ライフサイエンスコーパス: calcified

1 lular immune reaction and ova (viable and/or calcified).

2 luded; 30 (25.2%) were moderately or heavily calcified.

3 ion length was 8.3 cm, and 44% were severely calcified.

4 lying plaque type (lipid: 0.63+/-1.23 mm(2); calcified: 0.81+/-1.44 mm(2); and fibrous: 1.20+/-1.52 m

5 uted tomography (CT) lesion was described as calcified (24x22x17.5 mm), connected with posterior leaf

6 Mg/Ca ratios of these Arctic-wide occurring calcified algae are sensitive to changes in both tempera

7 structed coral reef communities comprised of calcified algae, corals, and reef pavement that were ass

8 mRNA expression levels were evaluated in 9 calcified and 8 normal aortic valves by RNA sequencing.

9 Additional prespecified endpoints were non-calcified and calcified plaque measures and high risk pl

10 The difference in cell density between calcified and decalcified cells can explain the differen

11 at using opacity we can discriminate between calcified and decalcified coccolithophores with an accur

12 ated different reflectivity patterns in both calcified and decalcified portions of the choroidal oste

13 low pH, whole colonies found at low pH site calcified and extended their skeleton at the same rate a

14 Affymetrix Human Transcriptome 2.0 arrays in calcified and noncalcified aortic valve tissue from 58 p

15 omas was analyzed by whole-mount staining of calcified and noncalcified human aortic valves, obtained

16 The 1.4-cm nodule has calcified and remains stable and metabolically inactive.

17 UHR CT improves visualization of calcified and stented vessels but may result in increase

18 rare cause of coronary thrombosis in highly calcified and tortious arteries in older individuals.

19 s, whereas others allow treatment of heavily calcified and tortuous segments.

20 d plaque (NCP), low-density NCP (NCP<30 HU), calcified and total plaque volumes, and corresponding pl

21 se To assess the relationship between total, calcified, and noncalcified coronary plaque burdens thro

22 ed as the absolute annual increase in total, calcified, and noncalcified plaque volume by quantitativ

23 areader agreement rates were high for total, calcified, and noncalcified plaques for both CT scanners

24 r stent expansion and the presence of large, calcified, and/or attenuated plaques were independent pr

25 initial loss of calcium was less in heavily calcified aortas and was associated with an increase in

26 To address this, calcified aortas from uremic mice were transplanted orth

27 3) whether, in AS with discordant MG, severe calcified aortic valve disease is generally detected.

28 ent with heavy AVC-load reflective of severe calcified aortic valve disease, emphasizing the clinical

29 lf of the patients were identified as severe calcified aortic valve disease, irrespective of flow.

30 with AS severity, allows diagnosis of severe calcified aortic valve disease.

31 odeling the mineralised material produced in calcified aortic valve disease.

32 ts, predominantly during manipulation of the calcified aortic valve while stent valves were being pos

33 Resected normal and calcified aortic valves were analyzed histologically.

34 In both subjects with normal and with calcified aortic valves, minimum diameter increased in s

35 ingeal arterial calcifications, necrotic and calcified areas in basal ganglia, dentato-olivary dyspla

36 Calcified areas of GA cross-linked tissue showed charact

37 Perl iron-positive signals colocalized with calcified areas or osteoblast-like cells in human vascul

38 hat neointimal hyperplasia is accelerated in calcified arteries and that this may be due in part to i

39 Neointimal cell proliferation in calcified arteries as assessed by proliferating cell nuc

40 e with multipotent and osteogenic markers in calcified arteries by immunostaining and fluorescence-ac

41 Treatments aimed at inhibiting restenosis in calcified arteries may differ from those that work in un

42 also observed ectopic expression of FGF23 in calcified arteries of alpha-kl(-/-) mice, which might ac

43 In calcified arteries, bone morphogenetic protein 2 (BMP-2)

44 ore-reef, turbid water encruster assemblages calcified at a mean rate of 757 (SD +/-317) g m(-2) y(-1

45 These calcified at mean rates of 20.1 (SD +/-27) and 4.0 (SD +

46 dominated by crustose coralline algae which calcified at rates of 105.3 (SD +/-67.7) g m(-2) y(-1) a

47 Thus, patients with a comparable calcified atherosclerosis burden generally carry a simil

48 , suggesting partial confounding by systemic calcified atherosclerosis.

