ライフサイエンスコーパス: cAMP receptor

1 ansduction through cAR1, the chemoattractant cAMP receptor.

2 sequence identity is with the Dictyostelium cAMP receptors.

3 cAMP receptor 1 (cAR1) of Dictyostelium couples to the G

4 Null mutation of Gbeta and cAMP receptor 1 and Galpha2 did not abolish electrotaxis

5 The cAMP receptor 1 gene CAR1 has two promoters that are dif

6 duced desensitization and down-regulation of cAMP receptor 1 impacts the sensitivities of chemotactic

7 However, cAMP receptor 1 protein and aggregation-stage adenylyl c

8 cAMP receptor 1 protein, cyclic nucleotide phosphodieste

9 llular cAMP binding to the G protein-coupled cAMP receptor 1, which initiates a signaling cascade lea

10 a specific inhibitor of the cAR1 serpentine cAMP receptor almost completely prevents the cAMP-induce

11 Synthesis of cAMP receptor and adenylyl cyclase A (ACA) is inhibited,

12 tion by inducing expression of genes such as cAMP receptors and adenylate cyclase.

13 actin causes a 50% reduction of cell surface cAMP receptors, and inhibits cAMP-induced increases in a

14 idium cells express a family of cell surface cAMP receptors, and these G-protein-coupled receptors ar

15 f the MAP kinase, DdERK2, triggered from the cAMP receptor, are little perturbed in the mutant; mobil

16 te growth; (iv) blockade of FPRL1 protein, a CAMP receptor, attenuates cSCC growth as well as the gro

17 This response requires cAMP receptors, but is independent of the coupled G alph

18 tion of GBF expression requires cell-surface cAMP receptors, but not heterotrimeric G-proteins.

19 d by stimulation of cell-surface, seven-span cAMP receptors, but this activation is independent of he

20 e identity with the Dictyostelium discoideum cAMP receptor cAR1 and the Aspergillus nidulans GPCR pro

21 Inhibiting the function of the cAMP receptor cAR1 blocks wave propagation, showing that

22 During mound development, the cAMP receptor cAR1 is in a low-affinity state and is pho

23 by extracellular cAMP through the serpentine cAMP receptor cAR1, with Dd-STAT tyrosine phosphorylatio

24 enylyl cyclase through the G protein-coupled cAMP receptor cAR1.

25 e four known cyclic adenosine monophosphate (cAMP) receptors (cAR1-4).

26 ve intracellular signals mediated by another cAMP receptor, CAR1 and/or CAR3.

27 inhibit starvation-induced expression of the cAMP receptor, cAR1, or G protein-mediated stimulation o

28 Signaling via the 7-transmembrane cAMP receptor CAR4 is essential for creating and maintai

29 ses are mediated by a family of cell surface cAMP receptors (cARs) that act on a specific heterotrime

30 es, a process that is mediated by serpentine cAMP receptors (cARs).

31 as a primary signal to activate cell surface cAMP receptors (cARs).

32 ulmination and ecmB expression, results from cAMP receptor-dependent tyrosine phosphorylation and nuc

33 n-2/3) complex activator SCAR (suppressor of cAMP receptor) diminishes F-actin mainly at the cup rim,

34 In Dictyostelium, 7-TM cAMP receptors direct chemotaxis and development but als

35 AMP (EPAC1), a multifunctional intracellular cAMP receptor, dynamically localizes to various cellular

36 one C7-14 cells, whereas other intracellular cAMP receptors, including the exchange proteins directly

37 EPAC, an intracellular cAMP receptor, is activated specifically by the cAMP ana

38 cAR1, a G protein-coupled cAMP receptor, is essential for multicellular developmen

39 sed to identify Dictyostelium genes encoding cAMP receptor-like proteins, CrlA-C.

40 um tuberculosis Rv3676 encodes a cyclic AMP (cAMP) receptor-like protein (CRP(Mt)) that has been impl

41 cAMP receptors mediate some signaling pathways via coupl

42 To do this, we replaced cAR1, the primary cAMP receptor of Dictyostelium, with a cAR1-green fluore

43 CF does not affect the cAMP receptor or its interaction with its associated G p

44 nduced genes such as those encoding the cAR1 cAMP receptor, phosphodiesterase, and the gp80 adhesion

45 This paper addresses possible roles of cAMP receptor phosphorylation in the cAMP-mediated stimu

46 rectly activated by cAMP), two intracellular cAMP receptors, play in this synergistic effect.

