ライフサイエンスコーパス: c-Maf

1 clin D3), 4p16 (FGFR3 and MMSET), and 16q23 (c-maf).

2 ic, osteopontin-positive chondrocytes in the c-maf-/-.

3 iched for the transcription factors IRF4 and c-Maf.

4 igher expression of the transcription factor c-Maf.

5 X6(5a) variants and other factors, e.g. MafA/c-Maf.

6 egulated by AP-1 and may also be a target of c-Maf.

7 fferent 3'-untranslated region compared with c-Maf.

8 ssion of the Th2-specific factors GATA-3 and c-Maf.

9 interleukin-4-specific transcription factor c-Maf.

10 ted with a decreased induction of GATA-3 and c-maf.

11 uired expression of the transcription factor c-Maf.

12 anoma cells resulted in the up-regulation of c-maf.

13 other cells is dependent on the presence of c-maf.

14 oncogenes: bcl-9, bcl-10, PAX-5, MMSET, and c-maf.

15 directly and indirectly via up-regulation of c-Maf.

16 MiR-155 is a microRNA that targets c-Maf.

17 R, releasing Twist2, which induces IL-10 via c-Maf.

18 Th2-inducing transcription factors GATA3 or c-Maf.

19 f the anti-inflammatory transcription factor c-Maf.

20 ific molecular target of p53 in microglia is c-Maf.

21 s in vivo required coexpression of Bcl-6 and c-Maf.

22 IL-10 and had increased mRNA expression for c-Maf, a transcription factor that upregulates IL-10 gen

23 butes to immune deviation in T1D by reducing c-Maf access to and transactivation of the IL-4 gene.

24 on of both cytokines, other factors, such as c-Maf act specifically on IL-22 and enable the separate

25 Thus, cartilage is a novel system in which c-Maf acts during development, where c-Maf is required f

26 Thus, c-Maf acts to preserve the identity and function of inte

27 Co-transfections using Pax6 and c-Maf alone revealed moderate and strong activations of

28 that bind the oncoproteins c-Jun, c-Fos and c-Maf (also called JUN, FOS and MAF, respectively), were

29 tinct gene programs, and validated roles for c-MAF and BCL6 as regulators affecting type 1 and type 3

30 Restoring c-Maf and Bmi1 expression in Twist-deficient macrophages

31 vitro translated proteins revealed that both c-Maf and c-Maf bound to NQO1 gene ARE as homodimers and

32 We have shown that the c-Maf and c-Myb transcription factors physically interac

33 a 10 amino acids at the carboxyl terminus of c-Maf and contains a different 3'-untranslated region co

34 d by DNA-binding transcription factors Pax6, c-Maf and CREB bound to its promoter region.

35 data demonstrate a novel mechanism of Pax6, c-Maf and CREB function, through regulation of chromatin

36 pression correlate with increased binding of c-Maf and CREB to the promoter and of CREB to DCR3, a br

37 Both c-Maf and Cryaa regulatory regions contain arrays of AP-

38 s, abolished T-bet expression, and increased c-MAF and GATA-3 protein in vivo.

39 neous induction of the transcription factors c-Maf and Gata-3, mediated by the kinases p38 MAPK and S

40 the expression of the transcription factors c-maf and GATA-3.

41 Both c-Maf and IL-10 induction during Th17 polarization depen

42 imulated PDCD4 degradation and expression of c-Maf and IL-10 production.

43 decreased expression of IL-7Ralpha, BATF and c-Maf and increased expression of Bcl11b and Lef1.

44 These results demonstrate that c-maf and its target binding site are not required for I

45 evels of the requisite transcription factors c-Maf and Jun B.

46 The synergy between c-Maf and JunB can be attributed to cooperative DNA bind

47 c-maf and junB mRNA, protein, and activity were signific

48 lation of the Th2-type transcription factors c-Maf and JunB, which consequently enhances IL-4 and IL-

49 ption factors have been described, including c-Maf and JunB.