49 althy animal arteries and ~0.1 micromolar in calcified atherosclerotic arteries owing to slower tissu

50 Although extensively calcified atherosclerotic lesions have been proposed to

51 Coronary artery calcified atherosclerotic plaque (CAC) predicts cardiova

52 nosis and can mimic arterial dissection, non-calcified atherosclerotic plaque and intraluminal thromb

53 tive value beyond its association with total calcified atherosclerotic plaque burden as assessed by c

54 Here we revealed that CPB isolated from calcified atherosclerotic plaques and artificially synth

55 with a tailored screening approach; that non-calcified baseline lung nodules greater than 300 mm(3),

56 mineral nanoparticles have been detected in calcified blood vessels, the nature and role of these pa

57 d bone tissue and the vasculature within the calcified bone matrix.

58 ows for rapid, simultaneous visualisation of calcified bone tissue and the vasculature within the cal

59 rapidly cleared all tested organs, including calcified bone, but the fluorescence of proteins and imm

60 ensory system in the premaxilla and a partly calcified braincase, which potentially refines estimates

61 n, there is a lack of information concerning calcified brown algae (Phaeophyta), which are not obliga

62 P2 depletion and increased cytosolic Ca(2+), calcified CaM N lobe interacts with helix B in place of

63 e, we reveal the competition of PIP2 and the calcified CaM N lobe to a previously unidentified site i

64 TE and TT were not associated with calcified carotid plaques in either sex.

65 focused on the intervening tissue, articular calcified cartilage (ACC) and its role in the initiation

66 and spectra were successfully obtained from calcified cartilage and subchondral bone for the first t

67 Bone and calcified cartilage can be fossilized and preserved for

68 There were large discrete areas of calcified cartilage in the hypertrophic zone, few signs

69 tic mice also exhibited an elevated ratio of calcified cartilage to total articular cartilage (CC/TAC

70 gnificantly reduced OARSI scores and CC/TAC (calcified cartilage to total articular cartilage), but i

71 subchondral bone turnover and hypertrophy in calcified cartilage, yet additional mechanical or metabo

72 rs of hypertrophic chondrocytes in articular calcified cartilage.

73 at the boundary of the subchondral bone and calcified cartilage.

74 comes susceptible following focal changes in calcified cartilage.

75 act loaded joints and to explore the role of calcified-cartilage stiffness on the biomechanics of hea

76 ed infection and EhV production, even though calcified cells and associated coccoliths had significan

77 V infection, were generally more abundant in calcified cells and enriched in purified, sorted coccoli

78 e presence of uncalcified CEP (P = .023) and calcified CEP (P = .007) in the sample were strong predi

79 erent combinations of disk, uncalcified CEP, calcified CEP, and subchondral bone components and were

80 direct visualization of the uncalcified and calcified CEP.

81 rt TE MR images, intact disk/uncalcified CEP/calcified CEP/bone samples exhibited bilaminar intermedi

82 the histologic appearance of uncalcified and calcified CEPs.

83 ions in optical absorption stemming from the calcified clusters and the associated cross-linking mole

84 y, known as opacity, to discriminate between calcified coccolithophores and coccolithophores with a c

85 ition in dominance from more to less heavily calcified coccolithophores".

86 ave suggested a worse prognosis after PCI of calcified compared with noncalcified lesions.

87 h between species even when reduced to their calcified components.

88 Whilst calcified coralline algae (Rhodophyta) appear to be espe

89 These well-preserved visual organs comprise calcified corneal lenses that are separated by interveni

90 nary CT angiography in patients with heavily calcified coronary arteries.

91 compared with SR coronary CT angiography of calcified coronary artery lesions, suggesting a potentia

92 and animal calcification models and in human calcified coronary artery.

93 Optimal plaque preparation of calcified coronary lesions is key to prevent stent failu

94 Patients with calcified coronary lesions were screened in 3 centers.

95 strategy for lesion preparation in severely calcified coronary lesions with high success rate, low p

96 n interventional cardiology for treatment of calcified coronary lesions.

97 an important interventional tool for heavily calcified coronary lesions.

