ライフサイエンスコーパス: bystander effect

1 ced the transfer of lacZ (media transferable bystander effect).

2 ical conjugation of the drug to the peptide (bystander effect).

3 als from irradiated cells (radiation-induced bystander effects).

4 es COX-2 activity, significantly reduced the bystander effect.

5 RGC death through the gap junction-mediated bystander effect.

6 of tumor infected), indicating a significant bystander effect.

7 n proposed to regulate the radiation-induced bystander effect.

8 ouracil (5-FU), which exhibited considerable bystander effect.

9 e effective than IGF-Ir/950st because of its bystander effect.

10 s of B16 tumor cells, indicative of a potent bystander effect.

11 y, the TK system exhibited a lower degree of bystander effect.

12 is in the tumors, likely contributing to the bystander effect.

13 a secreted factor may also contribute to the bystander effect.

14 s reduced throughout the veins, confirming a bystander effect.

15 ore sensitive to CMDA and could mount a good bystander effect.

16 is secreted extracellularly, resulting in a bystander effect.

17 lar communication (GJIC) to produce a strong bystander effect.

18 ed cells is consistent with the absence of a bystander effect.

19 cell growth by 50%, and the magnitude of the bystander effect.

20 ent with GCV, which was mediated by a strong bystander effect.

21 h do not express HSV-tk, has been called the bystander effect.

22 t can guide the design of BEs with a reduced bystander effect.

23 a necessary tumour adaptation rather than a bystander effect.

24 g the target antigen in addition to a strong bystander effect.

25 nker to generate a more potent and sustained bystander effect.

26 with directly damaged cells by means of the bystander effect.

27 away from consideration of this finding as a bystander effect.

28 ring, non-transduced cells, thus revealing a bystander effect.

29 ustainability of protection and the observed bystander effect.

30 rapeutic targets for the exploitation of the bystander effect.

31 e mechanisms may be involved in transmitting bystander effects.

32 t therapeutic gene expression with resultant bystander effects.

33 through a combination of cross-reactive and bystander effects.

34 s corresponds to genetic defects rather than bystander effects.

35 t the transfer of the TRAIL gene resulted in bystander effects.

36 ll as to prevent deleterious tissue-damaging bystander effects.

37 igher mutant yield than expected assuming no bystander effects.

38 rs, suggesting contribution of crossfire and bystander effects.

39 entifically-based design of BEs with reduced bystander effects.

40 ce markers, and their distribution indicates bystander effects.

41 hromosome instability via macrophage-induced bystander effects.

42 rgeting of noncancer cells in the tumor, and bystander effects.

43 al (i.e., cancerous or senescent) may induce bystander effects.

44 fic molecular mechanism for these persistent bystander effects.

45 dual-chamber coculture system for detecting bystander effects.

46 ll response was highly specific with minimal bystander effects.

47 er cells surviving from rapid PDT damage via bystander effects.

48 n normal cells, thus exerting an anti-tumor "bystander" effect.

49 ptosis to nearby cells is referred to as the bystander effect, a process that is integral to tissue h

50 their therapeutic efficacy by facilitating a bystander effect against antigen-negative tumor cells.

51 t occur along with the decreased TP53/CDKN1A bystander effect also would expectedly favor enhanced ce

52 ctors that directly or indirectly leads to a bystander effect and a second caspase-2-dependent proces

53 tic efficiency of VSV by generating a strong bystander effect and by contributing to the activation o

54 d recipients in patterns consistent with the bystander effect and congestible altruism.

55 ents and used these games to investigate the bystander effect and congestible altruism.

56 H2AX phosphorylation is an early step in the bystander effect and that the DNA DSBs underlying gamma-

57 this study, we investigated the E1A-mediated bystander effect and the mechanisms that may be associat

58 role in the regulation of radiation-induced bystander effects and that mitochondria-dependent NF-kap

59 secreted by normal cells in mediating this 'bystander effect', and document that normal cells induce

60 there are others who could be generous (the bystander effect) and also less generous when there are

61 propagation of genomic instability through a bystander effect, and offers a novel theory for the role

62 ch are based on molecular mimicry and/or the bystander effect, and suggests that the autoimmune proce

63 However, adaptive responses, bystander effects, and death-inducing effect may influen

64 ree cancer cell lines for 5FC sensitization, bystander effects, and formation of 5-fluorouracil metab