50 TBP was also part of c-Maf and MafA (two other large Maf proteins)-containing

51 gism promotes activation of transcription by c-Maf and MafA on the alphaB-crystallin promoter, and is

52 gene signatures were observed in cases with c-MAF and MAFB activation and CCND1 and CCND3 activation

53 of genes encoding the transcription factors c-Maf and Mafb and directly promoted expression of trans

54 embers of the large Maf family, specifically c-Maf and MafB.

55 hey increased nuclear Nrf2 levels, prevented c-Maf and MafG induction, and prevented the fall in Nrf2

56 ell at 20 hours after LCA treatment, whereas c-Maf and MafG remained persistently induced.

57 Nuclear levels of c-Maf and MafG, which can negatively regulate ARE, were

58 We identify transcription factors, c-Maf and NFIL3, and negative co-stimulatory molecules,

59 der Tr1-skewing conditions, the AhR bound to c-Maf and promoted transactivation of the Il10 and Il21

60 periments revealed that CBP and p300 bind to c-Maf and Prox-1 but not to Sox-1.

61 expression of the key transcription factors c-Maf and Prox1.

62 file characterized by both the expression of C-MAF and the production of IL-4 and IL-10.

63 ter binding of the proinflammatory inhibitor c-Maf and the transcriptional repressor Bmi1.

64 Maf (c-Maf) and Mafb transcription factors (TFs) have compens

65 multiple myeloma SET domain [MMSET]), 16q23 (c-maf), and 20q11 (mafB).

66 volved in Th2 development (IL-4, GATA-3, and c-maf), and decreased mRNA for genes involved in Th1 dev

67 sion of the transcriptional repressor factor c-Maf, and a decreased binding of GAP-12 to the gene pro

68 ta was also synergistic with IL-27 to induce c-Maf, and it induced Stat1-independent IL-10 expression

69 ociated with sustained expression of GATA-3, c-MAF, and JunB in an IL-4-independent manner.

70 ns of Pax6/Pax6(5a), large Mafs (MafA, MafB, c-Maf, and NRL), Sox1, Sox2, Six3, and RARbeta/RXRbeta.

71 /RXRbeta, and lens fiber-factors Pax6, MafA, c-Maf, and NRL.

72 s of distinct cell types in the gonad: MAFB, C-MAF, and VCAM1.

73 influenced by known genetic lesions, such as c-MAF- and MAFB-, CCND1- and CCND3-, and MMSET-activatin

74 Conversely, c-Maf antagonized type 1 programming, largely through re

75 c-Maf appears to function primarily in Treg specializati

76 l hydrocarbon receptor, along with STAT3 and c-Maf, are recruited to promoter elements on Entpd1 and

77 and enhanced by IL-21 expression through the c-Maf/aryl hydrocarbon receptor pathway, independent of

78 Thus, we define c-Maf as a crucial cell-intrinsic brake in the type 1 ef

79 Here, we identify c-Maf as a crucial negative regulator of murine T-bet(+)

80 3 development and ILC1 conversion solidified c-Maf as a gatekeeper of type 1 regulatory transformatio

81 tudy, we identified the transcription factor c-Maf as a universal regulator of Tgammadelta17 cell dif

82 Here, we identified c-Maf as an essential regulator of ILC3 homeostasis and

83 transcriptional factor Bcl6 as well as IRF4, c-Maf, Batf, and STAT3/5.

