal membranes, we redesigned it by introducing a membrane anchor group based on negative

28 This can be overcome by introducing a minuscule amount of long flexible polym

29 ime monitoring of metabolic rate stimulation by introducing a mitochondrial uncoupling agent to the m

30 Here, these problems are addressed by introducing a mixture of tungsten microparticles disp

31 By introducing a moire superlattice potential (via align

32 g of nonwoven mats of electrospun nanofibers by introducing a near-infrared (NIR) dye such as indocya

33 ation of an upward flux of reduced compounds by introducing a negative flux of DO as a lower boundary

34 ere, we attempt to ameliorate this situation by introducing a new circular element assembly algorithm

35 scribe a compelling solution to this problem by introducing a next-generation set of fully functional

36 We address this key challenge by introducing a nongenetic molecular platform for cell-

37 timized a SH-SY5Y cell based tauopathy model by introducing a novel 5-fold Tau mutation eliminating t

38 ere we address the aforementioned limitation by introducing a novel methodological framework for reco

39 In this study, we circumvent this by introducing a novel treatment protocol that enables t

40 hope for the treatment of many malignancies by introducing a number of novel strategies that exploit

41 samples for changes in their physical state by introducing a perdeuterated palmitoyl chain in either

42 oach for silicon-based nanophotonic circuits by introducing a periodic array of silicon strips betwee

43 By introducing a perturbation onto the Au(22) surface, s

44 The defects are rescued by introducing a phase-separation motif from an unrelate

45 NN(C-part) incorporates process knowledge by introducing a photosynthetic response based on the li

46 Here we take steps towards this objective by introducing a probabilistic decoding framework based

47 etic Skyrmions formed in magnetic thin films by introducing a pulsed heat spot using micromagnetic si

48 global assessments of plastic pollution risk by introducing a quantifiable link between animals and t

49 By introducing a rotational twist in their geometry, asy

50 heir dynamical glass transition temperatures by introducing a scalar field called "softness," a quant

51 tomatic social self-administration procedure by introducing a screen between the self-administration

52 GaAs can be transformed into the beta-phase by introducing a Se-pretreatment period at the initial g

53 targeting Met could be dramatically improved by introducing a second binding site that recognizes an

54 rds the target gases can be largely improved by introducing a second metal ion.

55 Only by introducing a secondary amine into the perovskite str

56 this work, we eliminated this chemical step by introducing a sensing layer modification using electr

57 s have been made to obtain active hydrolases by introducing a Ser -> Cys exchange at the respective c

58 Herein, we overcome these challenges by introducing a simple and practical technique named mu

59 Here, we bridge this gap by introducing a simple model for microbial systems able

60 e consequences of this postulate are studied by introducing a simple model of RBC osmotic behavior su

61 By introducing a single adaptive substitution, G218E, in

62 of any driver gene mutations, now transform by introducing a single KRAS mutation and form adenosqua

63 By introducing a single mutation without direct ligand c

64 nd protein yield in both MDCK cells and eggs by introducing a single substitution, G218E, into HA, wh

65 broadly tunable effective magnetic responses by introducing a single, nonmagnetic doping particle at

66 We thus modified the effective medium model by introducing a single-parameter descriptor, reff.

67 e two key scenarios to delay nucleation: (i) by introducing a slow activation step for the assembling

68 raction networks in a modifiable environment by introducing a soluble peptide that selectively disrup

69 onfullerene small-molecular acceptors (SMAs) by introducing a stiff donor that also shows low miscibi

70 vely examines territorial aggression induced by introducing a stimulus mouse into the home-cage of a

71 In addition, by introducing a stimulus-responsive disulfide bond into

72 tients restructure the decision-making frame by introducing a strong emotional dimension.

73 We track the particle motion, and by introducing a structural order parameter, we measure

74 We addressed confounding ceiling effects by introducing a subset approach and ensured correct mod

75 lated architecture evolved from the template by introducing a suitable chromophore for harvesting pho

76 By introducing a suitable nonlocal entropy rate ([Formul

77 The present study intends to achieve this by introducing a systematic approach for tDCS analysis.

78 By introducing a tilted THz ultra-broadband polarizer, w

79 on model is proposed, which is characterized by introducing a time window mechanism for dynamic data

80 By introducing a trace amount of hydrazine into the syst

81 ion of the gravity model is further proposed by introducing a truncation radius.

