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1 al fibroblast MMP production is regulated by cadherin 11.
2 ion of beta-catenin as well as the oncogenic cadherin 11.
3 ated with downregulation of beta-catenin and cadherin 11.
4 e FLS express other cadherins in addition to cadherin 11.
5 roteins were determined to be N-cadherin and cadherin 11.
6 so expressed a 115-kDa mesenchymal cadherin, cadherin-11.
7 the transmembrane and cytoplasmic domains of cadherin-11.
8 ly in part through the precise regulation of Cadherin-11.
9 nct characteristic of fibroblasts expressing cadherin-11.
10                                  Transfected cadherin-11 also localizes to focal adhesions in differe
11 e anti-inflammatory agent celecoxib can bind cadherin-11, an adhesion molecule important in rheumatoi
12  members and demonstrated distinct roles for cadherin-11 and cadherin-13 in synapse development.
13           However, coexpression of wild-type cadherin-11 and the splice variant promotes a dramatic i
14 nes expressing wild-type cadherin 11, mutant cadherin 11, and empty vector-transfected controls.
15  migration marker genes including Periostin, Cadherin 11, and Mmp2 while repressing markers of valve
16  different classes of cadherins (N-cadherin, cadherin 11, and protocadherin 19) results in homotypic
17 nstrate that FLS express both N-cadherin and cadherin 11, and suggest that these cadherins are not co
18    A set of nine genes that included GPCR11, cadherin 11, annexin A1, vimentin, lactate dehydrogenase
19 dherins using either anti-N-cadherin or anti-cadherin 11 antibodies suggests that these cadherins are
20 ing domains (CBS) in the cytoplasmic tail of cadherin-11 are required for cell migration and invasion
21 ipose tissue inflammation and thus highlight cadherin-11 as a potential therapeutic target for the ma
22                                We identified cadherin-11 as essential for the development of the syno
23                          Exogenous wild-type cadherin-11 association with and membrane recruitment of
24 unctionally important binding partner of the Cadherin-11/B-Catenin complex in zipper-like cell-to-cel
25 asts can be targeted by mAb directed against cadherin-11 (cad-11), a mesenchymal cadherin that fibrob
26                                              Cadherin-11 (Cad-11, also known as OB cadherin or CDH11)
27                          Expression of human cadherin-11 (Cad11), also known as osteoblast cadherin,
28    However, despite the lack of cell surface cadherin 11, cadherin 11-null mouse FLS cells still form
29 We developed L cell transfectants expressing cadherin-11, cadherin-11 fusion proteins, and anti-cadhe
30  three of the ten candidates in human urine: cadherin 11 (CDH11), macrophage mannose receptor C1 (MRC
31 a1 and its downstream effector, OB-cadherin [cadherin 11 (CDH11)], regulate porcine myofibroblast phe
32                      Among various proteins, Cadherin-11 (CDH11) has been reported to be overexpresse
33                                              Cadherin-11 (CDH11) is increased in wound healing and fi
34 ive candidate biomarkers of kidney fibrosis: Cadherin-11 (CDH11), Sparc-related modular calcium bindi
35                          In focal adhesions, cadherin-11 co-localizes with beta1-integrin and paxilli
36 hered to cadherin-11-Fc, and transfection of cadherin-11 conferred the formation of tissue-like sheet
37 ehavior of L cells stably transfected with a cadherin 11 construct that lacked the juxtamembrane cyto
38 und pool of beta-catenin associated with the cadherin-11 cytoplasmic domain.
39           Together, these data implicate the cadherin-11 cytoplasmic JMD as a regulator of alpha-cate
40                                              Cadherin-11-deficient mice displayed increased stromal p
41                                              Cadherin-11-deficient mice have a hypoplastic synovial l
42         Higher expression levels of IL-33 in cadherin-11-deficient mice mediated ILC2 activation, res
43 nt with reduced adipose tissue inflammation, cadherin-11-deficient mice were protected from obesity-i
44       Furthermore, the actin cytoskeleton in cadherin-11 deltaJMD cells revealed a more extensive cor
45 rcalation into monolayers reflecting reduced cadherin-11-dependent cell motility on other cells.