84 5 (CXCR5), musculoaponeurotic fibrosarcoma (c-Maf), Bcl6, basic leucine zipper transcription factor

85 The corresponding cellular protein, c-Maf belongs to a family of related bZip proteins toget

86 Furthermore, mutation of a defined c-maf binding site within the proximal IL-4 promoter, wh

87 sion of 22 genes whose promoters contained a c-Maf binding site, including hyaluronan synthase 1 (HAS

88 driven luciferase reporter activity, reduces c-Maf binding to the IL-4p in chromatin immunoprecipitat

89 demonstrate that despite normal expression, c-Maf binds poorly to the IL-4 promoter (IL-4p) in NOD C

90 We demonstrate that c-maf binds this site in vivo and synergistically augmen

91 ssion of the transcription factors Bcl-6 and c-Maf, both of which are needed for development of folli

92 slated proteins revealed that both c-Maf and c-Maf bound to NQO1 gene ARE as homodimers and heterodim

93 We found that c-Maf bound to the Il22 promoter and was both necessary

94 The co-activation of c-Maf by CBP/p300 requires histone acetyltransferase act

95 tion of transcriptional activation domain of c-Maf (c-Maf) led to significant loss of MARE-mediated p

96 Immunoblotting demonstrates that c-Maf can be modified at lysine 33 by SUMO-1 (small ubiq

97 Thus, transgenic c-Maf can strongly influence autoimmune disease developm

98 eloid cell lines, we inducibly expressed the c-Maf cDNA in 2 bipotent human myeloid progenitor cells.

99 bated intestinal T(H)17 responses, even in a c-Maf-competent environment.

100 e of alternative mediators in the absence of c-Maf, consistent with the observation that a functional

101 c-Maf controlled T(reg) cell-derived IL-10 production an

102 It was not known whether c-Maf controlled the transcription of other Th2 cytokine

103 equent stages of lens morphogenesis, whereas c-Maf controls terminal differentiation of lens fibers,

104 h2-specific transcription factors GATA-3 and c-maf correlated with the increased production of Th2 cy

105 ing lens development, link together the Pax6/c-Maf/crystallin regulatory network, and suggest a novel

106 al co-activator p300 and we demonstrate that c-Maf D90V enhances p300 recruitment in a cell-type depe

107 In contrast to wild-type protein, the c-Maf D90V mutant protein is not inhibited by protein ki

108 c-Maf deficiency in T(reg) cells led to profound dysbios

109 Phenotypic and transcriptomic profiling of c-Maf-deficient CCR6(-) ILC3s revealed a hyper type 1 di

110 In c-Maf-deficient murine macrophages, IL-10 production is

111 ells and follicular regulatory T cells, were c-Maf dependent.

112 ules, and general immune homeostasis are not c-Maf dependent.

113 usive evidence that the transcription factor c-Maf directed the tissue-specific expression of IL-4.

114 On the molecular level, c-Maf directly restrained T-bet expression.

115 in Stat6-deficient CD4 and CD8 T cells, and c-Maf directly transactivated IL-10 gene expression thro

116 ow in this article that introduction of Maf (c-Maf) does induce the capacity to express IL-21.

117 errant or reduced expression of Prox1, Pax6, c-Maf, E-cadherin and alpha-, beta- and gamma-crystallin

118 Here, c-Maf enforced Tgammadelta17 cell identity by promoting

119 ption factor motif enrichment, revealed that c-Maf enforces ILC3 identity.

120 that IL-6 plays a unique role in initiating c-Maf expression after TCR engagement, and may subsequen

121 e defect was associated with a deficiency in c-Maf expression and could be rescued completely by c-Ma

122 It also induced GATA-3 and c-maf expression and downregulated IL-12Rbeta2 chain exp

123 T-cell receptor (TCR)/CD28-induced IL-4 and c-Maf expression and, conversely, enhanced interferon ga

124 Here, we show that Pax6 directly regulates c-Maf expression during lens development.

125 c-Maf expression in effector cells was regulated by IL-4

126 Importantly, beta-glucan treatment reduced c-MAF expression in macrophages and monocytes from patie

127 ed by p53 and negatively regulate Twist2 and c-Maf expression in microglia and the RAW macrophage cel

128 IL-6 induces similar c-Maf expression in protein kinase Ctheta-deficient CD4(

129 Northern analysis revealed that c-Maf expression increases 2 h after t-BHQ treatment.

130 lecting, at least in part, the dependence of c-Maf expression on Ca2+/NFAT signaling.