82 Also, by introducing a tunable resolution parameter, MrTADFind

83 s of xanthin-8-yl-benzenesulfonamides mainly by introducing a variety of linkers and substituents att

84 ated as one of diffractive wave propagation, by introducing a virtual wave field that we term the pha

85 We further tested this by introducing a water-soluble PIP2 analogue (diC8 -PIP2

86 Herein, by introducing abundant Al into the transition-metal lay

87 with continuous delayed feedback modulation by introducing adaptive pulsatile linear delayed feedbac

88 n proposed to break the scaling relationship by introducing additional active sites; however, positiv

89 We contribute to this debate by introducing additional data and analysis, with the ex

90 L-PBWT-Query, we further speed up PBWT-Query by introducing additional data structures that allow us

91 was short-lived and was subsequently refined by introducing additional fluxing agents.

92 e modifies the kinetics of electrodeposition by introducing additional overpotential due to its bulk-

93 By introducing additional Pi, higher than the concentrat

94 lars affects the band gap in a lesser extent by introducing additional states in the valence or the c

95 we have begun to tackle the challenges of EM by introducing additional steps to the existing method f

96 Voluntary abstinence can be accomplished by introducing adverse consequences of continued drug se

97 By introducing Al2 O3 capping, carrier field effect mobi

98 By introducing alanine mutations in the AZIN protein, we

99 viral, membrane-disrupting activity of CLR01 by introducing aliphatic ester arms into each phosphate

100 any binary AuHn at P < 300 GPa was overcome by introducing alkali atoms as reductants.

101 odify the backbone structure of Dlin-MC3-DMA by introducing alkyne and ester groups into the lipid ta

102 sents a means to eliminate these limitations by introducing an active scatterer in a mechanical meta-

103 eting specificity, which we further improved by introducing an additional non-PAM-interacting mutatio

104 By introducing an additional phenyl ring to the N-10 phe

105 ds enhancing photosynthesis in higher plants by introducing an algal CO(2)-concentrating mechanism, w

106 on (e.g., punishment or electric barrier) or by introducing an alternative nondrug reward in a discre

107 By introducing an amphiphilic conjugated polyelectrolyte

108 rgical wards outside the ICU may be improved by introducing an automated MEWS-based early warning sys

109 used by deletion of tRNA genes, were rescued by introducing an ectopic copy of a single tRNA gene.

110 text]O, and both can be mapped on each other by introducing an effective temperature shift of [Formul

111 ne production (up to 2.64 mg/L) was achieved by introducing an exogenous mevalonate pathway.

112 led A3A expression in the THP1 AML cell line by introducing an inducible A3A gene.

113 dence of the critical field can be described by introducing an interaction term into the Bean-Livings

114 Blocking NS2 palmitoylation by introducing an NS2/C113S mutation reduced NS2-NS3 aut

115 n the two plasmon modes is then demonstrated by introducing aqueous solutions of various refractive i

116 By introducing archaerhodopsin into engrailed-1-positive

117 By introducing auxiliary guided-mode (GM) fields that pr

118 We achieve genotyping by introducing barcoded genetic variants into cells as p

119 es in the search of water-soluble indirubins by introducing basic centers.

120 We propose bcGST, a bias-corrected GST by introducing bias-correction terms in the contingency

121 collapse and/or renew vertebral body height by introducing bone cement into fractured vertebrae.

122 the cavities could be simultaneously filled by introducing both cisplatin and triflate concurrently,

123 ctivity, and agonist activity were modulated by introducing bulkier N-substituents, a 2-fluoro substi

124 and synthesized with distinct steric effects by introducing bulky amido moieties to ortho- or para-po

125 in engineering more drought-resistant crops by introducing CAM into C(3) plants.

126 This behavior can be modified by introducing CDs into the system to encapsulate the RA

127 Herein, we overcome these problems by introducing chaotropic effects in SFC separations usi

128 e accessibility of superlattice morphologies by introducing charges in a controlled manner.

129 yield up to 31 % and |g(lum) | up to 0.240) by introducing chiral substituents onto the macrocyclic

130 osstalk between both subunit epsilon domains by introducing chromosomal atpC missense mutations in th

131 re we extend the method to quantifying CnClm by introducing CnClm specific response factors (RFs) tha

132 ve this, we alter the bagged-boosting scheme by introducing collaboration between the multi-model's c

133 econdary phosphines, we modify the synthesis by introducing controlled amounts of "functional" second

134 way to surpass the standard quantum limit is by introducing correlations between the position/momentu

135 e and near-infrared spectrum can be improved by introducing cost-effective, rapid, and high-throughpu

136 HIV-1 shows marked CpG suppression, and by introducing CpGs into its genome, we show that ZAP ef

137 he catalytic performance is further enhanced by introducing cyano groups to the CoPc molecule.