65 ecretable form that enhances apoptosis via a bystander effect; and (b) an ER-targeted TRAIL that is r

66 Therefore, the thermal bystander effect appears to be an active process in whic

67 n microdosimetric estimation in support of a bystander effect appears to be consistent, direct proof

68 The mechanisms underlying the bystander effect are obscure, but genomic instability su

69 the use of antibody-drug conjugates having a bystander effect are providing new tools to fight hetero

70 Bystander effects are nontargeted effects observed in ce

71 ed senescence and senescence progression via bystander effects are significant causes of this prematu

72 CD/5-FC treatment strategy by increasing the bystander effect as well as the efficacy of radiotherapy

73 t extensive apoptosis without evidence for a bystander effect at the maximal viral dose (i.e., 2.5 x

74 We coin this phenomenon "active thermal bystander effect" (ATBE).

75 Danio rerio, for our studies on the in vivo bystander effect between embryos irradiated with high-do

76 diated neighboring cells, referred to as the bystander effect (BSE), is not well understood in terms

77 ing about how inflammatory cytokines mediate bystander effects, but questions in this area are import

78 es and membrane-permeable drugs, mediating a bystander effect by which neighboring antigen-negative c

79 reted MDA-7/IL-24 protein induces antitumor "bystander" effects by promoting its own expression.

80 insic antiproliferation activity, can cause 'bystander effect' by inducing export of growth suppressi

81 bsence of AIPL1 could be due to an indirect 'bystander effect' caused by rod photoreceptor death or a

82 uced genomic instability, death-inducing and bystander effects, clastogenic factors and transgenerati

83 s in nonirradiated cells (death-inducing and bystander effects, clastogenic factors) and perpetuate g

84 Compound (+/-)-7also exhibited good bystander effect compared to 5-aziridinyl-2,4-dinitroben

85 blood and by evaluating its persistence and bystander effect compared to oral immunotherapy (OIT).

86 cant reduction in IC(50) values and improved bystander effect compared with wild-type bCD.

87 ugh we did not observe an indirect cytotoxic bystander effect conveyed to nontransduced tumor cells i

88 We also report data showing that the bystander effect could be successfully induced in naive

89 Possible low-dose IR-induced bystander effects could impact our evaluation of human h

90 To distinguish bystander effects, equal erythemal doses of two UVB wave

91 tained its efficacy and continued to exert a bystander effect even after the depletion of antigen-pos

92 s enzyme/prodrug strategy exhibited a potent bystander effect, even when <10% of the cells were trans

93 viduals do not harbor virus, and therefore a bystander effect has been postulated to mediate apoptosi

94 Although radiation-induced bystander effects have been demonstrated in a number of

95 proximity to cells that are." Although these bystander effects have been demonstrated with a variety

96 carcinoma and that apoptosis and significant bystander effects have been identified as the mechanisms

97 Macrophage-induced bystander effects have been implicated as an important m

98 Bystander effects have been observed largely by using si

99 Although radiation-induced bystander effects have been well described over the past

100 as radiation-induced genomic instability and bystander effects have challenged this dogma.

101 ich lower nitric oxide levels, prevented the bystander effect in both protocols.

102 sly in CD4C/Nef Tg mice and likely through a bystander effect in CD11c/Nef Tg mice.

103 nduce GCV sensitivity and test the potential bystander effect in established pancreatic carcinoma cel

104 e, which blocks gap-junctions, prevented the bystander effect in mixing but not in media transfer pro

105 signal into the medium, which could induce a bystander effect in partnered naive embryos sharing the

106 on of the HSV-TK gene elicited a significant bystander effect in the presence of GCV.

107 cally modified to express HSV-TK, and on the bystander effect in which unmodified target cells are ki

108 w that X-irradiation induces medium-mediated bystander effects in AGO1522 normal human fibroblasts.

109 cells seemed to be involved in tumor-induced bystander effects in animals because CCL2-null tumor-bea

110 chieving high on-target editing with minimal bystander effects in both in vitro and in vivo settings.

111 g cells, TGF-beta and NO were found to mimic bystander effects in cell populations lacking DNA synthe

112 (223)Ra-induced antiproliferative/cytotoxic bystander effects in delayed growth of DTC xenografts.

113 alpha-particle microbeam irradiation-induced bystander effects in human tissue models, which preserve

114 this methodology to reveal radiation-induced bystander effects in pancreatic cancer cells.