98 my (CA) can be utilized in treating severely calcified coronary lesions; however, the temporal trends

99 Pathological studies suggest that calcified coronary nodules are a rare cause of thromboti

100 associated with an increased progression of calcified coronary plaque and a reduced progression of n

101 Although age and sex distributions of calcified coronary plaque have been well described in th

102 We examined the distributions of NCP and calcified coronary plaque in healthy 30- to 74-year-old

103 Atorvastatin reduced non-calcified coronary plaque volume relative to placebo: me

104 In human aortic valves, calcified cusps were stiffer and had more collagen depos

105 s, stent frame underexpansion due to heavily calcified cusps, suboptimal placement of the prosthesis,

106 lly silent, a proportion of individuals with calcified cysticerci develop seizures from these lesions

107 issed by CT in patients with apparently only calcified cysticercosis and could be considered for diag

108 safety and effectiveness of IVL in severely calcified de novo coronary lesions.

109 oup A) primary IVL therapy for patients with calcified de-novo lesions (n=39 lesions), (group B) seco

110 cient DNA from five specimens of Neanderthal calcified dental plaque (calculus) and the characterizat

111 Historic calcified dental plaque (dental calculus) can provide a

112 Calcified dental plaque (dental calculus) preserves for

113 nt a small group of malformations containing calcified dental tissues of both epithelial and mesenchy

114 eby Vn plays an active role in orchestrating calcified deposit formation.

115 anic nanoparticles are found not only within calcified deposits but also in areas devoid of microscop

116 We show that (18)F-NaF adsorbs to calcified deposits within plaque with high affinity and

117 V) (OR, 1.34; 95% CI, 1.04-1.73; P = 0.023), calcified drusen (OR, 1.33; 95% CI, 1.04-1.72; P = 0.025

118 4.24; P = 0.023), the complement pathway and calcified drusen (OR, 3.75; 95% CI, 1.79-7.86; P < 0.001

119 additionally associated with the presence of calcified drusen (P = 5.38 x 10(-6)).

120 ile many severe retinal abnormalities (i.e., calcified drusen, drusenoid pigment epithelium detachmen

121 l periodontitis in adolescents is the partly calcified, dysbiotic bacterial biofilm, which interacts

122 Calcified eggshells protect developing embryos against e

123 tic acid (EDTA) that were designed to target calcified elastic lamina when administrated by intraveno

124 nation of dental fossils, because the highly calcified enamel that covers teeth causes them to be amo

125 The formation of the calcified endoskeleton of the sea urchin embryo is a val

126 ls can be further modulated with time by the calcified environment, thus contributing to the age-depe

127 ontrolling the amount and the quality of the calcified extracellular matrix.

128 ly the close association of macrophages with calcified fibers.

129 s increases-which is relevant to bone and to calcified fibrotic tissues, including diseased muscle.

130 esence of some internal echogenic debris and calcified foci in their dependent part.

131 10% (summer) to >90% (winter) of the heavily calcified form.

132 The calcified, hard-shelled dinosaur egg evolved independent

133 uld be triggered by resuspension of healthy, calcified host cells in an EhV-free, 'induced media'.

134 eNOS expression was reduced in calcified human aortic valves in a side-specific manner.

135 DRP1 protein was observed in calcified human aortic valves, and DRP1 RNA interference

136 scopic analyses of both the hydrogels and of calcified human plaques, we demonstrate that calcific mi

137 ied media of human femoral artery tissue and calcified human valves.

138 Cortical remodeling, limb isometry, and thin calcified hypertrophic metaphyseal cartilages indicate a

139 al environment become relatively more highly calcified, implying a positive climatic feedback.

140 lso suggested that coccolithophores are less calcified in more acidic conditions.

141 2% and 0.6% glutaraldehyde (GA), and further calcified in vitro to simulate graft calcifications upon

142 plaques were noncalcified, 17 mixed, and 22 calcified; in the non-IRAs, 5 plaques were noncalcified,

143 Except for the optical system, as in the calcified lenses of trilobite and ostracod arthropods, o

144 omoting infiltration of macrophages into the calcified lesion to form osteoclast-like cells.

145 er in nonanatomical resection and suspicious calcified lesions in hepatoduodenal ligament were also r

146 -related vascular remodeling and presence of calcified lesions in PAH remain unexplored.

147 p B) secondary IVL therapy for patients with calcified lesions in which noncompliant balloon dilatati

148 safety of intravascular lithotripsy (IVL) in calcified lesions of an all-comers cohort.

