ライフサイエンスコーパス: by replacing

1 2)) can be increased from ~1.0 to 1.2-1.3 eV by replacing ~10% of the sulfur atoms with oxygen atoms

2 O1A disrupting the last 2 C-terminal domains by replacing 61 amino acids with a novel 91-amino-acid s

3 The mu2 binding geometry is achieved by replacing a belt-sulfur atom (S2B) and highlights the

4 Hence, by replacing a conventional generic NKA model with our r

5 ct hematological and immunological disorders by replacing a diseased blood system with a healthy one,

6 we demonstrate conductance switching in DNA by replacing a DNA base with a redox group.

7 teracts with the ligand-binding domain of AR by replacing a high-affinity labeled ligand (IC(50) 0.4

8 By replacing a hydrophobic leucine in the center of the

9 we report a novel viral glycoprotein created by replacing a natural receptor-binding sequence of the

10 lished concept of oligospiroketal (OSK) rods by replacing a part or all ketal moieties by thioketals

11 By replacing a percentage of the bridging ligand (tereph

12 Solubility of the template was improved by replacing a planar aryl linker with a saturated pyrro

13 vates membrane lipids when phosphate starved by replacing a portion of its phospholipids with monoglu

14 By replacing a pyrrolic unit within the porphyrin framew

15 nana shape of the molecule can be controlled by replacing a Si atom within the dithienosilole fragmen

16 dically improved, without extra expenditure, by replacing a small number of protected areas with new

17 l approach to create new functional proteins by replacing a specific amino acid in a protein with its

18 We created 12 GLIC-5-HT(3A)-ICD chimeras by replacing a variable number of amino acids in the sho

19 llele of ABC-me (ABC-me(+/-)) were generated by replacing ABC-me exons 2 and 3 with a neomycin resist

20 soluble NPC1 lumenal domain 2 was engineered by replacing adjacent transmembrane domains with antipar

21 markably, normal KNL1 function is maintained by replacing all modules with a short array of naturally

22 enic CE(NiP) in which the P gene was mutated by replacing all of the start codons (AUG) for tPs with

23 A series of PeIA analogs were synthesized by replacing amino acid residues in the second disulfide

24 solubility and stability of these analogues by replacing amino acids further away from the motif.

25 These data reveal that by replacing an activating complex of Batf and Irf-4 at

26 dology can be extended to pyridine synthesis by replacing an alkyne with a nitrile.

27 fic cleavage by ERManI and GMIA was explored by replacing an essential enzyme-bound Ca(2+) ion with a

28 caffold was realized in a synthetic sequence by replacing an interhelical ionic bond with a covalent

29 that cannot be converted to PKa was prepared by replacing Arg371 with alanine at the activation cleav

30 eriplasmic end of helix VI) were constructed by replacing Asp with Glu, Gln, or Cys and R175 with Gln

31 ycosylation site was eliminated individually by replacing asparagine (N) with glutamine (Q), and a do

32 markedly diminished cAMP generating capacity by replacing aspartic acid with alanine at position 426

33 ion of Serbian margarines should be improved by replacing atherogenic TFA and SFA with beneficial one

34 ovide as much granularity as possible, e.g., by replacing bar graphs with scatter plots wherever feas

35 Wnt signaling turns ZEB1 into an activator by replacing binding of CtBP/BRG1 in favor of p300.

36 Improvement in maternal care imposed by replacing biological EL dams with foster CD-1 mothers

37 A new nomogram was developed by replacing body site and Clark level from the MSKCC mo

38 alcium-selective currents, which was reduced by replacing Ca(2+) with Ba(2+) and reversed by SOC inhi

39 with 1.5X branched chain amino acids (BCAAs) by replacing carbohydrate calories (ketogenic).