47 Thus, cAR2 appears to be a cAMP receptor present on a restricted subset of prestalk

48 ose) activation, and three binding sites for cAMP receptor protein (CRP or CAP) were identified upstr

49 binding sites of Mycobacterium tuberculosis cAMP receptor protein (CRP(Mt)) at endogenous expression

50 The Escherichia coli cAMP receptor protein (CRP) activates transcription init

51 Binding of cAMP receptor protein (CRP) and CytR mediates both posit

52 of such diverse DNA-binding molecules as the cAMP receptor protein (CRP) and Din-family site-specific

53 Many of these genes were members of the cAMP-cAMP receptor protein (CRP) and guanosine tetraphosphate

54 measurements were performed on solutions of cAMP receptor protein (CRP) and on solutions of the T127

55 ia coli CytR regulon is activated by E. coli cAMP receptor protein (CRP) and repressed by a multiprot

56 ns between two gene regulatory proteins, the cAMP receptor protein (CRP) and the cytidine repressor (

57 wn, the structural homology of PrfA with the cAMP receptor protein (Crp) and the finding of constitut

58 efine a CRP(Mt) DNA motif that resembles the cAMP receptor protein (CRP) binding motif model for Esch

59 ork, sequences matching the Escherichia coli cAMP receptor protein (CRP) binding motif were identifie

60 We show that the cAMP receptor protein (Crp) binds to DNA as several diff

61 ctivated by binding of the cyclic AMP (cAMP)-cAMP receptor protein (CRP) complex to a CRP binding sit

62 adenosine cyclic-3',5'-monophosphate (cAMP)-cAMP receptor protein (CRP) complex.

63 es may be regulated by the cyclic AMP (cAMP)-cAMP receptor protein (CRP) complex.

64 Escherichia coli cAMP receptor protein (CRP) controls more than 20 genes.

65 The Escherichia coli cAMP receptor protein (CRP) displays biphasic characteri

66 for a transcription factor belonging to the cAMP receptor protein (CRP) family caused growth defects

67 CooA, a member of the cAMP receptor protein (CRP) family, is a CO-sensing tran

68 Activation of the cAMP receptor protein (CRP) from Escherichia coli is hig

69 In the transcription factor cAMP receptor protein (CRP) from Escherichia coli, the a

70 The cAMP receptor protein (CRP) from Mycobacterium tuberculo

71 hermodynamic role of binding of an operon to cAMP receptor protein (CRP) in the activation of transcr

72 The effects of varying amounts of cAMP receptor protein (CRP) in the presence and absence

73 Although cAMP binding to wild type cAMP receptor protein (CRP) induces specific DNA binding

74 in the cAMP-induced allosteric activation of cAMP receptor protein (CRP) involve interfacial communic

75 A homologue of the Escherichia coli cAMP receptor protein (CRP) is linked to the guanylyl cy

76 n Escherichia coli, the transcription factor cAMP receptor protein (CRP) is responsible for much of t

77 The cAMP receptor protein (CRP) of Escherichia coli exists i

78 The cAMP receptor protein (CRP) of Escherichia coli is a tra

79 The cAMP receptor protein (CRP) of Escherichia coli undergoe

80 lator HapR, as well as the cyclic AMP (cAMP)-cAMP receptor protein (CRP) regulatory complex.

81 FixK2 belongs to the cAMP receptor protein (CRP) superfamily.

82 any HapR targets coincide with sites for the cAMP receptor protein (CRP) that regulates the transcrip

83 in-protein interactions between CytR and the cAMP receptor protein (CRP) that underlie differential r

84 he cAMP-ligated T127L/S128A double mutant of cAMP receptor protein (CRP) was determined to a resoluti

85 Potential Fnr, cyclic AMP (cAMP)-cAMP receptor protein (Crp), and sigma(F) regulatory sit

86 gulator of the arr operon, cyclic AMP (cAMP)-cAMP receptor protein (CRP), could bind simultaneously w

87 f transcription by a mechanism that requires cAMP receptor protein (CRP), cyclic AMP (cAMP) and a CRP

88 AMP) interacts with the transcription factor cAMP receptor protein (CRP), forming active cAMP-CRP com

89 ide a feedback loop to the global regulator, cAMP receptor protein (CRP), in carbon source transition

90 By analogy to the homologous cAMP receptor protein (CRP), it has been proposed that e

91 ), the essential allosteric activator of the cAMP receptor protein (CRP), master regulator of carbon

92 hate (cAMP), the allosteric activator of the cAMP receptor protein (CRP), master regulator of carbon

93 Instead, we find that cells lacking the cAMP receptor protein (CRP), which regulates expression

94 ion is repressed by a three-protein complex (cAMP receptor protein (CRP)-CytR-CRP) that is stabilized

95 extension analysis confirmed that P1 is the cAMP receptor protein (CRP)-dependent promoter.

