ライフサイエンスコーパス: calcific

1 NH-White women had higher fibro-calcific (256 mm3/cm2, P=0.002) and fibrotic volumes (14

2 High-gradient AS had higher fibro-calcific (295 versus 219 mm(3)/cm(2); P<0.001) and calci

3 he presence and severity of abdominal aortic calcific (AAC) deposits at the levels of the first throu

4 Aortic stenosis (AS) involves calcific and fibrotic degeneration of the valve tissue.

5 Calcific and noncalcific tendinitis of the shoulder can

6 ified the AV tissue composition by fibrotic, calcific, and fibro-calcific volumes, and the fibro-calc

7 There was no difference in total, calcific, and noncalcific plaque volume progression.

8 have experienced a rise in the prevalence of calcific aortic and mitral disease, owing in part to pop

9 The prevalence of calcific aortic stenosis (AS) and of cardiac amyloidosis

10 RATIONALE: Calcific aortic stenosis (AS) is characterized by calciu

11 Calcific aortic stenosis (AS) is characterized by calciu

12 gh highly heritable, the genetic etiology of calcific aortic stenosis (AS) remains incompletely under

13 Calcific aortic stenosis (AS) restricts the aortic valve

14 , there are no proven medical treatments for calcific aortic stenosis (AS).

15 Calcific aortic stenosis (cAS) affects 3% of individuals

16 mphocytes infiltrating the valve leaflets in calcific aortic stenosis (CAS) and determine whether the

17 Calcific aortic stenosis (CAS) is the most common valvul

18 Valve lesions in degenerative calcific aortic stenosis (CAS), a disorder affecting 3%

19 (n = 22) and patients with mild to moderate calcific aortic stenosis (mi-moAS, n = 17), severe calci

20 rolled trial, patients >50 years of age with calcific aortic stenosis (peak aortic jet velocity >2.5

21 ients (mean age, 72 8 years; 21% women) with calcific aortic stenosis (peak aortic jet velocity, 3.36

22 to Treat Osteoporosis on the Progression of Calcific Aortic Stenosis 2) of participants with mild or

23 Calcific aortic stenosis and degenerative mitral regurgi

24 By contrast, the prevalence of calcific aortic stenosis and degenerative mitral valve d

25 Transcatheter devices designed for calcific aortic stenosis are not optimised for use in na

26 dient of >30 mm Hg were found to have severe calcific aortic stenosis at operation.

27 Human calcific aortic stenosis cusps demonstrated immunohistoc

28 Meanwhile, deaths from calcific aortic stenosis have continued to rise in the p

29 vement of other valves, together with senile calcific aortic stenosis have emerged as the most common

30 The pathobiology of calcific aortic stenosis involves an active inflammatory

31 BACKGROUND AND PURPOSE: Calcific aortic stenosis is a chronic inflammatory disea

32 Calcific aortic stenosis is a common disease, and some o

33 "Degenerative" or calcific aortic stenosis is a complex, multifaceted, sys

34 Calcific aortic stenosis is a progressive disease with n

35 Prevalence of calcific aortic stenosis is growing in ageing population

36 t studies have supported the hypothesis that calcific aortic stenosis is the product of an active inf

37 Calcific aortic stenosis is the third most common cardio

38 2% of individuals >60 years are affected by calcific aortic stenosis to the extent that surgical int

39 A randomized clinical trial of patients with calcific aortic stenosis undergoing SAVR at 18 North Ame

40 ean age 68+/-12 years) with mild to moderate calcific aortic stenosis was conducted.

41 On progression to its most severe form, calcific aortic stenosis, CAVD becomes debilitating and

42 sclerotic cardiovascular disease (ASCVD) and calcific aortic stenosis, with no pharmacological treatm

43 Native leaflets showed persistent calcific aortic stenosis-like disease activity with posi

44 Following TAVR, there is ongoing calcific aortic stenosis-like disease with architectural

45 e procedure in high-risk adult patients with calcific aortic stenosis.

46 have failed to demonstrate the reduction of calcific aortic stenosis.

47 hanistically involved in the pathobiology of calcific aortic stenosis.

48 re additional etiological factors for senile calcific aortic stenosis.

49 aortic valve calcification in patients with calcific aortic stenosis.