40 emical desalination systems can be decreased by replacing carbon-based electrodes with intercalating

41 sensitivity of cardiac muscle can be reduced by replacing cardiac troponin I with its skeletal or neo

42 m of phenylthiazole antibiotics was expanded by replacing central thiazole with a pyrazole ring while

43 We also modified the experimental system by replacing CFP with the SgrS small RNA, which regulate

44 ines markedly improves the stability of HP35 by replacing charged with nonpolar residues, stabilizing

45 esterol required to promote influenza fusion by replacing cholesterol with other sterols and assaying

46 nimals with the receptor antagonist RP67580, by replacing ClO(-) with SP in vivo, and by immunofluore

47 n (CSR) generates different antibody classes by replacing Cmu with a downstream CH.

48 nditions promote SGG colonization of the gut by replacing commensal enterococci in their niche.

49 ms, we disrupted the Speg gene locus in mice by replacing common exons 8, 9, and 10 with a lacZ gene.

50 By replacing components of this model, we demonstrate th

51 nerated phosphomimetic knock-in mouse models by replacing conserved serines 1712 and 1836 with aspart

52 By replacing conventional phase 3 testing of vaccine can

53 icient CPPs can be derived from maurocalcine by replacing Cys residues by isosteric 2-aminobutyric ac

54 educed SR K(+) channel conduction 35 and 88% by replacing cytosolic K(+) for Na(+) or Cs(+) (respecti

55 this amino acid to trimerization and fusion by replacing D188 with alanine (D188A) or lysine (D188K)

56 ommend the modification of the AIDA protocol by replacing d3-2,4-dinitrophenylhydrazine with (15)N- o

57 from scratch, bacteria can repair ribosomes by replacing damaged proteins in situ, thereby saving si

58 sity were initiated within 8 wk in the OW/OB by replacing deficiencies in Western diets without requi

59 multiple blood indicators in the sample chip by replacing different types of enzyme in alginate bead

60 onal burden of variance component estimation by replacing direct matrix operations with iterative and

61 cells able to give rise to monoclonal glands by replacing each other following a pattern of neutral d

62 eras, and gL point mutants could be restored by replacing EBV gB with Rh gB.

63 dress the roles of Gli2 ciliary localization by replacing endogenous Gli2 with Gli2(DeltaCLR), a Gli2

64 By replacing endogenous NuMA with membrane-binding-defic

65 These two models were tested by replacing endogenous protein with ZP2 that cannot be

66 behavior of rabbit psoas skeletal myofibrils by replacing endogenous Tm and troponin (Tn) with recomb

67 ted 1 here) that was generated from GCN4-pLI by replacing every third alpha-amino acid residue with t

68 Slurp1-deficient mice (Slurp1(-/-)) created by replacing exon 2 with beta-gal and neo cassettes.

69 t, and pluripotent stem cells are maintained by replacing FGF2-containing media daily, while tissue-s

70 DAIP variants were prepared by replacing four of five glutamines for asparagines in

71 strength of GAL80-mediated negative feedback by replacing GAL80 promoter is necessary and sufficient

72 saccharomyces pombe cells switch mating type by replacing genetic information at the expressed mat1 l

73 osaccharides (COs) and insoluble chitin, and by replacing GlcNAc with 2-acylamido analogues of GlcNAc

74 , we found a highly selective CCK-2R agonist by replacing Gly in a CCK-8 derivative with Glu.

75 chain entropy by introducing cross-links or by replacing glycines.

76 structural basis for chromosome segregation by replacing H3 at centromeres.

77 ve anthropomorphic impacts on the ecosystem; by replacing impacts with ecosystem services the EBM-DPS

78 ry guidelines to improve dietary fat quality by replacing intake of SFAs with n-6 and n-3 PUFAs.

79 at many of these limitations can be overcome by replacing interferometric optics with a two-dimension

80 The effective hole doping is achieved by replacing Ir with Rh atoms, with the chemical potenti

81 -function of the domain-11 IGF2 binding site by replacing isoleucine with alanine in the CD loop (exo

82 juxtamembrane (JM) domain in EGFR signaling by replacing it with a (GGS)(10) unstructured sequence.