96 quired integration host factor (IHF) and the cAMP receptor protein (CRP).

97 map ligand-induced conformational changes in cAMP receptor protein (CRP).

98 with the cyclic AMP (cAMP) activated form of cAMP receptor protein (CRP).

99 cherichia coli molecular chaperone GroEL and cAMP receptor protein (CRP).

100 of three synthetic promoters by cNMP-ligated cAMP receptor protein (CRP)/mutant complexes was determi

101 igh-level ompT transcription is dependent on cAMP receptor protein (CRP); (ii) ToxR not only interfer

102 ied affinities of Synechocystis sp. PCC 6803 cAMP receptor protein (SyCrp1), the Escherichia coli Crp

103 of transcriptional regulators similar to the cAMP receptor protein and fumavate nitrate reduction fro

104 ocess integrating the associated regulators, cAMP receptor protein and KdgR.

105 regulated by two transcription factors, the cAMP receptor protein and the fumarate and nitrate reduc

106 t cstA is regulated by the cyclic AMP (cAMP)-cAMP receptor protein complex and transcribed by Esigma(

107 synthesis of SecB may be related to the cAMP-cAMP receptor protein complex-mediated activation.

108 with the osmolarity-dependent binding of the cAMP receptor protein CRP to a site within the proP P1 p

109 regulated by CooA, which is a member of the cAMP receptor protein family of transcriptional regulato

110 The cAMP receptor protein from Mycobacterium tuberculosis (C

111 The cAMP receptor protein of Escherichia coli, CRP, was empl

112 ncoding adenylate cyclase) and crp (encoding cAMP receptor protein) deletion mutants revealed that cA

113 ntext constant in Escherichia coli cAMP-CRP (cAMP receptor protein) regulated gal promoters by in vit

114 s between critical residues in CytR and CRP (cAMP receptor protein), is disrupted by exogenous cytidi

115 similar to the arrangement of class II CRP (cAMP receptor protein)- and FNR (fumarate and nitrate re

116 to determine the specificity within the CRP (cAMP receptor protein)/FNR (fumarate and nitrate reducta

117 transcription by competing for binding with cAMP receptor protein, a global activator.

118 te activator protein (CAP; also known as the cAMP receptor protein, CRP) is a textbook example of mod

119 The Escherichia coli cAMP receptor protein, CRP, is a homodimeric global tran

120 The activated Escherichia coli cAMP receptor protein, CRP, is capable of regulating the

121 the mycobacterial regulon controlled by the cAMP receptor protein, CRP.

122 The recent discovery of Epac, a novel cAMP receptor protein, opens up a new dimension in study

123 dition to SiaR-mediated repression, CRP, the cAMP receptor protein, was shown to activate expression

124 sion of the homodimeric transcription factor cAMP receptor protein.

125 endent of the global cAMP signal transducer, cAMP receptor protein.

126 ntP requires activation by cyclic AMP (cAMP)-cAMP receptor protein.

127 diated at least in part by cyclic AMP (cAMP)-cAMP receptor protein.

128 r to the consensus core motifs recognized by cAMP receptor protein/FNR family.

129 Transcription activation by cyclic AMP (cAMP) receptor protein (CAP) is the classic paradigm of

130 regulatory molecules, including cyclic AMP (cAMP) receptor protein (CRP) and c-di-GMP, were substant

131 ant of 3',5'-cyclic adenosine monophosphate (cAMP) receptor protein (CRP) by cAMP changes from an exo

132 ine-responsive protein (Lrp) and cyclic AMP (cAMP) receptor protein (CRP) in the transcriptional acti

133 The cyclic AMP (cAMP) receptor protein (CRP) indirectly increases ltxA e

134 In this study, the cyclic AMP (cAMP) receptor protein (CRP) is shown to be involved in

135 ctivation can be enhanced by the cyclic AMP (cAMP) receptor protein (CRP) protein.