46                               Thus, synovial cadherin-11 determines the behavior of synovial cells in
47                    Additionally, cleavage of cadherin-11 does not affect binding to beta-catenin and
48 proteases cleave the extracellular domain of cadherin-11 during CNC migration.
49                                              Cadherin 11 engagement stimulates increased synthesis of
50                                     To mimic cadherin 11 engagement, human RA synovial fibroblasts we
51             This up-regulation required cell cadherin 11 engagement, since a mutant Cad-11-Fc with re
52 gan culture system, we provide evidence that cadherin-11 expressed in fibroblast-like synoviocytes pl
53                                              Cadherin-11-expressing cells exhibit modest changes in c
54         The downregulation of cadherin-11 in cadherin-11-expressing metastatic PC3 cells decreases ce
55 cluding MMP-7 and MMP-15, are upregulated in cadherin-11-expressing, but not in cad11-DeltaJMD-expres
56                                              Cadherin 11 expression in rheumatoid synovial tissue was
57                                              Cadherin 11 expression was observed at points of cell-ce
58                   These results suggest that cadherin-11 expression may be well correlated with the i
59                               Interestingly, cadherin-11 expression was also detected via immunohisto
60  with a chimeric construct consisting of the cadherin 11 extracellular domain linked to the human IgG
61              Furthermore, treatment with the cadherin 11-Fc fusion protein diminished the invasive ca
62 st-like synoviocytes treated with a blocking cadherin 11-Fc fusion protein or control immunoglobulin
63 blast-like synoviocyte organ cultures with a cadherin-11-Fc fusion protein efficiently abrogated lini
64                               FLS adhered to cadherin-11-Fc, and transfection of cadherin-11 conferre
65                              Here, we cloned cadherin-11 from human rheumatoid arthritis (RA)-derived
66                     We provide evidence that Cadherin-11 functions as target of the Prdm8/Bhlhb5 repr
67 L cell transfectants expressing cadherin-11, cadherin-11 fusion proteins, and anti-cadherin-11 mAb.
68 reates a fusion gene in which the osteoblast cadherin 11 gene (CDH11) promoter region on 16q22 is jux
69                                              Cadherin 11 has recently been identified on fibroblast-l
70                                   Absence of cadherin 11 in a mouse rheumatoid arthritis (RA) model l
71                     Abundant connexin 43 and cadherin 11 in pellets demonstrated cell-cell junctions
72  these in vitro studies implicate a role for cadherin 11 in promoting cell invasion and contribute in
73                       To examine the role of cadherin 11 in regulating the invasive behavior of fibro
74            Expression of both N-cadherin and cadherin 11 in the synovial lining was demonstrated by i
75                        The downregulation of cadherin-11 in cadherin-11-expressing metastatic PC3 cel
76             Here, we show that expression of cadherin-11 in cadherin-11-negative C4-2B4 cells increas
77            Together, these studies implicate cadherin-11 in synovial tissue and lining layer formatio
78  antigen (LFA)-1], alpha4beta1 integrin, and cadherin-11 in the development of synovial inflammation.
79        These findings support a key role for cadherin-11 in the specific adhesion of FLS and in synov
80  the expression of the mesenchymal cadherin, cadherin-11, in breast cancer cell lines.
81                                              Cadherin 11 is a homophilic cell-to-cell adhesion molecu
82   Immunohistochemical analysis revealed that cadherin 11 is abundantly expressed in cells at the cart
83  N-cadherin, P-cadherin, and the mesenchymal cadherin-11 is actually elevated in invasive breast canc
84                            The "mesenchymal" cadherin-11 is expressed in the CNC during migration yet
85        At the time of mesenchymal induction, cadherin-11 is expressed in the mesenchyme but not in th
86              However, the mechanism by which cadherin-11 is involved in this process is not known.
87                                              Cadherin-11 is localized to a detergent-soluble pool and
88               Immunocytochemistry shows that cadherin-11 is localized to the cell membrane at sites o
89                                              Cadherin-11 is unique among cadherins in that it exists
90                               In particular, cadherin-11 is upregulated during tumour and inflammator
91         We found that expression of a mutant cadherin-11 lacking the cytoplasmic juxtamembrane domain
92                           Here, we show that cadherin-11 localizes to focal adhesions and promotes ad
93                            Importantly, anti-cadherin-11 mAb blockade similarly improved inflammation
94 in-11, cadherin-11 fusion proteins, and anti-cadherin-11 mAb.