83 to associate a tone with a strong footshock by replacing it with a much weaker one during memory ret

84 city of W69 to conformational changes of Env by replacing it with a series of residues with aliphatic

85 ad, when the AWI is removed from the samples by replacing it with a solid-liquid interface, the inter

86 FVIII C domains, we eliminated the C1 domain by replacing it with the homologous C2 domain.

87 d the function of HEV ORF3 can be maintained by replacing it with the well-characterized viroporin in

88 T in which the NTE of mouse cTnT was removed by replacing its 1-73 residues with the corresponding 1-

89 The substrates were pPR itself, inactivated by replacing its catalytic nucleophile (S132A-pPR), and

90 delta-amino acid residue, a dipeptide mimic, by replacing its central amide moiety with an (E) C(beta

91 -loop domain from the BCoV 5' UTR was tested by replacing its counterpart in the MHV genome.

92 ma virus (RSV) Env can be made Vpu sensitive by replacing its CTD with the GaLV Env CTD.

93 In the present study, we modified RSV F by replacing its cytoplasmic tail (CT) domain or its CT

94 primary structure of yeast cyclophilin CPR1 by replacing its homologous sequence resulted in a hybri

95 muscle to be moderately stretch-activatable by replacing its myosin isoform with an embryonic isofor

96 We produced a chimeric CESA5 by replacing its N-terminal zinc finger with its CESA6 c

97 boxyl terminus of Hsc70-interacting protein) by replacing its natural substrate-binding domain with a

98 nces fused to nAuORF2, in a manner abolished by replacing its non-AUG initiation codon (AUA) start co

99 amins, we reengineered the classical dynamin by replacing its PHD with a polyhistidine or polylysine

100 neither by removing the early stop codon nor by replacing its SECIS element.

101 pression was targeted to the yeast cell wall by replacing its signal peptide, serine-threonine-rich r

102 ngineered the human A(2A) adenosine receptor by replacing its third intracellular loop with apocytoch

103 this hypothesis, we targeted ADAM10 to rafts by replacing its transmembrane and cytosolic regions wit

104 Converting dimeric PSGL-1 to a monomer by replacing its transmembrane domain did not alter its

105 By replacing key amino acid residues in AmTrac we constr

106 s, was engineered into sperm whale myoglobin by replacing Leu29 and Phe43 with Glu and His, respectiv

107 By replacing leucine with glycine in the zebrafish MetRS

108 e designed a mutant form of PAR4, "PAR4SFT," by replacing LGL194-196 at the base of transmembrane dom

109 We show improved power conversion efficiency by replacing lithium salts, typical p-dopants for spiro-

110 atterns and to maintain these configurations by replacing lost atoms with surplus atoms from a reserv

111 sible approach to treating neurodegeneration by replacing lost neurons.

112 o determine if IOP control can be maintained by replacing lost TM cells, we transplanted TM-like cell

113 By replacing LptD residues with an unnatural amino acid

114 However, removing the charge by replacing Lys53 with methionine caused more than a mi

115 tylation of lysine 310 by depleting SIRT1 or by replacing lysine 310 with acetyl-mimetic glutamine in

116 By replacing lysine residues at proposed phospholipid-bi

117 The mat1 switching occurs by replacing mat1 with a copy derived from a silenced "d

118 By replacing meat with the devised plant alternatives-do

119 sustainable restoration of yeast cell growth by replacing missing protein ion transporters with imper

120 Further stabilization is realized by replacing monofunctional ligands with difunctional ve

121 in mTOR-targeting selectivity were achieved by replacing morpholine in pyrazolopyrimidine inhibitors

122 eatment of Duchenne muscular dystrophy (DMD) by replacing mutant dystrophin or restoring dystrophin-a

123 ate inhibition of MYC-mediated transcription by replacing MYC/MAX heterodimers with Omomyc/MAX hetero

124 By replacing naphthyl with quinoline moieties, we prepar

125 can be re-targeted to sequences of interest by replacing native DNA-binding domains (DBDs) with engi

126 ific DNA polymerization has been established by replacing native dNTPs with dNTPalphaSe.