149 ndetected viable cysts in patients with only calcified lesions on brain CT.

150 Mean diameter stenosis of calcified lesions was 71.8+/-13.1% at baseline, decrease

151 cantly associated with new ischemic lesions; calcified lesions were negatively associated.

152 Seventy-eight calcified lesions were treated using the Shockwave C(2)

153 4), and 19 additional patients with severely calcified lesions were treated with DA+DCB.

154 Patients with PAH display features of calcified lesions within the distal pulmonary arteries (

155 A+DCB, 81.3% for DCB (P=0.78), and 68.8% for calcified lesions.

156 nd formation of osteoclast-like cells in the calcified lesions.

157 ith a shift toward increasingly fibrotic and calcified lesions.

158 y facilitated stent implantation in severely calcified lesions.

159 In contrast to other studies of calcified macroalgae, however, we observed an increase i

160 or part of the mitral annulus, with markedly calcified margins, and no significant impact on the valv

161 that drove the preferential loss of heavily calcified marine biota.

162 This may be especially important for calcified marine herbivores, such as the pinto abalone (

163 Calcified marine organisms typically experience increase

164 trabeculae, loss of osteocytes, presence of calcified marrow, and elevated expression of osteocalcin

165 Amorphous calcified material (size, 0.55-1.8 mm) was identified in

166 The accumulation of calcified material in cardiovascular tissue is thought t

167 plasma protein involved in the regulation of calcified matrix metabolism.

168 ted tomography are agglomerations of smaller calcified matrix vesicles.

169 od vessels in bone are deeply encased in the calcified matrix, imaging techniques that are applicable

170 ntiated type of chondrocytes that produces a calcified matrix.

171 expression of androgen receptor (AR) in the calcified media of human femoral artery tissue and calci

172 ty, PPV, NPV, and accuracy of hyperdense non-calcified mediastinal and hilar lymph nodes, known as "b

173 Interestingly, while individual polyps calcified more and extended faster at low pH, whole colo

174 Our finding that the most heavily calcified morphotype dominates when conditions are most

175 /-) mice, these mice neither accumulate dead calcified myofibers nor lose ambulation.

176 aces helices A and B with the apo C lobe and calcified N lobe, respectively.

177 ntly higher adsorption coefficients than non-calcified (naked) cells.

178 ed increase in apoptotic chondrocytes in the calcified nasal septum.

179 nd timing of PE episodes in individuals with calcified NCC are variable and commonly chronic, sometim

180 % of the patients with recurrent seizures in calcified neurocysticercosis (NCC).

181 ial prevention and treatments of symptomatic calcified neurocysticercosis (NCC).

182 Serum samples from 39 patients with calcified neurocysticercosis and no viable parasites on

183 The calcified nodule has been suggested as a rare cause of c

184 nning is extremely sensitive and detects non-calcified nodules (NCNs) in 24-50% of subjects, suggesti

185 n, an independent core laboratory identified calcified nodules as distinct calcification with an irre

186 rrored the origin of most thrombotic events, calcified nodules caused fewer major adverse events duri

187 y, distribution, predictors, and outcomes of calcified nodules have never been described.

188 Calcified nodules in untreated nonculprit coronary segme

189 Thus, the prevalence of calcified nodules was 17% per artery and 30% per patient

190 Overall, 314 calcified nodules were detected in 250 of 1573 analyzabl

191 Two or more calcified nodules were detected in 48 coronary arteries

192 The calcified nodules were located <40 mm from the ostium of

193 Patients with calcified nodules were significantly older and had more

194 and 86% of left circumflex arteries, whereas calcified nodules within the right coronary arteries wer

195 usp retraction, stiffening, and formation of calcified nodules.

196 Our results demonstrate that 'calcified' nodules formed from PAVICs grown in OST+TGF-b

197 esence and extent of atherosclerotic plaque (calcified, noncalcified, or mixed), and obstructive lesi

198 are embedded within a matrix that is heavily calcified on the nanoscale.

199 es had higher DeltaT compared with mixed and calcified (p < 0.01) plaques.

200 5 plaques were noncalcified, 8 mixed, and 27 calcified (P=0.005).

201 ting to the development of proliferative and calcified PA lesions.