50 =65 years of age who were undergoing AVR for calcific aortic stenosis.

51 redicts disease progression in patients with calcific aortic stenosis.

52 eview focuses on technologies at the core of calcific aortic valve disease (CAVD) and drug target res

53 Calcific aortic valve disease (CAVD) and stenosis have a

54 Calcific aortic valve disease (CAVD) increasingly afflic

55 Calcific aortic valve disease (CAVD) is a highly prevale

56 Calcific aortic valve disease (CAVD) is a prevailing dis

57 Calcific aortic valve disease (CAVD) is a prevalent valv

58 Calcific aortic valve disease (CAVD) is a widely prevale

59 Calcific aortic valve disease (CAVD) is an increasingly

60 Calcific aortic valve disease (CAVD) is characterized by

61 Calcific aortic valve disease (CAVD) is common in people

62 Calcific aortic valve disease (CAVD) is the most common

63 Calcific aortic valve disease (CAVD) is the most common

64 Calcific aortic valve disease (CAVD) is the most common

65 Calcific aortic valve disease (CAVD) is the most common

66 Calcific aortic valve disease (CAVD) occurs when subpopu

67 An insufficient understanding of calcific aortic valve disease (CAVD) pathogenesis remain

68 The morbidity and mortality rates of calcific aortic valve disease (CAVD) remain high while t

69 Calcific aortic valve disease (CAVD) resulting in aortic

70 In calcific aortic valve disease (CAVD), activated T lympho

71 lecular pathways constituting biomarkers for calcific aortic valve disease (CAVD), including extra-ce

72 In calcific aortic valve disease (CAVD), mechanosensitive v

73 xPL-apoB and Lp(a) have been associated with calcific aortic valve disease (CAVD).

74 t lipoprotein(a) [Lp(a)] was associated with calcific aortic valve disease (CAVD).

75 ein-associated phospholipase A2 (Lp-PLA2) in calcific aortic valve disease (CAVD).

76 genetic and potentially causal mediators of calcific aortic valve disease allows opportunities for t

77 olved in myxomatous mitral valve disease and calcific aortic valve disease and to redefine the term d

78 Phosphate may be a novel risk factor for calcific aortic valve disease and warrants further study

79 Human control and calcific aortic valve disease aortic valve leaflets and

80 sights suggest that the processes leading to calcific aortic valve disease are metabolically active f

81 Ten-year absolute risk of calcific aortic valve disease by categories of lipoprote

82 of particularly dire clinical relevance, as calcific aortic valve disease can progress rapidly to ao

83 Calcific aortic valve disease currently lacks effective

84 cal therapies that impact the progression of calcific aortic valve disease do not currently exist.

85 (vi) The incidence of calcific aortic valve disease has increased seven-fold d

86 ionship between C-reactive protein (CRP) and calcific aortic valve disease in a large, randomly selec

87 The 10-year absolute risk of calcific aortic valve disease increased with higher lipo

88 we review the role of hemodynamic forces in calcific aortic valve disease initiation and progression

89 erstanding of the complex mechanisms driving calcific aortic valve disease initiation and progression

90 Calcific aortic valve disease is a common condition and

91 NA methylation in the promoter of H19 during calcific aortic valve disease is associated with a highe

92 Calcific aortic valve disease is characterized by an abn

93 Calcific aortic valve disease is common in the elderly,

94 Calcific aortic valve disease is dramatically increasing

95 The prevalence of calcific aortic valve disease is increasing with aging o

96 y sought to test the hypothesis that risk of calcific aortic valve disease is the highest when both p

97 Calcific aortic valve disease is the most common indicat

98 Calcific aortic valve disease is the pathological remode

99 pharmacotherapy has proven effective to halt calcific aortic valve disease progression, with invasive

100 stics and therapeutics to alleviate or delay calcific aortic valve disease progression.

101 Calcific aortic valve disease sits at the confluence of

102 This review highlights aspects of calcific aortic valve disease that encompass the entire

103 and STAT5 are upregulated and colocalized in calcific aortic valve disease tissue compared with contr

104 ss index, the multivariable adjusted HRs for calcific aortic valve disease were 1.6 (95% CI: 1.3-1.9)

105 a]) increase the risk of atherosclerosis and calcific aortic valve disease, affecting millions of pat

106 leads to bicuspid aortic valve formation and calcific aortic valve disease, but knowledge is very lim

107 In calcific aortic valve disease, the valve cusps undergo r

108 patients (age 72+/-8 years, 30% women) with calcific aortic valve disease, therefore predisposed to

109 rapies, these do not reduce Lp(a) or risk of calcific aortic valve disease, which has no available dr

110 bolism markers as potential risk factors for calcific aortic valve disease.