127 P3, was suggested to form an alternative CBC by replacing NCBP2.

128 s can be prepared in moderate to good yields by replacing NCS with N-bromosuccinimide (NBS) and N-iod

129 inine ratio was lower, but could be improved by replacing non-targeted creatinine measurements with a

130 ol accumulation and damage, which is rescued by replacing Nrf1 exogenously.

131 ble for depositing the histone variant H2A.Z by replacing nucleosomal H2A with H2A.Z.

132 by Ti, Mn, Co, Ni, or Si and F anion doping by replacing O on the fully hydroxylated surface.

133 as pyrrolic/graphitic-nitrogen, were formed by replacing of oxygen-containing functional groups.

134 Contractile function was rescued by replacing oleate with a medium-chain fatty acid or by

135 Additional WNV chimeric viruses made by replacing one or more W956IC genes with the lineage 1

136 ng with a biphenyl lead, bioisosteres formed by replacing one phenyl by pyridine or pyrimidine showed

137 anic colloidal nanocrystals were synthesized by replacing organic capping ligands on chemically synth

138 gy preserves the health of cells and tissues by replacing outdated and damaged cellular components wi

139 Specifically, this can be accomplished by replacing pairs of not necessarily adjacent C atoms w

140 tion-defective, but activity can be restored by replacing patches of Tn3 resolvase R interface residu

141 ion in CO2 reduction is further demonstrated by replacing Pd with Rh.

142 ed the hydrophobic moment of the alpha-helix by replacing Phe(604), Ile(608), or Ile(612) by Gln.

143 pi conjugation was systematically extended (by replacing phenyl with naphthyl), fluorescence quantum

144 Addition of pyridine is known to unfold DNA by replacing pi-pi stacking interactions between bases,

145 yres actively reduce their phosphorus demand by replacing polar membrane phospholipids with those lac

146 ab-coated rods on cells was enhanced further by replacing polystyrene particles with pure chemotherap

147 escribe a process to overcome the challenges by replacing poor performing genes during platform trans

148 We explored this hypothesis by replacing previously identified domains and critical

149 ting the climate forcing of metal production by replacing primary production.

150 y profile of proline cis-trans isomerization by replacing Pro32 with a series of 4-fluoroprolines via

151 ol methacrylate) appears to enhance activity by replacing protein-water interactions, thereby preserv

152 This property could be restored in 2009/NS1 by replacing R108, E125, and G189 with residues correspo

153 Refining the m-CS by replacing RAS with RAS-RAF pathway and adding SMAD fa

154 The acceleration is achieved by replacing regular KMC jumps in trapping energy basins

155 tients with severe combined immunodeficiency by replacing resident thymus cells.

156 dence as we perturb the Ru honeycomb lattice by replacing Ru with Li.

157 By replacing SEPT6 by SEPT8 or SEPT11, it is possible to

158 ng the macronutrient composition of the diet by replacing SFAs with unsaturated fatty acids, as well

159 52 mutants were made by replacing single or clustered charged amino acids wit

160 P2X2, P2X3, and P2X6 subunits were generated by replacing single, homologous amino acids particularly

161 A mutant constructed by replacing SL4 with a shorter sequence-unrelated stem-

162 ed from enhancing the solubility of chlorine by replacing some of the iodine with bromine to shrink t

163 cacy of the CREKA peptide was then increased by replacing some residues with nonproteinogenic counter

164 Offset overcorrection by replacing standard with HO stems improved ROM for ADL

165 ly of sodium-ion battery electrodes obtained by replacing stepwise the oxygen atoms with sulfur atoms

166 They can then be modified by replacing surface-bound proteins with engineered, het

167 in lesion uptake measurements can be reduced by replacing SUV with SUR as the uptake measure.