138 CCK-1R selectivity was achieved mostly by introducing d- N-methyl-Asp instead of Asp at the pen

139 By introducing D2 in the headspace, hydrogen production

140 ivate E. coli dihydrofolate reductase (DHFR) by introducing D27G,N,F chromosomal mutations in a key c

141 ion of protein expression in mammalian cells by introducing defined RNA hairpins, termed 'regulation

142 nicity, we generated three recombinant PEDVs by introducing deletions or a mutation in the two motifs

143 East, West, and South moieties were altered by introducing different building blocks defined as poin

144 of surface states of the Si wafer is changed by introducing different densities of doping.

145 77 framework and then tuning its environment by introducing different functional groups to the surrou

146 meter modulation impacts the observed points by introducing directionality in their repulsion structu

147 grown on YAlO(3) is relaxed at the interface by introducing dislocations.

148 We also address the camera speed limitation by introducing Distributed Planar Imaging (DPI), a scale

149 II (TOP2) relieves topological stress in DNA by introducing double-strand breaks (DSBs) via a transie

150 ally controlled dynamic behavior is prepared by introducing dynamic moieties capable of reversible ad

151 ased supramolecular system has been prepared by introducing eight corannulene moieties in a porphyrin

152 ynthesis can transform the chemical industry by introducing electricity-driven processes that are mor

153 We improve on past work by introducing enhancements to automate learning of subs

154 e site ambiguity due to the genomic sequence by introducing equivalent junction, which is the set of

155 ves of 5-aza-7-deazaguanine were synthesized by introducing ethynyl, 1,7-octadiynyl, and tripropargyl

156 ntermediate 1,2-oxazoline, is often bypassed by introducing extra synthetic steps to avoid the presen

157 We demonstrate the utility of linear donors by introducing fluorescent protein tags in human cells a

158 ITIC-Th1, has been designed and synthesized by introducing fluorine (F) atoms onto the end-capping g

159 son-Gilford progeria syndrome cells and mice by introducing frameshift mutations in the LMNA gene.

160 Moreover, the process can be repeated by introducing fresh reagent into the microchamber.

161 ite of catalysis was successfully programmed by introducing functional groups (modulators) to the org

162 OSGEPL1 activity was greatly enhanced by introducing G38A in hmtRNAIle or the A28:U42 base pai

163 maps, but relax the heatmap grid constraints by introducing gaps between rows and/or columns that are

164 anced ambipolar charge transport is achieved by introducing graphene electrodes because of the reduce

165 By introducing graphene encapsulation, proteins in solut

166 this article, we circumvent these challenges by introducing graphene-based multi-level (>16) and non-

167 We modified its sequence inter alia by introducing HbYX, RYX, or RHbX C-terminal extensions

168 pathogens that target the skin are generated by introducing human skin grafts to immunocompromised ro

169 By introducing hybrid random antenna arrays with small m

170 some of the sheets are drastically weakened by introducing in-plane porosity.

171 lization undermines instrumental rationality by introducing inaccuracies into the representational ma

172 rophoblast stem (TS)-like cell reprogramming by introducing individual TS cell-specific 'CAG' factors

173 at this fundamental limitation can be lifted by introducing internal, spatially varying electric fiel

174 sclination lines are stabilized in this work by introducing into a nematic liquid crystal mixture a c

175 ges of low-flowing microvessels were enabled by introducing inverse variance in conjunction with spec

176 Moreover, by introducing isotopically enriched functional groups i

177 ge or other non-redox reactions/interactions by introducing kansui, which was confirmed by SDS-PAGE,

178 re, we further modified these trimer designs by introducing leucine residues at V3 positions 306 and

179 ng that the enhanced viability is eliminated by introducing lidocaine, an ATPase inhibitor.

180 Here, we bypass the use of invasive triggers by introducing light-stabilized dynamic materials that c

181 ction by mutating selected Ca(2+)-ligands or by introducing Lys residues in the membrane-binding loop

182 ion can revolutionize information technology by introducing machines capable of recognizing patterns

183 ce long-range ferromagnetism (FM) in TMDs is by introducing magnetic dopants to form a dilute magneti

184 By introducing methane at low pressures into the H(2)S +

185 challenged the carbon neutrality hypothesis by introducing metric indicators to assess the global wa

186 nstrate the programming of deletion patterns by introducing microhomology to specific locations in th

187 GBAi was engineered by introducing modifications in Galphai that preclude co

188 alters the natural composition of seascapes by introducing monoculture patches.