111 index together conferred a 3.5-fold risk of calcific aortic valve disease.

112 ein(a) and high body mass index with risk of calcific aortic valve disease.

113 mass index are both causal risk factors for calcific aortic valve disease.

114 f lncRNAs and the DNA methylation pattern in calcific aortic valve disease.

115 ented that lncRNA H19 (H19) was increased in calcific aortic valve disease.

116 Calcific aortic valve sclerosis involves inflammatory pr

117 chocardiographic or radiological evidence of calcific aortic valve sclerosis, an early and subclinica

118 Calcific aortic valve stenosis (AS) is a life-threatenin

119 Calcific aortic valve stenosis (CAVS) is a frequent and

120 Calcific aortic valve stenosis (CAVS) is a major health

121 ntribute to cardiovascular disease (CVD) and calcific aortic valve stenosis (CAVS) is substantial.

122 Calcific aortic valve stenosis (CAVS) is the most freque

123 ery disease (CAD), ischemic stroke (IS), and calcific aortic valve stenosis (CAVS).

124 e is currently no medical therapy to prevent calcific aortic valve stenosis (CAVS).

125 ) levels will effectively reduce the risk of calcific aortic valve stenosis and CVD.

126 n are strong risk factors for development of calcific aortic valve stenosis and predict severity of t

127 cent studies that highlight Lp(a) in CVD and calcific aortic valve stenosis and propose pathways to c

128 t elevated Lp(a) is causally associated with calcific aortic valve stenosis and the need for aortic v

129 educe the risk of cardiovascular disease and calcific aortic valve stenosis in patients with elevated

130 tic underpinning for PALMD's contribution to calcific aortic valve stenosis pathology.

131 c risk factor for cardiovascular disease and calcific aortic valve stenosis, but no approved specific

132 Atrial fibrillation, calcific aortic valve stenosis, mitral regurgitation, an

133 hypertension, diabetes, atrial fibrillation, calcific aortic valve stenosis, mitral regurgitation, an

134 atherosclerotic cardiovascular disease, and calcific aortic valve stenosis.

135 tic valve samples derived from patients with calcific aortic valve stenosis.

136 ties including ascending aortic dilation and calcific aortic valve stenosis.

137 ions with existing cardiovascular disease or calcific aortic valve stenosis.

138 a risk factor for cardiovascular disease and calcific aortic valve stenosis.

139 factor for cardiovascular disease (CVD) and calcific aortic valve stenosis.

140 e system for treatment of severe symptomatic calcific aortic valve stenosis.

141 in the endothelial and deeper cell layers of calcific aortic valve tissue but not in normal aortic va

142 eins in nonfibrotic/noncalcific and fibrotic/calcific aortic valve tissues by proteomics and immunohi

143 Microarray profiling of human calcific aortic valves and normal controls demonstrated

144 ed in atherogenesis, is upregulated in human calcific aortic valves.

145 hat DUSP26 was significantly up-regulated in calcific aortic valves.

146 here is no known pharmacological therapy for calcific aortic valvular sclerosis or stenosis.

147 ation between CRP levels and the presence of calcific aortic-valve disease or incident aortic stenosi

148 ppears to be a poor predictor of subclinical calcific aortic-valve disease.

149 d the morphologic features characteristic of calcific AoV stenosis, whereas less flow dependence was

150 nosteogenic mechanisms, such as formation of calcific apoptotic nodules.

151 roscopic examination revealed that acellular calcific areas were surrounded by DiI-labeled TBMCs, sug

152 of cardiovascular causes, including advanced calcific arterial and valvular disease; however, the mec

153 ecognized than is the case for age-dependent calcific arterial changes, are not easily extrapolated t

154 eas-kidney transplant recipients with severe calcific arterial disease.