202 The diagnostic accuracy of CT to detect calcified plaque (83% versus 92%), necrotic core (80% ve

203 The presence and severity of coronary artery calcified plaque (CAC) differs markedly between individu

204 l atherosclerosis imaging of coronary artery calcified plaque (CAC) to the primary prevention of coro

205 plaque (HR, 58.06; P = .005) or exclusively calcified plaque (HR, 32.94; P = .02).

206 -related risk of CHD (CASR), coronary artery calcified plaque (PTPRN2), and kidney function (CDH23, H

207 is, macrophage area, necrotic core area, and calcified plaque area was evaluated by using recursive p

208 ile mixed plaque at coronary CT angiography, calcified plaque at intravascular US, and lipid-rich pla

209 Calcified plaque at the proximal stent edge (relative ri

210 for uptake was significantly associated with calcified plaque burden (P < 0.0001) and cardiovascular

211 Tracer uptake was compared with calcified plaque burden and cardiovascular risk factors.

212 coronary plaque characteristics and overall calcified plaque burden confer an increased risk of coro

213 orded in 188 (47%), any plaque in 214 (53%), calcified plaque in 151 (38%), and noncalcified/mixed pl

214 supplements and measures of subclinical CVD (calcified plaque in the coronary artery, carotid artery,

215 These data illustrate that calcified plaque limited intravascular drug delivery, an

216 respecified endpoints were non-calcified and calcified plaque measures and high risk plaque features

217 e, a proximal segment with either a mixed or calcified plaque or a stenosis >50% is equivalent to a 5

218 However, statin therapy reduced non-calcified plaque volume and high-risk coronary plaque fe

219 Calcified plaque was negatively associated with efaviren

220 es were higher in patients with CAV, whereas calcified plaque was not (median 0.0 vs 0.0, P = .510).

221 therosclerosis was regarded as definite if a calcified plaque was seen in the wall of an artery and p

222 re of noncalcified and calcified plaque, and calcified plaque were significantly higher among men wit

223 cified plaque, a mixture of noncalcified and calcified plaque, and calcified plaque were significantl

224 t or supplements with any of our measures of calcified plaque, and no greater mortality risk was obse

225 alyzed separately: CAC score >0, any plaque, calcified plaque, noncalcified/mixed plaque, segment inv

226 re negatively associated with any plaque and calcified plaque, respectively.

227 o human peripheral arteries with substantial calcified plaque.

228 abetes mellitus mainly led to an increase in calcified plaque.

229 ndent association with annual progression of calcified plaque.

230 1, P=0.002; fibrous plaque: r=0.54, P<0.001; calcified plaque: r=0.59, P<0.001; total plaque: r=0.62,

231 f coronary artery calcium, mixed plaque, and calcified plaque; higher CCL2 levels were associated wit

232 ) and of any plaque; noncalcified, mixed, or calcified plaque; or stenosis on coronary CT angiography

233 ; 95% CI, 0.15-0.85) and more often had only calcified plaques (38% versus 16%; ORadjusted=3.57; 95%

234 he number of proximal segments with mixed or calcified plaques (C-index 0.64, p < 0.0001) and the num

235 Attenuated plaques evolved into calcified plaques after stent implantation.

236 aled fewer mixed plaques and more often only calcified plaques among athletes, suggesting a more beni

237 raphy showed a better agreement with ICA for calcified plaques compared with SR coronary CT angiograp

238 of HRM (defined as noncalcified or partially calcified plaques) in the LMCA.

239 with fewer mixed plaques and more often only calcified plaques.

240 Total plaque index (calcified plus noncalcified plaque) was defined as plaqu

241 ves (n = 52) dissected into noncalcified and calcified portions were subjected to mRNA extraction, re

242 CT angiography revealed a large partially calcified pseudoaneurysm arising from the right lateral

243 ant of (14)C-labeled, declining 5.5-fold per calcified quadrant (p=0.05, n=7).

244 Multivariable analysis identified calcified raphe and excess leaflet calcification (define

245 Calcified raphe and excess leaflet calcification were as

246 Both calcified raphe plus excess leaflet calcification were f

247 ing mediator resolvin E1 was dysregulated in calcified regions and acted as a calcification inhibitor

248 Compared with noncalcified portions, calcified regions exhibited elevated transcripts for CD8

249 METHODS AND DRP1 was enriched in calcified regions of human carotid arteries, examined by

250 entify degrees of cross-linking and detected calcified regions with high chemical specificity, an abi

251 higher in noncalcified regions compared with calcified regions.

