ライフサイエンスコーパス: c-Src kinase

1 to explore the conformational landscape of a c-Src kinase.

2 ormations near the inhibitor binding site in c-Src kinase.

3 ns were mainly mediated by activation of the c-Src kinase.

4 es the tyrosine phosphorylation of villin by c-Src kinase.

5 sp90 does not influence the almost identical c-Src kinase.

6 ced death by suppressing early activation of c-Src kinase.

7 inic receptor couples to Ca(2+) channels via c-src kinase.

8 st precursors, is tyrosine-phosphorylated by c-Src kinase.

9 essing glutamate-induced early activation of c-Src kinase.

10 pstream elements, such as p38 MAP kinase and c-Src kinase.

11 sine kinase but not of the highly homologous c-Src kinase.

12 cted a specific interaction between CD44 and c-Src kinase.

13 c, G6G is a potent inhibitor of both Abl and c-Src kinases.

14 Mechanistically, c-Src kinase activated by TLR3 engagement phosphorylates

15 ediated formation of Shc.c-Src complexes and c-Src kinase activation are early events in Ras-dependen

16 Previously, we demonstrated a role for c-Src kinase activation in Ox-PAPC-induced IL-8 transcri

17 sion kinase phosphorylation was dependent on c-Src kinase activation, for which caveolin-1 was requir

18 ts indicate that HA binding to CD44 promotes c-Src kinase activation, which, in turn, increases Twist

19 xpressing clones exhibited increased Akt and c-Src kinase activities, as well as higher levels of mat

20 possessing elevated EGF receptor (EGF-R) and c-Src kinase activities.

21 osphorylation also depended on both EGFR and c-Src kinase activities.

22 tTG function (monodansylcadaverine; MDC) or c-Src kinase activity (PP2) disrupted the formation of t

23 Agonists of the CaR can stimulate increased c-SRC kinase activity and increased extracellular signal

24 c-Src kinase activity and phosphorylations at Src Tyr-41

25 phorylation of FAK in the liver, we measured c-Src kinase activity and the abundance of 3 major prote

26 t osteoclastic bone resorption requires both c-Src kinase activity and the targeting of Src kinase by

27 VEGF stimulation specifically activated c-Src kinase activity but not that of other related Src

28 d levels of Bcl-x(L.) However, inhibition of c-Src kinase activity by PP2 in vector control cells did

29 They also show that c-Src kinase activity can be used differently by individ

30 on, in the presence of EGFR TKIs, inhibiting c-Src kinase activity decreased cell growth in SUM229 ce

31 n Rat-2 cells transiently stimulated Hck and c-Src kinase activity in the absence of extracellular si

32 nism of c-Src regulation have suggested that c-Src kinase activity is downregulated by phosphorylatio

33 nd sufficient to induce IGF-IR upregulation, c-Src kinase activity is necessary, but alone is insuffi

34 c-Src kinase activity is required for the cytoskeletal t

35 Pharmacological blockade of c-Src kinase activity or decreased expression of endogen

36 rast, pharmacologic inhibition of endogenous c-Src kinase activity or small interfering RNA-mediated

37 Further analyses revealed that c-src kinase activity was dramatically elevated in cultu

38 Furthermore, c-Src kinase activity was found to be increased in the h

39 Hepatic c-Src kinase activity was unaltered, but LAR protein was

40 tantly, erbB2:EGFr heterodimer formation and c-src kinase activity were also elevated in TPA-treated

41 In one such cell line, SUM229, inhibiting c-Src kinase activity with either a dominant-negative c-

42 wer c-Src phosphotyrosine 527 level, greater c-Src kinase activity, and increased tyrosine phosphoryl

43 Independent of c-Src kinase activity, c-Src is associated with an N-ter

44 as accompanied by an EGF-induced increase in c-Src kinase activity, relocalisation of c-Src to the ce

45 cortactin was found uncoupled of endogenous c-Src kinase activity, thus further supporting the hypot

46 with its receptor leads to the activation of c-Src kinase activity, which in turn facilitates the bin

47 rc kinase recruitment to CD44 and stimulates c-Src kinase activity, which, in turn, increases tyrosin

48 , myristoylation exerts a positive effect on c-Src kinase activity.

49 TCDD) was accompanied by rapid activation of c-Src kinase activity.

50 tivation of JAK2 by Ox-PAPC was dependent on c-Src kinase activity.

51 cells, while it had no detectable effect on c-Src kinase activity.

52 e swelling, which triggers via integrins and c-Src kinase an activation of the epidermal growth facto

53 ine-rich sequence) as negative regulators of c-Src kinase and demonstrate a new function for these ph

54 High cytoplasmic c-Src kinase and high membrane phosphorylated activated

55 ctivation is required for acid activation of c-Src kinase and NHE3.

56 5-HT stimulated tyrosine phosphorylation of c-Src kinase and PKC delta.