155 ic aortic stenosis (mi-moAS, n = 17), severe calcific AS (sAS, n = 26), and both sAS and severe coron

156 Calcific AS is a common chronic progressive condition am

157 Calcific AS is characterized by aortic valve leaflet lip

158 Data from 889 patients, mainly White, with calcific AS who underwent Doppler echocardiography and m

159 genesis and as markers of prognostication of calcific AS.

160 d atherosclerosis and Alzheimer's disease to calcific AS.

161 ontrol subjects and compared with those with calcific atherosclerosis (calcium score >0).

162 Calcific atherosclerosis is a major challenge to intralu

163 affecting 2 siblings with aortic hypoplasia, calcific atherosclerosis, systolic hypertension, and pre

164 ed arterial bed confirmed uptake in areas of calcific atherosclerotic plaque on intravascular imaging

165 s10455872), associated with Lp(a) levels, in calcific AVS.

166 chanistically based approach and may prevent calcific bioprosthetic heart valve failure.

167 nary arteries from patients with and without calcific cardiovascular disease and detected spherical c

168 into pathophysiological processes underlying calcific cardiovascular disease.

169 of nuclear factor-kappaB ligand signaling in calcific cardiovascular disease.

170 opic therapy failed to benefit patients with calcific chronic pancreatitis.

171 AV calcification, and greater expression in calcific compared with normal or fibrotic AV tissue.

172 Background Quantifying the fibrotic and calcific composition of the aortic valve at CT angiograp

173 t with limited cutaneous scleroderma in whom calcific constrictive pericarditis developed.

174 However, calcific constrictive pericarditis is considered rare in

175 valuation of Treatment Strategies for Severe Calcific Coronary Arteries: Orbital Atherectomy Versus C

176 owth factor beta1 activity may predispose to calcific degeneration.

177 ptomatic status and outcome of patients with calcific degenerative aortic stenosis (AS).

178 Vascular function in calcific degenerative AS is conditioned by the upstream

179 heterogenous soft tissue mass with internal calcific densities was noted in the retroperitoneum.

180 ne the relative prognostic value of coronary calcific deposits and coronary angiographic findings for

181 wledge of the typical locations of cartilage calcific deposits as well as their appearance on various

182 Calcific deposits develop in 20-40% of children with juv

183 BAC is defined as two linear calcific deposits forming the rail-road track pattern, w

184 We examined calcific deposits from 5 children with juvenile DM (2 bo

185 Anterior and posterior wall calcific deposits in the aorta at the level of the first

186 M and EDX analyses confirmed the presence of calcific deposits in the interior of the opacified hydro

187 3 (91%) had hypertension, 26 (29%) had small calcific deposits in the valve cusps, and 46 (51%) had s

188 The radiographic finding of abdominal aortic calcific deposits is an indicator of the presence of aor

189 The impact of abdominal arterial calcific deposits on the prediction of cardiovascular di

190 space with contiguous extracellular matrix, calcific deposits, and microvessels.

191 n osteogenic cell fate and creating damaging calcific deposits, which can be prevented by inhibiting

192 symptom relief associated with rotator cuff calcific deposits.

193 that can be useful for the fragmentation of calcific deposits.

194 mes in percutaneous coronary intervention in calcific disease and the evidence supporting these tools

195 umerous biological processes are involved in calcific disease, including matrix remodelling, transcri

196 ic patient with advanced peripheral arterial calcific disease, who had frequent life-threatening epis

197 rreflectivity, which matched with regressing calcific drusen as visualized by cSLO infrared (IR) and

198 lar disease and opens up new perspectives on calcific EV biogenesis, release and functions within and

199 r repeatability for fibrotic (ICC, 0.99) and calcific (ICC, 0.99) aortic valve tissue volume measurem

200 ast-like properties, thereby fostering fibro-calcific leaflet remodelling and eventually resulting in

201 g from microscopic changes to profound fibro-calcific leaflet remodelling, culminating in aortic sten

202 Calcific leaflets also exhibit tenascin-C, which may fac

203 cal particles may play a fundamental role in calcific lesion formation.

204 Retrospective review of records revealed 112 calcific lesions in 80 women (aged 31-85 years) who unde

205 s of age, Sox9(fl/+);Col2a1-cre mice develop calcific lesions in heart valve leaflets associated with

206 is a new technique for treatment of severely calcific lesions that uses acoustic shock waves in a bal

207 ate particles, regardless of the presence of calcific lesions.