168 mation in the absence of viral oncoproteins, by replacing SV40 large T and small T antigens with sh-p

169 ctions can be used to develop novel yogurts, by replacing synthetic preservatives and improving the a

170 ooking and discarding the soaking water, and by replacing tea and coffee at meals with vitamin C-rich

171 amination of TBDx scanty smears was explored by replacing the "positive" result of slides with 1-9 AF

172 ward the creation of such composite proteins by replacing the 10-residue long original alpha-helical

173 activity with carbocyclic LNA (cLNA) analogs by replacing the 2'-oxygen atom in LNA with an exocyclic

174 zol-4-yl]ethynyl]benzonitrile), was modified by replacing the 2-fluoromethyl substituent with an amin

175 ng and hydroperoxide-decomposing antioxidant by replacing the 2-methyl substituent with an alkyltellu

176 twofold improvement in potency was achieved by replacing the 226-aa N6 spacer with a novel 17-aa pep

177 ional cores of Slo1 channels to be expressed by replacing the 827-amino acid gating ring with short t

178 regenerative process is completely restored by replacing the ablated eCSCs with the progeny of one e

179 AOX2 rescued the im defect by replacing the activity of PTOX in the desaturation st

180 e efficiently copied sequences are generated by replacing the adenine nucleobase with diaminopurine,

181 that modify cytosine exclusively were formed by replacing the adenine target recognition domain (TRD)

182 hile they burn in air, this can be prevented by replacing the air with nitrogen.

183 The clock can be stopped by replacing the alkanes with the superior guest 4,4'-di

184 s [3]rotaxane is obtained in excellent yield by replacing the amine with a diamine, thus showing the

185 tion of the quinoline ring of tipifarnib and by replacing the amino group by OMe.

186 This was demonstrated by replacing the amino group with a more basic guanidine

187 Improved potency was achieved by replacing the androstane nucleus with a pregnane nucl

188 e to the detection of other analytes, merely by replacing the anti-human IgE aptamer/cDNA G1 pair wit

189 array offers an easier manufacturing process by replacing the antibody printing step with DNA printin

190 Further study revealed that by replacing the aryl substitution on the imidazole ring

191 graphic studies of Fe(II)-M121E azurin (Az), by replacing the axial Met121 and Cu(II) in wild-type az

192 hiometries were compared with those obtained by replacing the bacteria by polystyrene microbeads to d

193 Electrochemical studies indicate that by replacing the BIPY(2+) units in homo[2]catenane HC(*7

194 A wing domain chimera was constructed by replacing the BirA wing with the nearly isosteric win

195 This TBR could be simplified further by replacing the blood samples with an image-based, sing

196 By replacing the C-terminal carboxylate of ubiquitin (Ub

197 Therefore, we modified the DENV NS1 by replacing the C-terminal cross-reactive epitopes with

198 By replacing the carboxylate group in peramivir with a p

199 d GalNAc FmlH antagonists such as compound 1 by replacing the carboxylate with a sulfonamide as in 50

200 ibitors by modifying the structure of NSAIDs by replacing the carboxylic acid functionality by sulfon

201 A resolution structure of an inactive form (by replacing the catalytic nucleophile Ser 221 with alan

202 Here, we produced variants by replacing the conserved Thr-18 residue in the small s

203 zoline-2-thione rings by oxygen atoms and/or by replacing the coordinating sulfur atoms by selenium a

204 itive detection of AFB1 and other mycotoxins by replacing the core recognition sequence of the aptame

205 to NMDAR-dependent Ca(2+) influx is lowered by replacing the CTD of GluN2B with that of GluN2A by ta

206 e thiophene head was simplified even further by replacing the cyclohexane ring with an isobutyl group

207 Altering the leaving group pK(a), by replacing the departing nucleoside with analogues, ha

208 athway in a computationally efficient manner by replacing the detailed model by a surrogate meta-mode

209 By replacing the DNP station with a butadiyne group, the

210 cule library to target new cellular proteins by replacing the effector domain of rapamycin with a com

211 a type III CRISPR system can be reprogrammed by replacing the effector protein, which may be relevant

212 Using this approach, we demonstrate that by replacing the electrolyte during regeneration for a s

213 scribed with the same mathematical formalism by replacing the electron-phonon coupling parameter in L

214 ed to use fuels or electricity to heat water by replacing the energy source with sunlight.