131 enhancer (CR1) recapitulated the endogenous c-Maf expression pattern in lens and retinal pigmented e

132 IL-27-driven c-Maf expression transactivates IL-21 production, which

133 Conversely, c-Maf expression was dependent on T-bet and regulated by

134 Co-culture led to upregulated c-Maf expression with no decrease in the proportion of T

135 s, Vav1 is selectively required for IL-4 and c-Maf expression, a requirement reflecting, at least in

136 IL-4 can up-regulate c-Maf expression, its binding to IL-10 promoter, and dos

137 ceptor (gammadeltaTCR) signal strength tuned c-Maf expression, which indicates that c-Maf is a core n

138 IL-10 expression also correlated with c-maf expression.

139 cus but also for inducing Il4, Il5, Il13 and c-Maf expression.

140 expression, but only partially by retroviral c-Maf expression.

141 macrophages likely via its ability to induce c-Maf expression.

142 Ca(2+) signal pathways, block IL-6-mediated c-Maf expression.

143 inflammatory and tolerogenic signals promote c-Maf expression.

144 These data suggest that c-Maf facilitates the initial chondrocyte terminal diffe

145 IL-4-producing mast cells do not express the c-maf factor.

146 We conclude that c-Maf has a critical and selective function in IL-4 gene

147 Pax6, c-Maf, Hsf4, Prox1, Sox1, and a few additional factors r

148 xhibit T(FH) features (including Batf, Bcl6, c-Maf, ICOS, and IL-21 expression) and are able to migra

149 those elements is essential, because loss of c-Maf, IL-21-signaling, or ICOS decreases the frequency

150 The overexpression of c-Maf in human hepatoblastoma (Hep-G2) cells led to the

151 in Th2 cells can provide the specificity for c-Maf in IL-4 expression during T cell development and d

152 he role of posttranslational modification of c-Maf in IL-4 production and Th cell-mediated autoimmune

153 y uncovers a novel and important function of c-Maf in macrophages and elucidates its transcriptional

154 ls can be recapitulated by overexpression of c-Maf in myeloid cell lines, we inducibly expressed the

155 Further, inhibiting c-Maf in myeloid progenitors, and consequent myeloid-lin

156 -4-independent and CD25-mediated function of c-maf in promoting the production of Th2 cytokines.

157 together, these data reveal a novel role for c-Maf in regulating T effector development, and they sug

158 This was in contrast to the role of c-Maf in the activation of Maf recognition element (MARE

159 nd super shift assays showed the presence of c-Maf in the ARE-nuclear protein complex.

160 and macrophages, we investigate the role of c-Maf in the transcriptional regulation of IL-10 and the

161 Thus, c-maf increases HIV-1 expression in IL-4-producing CD4 T

162 Here, we provide evidence demonstrating that c-maf, independent of IL-4, is essential for normal indu

163 c-Maf induces changes in nuclear DNA-binding activities

164 two genes in the SLI1 region: that encoding c-maf-inducing protein (CMIP, minP = 5.5 x 10(-7) at rs6

165 -stimulated production of IL-4/IL-21 through c-Maf induction is responsible for impaired Th1 differen

166 c-Maf induction requires both IL-6- and TCR-initiated si

167 ze Th17 immunity by IL-10 production through c-Maf induction.

168 [cyclin D1]; 4p16 [FGFR3 and MMSET]; 16q23 [c-maf]) involved in nearly half of MM tumors.

169 tuned c-Maf expression, which indicates that c-Maf is a core node that connects gammadeltaTCR signals

170 In this article, we show that c-Maf is a critical transcription factor regulating this

171 Therefore, c-Maf is a novel regulator of Treg specialization, which

172 c-maf is a T helper (Th)2 cell-specific transcription fa

173 Taken together, these data demonstrate that c-Maf is an indispensable yet constitutive transcription

174 Although c-Maf is crucial for Th2 differentiation and production

175 The transcription factor c-Maf is essential for the induction of IL-10 by Tr1 cel

176 Furthermore, c-Maf is expressed constitutively in resting monocytes/m

177 c-maf is expressed in hypertrophic chondrocytes during f

178 Sumoylation of c-Maf is increased in NOD CD4 cells as compared with CD4

179 As in other T cells, c-Maf is induced in Tregs by IL-6 and TGF-beta, suggesti

180 We demonstrate that c-Maf is one of the physiological mediators of IL-10's i

181 ith non-small cell lung cancer (NSCLC) where c-MAF is overexpressed.