136 The cyclic AMP (cAMP) receptor protein (CRP) strongly enhanced hapA tran

137 onstrate that the binding of the cyclic AMP (cAMP) receptor protein (CRP) to a site centered at -34.5

138 A gene encoding a cyclic AMP (cAMP) receptor protein (CRP) was identified as the site

139 mologous to the Escherichia coli cyclic AMP (cAMP) receptor protein (CRP), regulates many aspects of

140 encode adenylate cyclase and the cyclic AMP (cAMP) receptor protein (CRP), respectively, derepressed

141 We show here that Fis and cyclic AMP (cAMP) receptor protein (CRP)-cAMP collaborate to activat

142 to be subject to control by the cyclic AMP (cAMP) receptor protein (CRP)-cAMP complexes.

143 ulated in response to glucose by cyclic AMP (cAMP) receptor protein (CRP).

144 at the level of transcription by cyclic AMP (cAMP) receptor protein (CRP).

145 ntrolled by the global regulator cyclic AMP (cAMP) receptor protein (Crp).

146 wth were not affected by loss of cyclic AMP (cAMP) receptor protein (CRP).

147 encode adenylate cyclase and the cyclic AMP (cAMP) receptor protein (CRP).

148 ced in a mutant defective in the cyclic AMP (cAMP) receptor protein, suggesting that intracellular cA

149 lon genes, its modulation by the cyclic AMP (cAMP) receptor protein-cAMP complex (CRP-cAMP) global re

150 irect, whereas repression by the cyclic AMP (cAMP) receptor protein-cAMP complex (CRP-cAMP) was likel

151 esting that neither RpoS nor the cyclic AMP (cAMP) receptor protein-cAMP complex is required for expr

152 bal transcription regulator Escherichia coli cAMP-receptor protein (CRP) and RNA polymerase along the

153 r by the regulators Lac repressor (LacR) and cAMP-receptor protein (CRP).

154 owledge, of PDEs directly interacting with a cAMP-receptor protein in a mammalian system, and highlig

155 create a consensus recognition site for the cAMP-receptor protein, CRP (CC-site), and one that was r

156 sitive phosphatase calcineurin and the major cAMP receptor, protein kinase A (PKA).

157 by two ubiquitously expressed intracellular cAMP receptors, protein kinase A (PKA) and exchange prot

158 The finding of an additional intracellular cAMP receptor provides an opportunity to further dissect

159 In Dictyostelium, the 7-TM cAMP receptors regulate GSK3 by parallel, antagonistic p

160 moattractant cAMP, acting through serpentine cAMP receptors, results in a rapid and transient stimula

161 omplex (Arp2/3), its regulator suppressor of cAMP receptor (SCAR), and filamentous actin to actin cap

162 ldrich Syndrome protein (WASP)/suppressor of cAMP receptor (Scar)/WASP family verprolin homologous (W

163 el tyrosine kinase, ZAK1, downstream of 7-TM cAMP receptor signaling that is required for GSK3 activa

164 YakA acts downstream of G-proteins, because cAMP receptors still couple to G-proteins in the yakA mu

165 f the promoter responsible for expression of cAMP receptor subtype 1, CAR1, during aggregation reflec

166 Signal transduction via a family of cAMP receptor subtypes (cARs) is critical for proper dev

167 dentity between these putative GPCRs and the cAMP receptors suggests the Crl receptors are unlikely t

168 C) is a ubiquitously expressed intracellular cAMP receptor that plays a regulatory role in suppressin

169 also with the rapid dephosphorylation of the cAMP receptor that we observe in response to DIF-1 and w

170 ctivity of which was stimulated by cAMP, and cAMP receptors that may function as regulatory subunits

171 mutants in a strain in which the endogenous cAMP receptors that mediate postaggregative gene express

172 igh-affinity interactions with the cytosolic cAMP receptor, the protein kinase A regulatory subunit (

173 nctions as a primary ligand for cell surface cAMP receptors throughout Dictyostelium discoideum devel

174 x through its interaction with suppressor of cAMP receptor/WASP family verprolin-homologous (SCAR/WAV

175 that ARPC1 and, by inference a suppressor of cAMP receptor/WASP-family verpolin homologous protein-AR

176 x downstream of its activator, suppressor of cAMP receptor/WASP-family verprolin homologous (Scar/WAV

177 Sequences of the cAMP receptors were used to identify Dictyostelium genes