208 in contributing osteoprogenitor cells to the calcific lesions.

209 nal coronary atherectomy in the treatment of calcific lesions.

210 ne for BMP-6, which is expressed in vascular calcific lesions.

211 Computed tomography-guided aspiration of the calcific masses was performed, and material aspirated fr

212 tant to understand the mechanisms leading to calcific mineral deposition and growth from the earliest

213 calcified human plaques, we demonstrate that calcific mineral formation and maturation results from a

214 Prevalence of calcific mitral stenosis (MS) increases with age; howeve

215 We analyzed long-term results of PMC for calcific mitral stenosis and the factors associated with

216 d outcome of 314 patients undergoing PMC for calcific mitral stenosis with 710 patients with noncalci

217 h late results of PMC are less satisfying in calcific mitral stenosis, long-term functional outcome d

218 rst-line treatment in selected patients with calcific mitral stenosis.

219 itral commissurotomy (PMC) remain debated in calcific mitral stenosis.

220 confidence in the ability to assess vascular calcific morphology in all studies with complementary un

221 rvations is uncertain, but the predominantly calcific morphology of the plaques in athletes indicates

222 ely investigated adults with isolated severe calcific MS and mitral valve area <=1.5 cm(2) from July

223 Patients with isolated severe calcific MS had a high burden of comorbidities, resultin

224 Of 491 patients with isolated severe MS, calcific MS was present in 200 (41%; age 78 +/- 11 years

225 all-cause mortality in patients with severe calcific MS.

226 Broncholithiasis occurs when peribronchial calcific nodes produce bronchial obstruction.

227 or erosion, but other mechanisms, including calcific nodules, embolism, spontaneous coronary artery

228 nd 12 months to assess progression of total, calcific, noncalcific, and low-attenuation plaque (necro

229 omputed Tomography (CT) was done to rule out calcific or soft plaques of the coronary arteries, small

230 intrinsic mitral valve disease (myxomatous, calcific, or ischemic MR).

231 tio, 83; P < 0.00001), 3 of 15 with tropical calcific pancreatitis (20%; odds ratio, 11.2; P = 0.04),

232 ulous pancreatic diabetes (n = 22), tropical calcific pancreatitis (n = 15), and non-insulin-dependen

233 Tropical pancreatitis, including tropical calcific pancreatitis and fibrocalculous pancreatic diab

234 mutation was identified in 1 of 15 tropical calcific pancreatitis patients.

235 trial was conducted in patients with chronic calcific pancreatitis undergoing Frey's procedure.

236 fibrocalculous pancreatic diabetes, tropical calcific pancreatitis, and non-insulin-dependent diabete

237 om rheumatic heart disease to a degenerative calcific pathogenesis.

238 contemporary theory related to the cause of calcific periarthritis and provide the latest evidence a

239 Contemporary theory suggests calcific periarthritis is the result of a cellular-media

240 al complications and resulted in substantial calcific plaque fracture in most lesions.

241 ulti-Ethnic Study of Atherosclerosis in whom calcific plaque was detected with CT.

242 percentage of coronary arteries affected by calcific plaque, was calculated for 3252 participants in

243 Male athletes demonstrated predominantly calcific plaques (72.7%), whereas sedentary males showed

244 Calcific plaques are more resistant to undergoing change

245 ug delivery, and controlled OAS treatment of calcific plaques resulted in greater drug permeability a

246 Calcific plaques, especially when present behind a previ

247 mature heart valves is sufficient to promote calcific processes in vitro, which can be attenuated by

248 88 mm(3)/cm(2); P<0.001), and a lower fibro-calcific ratio (0.90 versus 1.45; P<0.001), although no

249 ic volumes (145 mm3/cm2; P<0.001), and fibro-calcific ratio (1.57; P=0.01) compared with Hispanic and

250 c, and fibro-calcific volumes, and the fibro-calcific ratio (fibrotic/calcific volume) as a measure o

251 e disease-prone fibrosa and colocalized with calcific regions as detected by immunohistochemistry.