189 orrection, and improves on the other methods by introducing more levels of decision tree classificati

190 ssembled more empirically realistic networks by introducing more persistent species with higher troph

191 able a paradigm shift in modern technologies by introducing multi-functional materials in the semicon

192 RTx requires facilitation of channel opening by introducing mutations in the pore, temperatures > 30

193 ivity and TCR can be achieved simultaneously by introducing MWCNTs in the Cu matrix, with control of

194 S(1)-T(1) energy gap can be rationally tuned by introducing N atoms into the aromatic scaffold and by

195 opes and thereby reduce their immunogenicity by introducing N-glycans within the V3 region of BG505 S

196 can be safely arc welded without hot cracks by introducing nanoparticle-enabled phase control during

197 emonstrate that these issues can be resolved by introducing nanoparticles of nucleants that control s

198 Enhancing the pool boiling performance by introducing nanoscale surface features is an attracti

199 ctility following myocardial infarction (MI) by introducing new cardiomyocytes (CMs) to replace lost

200 Progress has been steadily made by introducing new features and algorithms (especially d

201 The problem can be solved by introducing new sensing mechanism based on an adiabat

202 This study seeks to address this problem by introducing new, to our knowledge, fluorescence-based

203 By introducing Ni by successive infiltration in the soli

204 ity, and (2) SspE inhibits phage propagation by introducing nicking damage to impair phage DNA replic

205 This result was also found by introducing nonsense mutation that completely dissoci

206 apid adaptive evolution in human populations by introducing novel genetic variants (haplotypes) at in

207 cations, often by manipulating the structure by introducing other lipids with different properties su

208 d structure and corresponding bandgap energy by introducing oxygen vacancies.

209 r-specific peptides and developed it further by introducing pathogen-specific MHC-II-restricted pepti

210 transmission dynamics of infectious diseases by introducing pathogens into susceptible environments.

211 This effect was attenuated in PC cells by introducing PC-associated SPOP mutants or upon knockd

212 Disrupting the YscU-YscP interaction by introducing point mutations at the interaction interf

213 By introducing point mutations in the GRK5 RHD-kinase do

214 By introducing point mutations, we identify key residues

215 se-finding and infection management in women by introducing point-of-care tests.

216 with high spatial resolution are established by introducing pre-gassed media into the gradient genera

217 s revolutionized the human healthcare system by introducing processes that facilitate rationale clini

218 stry, biology, medicine and material science by introducing programmable and responsive behaviour to

219 ed framework for mapping enhancer-gene pairs by introducing random combinations of CRISPR/Cas9-mediat

220 By introducing rationally selected combinations of foldi

221 Here we close this gap by introducing reaction nanoscopy based on three-dimensi

222 a possibility for further chemical labeling by introducing reactive spirolactone moieties.

223 improve the generalization of neural network by introducing related tasks into the training process.

224 duced in conditional adult cilia mutant mice by introducing renal injury.

225 In this review, we begin by introducing SAAs and describe how model systems and n

226 tes that a two-electron reduction is induced by introducing sacrificial electron donors that facilita

227 lectronic devices on nondevelopable surfaces by introducing shear slip of thin-film circuit component

228 Previous works have addressed this issue by introducing shifts in the evolutionary model occurrin

229 er carrying restriction enzyme sites created by introducing silent mutations.

230 , macroscopic robust supramolecular membrane by introducing silver-nitrogen coordinate bonding into p

231 Here, seven novel PIs were synthesized, by introducing single atom changes such as an exchange o

232 We extend these studies here by introducing single-backbone H-bond impairing modifica

233 By introducing site-directed Cys residues in bacterial i

234 nst invading phages and conjugative plasmids by introducing site-specific double-stranded breaks in t

235 By introducing site-specific substitutions within the C-

236 uce tortuous thermal paths (i.e. labyrinths) by introducing slits to control the impact of the unobst

237 OS ranges from partially to entirely blocked by introducing slits, s = 95, 195, 245, 295 and 395 nm.

238 By introducing small-sized base pillars between the slab

239 ance to in vivo Treg biology was established by introducing some of the subtle Foxp3 mutations into t

240 al (2D) MoS2 semiconductors can be modulated by introducing specific defects.

241 3 NH3 PbI3 perovskite is chemically modified by introducing SrCl2 in the precursor solution.

242 MCS centers have improved patient management by introducing standardized driveline protocols, leading

243 lts highlight the gains in accuracy achieved by introducing statistical models into fusion detection,

244 ween the recognition sites can be controlled by introducing steric "speed bumps" or electrostatically

245 antly increased opsin stability, most likely by introducing structural rigidity and promoting recepto

246 esent a SAR of the sulfonylpyridine molecule by introducing substituents on the aromatic regions.