182 udy, we report that the transcription factor c-Maf is required for normal chondrocyte differentiation

183 n which c-Maf acts during development, where c-Maf is required for normal chondrocyte differentiation

184 Thus, c-Maf is required for the differentiation of the vertebr

185 r knowledge, we show for the first time that c-Maf is subjective to tyrosine phosphorylation in Th ce

186 pper transcription factor Maf (also known as c-Maf) is central to osteoblast lineage commitment.

187 more, Twist2, a transcriptional activator of c-Maf, is increased in p53-deficient microglia.

188 ranscriptional regulator of IL10 in T cells, c-Maf, is significantly decreased by physiological level

189 his report, we have investigated the role of c-Maf (large Maf) containing the transcriptional activat

190 ore ARE sequence is essential for binding of c-Maf leading to repression of NQO1 gene expression.

191 transcriptional activation domain of c-Maf (c-Maf) led to significant loss of MARE-mediated p53 gene

192 ivity and prevented the increase in MafG and c-Maf levels.

193 iate these phenotypic changes indicated that c-Maf likely plays a key role in myeloid cell developmen

194 tin immunoprecipitation assays, and enhances c-Maf localization into promyelocytic leukemia nuclear b

195 of Pax6 and c-Maf to multiple regions of the c-Maf locus in lens chromatin.

196 elopment and function including Pax-6, Six3, c-Maf, Maf1, Sox-4, Foxc1, Rx, and Ldb2 were present amo

197 multiple myelomas harboring cyclin D1/D3 or c-MAF/MAFB translocations.

198 oxic bile acid induces a switch from Nrf2 to c-Maf/MafG ARE nuclear binding, which leads to decreased

199 ell development; therefore, abnormalities in c-Maf may contribute to reduced IL-4 production by CD4 c

200 Pax6 and c-Maf, Pax6 has a neutral effect on c-Maf-mediated alphaA-crystallin promoter activation.

201 CD4+ T cells and NK T cells from c-maf(-/-) mice were markedly deficient in IL-4 producti

202 cers and nonproducers have similar Gata3 and c-maf mRNA expression.

203 nding to the c-Maf promoter and induction of c-Maf mRNA.

204 We report a semi-dominant mouse c-Maf mutation recovered after ENU mutatgenesis which re

205 Unlike null and loss-of-function c-Maf mutations, which cause severe runting and renal ab

206 results together led to the conclusion that c-Maf negatively regulates ARE-mediated detoxifying enzy

207 Neither c-Maf nor JunB induced Th2 development in Stat6-deficien

208 c-Maf-null macrophages exhibit strongly impaired IL-10 p

209 d to enhance LPS-induced IL-10 production in c-Maf-null macrophages.

210 In c-maf-null mice, fetal bone length is decreased approxim

211 mature hypertrophic chondrocytes at E15.5 in c-maf-null tibiae, with decreased expression domains of

212 rmal proliferation rate and apoptosis in the c-maf-null.

213 ecrease in MMP-13 expression at E15.5 in the c-maf-null.

214 revious novel finding that the protooncogene c-Maf of the basic leucine zipper family of transcriptio

215 pers with c-Jun, JunB or c-Fos, but not with c-Maf or MafB.

216 Knockdown of c-Maf or MafG individually blunted the LCA-induced decre

217 Knockdown of c-Maf or MafG individually increased the expression of G

218 the expression of Pax-6, alphaA-crystallin, c-maf, or PDGF-R alpha.