115 The role of radiation-induced bystander effects in radiation therapy remains unclear.

116 this model is attractive for characterizing bystander effects in retinal degeneration.

117 proved toxicity similar to CA4 and displayed bystander effects in vitro.

118 ion in the tumors, indicative of significant bystander effects in vivo.

119 ults define a pathway for macrophage-induced bystander effects in which TNF-alpha triggers TNFRSF1b r

120 The "radiation-induced bystander effect," in which irradiated cells can induce

121 A key feature of newer ADCs is the "bystander effect," in which nearby cancer cells are also

122 Pronounced "bystander effects" including neighboring cells were note

123 d embryos was unlikely to be involved in the bystander effect induced through the IECM because of the

124 F-alpha acts as a diffusible mediator of the bystander effects induced by macrophages, an effect caus

125 We further revealed that this bystander effect (induced through IECM) was rapidly abol

126 We further demonstrated that this bystander effect (induced through partnering) could be s

127 ription predisposes non-replicating cells to bystander effect-induced DNA DSBs, we examined two types

128 The radiation-induced bystander effect is a prime example of this effect, wher

129 The radiation-induced bystander effect is defined as "the induction of biologi

130 el stochastic model of the radiation-induced bystander effect is developed that takes account of spat

131 underlying mechanism(s) of radiation-induced bystander effect is still unclear.

132 The importance of bystander effects is becoming more appreciated, as studi

133 -1 TK for metabolism and sensitivity to GCV, bystander effect killing and induction of apoptosis.

134 entrations, cell sensitivity to the drug and bystander effect killing were diminished but still effec

135 s evident and CMV-specific ACT may trigger a bystander effect leading to additional T cell responses

136 ro results suggest that the observed in vivo bystander effect leading to tumor cell growth inhibition

137 infected somatic neurons would thus permit a bystander effect, leading to activation of the sensory a

138 ctivated at the site of the imprint, a rapid bystander effect-like spreading of secondary singlet oxy

139 ansfer of E1A into tumors, suggesting that a bystander effect may also be associated with E1A.

140 n-induced genomic instability and untargeted bystander effects may reflect inter-related aspects of i

141 Non-targeted (bystander) effects may influence these cells' response t

142 of a significant radiation quality-dependent bystander effect, measured as chromosomal damage in the

143 Notably, it exhibited a significant bystander effect mediated by the caspase-3-triggered ext

144 cell mismatch, epitope spread or drift, the bystander effect, molecular mimicry, anti-idiotype theor

145 e findings also offer an explanation for the bystander effect observed in the LNs of AIDS patients, w

146 A strong bystander effect occurred because of methylselenol relea

147 ute negative, yet proliferation-independent, bystander effect of irradiated recipients on transplante

148 ion of the RUNX3 canonical CGI promoter is a bystander effect of oncogenic immortalization and not li

149 signaling may play an important role in the bystander effect of radiation.

150 g cells showed the proapoptotic activity and bystander effect of the TRAIL gene to be not transferabl

151 To further demonstrate the bystander effect of the TRAIL gene, we constructed plasm

152 This bystander effect of viral infection on activated T cells

153 We hypothesized that bystander effects of H-FIRE tumor cell ablation, mediate

154 The low IC(50), high selectivity, and good bystander effects of nitrobenzylphosphoramide mustards i

155 n of most human lymphomas, presumably due to bystander effects of the immunoglobulin gene remodeling

156 No bystander effect on CD34(+) cells was observed.

157 f type I NKT cell response, suggesting their bystander effect on gammadelta T cells.

158 o digital PCR by analyzing the radiation and bystander effect on individual IMR90 human lung fibrobla

159 found that the E1A transfectants exhibited a bystander effect on inhibition of tumor growth.

160 binant adenoviral vector and elicit a potent bystander effect on neighboring tumor cells.

161 e examined whether B(regs) treatment and its bystander effect on regulatory T cells are associated wi

162 infected with AdCMV.CD exhibited a profound bystander effect on the growth of neighboring cells, whi

163 ntended yet crucial consequence: it exerts a bystander effect on the microbiome, changing its bacteri

164 recipients pose a proliferation-independent bystander effect on transplanted HSCs is unclear.

165 r, our results suggested that E1A mediates a bystander effect on tumor suppression by inhibiting angi

166 ting from ongoing HIV replication leading to bystander effects on B cells.