247 antized observables like circular dichroism, by introducing symmetry indicators in amorphous systems.

248 s with desired specificity can be engineered by introducing T-cell receptors (TCRs) specific for anti

249 By introducing targeted combinations of changes in multi

250 By introducing TCNQ (7,7,8,8-tetracyanoquinodimethane) i

251 ique and implicit context for social bonding by introducing temporal and affective frameworks, which

252 We interpret these empirical results by introducing the "propinquity model," in which we cont

253 se disorders, we generated Disc1 mutant mice by introducing the 129S6/SvEv 25-bp deletion Disc1 varia

254 eated transgenic mice carrying this mutation by introducing the alanine to threonine mutation at posi

255 formation of C circles) are rapidly induced by introducing the APB-like condensates together with BL

256 This observation is rationalized by introducing the concept of a dynamic, "effective" adh

257 Here, we try to tackle this challenge by introducing the concept of a reprogrammable hologram

258 By introducing the concept of levels to reflect family r

259 xposome to children's health risk assessment by introducing the concept of Lifestage Exposome Snapsho

260 ce of the drop-in MasSpec Pen during surgery by introducing the device into the animal upper gastroin

261 Lowering the DNA replication initiation rate by introducing the dnaA(Sx) allele or by overexpressing

262 eosinophil overabundance on dystrophinopathy by introducing the dystrophin mutation into IL-5 transge

263 -2 (DC(50) = 0.7 and 3.0 muM), respectively, by introducing the E3 ligase cereblon-binding ligand pom

264 By introducing the H-bonding disrupter, LiClO(4), it was

265 r cell line (JE6-1(REP-iNKT)) was engineered by introducing the human iNKT-TCR into a human leukemic

266 This activity is eliminated by introducing the LALA mutation to the Fc region (MW05/

267 Specifically, increasing channel activity by introducing the mutation K1250A or pretreating with t

268 I will conclude by introducing the new directions that this dynamic rese

269 eir performances can be effectively enhanced by introducing the piezo-phototronic effect.

270 ssible concentration of metals were measured by introducing the prepared samples into the inductively

271 transmitted terahertz field can be observed by introducing the resonances of the meta-atoms.

272 a clinically relevant mouse model of ACDMPV by introducing the S52F FOXF1 mutation into the mouse Fo

273 rus (ZIKV) VLP production level was enhanced by introducing the same F108A mutation into the ZIKV env

274 to engineer spintronic Terahertz generation by introducing the scattering lifetime and the interface

275 diographic rhizarthrosis and non-erosive hOA by introducing the transcriptional factors Oct4, Sox2, K

276 By introducing the two-part semi-parametric model, SDA i

277 f the RTS,S malaria vaccine could be reduced by introducing the vaccine at the sub-national level and

278 By introducing the vinyl group as a repeating subunit, o

279 ccurring substitutions in BTX autoresistance by introducing them into rat Nav1.4 muscle Na(+) channel

280 ltering the rubrene/C(60) interface kinetics by introducing thin interlayers.

281 ble mNeonGreen SARS-CoV-2 (icSARS-CoV-2-mNG) by introducing this reporter gene into ORF7 of the viral

282 cid sequence of the highly cardiotoxic LC H6 by introducing three residue mutations, designed to redu

283 Pt-group metals can be boosted significantly by introducing topological order.

284 nges in firing patterns of in-vitro networks by introducing training regimens with respect to stages

285 a vascular progenitor state expressing CD34, by introducing transcription factors OCT4, SOX2, KLF4 an

286 acterize a large part of the family of PFASs by introducing transformation fractions that translate e

287 ith improved photoluminescence quantum yield by introducing trifluoroacetate anions to effectively pa

288 Here, by introducing two amino acid substitutions into the bet

289 nancy involvement of dissected tumor margins by introducing two crucial classification parameters nam

290 We want to fill this gap by introducing two fundamental theories concerning metab

291 generalize heterodyne configurations of PiFM by introducing two new schemes: harmonic heterodyne dete

292 By introducing two sulfur atoms to a single carboxylate

293 sslinkable chitosan in situ-forming hydrogel by introducing two-dimensional nanoclay particles with i

294 ocalization of the cognate mRNA were rescued by introducing untagged mRNA coding for mutant non-local

295 n between personal and professional behavior by introducing usage of a marital infidelity website as

296 Thus, by introducing variations in the substitution at C5, the

297 laments on the lateral membrane organization by introducing various phase-separated lipid mono- and b

298 By introducing various substituent groups onto the bisca

299 By introducing visual assessment checkpoints into an ite

300 climate change would be greatly facilitated by introducing wider genetic diversity for heat resilien