219 xpression and could be rescued completely by c-Maf overexpression in T cells.

220 the transcription factors NFATc2, NF-kB p65, c-Maf, p300, Brg1, STAT6, and GATA-3 assemble at the Il4

221 activation of alphaB-crystallin by Pax6 and c-Maf, Pax6 has a neutral effect on c-Maf-mediated alpha

222 The transcription factor c-Maf plays a critical and selective role in IL-4 gene t

223 It remains unclear whether c-maf possesses any IL-4-independent function in regulat

224 c-Maf promoted ILC3 accessibility and supported RORgamma

225 The authors found that c-Maf promoted TAMs' immunosuppressive activity, governe

226 erized a novel FGF2-responsive region in the c-Maf promoter (-272/-70, FRE).

227 and thereby decreased Twist2 binding to the c-Maf promoter and induction of c-Maf mRNA.

228 We show that Stat3 binds the c-maf promoter in CD4 T cells after IL-6 stimulation, an

229 L-6 stimulation, and also transactivates the c-maf promoter in reporter gene assays.

230 A 1.3-kb c-Maf promoter with a 1.6-kb upstream enhancer (CR1) rec

231 d the complex allowing Twist2 to bind to the c-Maf promoter.

232 of MafA and MafB along with two forms of the c-Maf protein.

233 site represents the 3' coding region of the c-maf proto-oncogene at 67.0 centimorgans (cM) on chromo

234 The c-maf proto-oncogene encodes a basic leucine zipper prot

235 oth CD4 and CD8 T-cells; here too transgenic c-Maf provided significant protection.

236 ding protein (CBP) and/or p300 interact with c-Maf, Prox-1, or Sox-1 to enhance transcription of crys

237 s fiber cell differentiation is regulated by c-Maf, Prox1 and Sox1.

238 y and distinct markers including N-cadherin, c-Maf, Prox1, and alphaA-, alphaB-, and beta-crystallins

239 and differentiation associated with altered c-Maf, Prox1, and p57 expression pattern in the anterior

240 Our results suggest that c-Maf recruits CBP and/or p300 to crystallin promoters l

241 versely, small interfering RNA inhibition of c-maf reduces HIV-1 transcription in IL-4-producing T ce

242 Pax6 and c-Maf regulate multiple stages of mammalian lens develop

243 , we have shown that the bZIP proto-oncogene c-Maf regulates expression of alphaA-crystallin (Cryaa)

244 Thus our data suggest that ICOS-induced c-Maf regulates IL-21 production that in turn regulates

245 tle is known about the mechanism that guides c-Maf regulation during early T cell activation.

246 -Maf, we examined the impact of p53 on known c-Maf regulators.

247 in mice, the transcription factors MafB and c-Maf repress a macrophage-specific enhancer repertoire

248 anscriptional mechanism, we identify a novel c-maf (required for IL-4 expression) transcription facto

249 Inhibition of IL-12 p40 gene expression by c-Maf requires the N-terminal transactivation domain, su

250 in vitro and in vivo experiments identify a c-Maf response element localized to nucleotides -196/-18

251 Nonetheless, the essential c-Maf-responsive element appears to be located elsewhere

252 Genetic loss of c-Maf resulted in a defect in IL-21 production and fewer

253 l lamina-specific transcription factors such c-Maf, Rora, and Satb1 are identified for the first time

254 When overexpressed, c-Maf selectively inhibits transcriptional activation of

255 d activators of transcription 4), T-bet, and c-maf showed reduced expression in UCB compared with AB

256 In addition, Batf-to-c-Maf signalling is an important determinant of IL-4 exp

257 c-Maf siRNA inhibited HAS1 expression in M. tuberculosis

258 tes IL-4 promoter, and ectopic expression of c-Maf skews primary T cell response toward the Th2 pathw

259 c-Maf small interfering RNA (siRNA) inhibited IL-10 prod

260 Ectopic expression of c-Maf stimulates not only exogenously transfected IL-10

261 stant B10.D2 mice, suggesting that increased c-Maf sumoylation contributes to immune deviation in T1D