57 D44 (a primary HA receptor) interaction with c-Src kinase and the transcriptional factor, Twist, in b

58 that activate the focal-adhesion kinase and c-Src kinase and their downstream MAP-ERK kinase/extrace

59 ulate osteoclast function by activating pp60(c-Src) kinase and alpha(v)beta3 integrin.

60 Activation of pp60(c-Src) kinase and phosphorylation of ERK were observed i

61 e assessed the involvement of protein kinase C, Src kinases, and proline-rich tyrosine kinase 2 in th

62 n by a mechanism dependent on protein kinase C, Src kinases, and proline-rich tyrosine kinase 2.

63 Epidermal growth factor receptor-kinase, c-src kinase, and focal adhesion kinase were phosphoryla

64 by the expression of a constitutively active c-Src kinase, and repressed by the expression of dominan

65 both CD44 (the hyaluronan (HA) receptor) and c-Src kinase are expressed in human ovarian tumor cells

66 PP1), in bulk solution and on the surface of c-Src kinase are reduced as the concentration of crowder

67 The roles of Akt and c-Src kinases as downstream targets of CEACAM6 signaling

68 duced PP1 inhibitor efficacy in experimental c-Src kinase assays in addition with BSAs.

69 In addition, Hsp90 also activated c-Src kinase associated with SREC-I, an activity that we

70 ion site of FAK, which is a reported site of c-Src kinase binding, is required for bacterial internal

71 TCDD appears to be limited to activation of c-Src kinase, but not kinases associated with activation

72 nonphagocytic NAD(P)H oxidases (NOX-1), and c-Src kinases (c-Src) were colocalized in the caveolae o

73 stimulates tyrosine kinases, including pp60(c-src) kinase (c-Src), focal adhesion kinase (FAK), and

74 nges the major binding pathway of PP1 toward c-Src kinase compared to that in dilute solution.

75 Met cells treated with inhibitors of MEK1 or c-Src kinases, completely blocked by expression of a cat

76 hat the expression of these genes in src- or c-src kinase-deficient cells did not differ from wild-ty

77 ormed complexes that included an active pp60(c-src) kinase, demonstrating that PP2A activity is not e

78 ulated kinase (Erk) MAPK, an event requiring c-Src kinase-dependent epidermal growth factor receptor

79 Here, we report that the c-Src kinase functions as a key adapter protein for the

80 ylated in TKX1 cells nor was a substrate for c-src kinase in an in vitro kinase assay.

81 lso enhanced the transformation potential of c-Src kinase in focus formation assays, and PELP1 overex

82 They also suggest a central role of c-src kinase in the cross-talk between tyrosine kinase r

83 ontains thermostable components that inhibit c-Src kinase in vitro.

84 c-Src kinase is a rate-limiting activator of osteoclast

85 In the presence of E2, c-Src kinase is activated by membrane ER46 and in turn p

86 rexpression of a dominant-negative mutant of c-Src kinase (K295R) in SK-OV-3.ipl cells impairs the tu

87 olo-like kinase 1 (Plk1) kinase by enhancing c-Src kinase-mediated tyrosine phosphorylation of Plk1.

88 Together, our results establish that c-Src kinase mediates stresses generated by E2 in long-t

89 d that TI-VAMP is phosphorylated in vitro by c-Src kinase on tyrosine 45 of the Longin domain.

90 Here we show that activated c-Src kinase phosphorylates Y281 and Y302 of Mdm2, resul

91 ific effects were prevented by deletion of a c-Src kinase phosphorylation DYD motif, identified in si

92 strongly suggest that CD44 interaction with c-Src kinase plays a pivotal role in initiating cortacti

93 binding of HA to SK-OV-3.ipl cells promotes c-Src kinase recruitment to CD44 and stimulates c-Src ki

94 Further studies using mutants of c-Src kinase revealed that Src mediates mitogen-activate

95 s show for the first time that Rap1 mediates c-Src kinase signaling and reveal mechanistic difference

96 ut virtual screening hits for three targets: c-SRC kinase, Smoothened receptor, and dopamine D1 recep

97 ther, these data demonstrate the role of the c-src kinase/STAT3 pathway in Ox-PAPC-mediated IL-8 expr

98 ol did not influence activity of recombinant c-Src kinase suggesting that its mechanism of action may

99 re, we investigate an inhibitor binding with c-Src kinase using atomistic molecular dynamics (MD) sim

100 c-Src kinase was not involved in the IL-8-mediated phosp

101 r402, which mediates the binding of RAFTK to c-Src kinase, was required for the phosphorylation of th

102 Activation of erbB2 and c-src kinase were also observed in the epidermis of TGF

103 tion, pyk2(K457A) blocked acid activation of c-Src kinase, which is also required for acid regulation

104 tive conformation of the catalytic domain of c-Src kinase while the tyrosine 416 in the activation lo

105 antibodies, indicating direct association of c-Src kinase with the Ca2+ channel.

106 ifts of the disordered N terminal (SH4UD) of c-Src kinase without reweighting or constraining the sim