167 replication could favor HIV persistence via bystander effects on our immune system.

168 It is known that ionizing radiation exerts "bystander effects" on nontargeted cells and that HSCs tr

169 adiation-induced genomic instability through bystander effects or increased mutation rates in cell pr

170 RKO cells do not exhibit adaptive response, bystander effect, or death-inducing effect, as measured

171 The bystander effect, originating from cells irradiated in v

172 ing the limitations imposed by the prodrugs' bystander effects, our findings show that yCD:UPRT/5-FC

173 ed sarcoma cells in vitro through direct and bystander effects (P < 0.01).

174 This model suggests that these so-called "bystander" effects play a significant role in determinin

175 This bystander effect precludes its safe applications require

176 Radiation-induced bystander effects refer to biologic responses in cells t

177 The term "bystander effects" refers to changes in naive cells shar

178 ontributes to disease or merely represents a bystander effect remains unclear.

179 The radiation-induced bystander effect (RIBE) increases the probability of cel

180 The radiation-induced bystander effect (RIBE) refers to a unique process in wh

181 Inspired by the radiation-induced bystander effect (RIBE), we used the mediators of RIBE t

182 The bystander effect seems dependent on the production of re

183 These findings may explain, in part, the bystander effect seen with p53 tumor suppressor gene the

184 he importance of cathepsin B in the enhanced bystander effect, suggesting that cathepsin B mediates l

185 should be effective in vivo and enhance the bystander effect, suggesting that FMG-based gene therapy

186 but were insufficient to explain the entire bystander effect, suggesting the recruitment of other me

187 the results obtained are a consequence of a bystander effect that is generated in vivo by factor(s)

188 issue culture models and determine whether a bystander effect that is initiated by the in vivo decay

189 to tumor cell death and to the activation of bystander effects that harness the immune system against

190 nt prodrug GCV conversion and activation for bystander effects that kill the surrounding untransduced

191 nt prodrug GCV conversion and activation for bystander effects that killed many surrounding untransdu

192 rioration in cone function and health was a "bystander effect" that followed the degeneration of rods

193 The "bystander effects" that lead to enormous reductions in t

194 ty, as do adjacent non-irradiated cells (the bystander effect); the importance to carcinogenesis rema

195 In the second, radiation-induced bystander effects, they arise in cells that receive no r

196 Like the increased intracellular ROS bystander effect, this "decreased TP53/CDKN1A response"

197 mechanism by which paclitaxel induces toxic bystander effect through generation of extracellular H(2

198 Although some ADCs employ the bystander effect to eliminate neighboring antigen-negati

199 to MHC II(lo) macrophages and were able by a bystander effect to induce the differentiation of the en

200 ms has allowed nontargeted responses such as bystander effects to be more carefully analysed.

201 This finding links the macrophage-induced bystander effects to colorectal carcinogenesis.

202 cific effects or, alternatively, that induce bystander effects to potentially increase the efficacy o

203 is critical to determine the contribution of bystander effects to the overall response so they can be

204 en more formally examined thresholds for the bystander effect, using both MuLv and lentiviral vectori

205 Bystander effect was also observed on the tumors generat

206 This cytotoxic bystander effect was also observed with other microtubul

207 ter, which agreed with the proposal that the bystander effect was an on/off response with a threshold

208 This toxic bystander effect was enhanced by CuZnSOD that converts O

209 ytotoxic effect of ADCs on target cells, the bystander effect was enhanced when HER2-negative cells w

210 The role of MAC in bystander effects was then assessed in mouse embryonic f

211 that DD1-mediated apoptosis also leads to a "bystander effect." We found that within 5 h of DD1 expre

212 esent study, ionizing radiation (IR)-induced bystander effects were investigated in two lung cancer c

213 disulfide bond were capable of exerting the bystander effect whereas equally potent conjugates linke

214 Bystander effects, whereby cells that are not directly e

215 echanism for the production of damage via a 'bystander' effect which may contribute to radiation-indu

216 to selective killing of malignant cells with bystander effect, which suggests that the TRAIL gene cou

217 emonstrate, unequivocally, the presence of a bystander effect with many biological end points.

218 tacks both tumor and stroma cells through a "bystander effect" without selectively deleting target-pr

219 These bystander effects would tend to cause further deteriorat