215 robed the requirements for particle assembly by replacing the entire first or third TM domain of HBsA

216 The utility of our system is demonstrated by replacing the enzymatically biased RNA-to-DNA reverse

217 which was optimized for metabolic stability by replacing the ester moiety with a methyl oxadiazole b

218 ed in existing photoluminescence instruments by replacing the excitation light source (short duty cyc

219 We generated a recombinant F-chimeric RSV by replacing the F gene of A2 with the F gene of 2-20, g

220 color-pure electroluminescence are obtained by replacing the F8 electron injector with ZnO, which is

221 Here, we generated MVA-B13R by replacing the fragmented 181R/182R genes of MVA with

222 MVA, we developed a novel vector, MVA-B13R, by replacing the fragmented anti-apoptotic genes 181R/18

223 This mouse was made by replacing the germline variable sequences of both the

224 ormance of the MTBDRsl LPA might be improved by replacing the gyrA wild-type probes by additional pro

225 tal groups, intentionality cues were removed by replacing the hand with a non-agentive ball (group 2)

226 By replacing the heme in a biosynthetic model of NORs, w

227 ther, a chimeric virus ( XG4J) was generated by replacing the indigenous X174 J gene with that of G4.

228 aired Siglec receptors, we generated a model by replacing the inhibitory domain of mouse Siglec-E wit

229 driven GFP in this strain could be abolished by replacing the intact ohrR gene with a mutant ohrR gen

230 1A, suggesting that nickel causes inhibition by replacing the iron.

231 elop along the lines of physics or economics by replacing the latter with the former.

232 c (HMMM) model with accelerated lipid motion by replacing the lipid tails with small organic molecule

233 Here, we tested this model by replacing the loop from Escherichia coli EnvZ, which

234 ays, but also was inexpensive and convenient by replacing the magnetic separation with filtration pla

235 We generated mosaic B hemagglutinins by replacing the major antigenic sites of the type B hem

236 nded, approximately 21 nt long, and designed by replacing the mature miRNA sequences of duplex within

237 for UFP) for two study areas in Boston (MA) by replacing the measured PNC term with an hourly model

238 nist to antagonist was successfully obtained by replacing the methyl group in position 6 of the 1,4-d

239 g, severe, murine model of C3G was developed by replacing the mouse C3 gene with the human C3 homolog

240 Ion Mobility Spectrometry (IMS) was improved by replacing the multicapillary column (MCC) with a capi

241 By replacing the N- and C-terminal residues of homooligo

242 y transformed into their activated analogues by replacing the N-benzyl protecting group with a N-tosy

243 sed to produce a functional Sgs1-BLM chimera by replacing the N-terminus of BLM with the disordered N

244 le or multiple Gly --> Leu substitutions) or by replacing the N-TM domain with those from other CD36

245 emarkably, nucleosome centering was achieved by replacing the native DNA-binding domain of Chd1 with

246 A conditional mutant, constructed by replacing the native promoter of the A. fumigatus uap

247 locking its oncolytic potential in the brain by replacing the neurotropic VSV glycoprotein with the g

248 cell permeable Pin1 inhibitors was designed by replacing the noncritical residues within the cyclic

249 l LGE MR imaging pulse sequence was modified by replacing the nonselective inversion pulse with a wid

250 of the natural product psammaplin A obtained by replacing the o-bromophenol unit by an indole ring.

251 By replacing the outer layer with fluorescently tagged,

252 cation of biotinylated nuclei was redesigned by replacing the outer nuclear-envelope-targeting domain

253 ( horizontal lineS)(2)], has been developed, by replacing the outer sulfur atoms of the thiazoline-2-

254 The lead variant was further modified by replacing the P1 Tyr residue with para-substituted Ph

255 R observed with its removal can be increased by replacing the phenol OH with a chlorine substituent,

256 Potency was enhanced by replacing the piperidine moiety by N,N-dibutyl, N,N-d

257 By replacing the polymeric donor PBDTBDD with its 2D-con

258 converts glycerol to clean hydrogen fuel and by replacing the problematical coke formed on the cataly

