ライフサイエンスコーパス: cachectic

1 Twelve patients were cachectic.

2 population, 16% of patients were found to be cachectic.

3 within 2 weeks) developed ascites and became cachectic.

4 1) less comorbidity, (2) cardiovascular, (3) cachectic, (4) metabolic, and (5) psychological.

5 eart failure (CHF), classified clinically as cachectic (8% to 35% weight loss over > or = 6 months be

6 etal muscle of patients with PDAC defined as cachectic and correlated with MEF2c.

7 th untreated iMSUD mice, which were severely cachectic and died </=28 days after birth.

8 (>500 mg/dL), hyperketonemic, polyuric, and cachectic and had to be killed after 6 weeks.

9 In the clinic, she was cachectic and reported significant abdominal discomfort

10 Most cachectic and some noncachectic patients with CHF show f

11 s (mean age, 61.9+/-10.9 years; 95% male; 25 cachectics) and 24 age-matched normal subjects (mean age

12 Ex vivo perfused hearts from cachectic animals exhibited marked contraction and relax

13 Weight loss in cachectic animals was also associated with a depletion o

14 Of these, 68 cachectic (body mass index [BMI]<20 kg/m2), 113 overweig

15 Surprisingly, the Cre(+) mice became cachectic by postnatal day 80 due to bilateral GCT.

16 l compared EPA diethyl ester with placebo in cachectic cancer patients for effects on weight and lean

17 he 24K material was also present in urine of cachectic cancer patients, but was absent from normal su

18 2 on the alpha-subunit in skeletal muscle of cachectic cancer patients, which would lead to muscle at

19 ignificant implications for the treatment of cachectic cancer patients.

20 in multiple cell types and were elevated in cachectic cancer patients.

21 milarly disrupted in muscle of patients with cachectic cancer.

22 Cachectic CHF patients are weaker and fatigue earlier.

23 Cachectic CHF patients show increased plasma levels of c

24 Plasma leptin levels are elevated in non-cachectic CHF, suggesting the possibility that leptin mi

25 one in impeding muscle protein catabolism in cachectic, critically injured children.

26 acts very differently than the prototypical cachectic cytokine, IL-1.

27 perhaps more analogous to those activated by cachectic cytokines.

28 rogeroid features, including short lifespan, cachectic dwarfism, lordokyphosis, cataracts, loss of su

29 bnormalities, sensorineural hearing loss and cachectic dwarfism.

30 e capacity determines the response to cancer cachectic effects.

31 system with the purpose of identifying early cachectic events.

32 in urine of most patients, and to which the cachectic factor is noncovalently bound.

33 ate the expression of muscle proteins may be cachectic factor specific.

34 The 24-kDa peak may be identified as the cachectic factor, a glycoprotein, whereas the peak at 67

35 o and in vivo models of muscle wasting, that cachectic factors are remarkably selective in targeting

36 exactly which products are targeted by these cachectic factors is not well understood.

37 ble to counteract the detrimental effects of cachectic factors on myogenic differentiation.

38 stent and increased kidney production of pro-cachectic factors, combined with a lack of kidney cleara

39 ion and elevated blood levels of soluble pro-cachectic factors, including activin A, directly linking

40 Similar changes were found when the cachectic group was compared with the control group.

41 an and cellular-level functional deficits in cachectic hearts outside of the catabolic in vivo enviro

42 is an anabolic steroid that has been used in cachectic hepatitis and AIDS patients.

43 loss, raising concerns that it might produce cachectic-like effects.

44 more, Pax7 was induced by serum factors from cachectic mice and patients, in an NF-kappaB-dependent m

45 so declined in Tibialis Anterior muscle from cachectic mice bearing murine colon adenocarcinoma or hu

46 induced chronic cachexia model revealed that cachectic mice develop perivascular fibrosis in major me

47 ock myostatin pathway signaling in normal or cachectic mice leads to hypertrophy or prevention of mus

48 These changes persisted when cachectic mice were acclimatized to 28 degrees C confirm

49 The more cachectic MLM3 models induced severe bone deterioration

50 chymal progenitors (MPs) from cancer-induced cachectic mouse muscle.

51 erved in the cardiac and skeletal muscles of cachectic murine models.

52 n cachexia, which was noticeably elevated in cachectic murine serum.