95                                              Cadherin-11 may mediate the interaction between malignan
96                                We found that cadherin-11 mediated fibroblast-like synoviocyte cell-to
97 e embryo, suggesting that a defined level of cadherin-11-mediated cell adhesion is required for migra
98               Here, we show that mesenchymal cadherin-11 modulates stromal fibroblast function.
99                                              Cadherin-11 mRNA and protein, as well as a variant form,
100 generated L cell clones expressing wild-type cadherin 11, mutant cadherin 11, and empty vector-transf
101 e, we show that expression of cadherin-11 in cadherin-11-negative C4-2B4 cells increases their spread
102              These observations suggest that cadherin-11 not only provides a physical link between PC
103 determined in FLS derived from wild-type and cadherin 11-null mice using immunofluorescence (IF), bio
104 from wild-type mice and 1 in FLS sample from cadherin 11-null mice.
105 espite the lack of cell surface cadherin 11, cadherin 11-null mouse FLS cells still formed intimate c
106 obox 1, loss of E-cadherin, up-regulation of cadherin 11, p120 isoform switching, activation of extra
107 ates including itself, fibronectin, ephrinB, cadherin-11, pcdh8 and pcdh8l (this work).
108 herin-11 splice variant promotes invasion of cadherin-11-positive breast cancer cells.
109                                  Cleavage of cadherin-11 produces an extracellular fragment that prom
110 mediated by FGF receptor signaling; and that cadherin-11 promotes epithelial cell motility in a manne
111             We propose that ADAM cleavage of cadherin-11 promotes migration by modifying its ability
112 ansferase 1 (DNMT1) and a 6-fold decrease in cadherin 11 protein expression.
113 ent also resulted in increased expression of cadherin-11 protein in human tumor biopsies in three out
114  suggest that stromal fibroblasts expressing cadherin-11 regulate adipose tissue inflammation and thu
115 derscore the existence of a pathway by which cadherin 11 regulates MMP production and has important i
116 t corresponding to the putative shed form of cadherin-11 retains biological activity by promoting CNC
117 erent mammalian cell lines, while endogenous cadherin-11 shows focal adhesion localization in primary
118              Also, short hairpin RNA (shRNA) cadherin 11 silencing almost completely inhibited Cad-11
119  These data suggest that the presence of the cadherin-11 splice variant promotes invasion of cadherin
120 cell invasion, but the mechanisms underlying cadherin-11 stimulated cell migration are still incomple
121 s and other cell types that normally express cadherin-11, such as stromal cells or osteoblasts or per
122          Adhesion to fibronectin mediated by cadherin-11/syndecan-4 complexes requires both the extra
123                                              Cadherin-11 therapeutics prevent and reduce arthritis in
124 emonstrated colocalization of N-cadherin and cadherin 11 to the same points of cell-cell contact.
125  crest (CNC) cell migration both by cleaving cadherin-11 to release a promigratory extracellular frag
126 ated a 2-fold increased invasive capacity of cadherin 11-transfected L cells compared with L cells tr
127 n cancer cells maintained in 3D (P < 0.001), cadherin-11 was downregulated (P < 0.001) and HER2 incre
128                                              Cadherin-11 was found to be expressed mainly in the syno
129                                    Recently, cadherin-11 was identified on fibroblast-like synoviocyt
130                One such potential biomarker, cadherin-11, was further evaluated at the protein level
131                       Cadherin-8, as well as cadherin-11, was mapped to a specific region of chromoso
132 alpha, and a cellular adhesion protein gene, cadherin 11, were markedly regulated in response to diff
133 ownstream targets of CXCR7/RDC1 are CD44 and cadherin-11, which are likely to contribute to the invas
134 has a propensity to metastasize to bone, and cadherin-11, which is an osteoblast cadherin aberrantly
135     We now show that expression of wild-type cadherin-11, with or without coexpression of the COOH-te
136 of the specific combination of renal markers cadherin-11, WT-1, Pax-2, and Wnt-4.

 
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