259 ed, single-component Cas9 variant engineered by replacing the protein's REC2 domain with the BCL-xL p

260 These phenotypes could be bypassed by replacing the PrP(C) signal sequence with that of pro

261 expression in Escherichia coli was obtained by replacing the pulE-K putative pilin genes of the Kleb

262 This main aim has been accomplished by replacing the rapidly hydrolyzable Schiff-base moiety

263 eliminated without compromising infectivity by replacing the RSV Gag N-terminal matrix (MA) domain w

264 By replacing the SBH loop with ligand-controlled RNA-cle

265 e photovoltage barrier can be readily broken by replacing the semiconductor/water interface with a se

266 This was achieved by replacing the single VSV glycoprotein (G) with human

267 er by providing electron shuttles (confirmed by replacing the sludge with humic acids), and (iii) Geo

268 y proposes to reform evolutionary psychology by replacing the standard nativist and internalist appro

269 SV-01, a chimeric virus (FL01) was generated by replacing the structural genes of type II PRRSV strai

270 prove the oxidative stability of the peptide by replacing the sulfur in lanthionine with a methylene

271 between the classes is artificially degraded by replacing the SVM model with an ad hoc k-means classi

272 silon = -RTln(C(w)/C(w) (sat)) was redefined by replacing the term (C(w)/C(w) (sat)) with the normali

273 , we have generated a soluble F (sF) protein by replacing the transmembrane and cytoplasmic tail doma

274 Here, we overcome this limitation by replacing the transmembrane domain with a soluble hex

275 We tested the effects of TREX1 D18N in vivo by replacing the TREX1 WT gene in mice with the TREX1 D1

276 r, GPHPVIVITGPHEE (KD approximately 500 nM), by replacing the two valine residues with tert-leucine a

277 iciency and simplify morphology measurements by replacing the typical fullerene acceptor with endohed

278 ribe the trapping of the captodative radical by replacing the vinylic carboxylic acid with an amide.

279 ve generated a mouse model of this condition by replacing the wild type gene with one encoding Kcnt1(

280 tor receptor (hMET) into glutamate receptors by replacing their extracellular binding domains with th

281 ncreases the sophistication of IBW equations by replacing them with a single universal equation that

282 channel gating and ion permeation was probed by replacing them with amino acid residues of increasing

283 ologies such as catalysis, might be feasible by replacing them with highly abundant metals.

284 By replacing these residues through site-directed mutage

285 re and function of this protein was assessed by replacing this domain with the F protein TM domains f

286 By replacing this N-terminal motif with well-characteriz

287 oride treatment or mimicking phosphorylation by replacing Thr-53, Thr-58, and Ser-71 residues with As

288 shapes is manipulated by removing a shape or by replacing training shapes with unfamiliar ones.

289 se telomeres either through gene deletion or by replacing TRF2 with a mutant that does not bind Rap1.

290 then create a "gain-of-function" mutant HC/B by replacing two nonaromatic residues at the tip of its

291 rated a nonphosphorylatable IQGAP1 construct by replacing Tyr-1510 with alanine.

292 ere we mimic phosphorylation of cytochrome c by replacing tyrosine 48 with p-carboxy-methyl-l-phenyla

293 A set of additional chimeras was made by replacing various W956IC gene regions with the Eg101

294 ost by W26A-HNP1 were restored progressively by replacing W26 with non-coded, straight-chain aliphati

295 within tissues, either by removing lipids or by replacing water with a high refractive index solution

296 2) O (MIL-37), into an extended 2D structure by replacing water with dimethylformamide (DMF) as the s

297 le of this phenomenon can only be elucidated by replacing wild type arrestin-1 in living animals with

298 50 degrees C to remove the Si-Cl termination by replacing with Si-H termination as confirmed by XPS,

299 effect of the Y21 pKa on dark state recovery by replacing Y21 with fluorotyrosine analogues that incr

300 [Re]-beta2 was further modified by replacing Y356 with 2,3,5-trifluorotyrosine to enable