53 e results suggest that UBR2 up-regulation in cachectic muscle is mediated by the p38beta-C/EBPbeta si

54 roducers of activin A, which in turn induces cachectic muscle loss.

55 Cachectic muscle wasting is a frequent complication of m

56 rs, and we verify their expression by MPs in cachectic muscle.

57 of this pathway (that is, SDF1 or CXCR4) in cachectic muscles increased the fiber area by 20%, prote

58 whose expression is specifically altered in cachectic muscles of Yoshida hepatoma-bearing rodents bu

59 ed SIRT1 loss induced NF-kappaB signaling in cachectic muscles that enhanced the expression of FOXO t

60 were significantly changed in the irradiated cachectic NHP compared to the non-irradiated NHP.

61 Radiographic imaging indicated that cachectic NHP lost as much as 50% of skeletal muscle.

62 was found to have a stronger correlation to cachectic organ volume loss than tumor volume, giving su

63 he ergoreflex was particularly overactive in cachectics (P<0.05), accompanied by marked muscle mass d

64 Mortality in the cachectic patients (n = 28) was 18% at 3 months, 29% at

65 Dehydroepiandrosterone was reduced in the cachectic patients (P<.02 versus control subjects).

66 ion are increased in both morbidly obese and cachectic patients compared with normal-weight recipient

67 not increased in morbidly obese patients but cachectic patients had a significantly lower incidence o

68 Compared with healthy control subjects, cachectic patients had reduced (appendicular) muscle mas

69 control subjects and noncachectic patients, cachectic patients had reduced plasma sodium and increas

70 Cachectic patients had the lowest blood flow (p < 0.002)

71 Cachectic patients receiving oversized donor hearts had

72 Cachectic patients showed an increase of total GH and im

73 In cachectic patients with advanced cancer, oral melatonin

74 th factor-I (IGF-I) axis were compared in 21 cachectic patients with CHF, 51 noncachectic patients an

75 Shortened survival applies particularly to cachectic patients with localized disease, thereby reinf

76 3B gradually increased from precachectic to cachectic patients, without differences in E3 ubiquitin

77 exercise limitation in CHF, particularly in cachectic patients.

78 ed weight loss in Alzheimer disease, even in cachectic patients.

79 Cachectic PDAC KIC mice exhibit severe sarcopenia with l

80 ing depleting anti-Ly6G Abs, attenuated this cachectic phenotype.

81 expressing AP neurons also attenuates cancer cachectic phenotypes and AP network hyperactivity.

82 promotes systemic inflammation, resulting in cachectic phenotypes.

83 In the cachectic population, the ventilatory response from ergo

84 crease muscle mass in athletes and also aged/cachectic populations.

85 istal loss of muscle and fat mass during the cachectic process is still not deeply investigated.

86 y was seen at 30 days for morbidly obese and cachectic recipients (12.7% and 17.7%, respectively) ver

87 Morbidly obese as well as cachectic recipients demonstrated nearly twice the 5-yea

88 patients and the use of oversized donors in cachectic recipients should be avoided.

89 s underlying mitochondrial remodeling in the cachectic skeletal muscle, through an integrative explor

90 We sought to find out whether the cachectic state in CHF provides additional prognostic in

91 The cachectic state is a strong independent risk factor for

92 The cachectic state is predictive of poor survival independe

93 The cachectic state was predictive of 18-month mortality ind

94 ss of estrogen treatment alone on BMD in the cachectic state.

95 involving organ crosstalks that underlie the cachectic state.

96 L-1alpha, IL-1beta, and TNFalpha can mediate cachectic states, how these molecules affect energy expe

97 The cachectic status was defined prospectively as a non-inte

98 e N-end rule pathway that is up-regulated by cachectic stimuli including proinflammatory cytokines an

99 -1alpha is elevated in the sera and liver of cachectic, suggesting a mechanism by which chronic IL-1R

100 The patients with RA were cachectic (their body cell mass was 14% lower than that

101 aller and exhibited profound delipidation in cachectic tumor-bearing mice.

102 S) confirmed the high tCho level observed in cachectic tumors that occurred because of an increase of

103 to identify metabolic signatures typical of cachectic tumors, using this information to analyze the

104 lower creatine levels were also detected in cachectic tumors.