262 rentiated in the presence of exogenous IL-4, c-maf(-/-) T cells produced approximately normal levels

263 rmore, we have examined the levels of GATA3, c-Maf, T-bet, and Ets-related molecule during human Th1/

264 Moreover, CS1 increased c-maf-targeted cyclin D2-dependent proliferation, -integ

265 ompletely restored Th2 development, inducing c-Maf, Th2-specific DNase I hypersensitive sites in the

266 the T(H)2-specific factors GATA3, STAT6 and c-Maf, the chromatin-remodeling enzyme Brg1 and RNA poly

267 three key elements: the transcription factor c-Maf, the cytokine IL-21, and the costimulatory recepto

268 ells identified the Th2 transcription factor c-Maf to be synergistically up-regulated by IL-6 plus TG

269 l type 2 (Th2)-specific transcription factor c-Maf to cells normally refractory to IL-4 production, s

270 residues is critical for the recruitment of c-Maf to IL-4 promoter and IL-4 production in Th cells.

271 that Stat6 functions upstream of GATA-3 and c-Maf to induce Th2 development.

272 ChIP assays revealed binding of Pax6 and c-Maf to multiple regions of the c-Maf locus in lens chr

273 to IL-4 promoter regions and synergizes with c-Maf to positively regulate IL-4 expression.

274 was induced by IL-27, acted in synergy with c-Maf to promote the development of Tr1 cells.

275 served is likely explained by the ability of c-Maf to transactivate the crystallin gene promoter.

276 and the IL-4-inducing transcription factor, c-maf, to augment IL-4 promoter activity as well as to e

277 Expression of c-Maf transactivated each of these promoters.

278 In immune system, c-Maf transactivates IL-4 promoter, and ectopic expressi

279 c-Maf transactivates the IL-4 gene promoting Th2 cell de

280 In transfected cells, sumoylation decreases c-Maf transactivation of IL-4p-driven luciferase reporte

281 A new long form of the c-Maf transcription factor (Lc-Maf) was identified and s

282 f the JCI, Liu and colleagues identified the c-Maf transcription factor as a master regulator of prot

283 We found impaired expression of c-Maf transcription factor functionally associated with

284 The c-maf transcription factor is selectively expressed in I

285 L-4 or other cytokines, rapidly up-regulates c-Maf transcription, as early as 3 h after TCR activatio

286 t beta-cell expression of hemagglutinin, the c-Maf transgene provided significant protection from spo

287 Surprisingly, when the c-Maf transgene was backcrossed with the NOD model of sp

288 rmore, by expressing GATA-3 in wild-type and c-maf transgenic Th1 cells, we demonstrate that the expr

289 llin is regulated by recruitment of Pax6 and c-Maf, two proteins regulating multiple processes of len

290 c-Maf undergoes tyrosine phosphorylation at Tyr(21), Tyr

291 to c-avian musculoaponeurotic fibrosarcoma (c-Maf)/V-maf musculoaponeurotic fibrosarcoma oncogene ho

292 Retroviral transduction of c-Maf was able to induce IL-10 expression in Stat6-defic

293 Up-regulation of c-Maf was dependent on Ca2+/nuclear factor of activated

294 interest, co-expression of CBP or p300 with c-Maf was found to synergistically co-activate each prom

295 To determine how p53 negatively regulates c-Maf, we examined the impact of p53 on known c-Maf regu

296 Because MafA, MafB, and c-Maf were each capable of specifically binding to and a

297 CD14(hi) cells have increased expression of c-Maf, which increases production of two key factors (hy

298 Here we identify the transcription factor c-Maf, which is induced by TGF-beta, as a downstream rep

299 The co-expression of c-Maf with MafG rescued the MafG repression of MARE but

300 established in vivo interactions of Pax6 and c-Maf with the alphaA-crystallin promoter in lens cells.