252 A rigid material was used for printing calcific regions, and a rubber-like material was used fo

253 s superior mechanical, hemocompatibility and calcific resistance properties in comparison with GORE-T

254 ia of the artery, known as Monckeberg medial calcific sclerosis, is notably different from the intima

255 roving pain and shoulder function in chronic calcific shoulder tendinitis and can result in complete

256 ICA confirmed 81% of calcific stenoses, 91% of mixed, and 67% of soft plaques

257 onal atherectomy is best suited for treating calcific stenoses, but the ability of rotational atherec

258 Calcific stenosis occurs frequently in aortic valves but

259 erial 3D printed models replicated the focal calcific structures of aortic stenosis.

260 Clinical aspects of acute calcific tendinitis are also reviewed.

261 The clinical presentation of acute calcific tendinitis can be quite dramatic.

262 gold standard technique for the treatment of calcific tendinitis due to its minimal invasiveness and

263 Calcific tendinitis frequently affects the rotator cuff

264 function and resorption of calcifications in calcific tendinitis.

265 py may have significant clinical benefit for calcific tendinitis; however, it requires intravenous se

266 US-guided percutaneous irrigation of calcific tendinopathy (local anesthesia, needle lavage,

267 ective case control study, 137 patients with calcific tendinopathy and 137 control group patients wit

268 nificant relationship was determined between calcific tendinopathy and rotator cuff tear.

269 s +/- 11.6; range, 24-69 years) with painful calcific tendinopathy diagnosed at US were prospectively

270 in the control group (37.2%) compared to the calcific tendinopathy group (23.4%) (p < 0.01).

271 Partial thickness was 81.3% in the calcific tendinopathy group and 70.6% in the control gro

272 In the calcific tendinopathy group, there was no significant re

273 Rotator cuff calcific tendinopathy is a common condition caused by th

274 forming US-guided percutaneous irrigation of calcific tendinopathy is procedure duration in hard and

275 Calcific tendinopathy of the rotator cuff is a common co

276 descriptive study included 86 patients with calcific tendinopathy of the rotator cuff treated with u

277 ultrasound-guided puncture and aspiration in calcific tendinopathy of the should in 86 patients treat

278 and aspiration is an effective treatment for calcific tendinopathy of the shoulder, resulting in a hi

279 pathy and 137 control group patients without calcific tendinopathy with shoulder pain, whose age, sex

280 gnaling becomes a new focus for the study of calcific tendinopathy, which affects 1-in-5 people over

281 The patients with calcific tendinopathy, who had been admitted with should

282 pared to patients with shoulder pain without calcific tendinopathy.

283 raphy (US)-guided percutaneous irrigation of calcific tendinopathy.

284 cations in the rotator cuff in patients with calcific tendonitis by using conventional radiography as

285 four patients clinically suspected of having calcific tendonitis of the rotator cuff were included.

286 quantification of aortic valve fibrotic and calcific tissue composition at CTA versus histologic exa

287 Fibrotic and calcific tissue composition were quantified using a vali

288 At CTA, fibrotic and calcific tissue composition were quantified using automa

289 ) 6, IL-1beta and TNFalpha isolated from the calcific tissues in JDM have also been implicated in the

290 Accurate identification of risk factors for calcific uremic arteriolopathy (CUA) is necessary to dev

291 (3) YKL-40 protein expression in human calcific valves co-localized with its putative receptor

292 s patients include catheters, AV grafts, and calcific valvular disease, all in conjunction with frequ

293 x9 function as a potential genetic basis for calcific valvular disease.

294 stological similarities between coronary and calcific valvular heart disease (aortic stenosis [AS] an

295 ted the association between apoE alleles and calcific valvular lesions in 802 patients undergoing tra

296 The only available therapeutic options for calcific vascular and valvular heart disease are invasiv

297 ular diseases, including atherosclerosis and calcific vasculopathies.

298 s or strategies for clinical intervention in calcific vasculopathies.

299 apoD, apoL-I, and apoM) were enriched in the calcific versus nonfibrotic/noncalcific tissues.

300 umes, and the fibro-calcific ratio (fibrotic/calcific volume) as a measure of valve phenotype.

301 ic (295 versus 219 mm(3)/cm(2); P<0.001) and calcific volumes (148 versus 88 mm(3)/cm(2); P<0.001), a

302 composition by fibrotic, calcific, and fibro-calcific volumes, and the fibro-calcific ratio (fibrotic