252 wever, challenging lesions, such as severely calcified, remain difficult to treat with DCB alone.

253 ally resolve and either disappear or leave a calcified scar that is associated with seizures.

254 establish, and eventually resolve, leaving a calcified scar.

255 Mean calcified segment length was 47.9 +/- 18.8 mm, calcium a

256 4% in noncalcified segments, 15.0% in mildly calcified segments, 27.0% in moderately calcified segmen

257 ldly calcified segments, 27.0% in moderately calcified segments, and 43.0% in severely calcified segm

258 ly calcified segments, and 43.0% in severely calcified segments.

259 on between the secreting mantle edge and the calcified shell edge to which the mantle adheres during

260 ey may require more energy to maintain their calcified shells and acid/base balance with ocean acidif

261 rate, higher salinity regimes, thicker, more calcified shells with a higher aragonite (nacreous layer

262 oach to localize a single component within a calcified skeleton.

263 Calcified skeletons are produced within complex assembla

264 m should calcifying anthozoans exist as less calcified (soft-bodied) forms in future oceans.

265 Hepatomegaly and small calcified spleen are typical findings in older homozygot

266 ing biological uptake and incorporation into calcified structures and, second, that scales may repres

267 Calcified structures such as otoliths and scales grow co

268 brae was reduced by 35%, the strength of the calcified tissue (sigmamax) was proportionate to a 38% i

269 reased in calcified tissue compared with non-calcified tissue and C-allele carriers exhibited increas

270 thickness were reduced, the weakening of the calcified tissue and the geometric component of strength

271 nally, docosahexaenoic acid was decreased in calcified tissue compared with non-calcified tissue and

272 llusc shells (and indeed to any invertebrate calcified tissue).

273 xplained by the location of the magnesium in calcified tissue.

274 is an important chemical repository, making calcified tissues important for measuring exposure.

275 factors, and alkaline phosphatase (Alpl) in calcified tissues of kl/kl mice.

276 (+)/osteocalcin(+) cells in the fibrotic and calcified tissues of nephrogenic systemic fibrosis patie

277 acterise structural remodelling in soft (non-calcified) tissues and to conduct in situ studies of nat

278 In vitro, Runx2(f/f) SMCs calcified to a much greater extent than those derived fr

279 tection of treatment response because of the calcified tumor matrix.

280 ave a greater number of OESs, whereas larger calcified tumors have larger OES diameter.

281 FD-OCT imaging of calcified tumors revealed a distinctive latticework patt

282 lectivity similar to spongy bone was seen in calcified tumors.

283 ence was relatively well preserved overlying calcified tumors.

284 of her left eye white, prominent, partially calcified tumour 1 disc diameter in diameter, 1,5 disc d

285 associated with higher FADS2 mRNA levels in calcified valve tissue, whereas FADS1 mRNA and other tra

286 rim increase was negligible in patients with calcified valves (0.56 +/- 0.85%; p < 0.001) and small e

287 rval [2.1-2.9]; P < 0.0001) in patients with calcified valves (12 +/- 3% at 20 years) relative to the

288 1.50 to 1.85]; p < 0.001), but not severely calcified valves (median 1.51 [IQR: 1.38 to 1.54]; p = 0

289 /4) were obtained in 251 patients (80%) with calcified valves and 661 (93%) with noncalcified valves

290 pression levels of RUNX2 were upregulated in calcified valves and associated with eQTL-SNPs.

291 YKL-40 expression in calcified valves and in an experimental pressure overloa

292 In the 251 patients with calcified valves who had good immediate results, 15-year

293 eter changes are negligible in patients with calcified valves, because tissue properties allow very l

294 dependent calcium channel was upregulated in calcified valves.

295 The presence of no plaques or purely calcified versus noncalcified plaques, plaque volume acc

296 Macrophages associated with regions of calcified vesicular structures in human carotid plaques

297 vascular smooth muscle cells (VSMCs) and in calcified vessels of patients with atherosclerosis, sugg

298 ification have modestly improved outcomes in calcified vessels, adverse event rates are still high.

299 catheters prevent their use in tortuous and calcified vessels.

300 Of particular interest is the finding of calcified vibrissae in Abcc6(-/-) mice, which facilitate

301 The mechanical properties of this calcified weapon enable extremely powerful punches to be